DE560928T1 - Vorrichtung zum behandeln einer lungengefässverengung und von asthma. - Google Patents
Vorrichtung zum behandeln einer lungengefässverengung und von asthma.Info
- Publication number
- DE560928T1 DE560928T1 DE0560928T DE92902708T DE560928T1 DE 560928 T1 DE560928 T1 DE 560928T1 DE 0560928 T DE0560928 T DE 0560928T DE 92902708 T DE92902708 T DE 92902708T DE 560928 T1 DE560928 T1 DE 560928T1
- Authority
- DE
- Germany
- Prior art keywords
- nitric oxide
- gas
- compound
- lumen
- vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000006673 asthma Diseases 0.000 title claims 3
- 238000010276 construction Methods 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims abstract 38
- 241000124008 Mammalia Species 0.000 claims abstract 8
- 239000002840 nitric oxide donor Substances 0.000 claims abstract 8
- 230000008695 pulmonary vasoconstriction Effects 0.000 claims abstract 4
- 206010006482 Bronchospasm Diseases 0.000 claims abstract 3
- 230000007885 bronchoconstriction Effects 0.000 claims abstract 3
- 239000007789 gas Substances 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 13
- 238000013270 controlled release Methods 0.000 claims 5
- 239000008177 pharmaceutical agent Substances 0.000 claims 5
- 239000003380 propellant Substances 0.000 claims 5
- WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 claims 4
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 4
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 4
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims 4
- XOWVFANEOZMPKG-REOHCLBHSA-N S-nitroso-L-cysteine Chemical compound OC(=O)[C@@H](N)CSN=O XOWVFANEOZMPKG-REOHCLBHSA-N 0.000 claims 4
- YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 claims 4
- 150000001540 azides Chemical class 0.000 claims 4
- 229960003711 glyceryl trinitrate Drugs 0.000 claims 4
- OWFXIOWLTKNBAP-UHFFFAOYSA-N isoamyl nitrite Chemical compound CC(C)CCON=O OWFXIOWLTKNBAP-UHFFFAOYSA-N 0.000 claims 4
- 229960002460 nitroprusside Drugs 0.000 claims 4
- 210000002345 respiratory system Anatomy 0.000 claims 4
- 239000004599 antimicrobial Substances 0.000 claims 3
- 230000004199 lung function Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- ZIIQCSMRQKCOCT-YFKPBYRVSA-N S-nitroso-N-acetyl-D-penicillamine Chemical compound CC(=O)N[C@@H](C(O)=O)C(C)(C)SN=O ZIIQCSMRQKCOCT-YFKPBYRVSA-N 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229960001639 penicillamine Drugs 0.000 claims 2
- PFWLFWPASULGAN-UHFFFAOYSA-N 7-methylxanthine Chemical compound N1C(=O)NC(=O)C2=C1N=CN2C PFWLFWPASULGAN-UHFFFAOYSA-N 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 208000000203 Hyaline Membrane Disease Diseases 0.000 claims 1
- 208000032571 Infant acute respiratory distress syndrome Diseases 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 206010028974 Neonatal respiratory distress syndrome Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960000265 cromoglicic acid Drugs 0.000 claims 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000002652 newborn respiratory distress syndrome Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 claims 1
- 229960004448 pentamidine Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Glass Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Exhaust Gas Treatment By Means Of Catalyst (AREA)
Claims (38)
1. Verwendung einer Stickoxidquelle bei der Herstellung eines inhalierbaren Medikamentes zur Verbesserung der
Lungenfunktion in einem Säuger.
2. Verwendung einer Stickoxidquelle bei der Herstellung
einer zur Verbesserung der Lungenfunktion in einem Säuger nützlichen Vorrichtung.
3. Verwendung einer Stickoxidquelle bei der Herstellung eines bei der Diagnose der Heilbarkeit chronischer
pulmonaler Vasokonstriktion in einem Säuger nützlichen
Diagnosemittels.
4. Verwendung nach Anspruch 1 oder 2, wobei der Säuger an pulmonaler Vasokonstriktion leidet.
5. Verwendung nach Anspruch 1 oder 2, worin der Säuger an Bronchokonstrxktion leidet.
6. Verwendung nach Anspruch 1, worin das inhalierbare
Medikament Stickoxidgas enthält.
7. Verwendung nach Anspruch 2, worin die Vorrichtung Stickoxidgas enthält.
8. Verwendung nach Anspruch 3, worin das Diagnosemittel eine Mischung aus Gasen, einschließlich Stickoxidgas, ist.
9. Verwendung nach einem der Ansprüche 1-5, worin die
Stickoxidquelle eine stickoxidfreisetzende Verbindung ist.
10. Verwendung nach Anspruch 9, worin es sich bei der stickoxidfreisetzenden Verbindung um S-Nitroso-N-acety!penicillamin,
S-Nitrosocystein, Nitroprussid, Nitrosoguanidin, GIy&zgr;eryltrinitrat, Isoamylnitrit,
anorganisches Nitrit, Azid oder Hydroxylamin handelt.
11. Verwendung nach Anspruch 7, worin die Vorrichtung zur Erleichterung der Einführung von Stickoxid in die Lungen
des Säugers ausgelegt ist.
12. Verwendung nach Anspruch 5, worin die Bronchokonstriktion mit Asthma in Zusammenhang steht.
13. Vorrichtung mit einer Stickoxidquelle und Anweisungen zum
Gebrauch dieser zur Verbesserung der Lungenfunktion.
14. Vorrichtung nach Anspruch 13, worin die Stickstoffquelle
ein Behälter komprimierten Gases ist.
15. Vorrichtung nach Anspruch 13, worin die Stickoxidquelle eine stickoxidfreisetzende Verbindung ist.
16. Vorrichtung nach Anspruch 13, worin die Anweisungen die Inhalation des Stickoxids oder der Stickoxidquelle
vorschreiben.
17. Inhalatorvorrichtung mit:
einem Gefäß, das Druckgas mit mindestens 1 ppm Stickoxid enthält;
einem Gehäuse, das ein Lumen definiert, wobei das Gefäß am Gehäuse befestigt ist, um das Gas in das Lumen
einzuleiten; und
einen Mechanismus zur kontrollierten Freisetzung des Gases aus dem Gefäß in das Lumen;
wobei das Lumen so konfiguriert ist, daß es das freigesetzte Gas in den Respirationstrakt einer Person einleitet,
und die Vorrichtung weniger als ca. 5 kg wiegt.
18. Vorrichtung nach Anspruch 17, wobei die Vorrichtung weniger als ca. 1 kg wiegt.
19. Vorrichtung nach Anspruch 17, wobei das Druckgas zusätzlich N2 umfaßt.
20. Vorrichtung nach Anspruch 17, worin das Lumen eine Rückatmungskammer umfaßt.
21. Vorrichtung nach Anspruch 17, worin das Gefäß zusätzlich ein verflüssigtes Treibmittel enthält.
22. Inhalatorvorrichtung mit
einem Gehäuse, das (a) eine einen inhalierbaren pharmazeutischen Wirkstoff enthaltende Kammer und (b) ein
mit dieser Kammer in Verbindung stehendes Lumen definiert ; und
ein Gefäß, das Druckgas mit mindestens l ppm Stickoxid
enthält, wobei das Gefäß einen Mechanismus zur kontrollierten Freisetzung des Gases in die Kammer aufweist,
wodurch der Wirkstoff im freigesetzten Gas suspendiert wird; wobei das Lumen so konfiguriert ist, daß es das
freigesetzte Gas in den Respirationstrakt eines Patienten leitet.
