ES2082732T1 - Dispositivos para tratar la vasoconstriccion pulmonar y el asma. - Google Patents

Dispositivos para tratar la vasoconstriccion pulmonar y el asma.

Info

Publication number
ES2082732T1
ES2082732T1 ES92902708T ES92902708T ES2082732T1 ES 2082732 T1 ES2082732 T1 ES 2082732T1 ES 92902708 T ES92902708 T ES 92902708T ES 92902708 T ES92902708 T ES 92902708T ES 2082732 T1 ES2082732 T1 ES 2082732T1
Authority
ES
Spain
Prior art keywords
nitric oxide
asthma
devices
treat lung
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES92902708T
Other languages
English (en)
Other versions
ES2082732T3 (es
Inventor
Warren M Zapol
Claes Frostell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27089304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2082732(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of ES2082732T1 publication Critical patent/ES2082732T1/es
Application granted granted Critical
Publication of ES2082732T3 publication Critical patent/ES2082732T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Saccharide Compounds (AREA)
  • Glass Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)

Abstract

SE PRESENTA UN METODO PARA TRATAR O PREVENIR LA BRONCOCONSTRICCION O LA VASOCONSTRICCION PULMONAR REVERSIBLE EN UN MAMIFERO, DICHO METODO INCLUYE PROVOCAR QUE EL MAMIFERO INHALE UNA CONCENTRACION TERAPEUTICAMENTE EFECTIVO DE OXIDO NITRICO GASEOSO (1, 10) O UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UN COMPUESTO LIBERADOR DE OXIDO NITRICO (106), Y UN DISPOSITIVO INHALADOR (102) QUE CONTIENE GAS DE OXIDO NITRICO Y/O UN COMPUESTO LIBERADOR DEL GAS DE OXIDO NITRICO.
ES92902708T 1990-12-05 1991-12-05 Tratamiento de la vasoconstriccion pulmonar reversible y de la broncoconstriccion. Expired - Lifetime ES2082732T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62286590A 1990-12-05 1990-12-05
US76723491A 1991-09-27 1991-09-27

Publications (2)

Publication Number Publication Date
ES2082732T1 true ES2082732T1 (es) 1996-04-01
ES2082732T3 ES2082732T3 (es) 1997-12-16

Family

ID=27089304

Family Applications (3)

Application Number Title Priority Date Filing Date
ES97105021T Expired - Lifetime ES2132043T3 (es) 1990-12-05 1991-12-05 Dispositivos para tratar vasoconstriccion pulmonar y asma.
ES92902708T Expired - Lifetime ES2082732T3 (es) 1990-12-05 1991-12-05 Tratamiento de la vasoconstriccion pulmonar reversible y de la broncoconstriccion.
ES04029366.4T Expired - Lifetime ES2288660T5 (es) 1990-12-05 1991-12-05 Uso de NO para tratar la hipertensión pulmonar persistente del recién nacido

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES97105021T Expired - Lifetime ES2132043T3 (es) 1990-12-05 1991-12-05 Dispositivos para tratar vasoconstriccion pulmonar y asma.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04029366.4T Expired - Lifetime ES2288660T5 (es) 1990-12-05 1991-12-05 Uso de NO para tratar la hipertensión pulmonar persistente del recién nacido

Country Status (17)

Country Link
US (2) US5873359A (es)
EP (4) EP0786264B1 (es)
JP (3) JP2701978B2 (es)
AT (3) ATE158509T1 (es)
AU (1) AU657726B2 (es)
CA (1) CA2097823C (es)
DE (9) DE69133584T4 (es)
DK (3) DK0560928T3 (es)
EE (1) EE03119B1 (es)
ES (3) ES2132043T3 (es)
GR (3) GR960300032T1 (es)
HK (3) HK1020686A1 (es)
LU (3) LU90886I2 (es)
LV (1) LV12201B (es)
NL (3) NL300081I2 (es)
SG (1) SG47527A1 (es)
WO (1) WO1992010228A1 (es)

