AU3237193A - S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof - Google Patents
S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereofInfo
- Publication number
- AU3237193A AU3237193A AU32371/93A AU3237193A AU3237193A AU 3237193 A AU3237193 A AU 3237193A AU 32371/93 A AU32371/93 A AU 32371/93A AU 3237193 A AU3237193 A AU 3237193A AU 3237193 A AU3237193 A AU 3237193A
- Authority
- AU
- Australia
- Prior art keywords
- nitrosothiols
- smooth muscle
- therapeutic uses
- muscle relaxants
- relaxants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80466591A | 1991-12-11 | 1991-12-11 | |
US804665 | 1991-12-11 | ||
US07/943,834 US5380758A (en) | 1991-03-29 | 1992-09-14 | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US943834 | 1992-09-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU3237193A true AU3237193A (en) | 1993-07-19 |
Family
ID=27122712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU32371/93A Abandoned AU3237193A (en) | 1991-12-11 | 1992-12-07 | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU3237193A (en) |
WO (1) | WO1993012068A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1875917A3 (en) * | 1990-12-05 | 2012-11-28 | The General Hospital Corporation | Use of NO for the treatment or prevention of reversible pulmonary vasoconstriction |
US5536241A (en) * | 1990-12-05 | 1996-07-16 | The General Hospital Corporation | Methods and devices for relaxing smooth muscle contractions |
US5570683A (en) * | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
US5823180A (en) * | 1995-04-03 | 1998-10-20 | The General Hospital Corporation | Methods for treating pulmonary vasoconstriction and asthma |
US6197745B1 (en) * | 1995-09-15 | 2001-03-06 | Duke University | Methods for producing nitrosated hemoglobins and therapeutic uses therefor |
US6916471B2 (en) | 1995-09-15 | 2005-07-12 | Duke University | Red blood cells loaded with S-nitrosothiol and uses therefor |
US6911427B1 (en) | 1995-09-15 | 2005-06-28 | Duke University | No-modified hemoglobins and uses therefore |
US6153186A (en) * | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
US6855691B1 (en) | 1995-09-15 | 2005-02-15 | Duke University | Methods for producing and using S-nitrosohemoglobins |
US5994294A (en) * | 1996-02-02 | 1999-11-30 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US6323211B1 (en) | 1996-02-02 | 2001-11-27 | Nitromed, Inc. | Compositions and methods for treating sexual dysfunctions |
US6294517B1 (en) | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US6232434B1 (en) | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
EP0941086A4 (en) * | 1996-11-01 | 2000-07-12 | Nitromed Inc | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
EP0979073A4 (en) * | 1997-03-31 | 2004-04-07 | Childrens Medical Center | Nitrosylation to inactivate apoptotic enzymes |
GB9720797D0 (en) * | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
EP1263428A2 (en) * | 2000-01-18 | 2002-12-11 | Buhimschi, Irina | Free radical scavengers for the treatment of premature birth |
EP2944648B1 (en) * | 2001-03-29 | 2019-11-13 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for the treatment of organ inflammation |
US6676855B2 (en) * | 2001-08-02 | 2004-01-13 | Duke University | Use of a blood-flow decrease preventing agent in conjunction with insufflating gas |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2998314B1 (en) | 2007-06-04 | 2020-01-22 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
EP2373296B1 (en) | 2008-12-03 | 2016-08-03 | Synergy Pharmaceuticals Inc. | Formulations of guanylate cyclase c agonists and methods of use |
WO2012037380A2 (en) | 2010-09-15 | 2012-03-22 | Synergy Pharmaceuticals Inc. | Formulations of guanylate cyclase c agonists and methods of use |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2328709A (en) * | 1940-06-27 | 1943-09-07 | Socony Vacuum Oil Co Inc | Method for stabilizing organic thionitrites |
-
1992
- 1992-12-07 WO PCT/US1992/010447 patent/WO1993012068A1/en active Application Filing
- 1992-12-07 AU AU32371/93A patent/AU3237193A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1993012068A1 (en) | 1993-06-24 |
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