23. Vorrichtung nach Anspruch 22, wobei der pharmazeutische Wirkstoff eine Bronchodilatator-Verbindung in flüssiger
oder fester Form umfaßt.
24. Vorrichtung nach Anspruch 23, worin die Verbindung ein Anticholinergikum, einen ß2-Agonisten, ein Methylxanthin,
einen Calciumkanalblocker, einen Glukokortikoid-Wirkstoff oder Cromolynnatrium umfaßt.
25. Vorrichtung nach Anspruch 22, wobei der pharmazeutische Wirkstoff eine stickoxidfreisetzende Verbindung umfaßt.
26. Vorrichtung nach Anspruch 25, worin die Verbindung aus der Gruppe ausgewählt ist, die aus S-Nitroso-N-acetylpenicillamin,
S-Nitrosocystein, Nitroprussid, Nitrosoguanidin, Glyceryltrinitrat, Isoamylnitrit, anorganischem
Nitrit, Azid und Hydroxylamin besteht.
27. Vorrichtung nach Anspruch 22, worin der pharmazeutische Wirkstoff ein Antimikrobiotikum umfaßt.
28. Vorrichtung nach Anspruch 27, worin das Antimikrobiotikum ein Antibiotikum umfaßt.
29. Vorrichtung nach Anspruch 27, worin das Antimikrobiotikum Pentamidin umfaßt.
30. Vorrichtung nach Anspruch 22, worin der pharmazeutische Wirkstoff ein oberflächenaktives Mittel umfaßt, das zur
Behandlung von Hyalin-Membran-Krankheit geeignet ist.
31. Vorrichtung nach Anspruch 22, worin das Gefäß auch einen Mechanismus zur kontrollierter Freisetzung des Gases in
das Lumen aufweist, auf eine Art und Weise, bei der die Kammer umgangen wird.
32. Vorrichtung mit
einem eine Stickoxiddonatorverbindung, die in einem komprimierten oder verflüssigten Treibgas suspendiert
ist, enthaltenden Gefäß;
einem Gehäuse, das (a) eine Öffnung, auf der das Gefäß angeordnet ist, und (b) ein Lumen, das mit dieser
Öffnung in Verbindung steht, definiert; und
einem Mechanismus zur kontrollierten Freisetzung des Treibmittels aus dem Gefäß in das Lumen, wodurch die suspendierte
Verbindung aus dem Gefäß in das Lumen hinein freigesetzt wird;
wobei das Lumen so konfiguriert ist, daß es die im freigesetzten Treibmittel suspendierte Verbindung in den
Respirationstrakt einer Person leitet.
33. Vorrichtung nach Anspruch 32, worin die Verbindung in Pulverform vorliegt.
34. Vorrichtung nach Anspruch 32, worin die Verbindung in einem biologisch-kompatiblen flüssigen Träger aufgelöst
oder suspendiert ist.
35. Vorrichtung nach Anspruch 32, worin es sich bei der Verbindung um S-Nitroso-N-acety!penicillamin, S-Nitrosocystein,
Nitroprussid, Nitrosoguanidin, Glyceryltrinitrat, isoamylnitrit, anorganisches Nitrit, Azid oder
Hydroxylamin handelt.
36. Vorrichtung mit:
einem Gefäß, das ein komprimiertes oder verflüssigtes Treibgas enthält;
einem Gehäuse, das (a) eine Kammer, welche eine Stickoxiddonatorverbindung enthält, und (b) ein Lumen,
das in Verbindung mit dieser Kammer steht, definiert;
einem Mechanismus zur kontrollierten Freisetzung von Gas aus dem Gefäß in die Kammer, wodurch die Verbindung
in dem Gas suspendiert wird,
wobei das Lumen so konfiguriert ist, daß es die Verbindung in den Respirationstrakt einer Person leitet.
37. Vorrichtung nach Anspruch 36, worin das Gas Stickoxidgas umfaßt.
38. Vorrichtung nach Anspruch 36, worin es sich bei der Stickoxiddonatorverbindung um S-Nitroso-N-acetylpenicillamin,
S-Nitrosocystein, Nitroprussid, Nitrosoguanidin, Glyceryltrinitrat, Isoamylnitrit, anorganisches
Nitrit, Azid oder Hydroxylamin handelt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62286590A | 1990-12-05 | 1990-12-05 | |
| US76723491A | 1991-09-27 | 1991-09-27 | |
| PCT/US1991/009111 WO1992010228A1 (en) | 1990-12-05 | 1991-12-05 | Devices for treating pulmonary vasoconstriction and asthma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE560928T1 true DE560928T1 (de) | 1994-09-22 |
Family
ID=27089304
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE200812000012 Active DE122008000012I2 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefassverengung und von Asthma. |
| DE69127756T Expired - Lifetime DE69127756T2 (de) | 1990-12-05 | 1991-12-05 | Verwendung von no zur behandlung oder prävention der bronchokonstriktion |
| DE69133575T Expired - Lifetime DE69133575T2 (de) | 1990-12-05 | 1991-12-05 | Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen |
| DE69133584A Expired - Lifetime DE69133584D1 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma |
| DE0560928T Pending DE560928T1 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum behandeln einer lungengefässverengung und von asthma. |
| DE69133584T Expired - Lifetime DE69133584T4 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma |
| DE122007000103C Pending DE122007000103I1 (de) | 1990-12-05 | 1991-12-05 | Verwendung von NO zur Behandlung der persistenten pulmonalen Hypertonie des Neugeborenen |
| DE0786264T Pending DE786264T1 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma |
| DE2002199002 Pending DE10299002I1 (de) | 1990-12-05 | 1991-12-05 | Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE200812000012 Active DE122008000012I2 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefassverengung und von Asthma. |
| DE69127756T Expired - Lifetime DE69127756T2 (de) | 1990-12-05 | 1991-12-05 | Verwendung von no zur behandlung oder prävention der bronchokonstriktion |
| DE69133575T Expired - Lifetime DE69133575T2 (de) | 1990-12-05 | 1991-12-05 | Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen |
| DE69133584A Expired - Lifetime DE69133584D1 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69133584T Expired - Lifetime DE69133584T4 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma |
| DE122007000103C Pending DE122007000103I1 (de) | 1990-12-05 | 1991-12-05 | Verwendung von NO zur Behandlung der persistenten pulmonalen Hypertonie des Neugeborenen |
| DE0786264T Pending DE786264T1 (de) | 1990-12-05 | 1991-12-05 | Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma |
| DE2002199002 Pending DE10299002I1 (de) | 1990-12-05 | 1991-12-05 | Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5873359A (de) |
| EP (4) | EP1875917A3 (de) |
| JP (3) | JP2701978B2 (de) |
| AT (3) | ATE367842T2 (de) |
| AU (1) | AU657726B2 (de) |
| CA (1) | CA2097823C (de) |
| DE (9) | DE122008000012I2 (de) |
| DK (3) | DK1516639T4 (de) |
| EE (1) | EE03119B1 (de) |
| ES (3) | ES2082732T3 (de) |
| GR (3) | GR960300032T1 (de) |
| HK (3) | HK1010101A1 (de) |
| LU (3) | LU90886I2 (de) |
| LV (1) | LV12201B (de) |
| NL (3) | NL300081I2 (de) |
| SG (1) | SG47527A1 (de) |