Families Citing this family (257)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU657726B2 (en) 1990-12-05 1995-03-23 General Hospital Corporation, The Devices for treating pulmonary vasoconstriction and asthma
US5570683A (en) * 1990-12-05 1996-11-05 The General Hospital Corporation Methods and devices for treating pulmonary vasoconstriction and asthma
GB9027234D0 (en) * 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
AU651882B2 (en) * 1991-05-14 1994-08-04 Visiomed Group Limited Aerosol inhalation device
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
DE4208880A1 (de) * 1992-03-19 1993-09-23 Boehringer Ingelheim Kg Separator fuer pulverinhalatoren
FR2695831B1 (fr) * 1992-09-24 1994-11-10 Air Liquide Installation et procédé de fourniture d'un mélange gazeux aux voies respiratoires d'un utilisateur.
DE69413528T2 (de) * 1993-04-06 1999-05-06 Minnesota Mining & Mfg Vorrichtung zum deagglomerieren für trockenpulverinhalatoren
US5427797A (en) * 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation
EP0621051B1 (de) * 1993-04-17 2001-08-22 MESSER GRIESHEIM AUSTRIA Ges.m.b.H. Gerät zur kontrollierten Zudosierung von NO zur Atemluft von Patienten
US5922610A (en) * 1993-07-06 1999-07-13 Aerocrine Ab System to be used for the determination of no levels in exhaled air and diagnostic methods for disorders related to abnormal no levels
SE9302478L (sv) * 1993-07-22 1994-11-07 Siemens Elema Ab Gasblandning och apparat för att tillföra gasblandningen till lungorna hos ett levande väsen
DE4327731C1 (de) * 1993-08-18 1994-11-10 Messer Griesheim Gmbh NO-haltiges Gasgemisch zur Behandlung pulmonaler Erkrankungen
DE4327732C1 (de) * 1993-08-18 1994-09-01 Messer Griesheim Gmbh NO-haltiges Gasgemisch zur Behandlung pulmonaler Erkrankungen
GB9320978D0 (en) * 1993-10-12 1993-12-01 Higenbottam Timohy W Nitric oxide treatment
US5558083A (en) * 1993-11-22 1996-09-24 Ohmeda Inc. Nitric oxide delivery system
AU700162B2 (en) * 1994-05-13 1998-12-24 Aradigm Corporation Narcotic containing aerosol formulation
DE4419860A1 (de) * 1994-06-07 1995-12-14 Hoechst Ag Verfahren und Filter zur Herstellung von NO¶2¶-freiem Stickstoffmonoxid mit schwefelhaltigen Polymeren
US5615669A (en) * 1994-07-22 1997-04-01 Siemens Elema Ab Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject
US6063407A (en) * 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US5665077A (en) * 1995-04-24 1997-09-09 Nitrosci Pharmaceuticals Llc Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
SE506208C2 (sv) 1995-07-05 1997-11-24 Aerocrine Systems Kb Anordning för uppsamling av gas från de övre luftvägarna och leverans av denna gas till inandningsluften i en respirator
RU2072241C1 (ru) * 1995-09-20 1997-01-27 Панина Елена Владимировна Способ формирования дыхательной газовой смеси и аппарат для его осуществления
DE69618133T2 (de) * 1995-10-13 2002-07-11 Siemens Elema Ab Trachealtubus und Vorrichtung für Beatmungssysteme
ATE209922T1 (de) * 1995-10-20 2001-12-15 Air Liquide Pharmazeutische zusammensetzung von stickstoffmonoxid
AU7529796A (en) * 1995-11-13 1997-06-05 Brigham And Women's Hospital S-nitroso-hemoglobin and therapeutic uses thereof
US5699790A (en) * 1996-03-21 1997-12-23 Ohmeda Inc. System for predicting NO2 concentrations
PT914103E (pt) * 1996-04-05 2006-09-29 Gen Hospital Corp Tratamento de uma hemoglobinopatia
US5765548A (en) * 1996-05-07 1998-06-16 Perry; Bryan J. Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equine
US5811437A (en) * 1996-05-21 1998-09-22 Eli Lilly And Company Methods of increasing nitric oxide synthesis
CA2206477A1 (en) 1996-07-10 1998-01-10 Ohmeda Inc. System for correcting no2 monitor
US5732694A (en) * 1996-12-13 1998-03-31 Ohmeda Inc. System for correcting NO2 monitor
US6720309B1 (en) 1996-07-17 2004-04-13 Leuven Research And Development, V.Z.W. Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene
EP0979088A4 (en) * 1996-07-17 2002-11-06 Gen Hospital Corp METHOD FOR INDUCING VASILATION AND TREATING PULMONAL HIGH BLOOD PRESSURE BY ADENOVIRUS-STEERED TRANSFER OF THE NITROGEN OXIDE SYNTHASE GENE
JP3880103B2 (ja) * 1996-07-18 2007-02-14 住友精化株式会社 医療用一酸化窒素混合ガスおよびその製造方法
SE9602959L (sv) * 1996-08-12 1998-02-09 Siemens Elema Ab Förfarande vid blandning av gaser och en anordning för blandning av gaser
AU3901497A (en) * 1996-08-13 1998-03-06 University Of Massachusetts Nitric oxide sensor
DE19734279A1 (de) * 1997-08-07 1999-02-11 Messer Griesheim Gmbh Wasserstoffhaltiges Medikament
US5732693A (en) 1996-10-02 1998-03-31 Ohmeda Inc. Pause control of nitric oxide therapy
DE59813457D1 (de) 1997-01-17 2006-05-11 Ino Therapeutics Gmbh Brunn Am Gesteuertes gasversorgungssystem
US6027713A (en) * 1997-03-06 2000-02-22 Meri Charmyne Russell Composition and method for the treatment of exercise induced pulmonary hemorrhage
SE9700940D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Powder inhaler IV
CA2225013C (en) 1997-04-04 2006-06-06 Institut Du N.O. Inc. Injection system for delivery of a gaseous substance
AU6872698A (en) * 1997-04-16 1998-11-11 Ohmeda Inc. Humidity compensation for fuel cell zeroing in respiratory gas measurement
US5918596A (en) * 1997-04-22 1999-07-06 Instrumentarium Corp. Special gas dose delivery apparatus for respiration equipment
FR2762992B1 (fr) * 1997-05-07 2000-08-25 Air Liquide Transporteurs de no a base de complexes polyazamacrocycles de fer et de cobalt
US6125846A (en) * 1997-05-16 2000-10-03 Datex-Ohmeda, Inc. Purge system for nitric oxide administration apparatus
US6656452B1 (en) * 1997-10-21 2003-12-02 The General Hospital Corporation Use of inhaled NO as anti-inflammatory agent
US6109260A (en) * 1998-02-18 2000-08-29 Datex-Ohmeda, Inc. Nitric oxide administration device with timed pulse
US6142147A (en) * 1998-03-31 2000-11-07 The General Hospital Corporation Nasal delivery system for inhaled nitric oxide