| WO (1) | WO1992010228A1 (de) |
Families Citing this family (261)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1516639T4 (en) * | 1990-12-05 | 2015-06-29 | Gen Hospital Corp | Use of NO to treat persistent pulmonary hypertension in newborns |
| US5570683A (en) * | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
| GB9027234D0 (en) * | 1990-12-15 | 1991-02-06 | Harris Pharma Ltd | An inhalation device |
| US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| AU651882B2 (en) * | 1991-05-14 | 1994-08-04 | Visiomed Group Limited | Aerosol inhalation device |
| US6029661A (en) * | 1991-08-26 | 2000-02-29 | 3M Innovative Properties Company | Powder dispenser |
| DE4208880A1 (de) * | 1992-03-19 | 1993-09-23 | Boehringer Ingelheim Kg | Separator fuer pulverinhalatoren |
| FR2695831B1 (fr) * | 1992-09-24 | 1994-11-10 | Air Liquide | Installation et procédé de fourniture d'un mélange gazeux aux voies respiratoires d'un utilisateur. |
| US5427797A (en) * | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
| WO1994023772A2 (en) * | 1993-04-06 | 1994-10-27 | Minnesota Mining And Manufacturing Company | Deagglomerators for dry powder inhalers |
| ATE204491T1 (de) * | 1993-04-17 | 2001-09-15 | Messer Griesheim Austria Ges M | Gerät zur kontrollierten zudosierung von no zur atemluft von patienten |
| DK0724723T3 (da) * | 1993-07-06 | 2000-10-23 | Kjell Alving | System til bestemmelse af NO-Nivveauer i udåndet luft og diagnostiske metoder til forstyrrelser relateret tilunormale NO-ni |
| SE501074C2 (sv) * | 1993-07-22 | 1994-11-07 | Siemens Elema Ab | Gasblandning och apparat för att tillföra gasblandningen till lungorna hos ett levande väsen |
| DE4327732C1 (de) * | 1993-08-18 | 1994-09-01 | Messer Griesheim Gmbh | NO-haltiges Gasgemisch zur Behandlung pulmonaler Erkrankungen |
| DE4327731C1 (de) * | 1993-08-18 | 1994-11-10 | Messer Griesheim Gmbh | NO-haltiges Gasgemisch zur Behandlung pulmonaler Erkrankungen |
| GB9320978D0 (en) * | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
| US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
| JP3911290B2 (ja) * | 1994-05-13 | 2007-05-09 | アラダイム コーポレーション | エアゾールを含む麻酔用処方 |
| DE4419860A1 (de) * | 1994-06-07 | 1995-12-14 | Hoechst Ag | Verfahren und Filter zur Herstellung von NO¶2¶-freiem Stickstoffmonoxid mit schwefelhaltigen Polymeren |
| US5615669A (en) * | 1994-07-22 | 1997-04-01 | Siemens Elema Ab | Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject |
| US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
| US5665077A (en) * | 1995-04-24 | 1997-09-09 | Nitrosci Pharmaceuticals Llc | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis |
| SE506208C2 (sv) | 1995-07-05 | 1997-11-24 | Aerocrine Systems Kb | Anordning för uppsamling av gas från de övre luftvägarna och leverans av denna gas till inandningsluften i en respirator |
| RU2072241C1 (ru) * | 1995-09-20 | 1997-01-27 | Панина Елена Владимировна | Способ формирования дыхательной газовой смеси и аппарат для его осуществления |
| DE69618133T2 (de) * | 1995-10-13 | 2002-07-11 | Siemens-Elema Ab, Solna | Trachealtubus und Vorrichtung für Beatmungssysteme |
| EP0855912B1 (de) * | 1995-10-20 | 2001-12-05 | L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude | Pharmazeutische zusammensetzung von stickstoffmonoxid |
| AU7529796A (en) * | 1995-11-13 | 1997-06-05 | Brigham And Women's Hospital | S-nitroso-hemoglobin and therapeutic uses thereof |
| US5699790A (en) * | 1996-03-21 | 1997-12-23 | Ohmeda Inc. | System for predicting NO2 concentrations |
| ATE331505T1 (de) * | 1996-04-05 | 2006-07-15 | Gen Hospital Corp | Behandlung einer hämoglobinstörung |
| US5765548A (en) * | 1996-05-07 | 1998-06-16 | Perry; Bryan J. | Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equine |
| US5811437A (en) * | 1996-05-21 | 1998-09-22 | Eli Lilly And Company | Methods of increasing nitric oxide synthesis |
| US5732694A (en) * | 1996-12-13 | 1998-03-31 | Ohmeda Inc. | System for correcting NO2 monitor |
| CA2206477A1 (en) | 1996-07-10 | 1998-01-10 | Ohmeda Inc. | System for correcting no2 monitor |
| US6720309B1 (en) * | 1996-07-17 | 2004-04-13 | Leuven Research And Development, V.Z.W. | Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene |
| CA2260771A1 (en) * | 1996-07-17 | 1998-01-22 | The General Hospital Corporation | Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene |
| JP3880103B2 (ja) * | 1996-07-18 | 2007-02-14 | 住友精化株式会社 | 医療用一酸化窒素混合ガスおよびその製造方法 |
| SE506778C2 (sv) * | 1996-08-12 | 1998-02-09 | Siemens Elema Ab | Förfarande vid blandning av gaser och en anordning för blandning av gaser |
| WO1998007020A1 (en) * | 1996-08-13 | 1998-02-19 | University Of Massachusetts | Nitric oxide sensor |
| DE19734279A1 (de) * | 1997-08-07 | 1999-02-11 | Messer Griesheim Gmbh | Wasserstoffhaltiges Medikament |
| US5732693A (en) | 1996-10-02 | 1998-03-31 | Ohmeda Inc. | Pause control of nitric oxide therapy |
| JP2001517108A (ja) | 1997-01-17 | 2001-10-02 | メッサー オーストリア ゲゼルシャフト ミット ベシュレンクテル ハフツング | 制御されるガス供給システム |
| US6027713A (en) * | 1997-03-06 | 2000-02-22 | Meri Charmyne Russell | Composition and method for the treatment of exercise induced pulmonary hemorrhage |
| SE9700940D0 (sv) * | 1997-03-14 | 1997-03-14 | Astra Ab | Powder inhaler IV |
| CA2225013C (en) | 1997-04-04 | 2006-06-06 | Institut Du N.O. Inc. | Injection system for delivery of a gaseous substance |
| WO1998046277A2 (en) * | 1997-04-16 | 1998-10-22 | Ohmeda, Inc. | Humidity compensation for fuel cell zeroing in respiratory gas measurement |
| US5918596A (en) * | 1997-04-22 | 1999-07-06 | Instrumentarium Corp. | Special gas dose delivery apparatus for respiration equipment |
| FR2762992B1 (fr) * | 1997-05-07 | 2000-08-25 | Air Liquide | Transporteurs de no a base de complexes polyazamacrocycles de fer et de cobalt |
| US6125846A (en) * | 1997-05-16 | 2000-10-03 | Datex-Ohmeda, Inc. | Purge system for nitric oxide administration apparatus |
| US6656452B1 (en) | 1997-10-21 | 2003-12-02 | The General Hospital Corporation | Use of inhaled NO as anti-inflammatory agent |
| US6109260A (en) * | 1998-02-18 | 2000-08-29 | Datex-Ohmeda, Inc. | Nitric oxide administration device with timed pulse |
| US6142147A (en) * | 1998-03-31 | 2000-11-07 | The General Hospital Corporation | Nasal delivery system for inhaled nitric oxide |