CA2254645A1 (en) * 1998-11-23 2000-05-23 Pulmonox Medical Corporation Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US20070086954A1 (en) * 1998-11-23 2007-04-19 Miller Christopher C Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
JP3641151B2 (ja) * 1999-02-04 2005-04-20 帝人株式会社 治療用ガス投入用呼吸マスク
US9486429B2 (en) * 1999-06-01 2016-11-08 Vanderbilt University Therapeutic methods employing nitric oxide precursors
US6346382B1 (en) * 1999-06-01 2002-02-12 Vanderbilt University Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
FR2795644B1 (fr) * 1999-07-02 2004-07-30 Air Liquide Sante Int Utilisations therapeutiques d'un melange helium/oxygene, en particulier dans le traitement de l'asthme
JP4932109B2 (ja) * 1999-07-12 2012-05-16 キャプニア インコーポレイテッド 頭痛、鼻炎及び他のありふれた病気を治す方法及び装置
EP1204870B1 (en) * 1999-08-02 2010-01-20 Duke University Method for determining physiological effects of hemoglobin
US6314956B1 (en) * 1999-09-08 2001-11-13 Duke University Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders
US7045152B2 (en) 1999-09-08 2006-05-16 Duke University Treating pulmonary disorders with gaseous agent causing repletion of GSNO
ATE323521T1 (de) 1999-09-22 2006-05-15 Instrumentarium Corp Verbesserung der sauerstoffversorgung in lebewesen mit gestörter sauerstoffversorgung
US6694969B1 (en) 1999-09-22 2004-02-24 Instrumentarium Corp. Method to improve oxygenation in subjects suffering impaired oxygenation
US6612306B1 (en) 1999-10-13 2003-09-02 Healthetech, Inc. Respiratory nitric oxide meter
AU778522B2 (en) 1999-10-29 2004-12-09 Orion Corporation Treatment or prevention of hypotension and shock
SE9903985D0 (sv) * 1999-11-03 1999-11-03 Aga Ab Use of nitric oxide
US20070039615A1 (en) * 1999-11-08 2007-02-22 Capnia, Incorporated Methods and apparatus for treating rhinitis
CA2389294A1 (en) * 1999-11-08 2001-05-25 Capnia, Incorporated Method and apparatus for relieving ailments using gases to increase the effectiveness of drugs
US20060172017A1 (en) 1999-11-08 2006-08-03 Capnia, Incorporated Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
US7516742B2 (en) * 1999-11-24 2009-04-14 Cardinal Health 207, Inc. Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing
US6581599B1 (en) 1999-11-24 2003-06-24 Sensormedics Corporation Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients
US6758214B2 (en) 2000-01-28 2004-07-06 Cyterra Corporation Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment
PL358375A1 (en) * 2000-04-13 2004-08-09 Innovata Biomed Limited Medicaments for treating respiratory disorders comprising formoterol and fluticasone
US6601580B1 (en) 2000-06-28 2003-08-05 The General Hospital Corporation Enhancing therapeutic effectiveness of nitric oxide inhalation
US6951215B1 (en) * 2000-07-14 2005-10-04 Tufts University Drug delivery device for animals
IL153956A0 (en) 2000-08-11 2003-07-31 Whitlock David R Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same
US6620106B2 (en) 2000-09-29 2003-09-16 Healthetech, Inc. Indirect calorimetry system
US6668828B1 (en) 2000-10-16 2003-12-30 Pulmonox Technologies Corporations System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient
SE0004229D0 (sv) * 2000-11-17 2000-11-17 Aga Ab Inhalation of nitric oxide
US7122018B2 (en) * 2000-12-26 2006-10-17 Sensormedics Corporation Device and method for treatment of wounds with nitric oxide
US7335181B2 (en) * 2000-12-26 2008-02-26 Pulmonox Technologies Corporation Nitric oxide decontamination of the upper respiratory tract
US6432077B1 (en) * 2000-12-26 2002-08-13 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
AUPR315401A0 (en) * 2001-02-16 2001-03-15 Resmed Limited An apparatus for supplying clean breathable gas
WO2002087673A1 (de) * 2001-04-25 2002-11-07 Messer Austria Gmbh Aerosoldosiergerät
US6749834B2 (en) * 2001-06-19 2004-06-15 World Precision Instruments, Inc. Methods and apparatus for therapeutic treatment of respiratory, cardiac and other pathologies
WO2003020211A2 (en) * 2001-09-05 2003-03-13 Cyterra Corporation Nitric oxide generation
US6575918B2 (en) 2001-09-27 2003-06-10 Charlotte-Mecklenburg Hospital Non-invasive device and method for the diagnosis of pulmonary vascular occlusions
US20030070674A1 (en) * 2001-10-12 2003-04-17 Bryan Perry Use of aerosolized compounds in the treatment of exercise induced pulmonary hemorrhage in an equine
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US20040110691A1 (en) * 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
US6627602B2 (en) * 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
US6472390B1 (en) * 2001-11-13 2002-10-29 Duke University Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
KR20040086267A (ko) * 2002-01-11 2004-10-08 데이비드 알. 휘트록 암모니아 산화 박테리아를 포함하는 조성물 및 그를사용하는 방법
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
US7086397B2 (en) * 2002-02-16 2006-08-08 Graham Lindley Spruiell Patient usable emergency medical kit
US20060088942A1 (en) * 2002-05-29 2006-04-27 Stamler Jonathan S Measuring nitric oxide in blood gases and treatments based thereon
AU2003279236B8 (en) * 2002-06-21 2009-02-19 Beth Israel Deaconess Medical Center, Inc. Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
MXPA05000223A (es) * 2002-06-28 2005-07-15 Univ New York State Res Found Dispositivo y metodo para suministrar un agente terapeutico.
AU2003259897B2 (en) * 2002-08-20 2008-04-03 Aga Ab Methods and devices for administration of therapeutic gases
US7681572B2 (en) * 2002-08-20 2010-03-23 Aga Ab Method and devices for administration of therapeutic gases
US7337776B2 (en) * 2002-08-20 2008-03-04 Aga Ab Methods for easing pain and anxiety from atrial or ventricular defibrillation
US8001962B2 (en) * 2002-08-23 2011-08-23 Sheiman Ultrasonic Research Foundation Pty Ltd. Nebulizing and drug delivery device
US7828739B2 (en) * 2002-08-27 2010-11-09 Precision Pulsus, Inc. Apnea detection system