| CA2254645A1 (en) * | 1998-11-23 | 2000-05-23 | Pulmonox Medical Corporation | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
| US20070086954A1 (en) * | 1998-11-23 | 2007-04-19 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
| JP3641151B2 (ja) * | 1999-02-04 | 2005-04-20 | 帝人株式会社 | 治療用ガス投入用呼吸マスク |
| US9486429B2 (en) * | 1999-06-01 | 2016-11-08 | Vanderbilt University | Therapeutic methods employing nitric oxide precursors |
| US6346382B1 (en) | 1999-06-01 | 2002-02-12 | Vanderbilt University | Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto |
| FR2795644B1 (fr) * | 1999-07-02 | 2004-07-30 | Air Liquide Sante Int | Utilisations therapeutiques d'un melange helium/oxygene, en particulier dans le traitement de l'asthme |
| CA2375679C (en) * | 1999-07-12 | 2008-09-23 | Capnia, Incorporated | Methods and apparatus for relieving headaches, rhinitis and other common ailments |
| CA2680378C (en) * | 1999-08-02 | 2013-09-24 | Duke University | Method for determining physiological effects of hemoglobin |
| US7045152B2 (en) * | 1999-09-08 | 2006-05-16 | Duke University | Treating pulmonary disorders with gaseous agent causing repletion of GSNO |
| US6314956B1 (en) * | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
| US6694969B1 (en) | 1999-09-22 | 2004-02-24 | Instrumentarium Corp. | Method to improve oxygenation in subjects suffering impaired oxygenation |
| DE60027403T2 (de) | 1999-09-22 | 2006-10-19 | Instrumentarium Corp. | Verbesserung der Sauerstoffversorgung in Lebewesen mit gestörter Sauerstoffversorgung |
| US6612306B1 (en) | 1999-10-13 | 2003-09-02 | Healthetech, Inc. | Respiratory nitric oxide meter |
| CA2388979C (en) | 1999-10-29 | 2010-09-14 | Orion Corporation | Treatment or prevention of hypotension and shock with use of an imidazole derivative |
| SE9903985D0 (sv) * | 1999-11-03 | 1999-11-03 | Aga Ab | Use of nitric oxide |
| US20070039615A1 (en) * | 1999-11-08 | 2007-02-22 | Capnia, Incorporated | Methods and apparatus for treating rhinitis |
| US6959708B1 (en) * | 1999-11-08 | 2005-11-01 | Capnia, Incorporated | Method for co-application of gases and drugs to potentiate their action in relieving headaches, angina and other ailments |
| US20060172017A1 (en) | 1999-11-08 | 2006-08-03 | Capnia, Incorporated | Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces |
| US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| US6581599B1 (en) * | 1999-11-24 | 2003-06-24 | Sensormedics Corporation | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients |
| US6758214B2 (en) | 2000-01-28 | 2004-07-06 | Cyterra Corporation | Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment |
| JP2003531123A (ja) * | 2000-04-13 | 2003-10-21 | イノバータ・バイオミッド・リミテッド | 医薬品 |
| US6601580B1 (en) * | 2000-06-28 | 2003-08-05 | The General Hospital Corporation | Enhancing therapeutic effectiveness of nitric oxide inhalation |
| US6951215B1 (en) * | 2000-07-14 | 2005-10-04 | Tufts University | Drug delivery device for animals |
| AU8484901A (en) * | 2000-08-11 | 2002-02-25 | David R Whitlock | Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same |
| WO2002026112A2 (en) | 2000-09-29 | 2002-04-04 | Healthetech, Inc. | Indirect calorimetry system |
| US6668828B1 (en) | 2000-10-16 | 2003-12-30 | Pulmonox Technologies Corporations | System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient |
| SE0004229D0 (sv) * | 2000-11-17 | 2000-11-17 | Aga Ab | Inhalation of nitric oxide |
| US7335181B2 (en) * | 2000-12-26 | 2008-02-26 | Pulmonox Technologies Corporation | Nitric oxide decontamination of the upper respiratory tract |
| US6432077B1 (en) * | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
| US7122018B2 (en) * | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
| AUPR315401A0 (en) * | 2001-02-16 | 2001-03-15 | Resmed Limited | An apparatus for supplying clean breathable gas |
| WO2002087673A1 (de) * | 2001-04-25 | 2002-11-07 | Messer Austria Gmbh | Aerosoldosiergerät |
| US6749834B2 (en) * | 2001-06-19 | 2004-06-15 | World Precision Instruments, Inc. | Methods and apparatus for therapeutic treatment of respiratory, cardiac and other pathologies |
| EP2565157B1 (de) | 2001-09-05 | 2017-10-04 | Geno LLC | Stickoxid-erzeugung |
| US6575918B2 (en) | 2001-09-27 | 2003-06-10 | Charlotte-Mecklenburg Hospital | Non-invasive device and method for the diagnosis of pulmonary vascular occlusions |
| US20030070674A1 (en) * | 2001-10-12 | 2003-04-17 | Bryan Perry | Use of aerosolized compounds in the treatment of exercise induced pulmonary hemorrhage in an equine |
| GB0125222D0 (en) * | 2001-10-19 | 2001-12-12 | Barts & London Nhs Trust | Composition for the treatment of microbial infections |
| US20040110691A1 (en) * | 2001-11-13 | 2004-06-10 | Stamler Jonathan S. | Thiol reactive agents as a therapeutic modality |
| US6472390B1 (en) * | 2001-11-13 | 2002-10-29 | Duke University | Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure |
| US6627602B2 (en) * | 2001-11-13 | 2003-09-30 | Duke University | Preventing desensitization of receptors |
| US20050244382A9 (en) * | 2002-01-11 | 2005-11-03 | Whitlock David R | Compositions including ammonia oxidizing bacteria and methods of using same |
| US20030170223A1 (en) * | 2002-02-01 | 2003-09-11 | Board Of Trustees Of Michigan State University | Pulmonary vasodilator surfactant compositions and method of use |
| US7086397B2 (en) * | 2002-02-16 | 2006-08-08 | Graham Lindley Spruiell | Patient usable emergency medical kit |
| WO2003102575A1 (en) * | 2002-05-29 | 2003-12-11 | Duke University | Measuring nitric oxide in blood gases and treatments based thereon |
| MXPA04012863A (es) * | 2002-06-21 | 2005-03-31 | Univ Pittsburgh | Uso farmaceutico de oxido nitrico, heme oxigenasa-1 y productos de degradacion de heme. |
| EP3335752A1 (de) * | 2002-06-28 | 2018-06-20 | The Research Foundation of the State University of New York | Therapeutikumausgabevorrichtung und -verfahren |
| US7337776B2 (en) * | 2002-08-20 | 2008-03-04 | Aga Ab | Methods for easing pain and anxiety from atrial or ventricular defibrillation |
| US7681572B2 (en) * | 2002-08-20 | 2010-03-23 | Aga Ab | Method and devices for administration of therapeutic gases |
| AU2003259897B2 (en) * | 2002-08-20 | 2008-04-03 | Aga Ab | Methods and devices for administration of therapeutic gases |
| US8001962B2 (en) * | 2002-08-23 | 2011-08-23 | Sheiman Ultrasonic Research Foundation Pty Ltd. | Nebulizing and drug delivery device |
| US7828739B2 (en) * | 2002-08-27 | 2010-11-09 | Precision Pulsus, Inc. | Apnea detection system |
| US6869402B2 (en) * | 2002-08-27 | 2005-03-22 | Precision Pulsus, Inc. | Method and apparatus for measuring pulsus paradoxus |
| US7531133B2 (en) * | 2002-09-10 | 2009-05-12 | Pulmonox Technologies Corporation | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
| WO2004032964A1 (ja) * | 2002-10-10 | 2004-04-22 | Ono Pharmaceutical Co., Ltd. | アレルギー性疾患治療剤 |
| US9138707B2 (en) | 2002-12-10 | 2015-09-22 | Sy Kimball | Portable, nitric oxide generator |
| CA2413834A1 (en) | 2002-12-10 | 2004-06-10 | 1017975 Alberta Limited | Nitric oxide gas generator |
| SE0300971D0 (sv) * | 2003-04-03 | 2003-04-03 | Aga Ab | Nitric oxide in treatment of inflammation |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| BRPI0414813A (pt) * | 2003-09-26 | 2006-11-14 | David R Whitlock | método para o uso de bactéria que oxidam a amÈnia |
| US7552731B2 (en) * | 2003-11-14 | 2009-06-30 | Remcore, Inc. | Remote control gas regulation system |
| WO2005077005A2 (en) * | 2004-02-04 | 2005-08-25 | The General Hospital Corporation | Enhancing the effectiveness of an inhaled therapeutic gas |
| US20050191245A1 (en) * | 2004-02-27 | 2005-09-01 | Adams Christopher P. | Nasal administration of calcium channel, blockers for treatment of hypertension and other cardiovascular disorders |
| JP2007526316A (ja) * | 2004-03-01 | 2007-09-13 | ルーメン セラピューティックス リミテッド ライアビリティ カンパニー | 疾患を処置するための組成物および方法 |
| US7994225B2 (en) * | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
| WO2005089738A2 (en) * | 2004-03-17 | 2005-09-29 | Mpex Pharmaceuticals, Inc. | Use and administration of bacterial efflux pump inhibitors |
| JP2007537267A (ja) * | 2004-05-11 | 2007-12-20 | センサーメディックス・コーポレイション | 一酸化窒素ガスの間欠的投与 |
| US8518457B2 (en) * | 2004-05-11 | 2013-08-27 | Pulmonox Technologies Corporation | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
| US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| EP1789119B1 (de) * | 2004-08-18 | 2017-10-18 | Geno LLC | Umwandlung von stickstoffdioxid (no2) zu stickoxid (no) |
| US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7814901B2 (en) * | 2005-03-09 | 2010-10-19 | Ric Investments, Llc | Nebulizing drug delivery device with increased flow rate |
| US7721729B2 (en) * | 2005-03-09 | 2010-05-25 | Ric Investments, Llc | Nebulizing drug delivery device for ventilator |
| US7631643B2 (en) | 2005-03-09 | 2009-12-15 | Ric Investments, Llc | Nebulizing drug delivery device with interlock detection and temperature protection |
| US8056557B2 (en) * | 2005-03-09 | 2011-11-15 | Ric Investments, Llc | Nebulizing drug delivery device with barrier |
| WO2006125123A2 (en) * | 2005-05-19 | 2006-11-23 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
| EP2021131B1 (de) * | 2005-05-23 | 2011-07-13 | Biosonic Australia Pty. Ltd. | Vorrichtung zur zerstäubung und flüssigkeitsfiltration |
| US7523752B2 (en) | 2005-09-21 | 2009-04-28 | Ino Therapeutics, Llc | System and method of administering a pharmaceutical gas to a patient |
| US8893717B2 (en) | 2005-09-21 | 2014-11-25 | Ino Therapeutics Llc | Systems and methods of administering a pharmaceutical gas to a patient |
| US7566308B2 (en) * | 2005-10-13 | 2009-07-28 | Cardiac Pacemakers, Inc. | Method and apparatus for pulmonary artery pressure signal isolation |
| US20070116785A1 (en) * | 2005-11-18 | 2007-05-24 | Miller Christopher C | Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant |
| EP1962869B1 (de) * | 2005-12-21 | 2013-03-20 | SolAeroMed Inc. | Behandlung von atemwegserkrankungen |
| US8790715B2 (en) | 2006-02-16 | 2014-07-29 | Ino Therapeutics Llc | Method and apparatus for generating nitric oxide for medical use |
| US20100313883A1 (en) * | 2006-04-20 | 2010-12-16 | Koninklijke Philips Electronics N.V. | Ultrasonic bebulilzer with metal coated ultrasonic genrator |
| US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| EP1903003B1 (de) | 2006-07-05 | 2017-07-05 | BSN medical GmbH | Verfahren zur photolytischen Erzeugung von Stickstoffmonoxid |
| US8079998B2 (en) * | 2006-10-20 | 2011-12-20 | Pulmonox Technologies Corporation | Methods and devices for the delivery of therapeutic gases including nitric oxide |
| US8887721B2 (en) * | 2006-11-07 | 2014-11-18 | The General Hospital Corporation | Attenuation of vasoactive oxygen carrier-induced vasoconstriction |
| WO2008079993A2 (en) * | 2006-12-22 | 2008-07-03 | Ikaria, Inc. | Combinations of nitric oxide and sulfide and methods of use and manufacture thereof |
| US20080193566A1 (en) * | 2007-02-09 | 2008-08-14 | Miller Christopher C | Use of high dose concentrations of gaseous nitric oxide |
| US8176915B2 (en) * | 2007-03-15 | 2012-05-15 | Koninklijke Philips Electronics N.V. | End-tidal gas estimation system and method |
| US8166971B2 (en) * | 2007-03-15 | 2012-05-01 | Ric Investments, Llc | End-tidal gas estimation system and method |
| CA2681308C (en) | 2007-03-23 | 2015-11-24 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| WO2009048521A1 (en) * | 2007-10-11 | 2009-04-16 | Duke University | Potentiating the effect of compound comprising nitric oxide |
| EP2534957B1 (de) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Abgabe von Aerosol-sprühbaren Produkten |
| WO2009086470A2 (en) * | 2007-12-27 | 2009-07-09 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide - donating compounds and uses thereof |
| EP2247381B1 (de) | 2008-01-28 | 2016-11-30 | Geno LLC | Umwandlung von stickstoffdioxid (no2) in stickstoffmonoxid (no) |
| US9649467B2 (en) | 2008-01-31 | 2017-05-16 | Syk Technologies, Llc | Nitric oxide reactor and distributor apparatus and method |
| DK2247297T3 (en) * | 2008-01-31 | 2019-03-11 | Univ Vanderbilt | THERAPEUTIC TREATMENT OF LUNG CONDITIONS |
| JP5623916B2 (ja) | 2008-01-31 | 2014-11-12 | バンダービルト・ユニバーシティＶａｎｄｅｒｂｉｌｔ Ｕｎｉｖｅｒｓｉｔｙ | 動脈瘤性くも膜下出血及び血管痙攣に対する医薬組成物 |
| US8720436B2 (en) * | 2008-01-31 | 2014-05-13 | Genosys, Inc. | Nitric oxide gel apparatus and method |
| US8434475B2 (en) | 2008-01-31 | 2013-05-07 | Genosys, Inc. | Nitric oxide reactor and distributor apparatus and method |
| US8501090B2 (en) * | 2008-03-24 | 2013-08-06 | Christian S. Minton | Anti-microbial gas apparatus and method |