US6869402B2 (en) * 2002-08-27 2005-03-22 Precision Pulsus, Inc. Method and apparatus for measuring pulsus paradoxus
US7531133B2 (en) * 2002-09-10 2009-05-12 Pulmonox Technologies Corporation Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma
AU2003272962A1 (en) * 2002-10-10 2004-05-04 Shuh Narumiya Remedies for allergic diseases
US9138707B2 (en) 2002-12-10 2015-09-22 Sy Kimball Portable, nitric oxide generator
CA2413834A1 (en) 2002-12-10 2004-06-10 1017975 Alberta Limited Nitric oxide gas generator
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
US9675637B2 (en) 2003-07-09 2017-06-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
CA2539974A1 (en) * 2003-09-26 2005-04-07 David R. Whitlock Methods of using ammonia oxidizing bacteria
US7552731B2 (en) * 2003-11-14 2009-06-30 Remcore, Inc. Remote control gas regulation system
WO2005077005A2 (en) * 2004-02-04 2005-08-25 The General Hospital Corporation Enhancing the effectiveness of an inhaled therapeutic gas
US20050191245A1 (en) * 2004-02-27 2005-09-01 Adams Christopher P. Nasal administration of calcium channel, blockers for treatment of hypertension and other cardiovascular disorders
JP2007526316A (ja) * 2004-03-01 2007-09-13 ルーメン セラピューティックス リミテッド ライアビリティ カンパニー 疾患を処置するための組成物および方法
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
CA2559208A1 (en) * 2004-03-17 2005-09-29 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
JP2007537267A (ja) 2004-05-11 2007-12-20 センサーメディックス・コーポレイション 一酸化窒素ガスの間欠的投与
US8518457B2 (en) * 2004-05-11 2013-08-27 Pulmonox Technologies Corporation Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
US7618594B2 (en) 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
CA2576957C (en) * 2004-08-18 2013-04-02 Geno Llc Conversion of nitrogen dioxide (no2) to nitric oxide (no)
US20070154570A1 (en) * 2004-09-29 2007-07-05 Miller Christopher C Use of nitric oxide in the treatment and disinfection of biofilms
US7721729B2 (en) * 2005-03-09 2010-05-25 Ric Investments, Llc Nebulizing drug delivery device for ventilator
US7814901B2 (en) * 2005-03-09 2010-10-19 Ric Investments, Llc Nebulizing drug delivery device with increased flow rate
US7631643B2 (en) 2005-03-09 2009-12-15 Ric Investments, Llc Nebulizing drug delivery device with interlock detection and temperature protection
US8056557B2 (en) * 2005-03-09 2011-11-15 Ric Investments, Llc Nebulizing drug delivery device with barrier
US8557300B2 (en) * 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
ATE516086T1 (de) * 2005-05-23 2011-07-15 Biosonic Australia Pty Ltd Vorrichtung zur zerstäubung und flüssigkeitsfiltration
US7523752B2 (en) * 2005-09-21 2009-04-28 Ino Therapeutics, Llc System and method of administering a pharmaceutical gas to a patient
US8893717B2 (en) 2005-09-21 2014-11-25 Ino Therapeutics Llc Systems and methods of administering a pharmaceutical gas to a patient
US7566308B2 (en) * 2005-10-13 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for pulmonary artery pressure signal isolation
US20070116785A1 (en) * 2005-11-18 2007-05-24 Miller Christopher C Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant
ES2414957T3 (es) * 2005-12-21 2013-07-23 Solaeromed Inc. Tratamiento de enfermedades respiratorias
US8790715B2 (en) 2006-02-16 2014-07-29 Ino Therapeutics Llc Method and apparatus for generating nitric oxide for medical use
US20100313883A1 (en) * 2006-04-20 2010-12-16 Koninklijke Philips Electronics N.V. Ultrasonic bebulilzer with metal coated ultrasonic genrator
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
EP1903003B1 (de) * 2006-07-05 2017-07-05 BSN medical GmbH Verfahren zur photolytischen Erzeugung von Stickstoffmonoxid
US8079998B2 (en) * 2006-10-20 2011-12-20 Pulmonox Technologies Corporation Methods and devices for the delivery of therapeutic gases including nitric oxide
CL2007003193A1 (es) * 2006-11-07 2008-07-04 Gen Hospital Corp Metodo para evitar o reducir la vasoconstriccion a continuacion de la administracion de un portador de oxigeno vasoactivo, que comprende oxido nitrico gaseoso y otro agente activo; composicion farmaceutica que comprende un inhibidor de fosfodiesteras
US20100143503A1 (en) * 2006-12-22 2010-06-10 Ikaria, Inc. Combinations of nitric oxide and sulfide and methods of use and manufacture thereof
US20080193566A1 (en) * 2007-02-09 2008-08-14 Miller Christopher C Use of high dose concentrations of gaseous nitric oxide
US8166971B2 (en) * 2007-03-15 2012-05-01 Ric Investments, Llc End-tidal gas estimation system and method
US8176915B2 (en) * 2007-03-15 2012-05-15 Koninklijke Philips Electronics N.V. End-tidal gas estimation system and method
CA2681308C (en) * 2007-03-23 2015-11-24 Geno Llc Conversion of nitrogen dioxide (no2) to nitric oxide (no)
WO2009048521A1 (en) * 2007-10-11 2009-04-16 Duke University Potentiating the effect of compound comprising nitric oxide
DK2230934T3 (da) 2007-12-14 2012-11-26 Aerodesigns Inc Afgivelse af aerosoliserbare næringsmiddelprodukter
US20090196930A1 (en) * 2007-12-27 2009-08-06 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof
WO2009097343A1 (en) 2008-01-28 2009-08-06 Geno Llc Conversion of nitrogen dioxide (no2) to nitric oxide (no)
US9649467B2 (en) 2008-01-31 2017-05-16 Syk Technologies, Llc Nitric oxide reactor and distributor apparatus and method
AU2009212693B2 (en) 2008-01-31 2014-05-01 Vanderbilt University Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage
US8434475B2 (en) 2008-01-31 2013-05-07 Genosys, Inc. Nitric oxide reactor and distributor apparatus and method
US8720436B2 (en) * 2008-01-31 2014-05-13 Genosys, Inc. Nitric oxide gel apparatus and method
KR20170005155A (ko) * 2008-01-31 2017-01-11 반더빌트유니버시티 폐의 용태에 따른 치료 방법
US8501090B2 (en) * 2008-03-24 2013-08-06 Christian S. Minton Anti-microbial gas apparatus and method
US20100040703A1 (en) * 2008-08-13 2010-02-18 Chris Miller Use of nitric oxide