| US20100040703A1 (en) * | 2008-08-13 | 2010-02-18 | Chris Miller | Use of nitric oxide |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| US10780241B2 (en) * | 2008-08-21 | 2020-09-22 | Vero Biotech LLC | Devices and methods for minimizing and treating high-altitude sickness |
| US10960168B2 (en) | 2008-08-21 | 2021-03-30 | Vero Biotech LLC | Delivery of high concentration nitric oxide |
| GB2463883A (en) * | 2008-09-25 | 2010-03-31 | Pharma Patents Ltd | A pharmaceutical composition comprising an A-SMase inhibitor and an NO-donor |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| AU2010248776B2 (en) * | 2009-05-15 | 2013-06-06 | Baudax Bio, Inc. | Sublingual dexmedetomidine compositions and methods of use thereof |
| KR101567125B1 (ko) | 2009-05-27 | 2015-11-06 | 이노 테라퓨틱스 엘엘씨 | 인덱싱된 밸브와 압축 캐니스터 조립체를 칼라에 결합하고 플런저 조립체로 선형 작동시켜 약물 전달 조절용 장치와 유체 소통상태가 되게 하는 방법 및 장치 |
| CA2763804C (en) | 2009-06-22 | 2018-02-06 | Geno Llc | Nitric oxide therapies |
| JP2011010865A (ja) | 2009-06-30 | 2011-01-20 | Ikaria Holdings Inc | 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法 |
| WO2011063335A1 (en) * | 2009-11-20 | 2011-05-26 | Geno Llc | Nitric oxide delivery system |
| JP5911475B2 (ja) | 2010-04-26 | 2016-04-27 | ゲノ エルエルシー | 超高純度一酸化窒素（ｎｏ）の送達 |
| DE102010016699A1 (de) | 2010-04-29 | 2011-11-03 | Maquet Gmbh & Co. Kg | Verfahren und Vorrichtung zur Applikation mindestens eines medizinischen Gases an einen mit Hilfe eines Beatmungsgeräts beatmeten Patienten |
| US8685467B2 (en) | 2010-08-03 | 2014-04-01 | J. W. Randolph Miller | Nitric oxide generation, dilution, and topical application apparatus and method |
| ES2711974T3 (es) * | 2010-09-10 | 2019-05-08 | Ino Therapeutics Llc | Composiciones, métodos y artículos que se refieren al óxido nítrico farmacéutico y los sistemas controlados de administración al paciente del mismo |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| US9776161B2 (en) | 2010-12-03 | 2017-10-03 | Koninklijke Philips N.V. | Method and arrangement for generating nitric oxide |
| AU2011328891B2 (en) | 2011-01-06 | 2014-11-20 | Mallinckrodt Hospital Products IP Limited | Gas delivery device and system |
| US10445846B2 (en) * | 2011-04-14 | 2019-10-15 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
| US9626650B2 (en) * | 2011-04-14 | 2017-04-18 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| FR2976260B1 (fr) † | 2011-06-09 | 2013-07-05 | Air Liquide | Procede de conditionnement de melanges no/n2 avec etapes de purge et rincage gazeux prealable |
| WO2013009998A2 (en) | 2011-07-12 | 2013-01-17 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into trans-dermal catheter |
| CA3003708C (en) | 2011-10-03 | 2019-01-15 | NitricGen, Inc. | Apparatus and method for generating nitric oxide in controlled and accurate amounts |
| US9572833B2 (en) | 2011-11-07 | 2017-02-21 | The General Hospital Corporation | Treatment of red blood cells |
| SG11201403094TA (en) | 2011-12-11 | 2014-10-30 | Recro Pharma Inc | Intranasal dexmedetomidine compositions and methods of use thereof |
| CN104411317A (zh) | 2012-03-15 | 2015-03-11 | Ino治疗有限责任公司 | 用于施用高浓度一氧化碳的方法 |
| FR2990858B1 (fr) * | 2012-05-24 | 2015-04-03 | Air Liquide Sante Int | Melange gazeux no/azote a teneur elevee en no pour traiter les detresses respiratoires hypoxemiantes severes |
| FR2991026B1 (fr) | 2012-05-24 | 2014-07-04 | Air Liquide Sante Int | Conditionnement a haute pression d'un melange gazeux no/azote |
| FR2991025B1 (fr) | 2012-05-24 | 2014-07-04 | Air Liquide Sante Int | Conditionnement d'un melange gazeux no/azote a haute concentration en no |
| KR102357044B1 (ko) | 2012-12-04 | 2022-02-08 | 말린크로트 파마슈티칼스 아일랜드 리미티드 | 일산화질소 전달 동안 투약량의 희석을 최소화하기 위한 캐뉼라 |
| US9795756B2 (en) | 2012-12-04 | 2017-10-24 | Mallinckrodt Hospital Products IP Limited | Cannula for minimizing dilution of dosing during nitric oxide delivery |
| EP2961479A4 (de) | 2013-02-28 | 2017-07-05 | Aires Pharmaceuticals, Inc. | Anorganische nitrite zur verbesserung der kardiopulmonalen hämodynamik |
| MX370385B (es) | 2013-03-15 | 2019-12-11 | Massachusetts Gen Hospital | Sintesis inspiratoria de oxido nitrico. |
| BR112015022468B1 (pt) | 2013-03-15 | 2022-11-01 | The General Hospital Corporation | Aparelho e método para síntese do gás óxido nítrico para inalação |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| US20140373836A1 (en) | 2013-06-25 | 2014-12-25 | Ino Therapeutics Llc | Methods of Reducing the Risk of Mortality Associated With a Medical Treatment |
| US9522247B2 (en) | 2013-06-28 | 2016-12-20 | L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Method of treating a patient having pulmonary hypertension by long term NO therapy |
| US9566407B2 (en) | 2013-06-28 | 2017-02-14 | L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Nasal cannula assembly with flow control passage communicating with a deformable reservoir |
| US9486600B2 (en) | 2013-06-28 | 2016-11-08 | L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Nasal cannula assembly with inhalation valves communicating with a deformable reservoir |
| US9517318B2 (en) | 2013-06-28 | 2016-12-13 | L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Method of delivering medical gases via a nasal cannula assembly with flow control passage communicating with a deformable reservoir |
| US9492626B2 (en) | 2013-06-28 | 2016-11-15 | L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Breathing assistance assemblies suitable for long term no therapy |
| US9522248B2 (en) | 2013-06-28 | 2016-12-20 | L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Breathing assistance apparatus for delivery of nitric oxide to a patient by means of a nasal cannula assembly with flow control passage |
| US10183039B2 (en) | 2013-07-15 | 2019-01-22 | Vanderbilt University | Methods for the production of collagen IV |
| FR3015000B1 (fr) | 2013-12-12 | 2016-05-27 | Air Liquide Sante (International) | Systeme de stockage et de distribution de melanges no/azote |
| WO2015120389A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
| PT3104854T (pt) | 2014-02-10 | 2020-06-26 | Respivant Sciences Gmbh | Estabilizadores de mastócitos para tratamento de doença pulmonar |
| WO2015157524A1 (en) * | 2014-04-09 | 2015-10-15 | 12th Man Technologies, Inc. | Systems and methods for high concentration nitric oxide delivery |
| EP4219679A3 (de) | 2014-04-15 | 2023-08-09 | Aobiome LLC | Ammoniak-oxidierender nitrosomonas eutropha stamm d23 |
| US11225640B2 (en) | 2014-04-15 | 2022-01-18 | Aobiome Llc | Ammonia oxidizing bacteria for treatment of psoriasis |
| EP2937089A1 (de) | 2014-04-23 | 2015-10-28 | Linde AG | Vorrichtung zur Behandlung von, zur Behandlung von Komplikationen aufgrund von und/oder Vorbeugung von Atemwegserkrankungen |
| AU2015252808B2 (en) | 2014-05-02 | 2019-02-21 | Excelsior Medical Corporation | Strip package for antiseptic cap |
| WO2016064928A1 (en) | 2014-10-20 | 2016-04-28 | Geno Llc | Nitrogen dioxide storage cassette |
| BR112017007841B1 (pt) | 2014-10-20 | 2022-11-08 | The General Hospital Corporation | Aparelho para gerar óxido nítrico |
| CN111603643B (zh) | 2015-04-02 | 2023-05-23 | 希尔－罗姆服务私人有限公司 | 呼吸装置的压力控制 |
| WO2016182822A1 (en) | 2015-05-08 | 2016-11-17 | Icu Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
| WO2017027387A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| WO2017027402A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| EP3347096A4 (de) * | 2015-09-09 | 2019-05-15 | Advanced Inhalation Therapies (AIT) Ltd. | Stickoxidinhalationstherapie für kleinkinder mit bronchiolitis |
| US9744190B2 (en) | 2016-01-15 | 2017-08-29 | Thomas Tait | Continuous gas generator |
| FI3407900T3 (fi) | 2016-01-27 | 2024-03-21 | Syk Tech Llc | Laitteisto typpioksidin paikalliseksi levittämiseksi ja menetelmiä |
| EP3413899A4 (de) * | 2016-02-12 | 2019-10-02 | Mallinckrodt Hospital Products IP Limited | Verwendung und überwachung von inhaliertem stickoxid mit linksventrikulären unterstützungsvorrichtungen |
| RU2768488C2 (ru) | 2016-03-25 | 2022-03-24 | Дзе Дженерал Хоспитал Корпорейшн | Системы доставки и способы для электрического плазменного синтеза оксида азота |
| EP3506893A4 (de) | 2016-08-31 | 2020-01-22 | Respivant Sciences GmbH | Cromolynzusammensetzungen zur behandlung von chronischem husten aufgrund von idiopathischer pulmonaler fibrose |
| AU2017339366A1 (en) | 2016-10-07 | 2019-04-11 | Respivant Sciences Gmbh | Cromolyn compositions for treatment of pulmonary fibrosis |
| SI3525865T1 (sl) | 2016-10-14 | 2023-01-31 | Icu Medical, Inc. | Razkuževalni pokrovčki za medicinske konektorje |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| EP4163253A1 (de) | 2017-02-27 | 2023-04-12 | Third Pole, Inc. | Systeme und vorrichtungen zur erzeugung von stickoxid |
| EP3585727B1 (de) | 2017-02-27 | 2022-03-16 | Third Pole, Inc. | Systeme und verfahren zur ambulanten erzeugung von stickoxid |
| US10239038B2 (en) | 2017-03-31 | 2019-03-26 | The General Hospital Corporation | Systems and methods for a cooled nitric oxide generator |
| WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
| AU2018358349A1 (en) * | 2017-11-02 | 2020-05-28 | Beyond Air, Inc. | Inhalation of nitric oxide |
| JP6618976B2 (ja) * | 2017-11-14 | 2019-12-11 | イノ セラピューティクス エルエルシー | 指標付弁と襟部を有する加圧容器組立体を係合するため、かつ薬物送達を調整するための装置と流体連通したプランジャ組立体により直線的に作動させるための装置および方法 |
| US20210386944A1 (en) * | 2018-10-12 | 2021-12-16 | Sanotize Research Development Corp. | Gas-evolving compositions and container and delivery systems |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| JP2022513096A (ja) | 2018-11-21 | 2022-02-07 | アイシーユー・メディカル・インコーポレーテッド | リング及びインサートを有するキャップを備える抗菌装置 |
| WO2020213398A1 (ja) * | 2019-04-19 | 2020-10-22 | 国立研究開発法人物質・材料研究機構 | 窒素系ガス徐放剤及びこれで構成された窒素系ガス徐放体、並びに該徐放体を用いた窒素系ガスの徐放方法、呼吸器具、包装体及び徐放装置 |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| EP3969416A4 (de) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | Systeme und vorrichtungen zur erzeugung von stickoxid |
| FR3103110B1 (fr) | 2019-11-15 | 2021-10-08 | Air Liquide | Dispositif de fourniture de gaz thérapeutique, en particulier de NO ou de N2O, à un patient |
| WO2021105900A1 (en) | 2019-11-25 | 2021-06-03 | Beyond Air, Inc. | System and method for delivery of gas to a tissue |
| US11691879B2 (en) | 2020-01-11 | 2023-07-04 | Third Pole, Inc. | Systems and methods for nitric oxide generation with humidity control |
| WO2021258025A1 (en) | 2020-06-18 | 2021-12-23 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| EP4433066A1 (de) * | 2020-11-12 | 2024-09-25 | Thermolife International, LLC | Verfahren zur erhöhung der blutsauerstoffsättigung |
| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| AU2021396147A1 (en) | 2020-12-07 | 2023-06-29 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
| US11975139B2 (en) | 2021-09-23 | 2024-05-07 | Third Pole, Inc. | Systems and methods for delivering nitric oxide |
| FR3127408B1 (fr) | 2021-09-29 | 2024-05-10 | Inosystems | Chariot hospitalier de transport de bouteille de gaz, notamment de NO médical |
| FR3137841B1 (fr) | 2022-07-18 | 2024-06-14 | Inosystems | Dispositif de délivrance de NO avec système de dosage d’urgence |
| FR3131538A1 (fr) | 2022-01-05 | 2023-07-07 | Inosystems | Dispositif de délivrance de NO avec système de dosage d’urgence |
| EP4209243B1 (de) | 2022-01-05 | 2024-08-14 | Inosystems | No-ausgabevorrichtung mit notfalldosiersystem |
| FR3132025A1 (fr) | 2022-01-24 | 2023-07-28 | Inosystems | Cartouche de stockage d’un mélange NO/azote et installation de fourniture de gaz associée |
| FR3133317B1 (fr) | 2022-03-09 | 2024-03-01 | Inosystems | Appareil de délivrance de NO avec système de ventilation manuelle |
| FR3133316B1 (fr) | 2022-03-09 | 2024-04-12 | Inosystems | Dispositif de délivrance de NO avec circuit de secours |
| FR3133315B1 (fr) | 2022-03-09 | 2024-03-22 | Inosystems | Appareil de délivrance de NO à deux sorties de gaz |
| FR3133318B1 (fr) | 2022-03-09 | 2024-03-22 | Inosystems | Dispositif de délivrance de NO avec circuit de secours à débit contrôlé |
| FR3136986B1 (fr) | 2022-06-24 | 2024-06-14 | Inosystems | Affichage de la dose de NO par un dispositif de fourniture de NO en phase de pause |
| FR3138773B1 (fr) | 2022-08-11 | 2024-08-02 | Inosystems | Installation de fourniture de gaz comprenant un ventilateur médical et un dispositif de délivrance de NO avec un système de dosage d’urgence |
| FR3145873A1 (fr) | 2023-02-20 | 2024-08-23 | Inosystems | Appareil de fourniture de gaz, tel du NO, à un patient avec comptage du temps total de traitement effectif |