US10960168B2 (en) 2008-08-21 2021-03-30 Vero Biotech LLC Delivery of high concentration nitric oxide
US8607785B2 (en) 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
US10780241B2 (en) * 2008-08-21 2020-09-22 Vero Biotech LLC Devices and methods for minimizing and treating high-altitude sickness
GB2463883A (en) * 2008-09-25 2010-03-31 Pharma Patents Ltd A pharmaceutical composition comprising an A-SMase inhibitor and an NO-donor
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
CA2762107A1 (en) * 2009-05-15 2010-11-18 Recro Pharma, Inc. Sublingual dexmedetomidine compositions and methods of use thereof
LT3210644T (lt) 2009-05-27 2019-02-11 Ino Therapeutics Llc Įrenginiai, skirti sugraduoto vožtuvo ir hermetiško kanistro įrenginio sukabinimui be sandariklio
EP2445508B1 (en) 2009-06-22 2018-11-14 VERO Biotech LLC Nitric oxide therapies
JP2011010865A (ja) 2009-06-30 2011-01-20 Ikaria Holdings Inc 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法
EP2501427B1 (en) * 2009-11-20 2018-03-21 Geno LLC Nitric oxide delivery system
EP3777937A1 (en) 2010-04-26 2021-02-17 VERO Biotech LLC Delivery of ultra pure nitric oxide (no)
DE102010016699A1 (de) 2010-04-29 2011-11-03 Maquet Gmbh & Co. Kg Verfahren und Vorrichtung zur Applikation mindestens eines medizinischen Gases an einen mit Hilfe eines Beatmungsgeräts beatmeten Patienten
US8685467B2 (en) 2010-08-03 2014-04-01 J. W. Randolph Miller Nitric oxide generation, dilution, and topical application apparatus and method
EP2613839B1 (en) * 2010-09-10 2018-12-12 INO Therapeutics LLC Compositions, methods and articles concerning pharmaceutical nitric oxide and controlled patient delivery systems thereof
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
JP2014501578A (ja) 2010-12-03 2014-01-23 コーニンクレッカ フィリップス エヌ ヴェ 一酸化窒素の生成方法及び装置
NZ739614A (en) 2011-01-06 2019-05-31 Mallinckrodt Hospital Products Ip Ltd Gas delivery device and system
US10853819B2 (en) * 2011-04-14 2020-12-01 Elwha Llc Cost-effective resource apportionment technologies suitable for facilitating therapies
US10445846B2 (en) * 2011-04-14 2019-10-15 Elwha Llc Cost-effective resource apportionment technologies suitable for facilitating therapies
FR2976260B1 (fr) † 2011-06-09 2013-07-05 Air Liquide Procede de conditionnement de melanges no/n2 avec etapes de purge et rincage gazeux prealable
EP3714932A1 (en) 2011-07-12 2020-09-30 ICU Medical, Inc. Device for delivery of antimicrobial agent into a transdermal catheter
CA2850935C (en) 2011-10-03 2018-08-07 Nitric Generation Technologies Llc Apparatus and method for generating nitric oxide in controlled and accurate amounts
CN104159591A (zh) 2011-11-07 2014-11-19 通用医疗公司 红细胞的处理
RU2692245C2 (ru) 2011-12-11 2019-06-24 Рекро Фарма, Инк. Интраназальные композиции дексмедетомидина и способы их применения
AU2013231976B9 (en) 2012-03-15 2017-12-14 Mallinckrodt Hospital Products IP Limited Methods of administering high concentrations of nitric oxide
FR2991025B1 (fr) 2012-05-24 2014-07-04 Air Liquide Sante Int Conditionnement d'un melange gazeux no/azote a haute concentration en no
FR2991026B1 (fr) 2012-05-24 2014-07-04 Air Liquide Sante Int Conditionnement a haute pression d'un melange gazeux no/azote
FR2990858B1 (fr) 2012-05-24 2015-04-03 Air Liquide Sante Int Melange gazeux no/azote a teneur elevee en no pour traiter les detresses respiratoires hypoxemiantes severes
US9795756B2 (en) 2012-12-04 2017-10-24 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
MX360652B (es) 2012-12-04 2018-11-12 Mallinckrodt Hospital Products Ip Ltd Cánula para minimizar la disolución de la dosificación durante la administración del óxido nítrico.
CA2902965C (en) 2013-02-28 2023-08-29 Aires Pharmaceuticals, Inc. Inorganic nitrite to improve cardiopulmonary hemodynamics
CA3112015A1 (en) 2013-03-15 2014-09-18 The General Hospital Corporation Inspiratory synthesis of nitric oxide
BR112015022468B1 (pt) 2013-03-15 2022-11-01 The General Hospital Corporation Aparelho e método para síntese do gás óxido nítrico para inalação
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
AU2014203438B2 (en) 2013-06-25 2019-06-20 Mallinckrodt Hospital Products IP Limited Methods of reducing the risk of mortality associated with a medical treatment
US9522248B2 (en) 2013-06-28 2016-12-20 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Breathing assistance apparatus for delivery of nitric oxide to a patient by means of a nasal cannula assembly with flow control passage
US9566407B2 (en) 2013-06-28 2017-02-14 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Nasal cannula assembly with flow control passage communicating with a deformable reservoir
US9492626B2 (en) 2013-06-28 2016-11-15 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Breathing assistance assemblies suitable for long term no therapy
US9522247B2 (en) 2013-06-28 2016-12-20 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Method of treating a patient having pulmonary hypertension by long term NO therapy
US9517318B2 (en) 2013-06-28 2016-12-13 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Method of delivering medical gases via a nasal cannula assembly with flow control passage communicating with a deformable reservoir
US9486600B2 (en) 2013-06-28 2016-11-08 L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Nasal cannula assembly with inhalation valves communicating with a deformable reservoir
WO2015009615A1 (en) * 2013-07-15 2015-01-22 Vanderbilt University Methods for the production of collagen iv
FR3015000B1 (fr) 2013-12-12 2016-05-27 Air Liquide Sante (International) Systeme de stockage et de distribution de melanges no/azote
DK3104853T3 (da) 2014-02-10 2019-12-09 Respivant Sciences Gmbh Behandling med mastcellestabilisatorer til systemiske forstyrrelser
WO2015120392A1 (en) 2014-02-10 2015-08-13 Patara Pharma, LLC Mast cell stabilizers for lung disease treatment
US20150290417A1 (en) * 2014-04-09 2015-10-15 12th Man Technologies. Inc. System and Method for High Concentration Nitric Oxide Delivery
US11225640B2 (en) 2014-04-15 2022-01-18 Aobiome Llc Ammonia oxidizing bacteria for treatment of psoriasis
US20170037363A1 (en) 2014-04-15 2017-02-09 Aobiome Llc Ammonia-oxidizing nitrosomonas eutropha strain d23
EP2937089A1 (en) 2014-04-23 2015-10-28 Linde AG Device for the treatment of, treatment of complications arising from, and/or prevention of respiratory disorders
EP3137122B1 (en) 2014-05-02 2019-09-04 Excelsior Medical Corporation Strip package for antiseptic cap
WO2016064928A1 (en) 2014-10-20 2016-04-28 Geno Llc Nitrogen dioxide storage cassette
JP6947633B2 (ja) 2014-10-20 2021-10-13 ザ ジェネラル ホスピタル コーポレイション 一酸化窒素の合成のためのシステム及び方法
AU2016243801B2 (en) 2015-04-02 2020-05-21 Hill-Rom Services Pte. Ltd. Manifold for respiratory device
EP3294404A4 (en) 2015-05-08 2018-11-14 ICU Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
WO2017027387A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of mast cell related disorders with mast cell stabilizers
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
WO2017042636A1 (en) * 2015-09-09 2017-03-16 Advanced Inhalation Therapies (Ait) Ltd. Nitric oxide inhalation therapy for infants with bronchiolitis
US9744190B2 (en) 2016-01-15 2017-08-29 Thomas Tait Continuous gas generator
ES2968200T3 (es) 2016-01-27 2024-05-08 Syk Tech Llc Aparato y métodos de aplicación tópica de óxido nítrico
FI3970730T3 (fi) * 2016-02-12 2024-05-28 Mallinckrodt Pharmaceuticals Ireland Ltd Järjestelmä inhaloidun typpioksidin käyttöä ja valvontaa varten vasemman kammion apulaitteiden kera
KR20190005839A (ko) 2016-03-25 2019-01-16 더 제너럴 하스피탈 코포레이션 산화질소의 전기 플라즈마 합성을 위한 전달 시스템 및 방법
AU2017321495A1 (en) 2016-08-31 2019-03-21 Respivant Sciences Gmbh Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
CN109803724A (zh) 2016-10-07 2019-05-24 瑞思皮万特科学有限责任公司 用于治疗肺纤维化的色甘酸组合物
EP4194043A1 (en) 2016-10-14 2023-06-14 ICU Medical, Inc. Sanitizing caps for medical connectors
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
WO2018157172A1 (en) 2017-02-27 2018-08-30 Third Pole, Inc. Systems and methods for generating nitric oxide
CA3054660C (en) 2017-02-27 2022-05-03 Third Pole, Inc. Systems and methods for ambulatory generation of nitric oxide
BR112019020317A2 (pt) 2017-03-31 2020-04-28 Massachusetts Gen Hospital sistemas e métodos para um gerador de óxido nítrico resfriado
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
CA3081341A1 (en) * 2017-11-02 2019-05-09 Beyond Air, Inc. Inhalation of nitric oxide
JP6618976B2 (ja) * 2017-11-14 2019-12-11 イノ セラピューティクス エルエルシー 指標付弁と襟部を有する加圧容器組立体を係合するため、かつ薬物送達を調整するための装置と流体連通したプランジャ組立体により直線的に作動させるための装置および方法
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11433215B2 (en) 2018-11-21 2022-09-06 Icu Medical, Inc. Antimicrobial device comprising a cap with ring and insert
EP3957604A4 (en) * 2019-04-19 2023-05-10 National Institute for Materials Science MEANS FOR DELAYING NITROGENOUS GAS RELEASE, NITROGENOUS GAS DELAYED RELEASE BODY THEREFOR, METHOD FOR NITROGENOUS GAS DELAYED RELEASE WITH THE DELAYED RELEASE BODY, RESPIRATOR, ENVELOPE AND DEVICE Z UR DELAYED RELEASE
EP3969415A4 (en) 2019-05-15 2023-08-16 Third Pole, Inc. ELECTRODES FOR NITRIC OXIDE GENERATION
EP3969416A4 (en) 2019-05-15 2023-11-01 Third Pole, Inc. SYSTEMS AND METHODS FOR GENERATING NITRIC OXIDE
FR3103110B1 (fr) 2019-11-15 2021-10-08 Air Liquide Dispositif de fourniture de gaz thérapeutique, en particulier de NO ou de N2O, à un patient
US20230338416A1 (en) 2019-11-25 2023-10-26 Beyond Air, Inc. Methods employing gaseous nitric oxide for inhibiting tumor growth
EP4069069A1 (en) 2020-01-11 2022-10-12 Third Pole, Inc. Systems and methods for nitric oxide generation with humidity control
US20210395905A1 (en) 2020-06-18 2021-12-23 Third Pole, Inc. Systems and methods for preventing and treating infections with nitric oxide
US11865139B2 (en) 2020-11-12 2024-01-09 Thermolife International, Llc Method of treating migraines and headaches
WO2022104157A1 (en) * 2020-11-12 2022-05-19 Thermolife International, Llc Methods of increasing blood oxygen saturation
WO2022125474A1 (en) 2020-12-07 2022-06-16 Icu Medical, Inc. Peritoneal dialysis caps, systems and methods
WO2023049873A1 (en) 2021-09-23 2023-03-30 Third Pole, Inc. Systems and methods for delivering nitric oxide
FR3127408B1 (fr) 2021-09-29 2024-05-10 Inosystems Chariot hospitalier de transport de bouteille de gaz, notamment de NO médical
FR3131538A1 (fr) 2022-01-05 2023-07-07 Inosystems Dispositif de délivrance de NO avec système de dosage d’urgence
EP4209243A1 (fr) 2022-01-05 2023-07-12 Inosystems Dispositif de délivrance de no avec système de dosage d'urgence
FR3137841A1 (fr) 2022-07-18 2024-01-19 Inosystems Dispositif de délivrance de NO avec système de dosage d’urgence
FR3132025A1 (fr) 2022-01-24 2023-07-28 Inosystems Cartouche de stockage d’un mélange NO/azote et installation de fourniture de gaz associée
FR3133315B1 (fr) 2022-03-09 2024-03-22 Inosystems Appareil de délivrance de NO à deux sorties de gaz
FR3133316B1 (fr) 2022-03-09 2024-04-12 Inosystems Dispositif de délivrance de NO avec circuit de secours
FR3133318B1 (fr) 2022-03-09 2024-03-22 Inosystems Dispositif de délivrance de NO avec circuit de secours à débit contrôlé
FR3133317B1 (fr) 2022-03-09 2024-03-01 Inosystems Appareil de délivrance de NO avec système de ventilation manuelle
FR3136986A1 (fr) 2022-06-24 2023-12-29 Inosystems Affichage de la dose de NO par un dispositif de fourniture de NO en phase de pause
FR3138773A1 (fr) 2022-08-11 2024-02-16 Inosystems Installation de fourniture de gaz comprenant un ventilateur médical et un dispositif de délivrance de NO avec un système de dosage d’urgence