| FR3146810A1 (fr) | 2023-03-21 | 2024-09-27 | Inosystems | Dispositif de calibration des capteurs d’un appareil de délivrance de NO |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3367332A (en) * | 1965-08-27 | 1968-02-06 | Gen Electric | Product and process for establishing a sterile area of skin |
| US3785377A (en) * | 1970-11-12 | 1974-01-15 | S Jorgensen | Plant, preferably for anaesthesia |
| US3745991A (en) * | 1971-02-22 | 1973-07-17 | Champion Spark Plug Co | Environmental contamination control device |
| US4010897A (en) * | 1976-03-31 | 1977-03-08 | Charles F. Kettering Foundation | Method and apparatus for home production and application of nitrogen fertilizer |
| IL57239A (en) * | 1979-05-08 | 1982-04-30 | Alamaro Moshe | Production of nitric oxides |
| US4297123A (en) * | 1980-02-07 | 1981-10-27 | Wyse Harold G | Method and apparatus for producing a nitrate fertilizer |
| US4336798A (en) * | 1980-10-06 | 1982-06-29 | Anthony V. Beran | Medical corrugated respiratory tube |
| SE438261B (sv) * | 1981-07-08 | 1985-04-15 | Draco Ab | Anvendning i dosinhalator av ett perforerat membran |
| US4484577A (en) * | 1981-07-23 | 1984-11-27 | Key Pharmaceuticals, Inc. | Drug delivery method and inhalation device therefor |
| US4534343A (en) * | 1984-01-27 | 1985-08-13 | Trutek Research, Inc. | Metered dose inhaler |
| US4592348A (en) * | 1984-12-17 | 1986-06-03 | Waters Iv William C | Aerosol inhaler |
| US4675174A (en) * | 1985-08-16 | 1987-06-23 | Alza Corporation | Veterinary dispenser delivering beneficial agent by gas power generated in situ |
| US4852561A (en) * | 1988-07-27 | 1989-08-01 | Sperry C R | Inhalation device |
| US4877589A (en) * | 1988-09-19 | 1989-10-31 | Hare Louis R O | Nitrogen fixation by electric arc and catalyst |
| US4915915A (en) * | 1988-10-11 | 1990-04-10 | Treharne Richard W | Water-powdered piezoelectric unit for producing nitrogen fertilizer |
| US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5208233A (en) * | 1989-09-15 | 1993-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5007419A (en) * | 1989-09-25 | 1991-04-16 | Allan Weinstein | Inhaler device |
| US5178138A (en) * | 1990-09-11 | 1993-01-12 | Walstrom Dennis R | Drug delivery device |
| US5155137A (en) * | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
| US5187305A (en) * | 1990-11-26 | 1993-02-16 | Glaxo Inc. | S-nitroso-N-alkonoylpenicillamines |
| US5396882A (en) * | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| DK1516639T4 (en) * | 1990-12-05 | 2015-06-29 | Gen Hospital Corp | Use of NO to treat persistent pulmonary hypertension in newborns |
| IL101406A (en) * | 1991-03-29 | 1998-02-08 | Brigham & Womens Hospital | Pharmaceutical compositions containing s-nitrosothiol derivatives |
| US5385937A (en) * | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
| AU3237193A (en) * | 1991-12-11 | 1993-07-19 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5427797A (en) * | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
-
1991
- 1991-12-05 DK DK04029366.4T patent/DK1516639T4/en active
- 1991-12-05 DE DE200812000012 patent/DE122008000012I2/de active Active
- 1991-12-05 DK DK92902708.4T patent/DK0560928T3/da active
- 1991-12-05 DE DE69127756T patent/DE69127756T2/de not_active Expired - Lifetime
- 1991-12-05 ES ES92902708T patent/ES2082732T3/es not_active Expired - Lifetime
- 1991-12-05 ES ES04029366.4T patent/ES2288660T5/es not_active Expired - Lifetime
- 1991-12-05 AU AU91498/91A patent/AU657726B2/en not_active Expired
- 1991-12-05 DE DE69133575T patent/DE69133575T2/de not_active Expired - Lifetime
- 1991-12-05 DE DE69133584A patent/DE69133584D1/de not_active Expired - Lifetime
- 1991-12-05 JP JP4502844A patent/JP2701978B2/ja not_active Expired - Lifetime
- 1991-12-05 ES ES97105021T patent/ES2132043T3/es not_active Expired - Lifetime
- 1991-12-05 DK DK97105021T patent/DK0786264T3/da active
- 1991-12-05 DE DE0560928T patent/DE560928T1/de active Pending
- 1991-12-05 EP EP07119550A patent/EP1875917A3/de not_active Withdrawn
- 1991-12-05 EP EP20040029366 patent/EP1516639B2/de not_active Expired - Lifetime
- 1991-12-05 EP EP97105021A patent/EP0786264B1/de not_active Revoked
- 1991-12-05 DE DE69133584T patent/DE69133584T4/de not_active Expired - Lifetime
- 1991-12-05 AT AT04029366T patent/ATE367842T2/de active
- 1991-12-05 DE DE122007000103C patent/DE122007000103I1/de active Pending
- 1991-12-05 AT AT92902708T patent/ATE158509T1/de active
- 1991-12-05 AT AT97105021T patent/ATE376850T1/de active
- 1991-12-05 CA CA002097823A patent/CA2097823C/en not_active Expired - Lifetime
- 1991-12-05 DE DE0786264T patent/DE786264T1/de active Pending
- 1991-12-05 DE DE2002199002 patent/DE10299002I1/de active Pending
- 1991-12-05 EP EP92902708A patent/EP0560928B1/de not_active Revoked
- 1991-12-05 SG SG1996002651A patent/SG47527A1/en unknown
- 1991-12-05 WO PCT/US1991/009111 patent/WO1992010228A1/en not_active Application Discontinuation
-
1994
- 1994-09-15 EE EE9400192A patent/EE03119B1/xx unknown
- 1994-12-09 US US08/353,508 patent/US5873359A/en not_active Expired - Lifetime
-
1995
- 1995-02-10 US US08/384,792 patent/US5485827A/en not_active Expired - Lifetime
-
1996
- 1996-06-30 GR GR960300032T patent/GR960300032T1/el unknown
-
1997
- 1997-02-20 JP JP03678597A patent/JP3510755B2/ja not_active Expired - Lifetime
- 1997-09-25 GR GR970402498T patent/GR3024865T3/el unknown
-
1998
- 1998-08-24 LV LVP-98-169A patent/LV12201B/en unknown
- 1998-09-24 HK HK98110945A patent/HK1010101A1/xx not_active IP Right Cessation
- 1998-09-24 HK HK99105833A patent/HK1020686A1/xx not_active IP Right Cessation
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1999
- 1999-01-01 GR GR990300018T patent/GR990300018T1/el unknown
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2002
- 2002-01-24 LU LU90886C patent/LU90886I2/xx unknown
- 2002-01-30 NL NL300081C patent/NL300081I2/nl unknown
- 2002-07-26 JP JP2002217936A patent/JP3718491B2/ja not_active Expired - Lifetime
-
2005
- 2005-09-22 HK HK05108350A patent/HK1076407A1/xx not_active IP Right Cessation
-
2007
- 2007-12-14 NL NL300327C patent/NL300327I2/nl unknown
- 2007-12-21 LU LU91404C patent/LU91404I2/fr unknown
-
2008
- 2008-04-01 NL NL300342C patent/NL300342I1/nl unknown
- 2008-04-30 LU LU91423C patent/LU91423I2/fr unknown
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