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3367332A (en) * 1965-08-27 1968-02-06 Gen Electric Product and process for establishing a sterile area of skin
US3785377A (en) * 1970-11-12 1974-01-15 S Jorgensen Plant, preferably for anaesthesia
US3745991A (en) * 1971-02-22 1973-07-17 Champion Spark Plug Co Environmental contamination control device
US4010897A (en) * 1976-03-31 1977-03-08 Charles F. Kettering Foundation Method and apparatus for home production and application of nitrogen fertilizer
IL57239A (en) * 1979-05-08 1982-04-30 Alamaro Moshe Production of nitric oxides
US4297123A (en) * 1980-02-07 1981-10-27 Wyse Harold G Method and apparatus for producing a nitrate fertilizer
US4336798A (en) * 1980-10-06 1982-06-29 Anthony V. Beran Medical corrugated respiratory tube
SE438261B (sv) * 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US4534343A (en) * 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4675174A (en) * 1985-08-16 1987-06-23 Alza Corporation Veterinary dispenser delivering beneficial agent by gas power generated in situ
US4852561A (en) * 1988-07-27 1989-08-01 Sperry C R Inhalation device
US4877589A (en) * 1988-09-19 1989-10-31 Hare Louis R O Nitrogen fixation by electric arc and catalyst
US4915915A (en) * 1988-10-11 1990-04-10 Treharne Richard W Water-powdered piezoelectric unit for producing nitrogen fertilizer
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5007419A (en) * 1989-09-25 1991-04-16 Allan Weinstein Inhaler device
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
US5187305A (en) * 1990-11-26 1993-02-16 Glaxo Inc. S-nitroso-N-alkonoylpenicillamines
US5396882A (en) * 1992-03-11 1995-03-14 The General Hospital Corporation Generation of nitric oxide from air for medical uses
AU657726B2 (en) 1990-12-05 1995-03-23 General Hospital Corporation, The Devices for treating pulmonary vasoconstriction and asthma
IL101406A (en) * 1991-03-29 1998-02-08 Brigham & Womens Hospital Pharmaceutical compositions containing s-nitrosothiol derivatives
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia
WO1993012068A1 (en) * 1991-12-11 1993-06-24 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5427797A (en) * 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation

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EP1516639B1 (en) 2007-07-25
NL300342I1 (nl) 2008-06-02
EP0560928A4 (en) 1993-12-01
EP0560928B1 (en) 1997-09-24
AU9149891A (en) 1992-07-08
DE69127756T2 (de) 1998-02-05
EP1516639A1 (en) 2005-03-23
NL300327I2 (nl) 2008-04-01
DE122007000103I1 (de) 2008-04-03
ES2082732T3 (es) 1997-12-16
DE69133584T4 (de) 2009-11-19
ATE376850T1 (de) 2007-11-15
DE122008000012I1 (de) 2008-08-14
EP1516639B2 (en) 2015-04-15
HK1076407A1 (en) 2006-01-20
JPH10158175A (ja) 1998-06-16
HK1020686A1 (en) 2003-06-19
DE560928T1 (de) 1994-09-22
LU91423I2 (fr) 2008-06-30
EP0786264A2 (en) 1997-07-30
DK0786264T3 (da) 2008-03-10
EP0786264A3 (en) 1997-08-13
CA2097823C (en) 1999-06-29
ATE367842T2 (de) 2007-08-15
EP1875917A2 (en) 2008-01-09
GR960300032T1 (en) 1996-06-30
LV12201B (en) 1999-05-20
DE122008000012I2 (de) 2012-04-12
GR3024865T3 (en) 1998-01-30
CA2097823A1 (en) 1992-06-06
EP1875917A3 (en) 2012-11-28
DE69127756D1 (de) 1997-10-30
SG47527A1 (en) 1998-04-17
DE10299002I1 (de) 2012-07-05
DK0560928T3 (da) 1997-12-01
DE69133584T2 (de) 2008-08-21
JP2701978B2 (ja) 1998-01-21
US5873359A (en) 1999-02-23
NL300081I1 (nl) 2002-04-02
LU91404I2 (fr) 2008-02-21
GR990300018T1 (en) 1999-06-30
LU90886I2 (fr) 2002-03-25
HK1010101A1 (en) 1999-06-11
JP3510755B2 (ja) 2004-03-29
ES2288660T3 (es) 2008-01-16
EP0560928A1 (en) 1993-09-22
NL300081I2 (nl) 2002-06-03
DE69133575D1 (de) 2007-09-06
ES2132043T3 (es) 2008-04-01
DE786264T1 (de) 2000-11-02
DK1516639T4 (en) 2015-06-29
ATE158509T1 (de) 1997-10-15
JPH06504778A (ja) 1994-06-02
US5485827A (en) 1996-01-23
EP0786264B1 (en) 2007-10-31
DE69133575T2 (de) 2008-04-17
EE03119B1 (et) 1998-10-15
WO1992010228A1 (en) 1992-06-25
JP2003111845A (ja) 2003-04-15
LV12201A (lv) 1999-01-20
DK1516639T3 (da) 2007-11-26
DE69133584D1 (de) 2007-12-13
AU657726B2 (en) 1995-03-23
JP3718491B2 (ja) 2005-11-24
ES2288660T5 (es) 2015-05-29
NL300327I1 (nl) 2008-03-03
ES2132043T1 (es) 1999-08-16

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