EP0941086A4 - Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses - Google Patents
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their usesInfo
- Publication number
- EP0941086A4 EP0941086A4 EP97946871A EP97946871A EP0941086A4 EP 0941086 A4 EP0941086 A4 EP 0941086A4 EP 97946871 A EP97946871 A EP 97946871A EP 97946871 A EP97946871 A EP 97946871A EP 0941086 A4 EP0941086 A4 EP 0941086A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nitrosated
- compositions
- inhibitor compounds
- phosphodiesterase inhibitor
- nitrosylated phosphodiesterase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paper (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/740,764 US5874437A (en) | 1996-11-01 | 1996-11-01 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US740764 | 1996-11-01 | ||
PCT/US1997/019870 WO1998019672A1 (en) | 1996-11-01 | 1997-10-31 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0941086A1 EP0941086A1 (en) | 1999-09-15 |
EP0941086A4 true EP0941086A4 (en) | 2000-07-12 |
Family
ID=26792881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97946871A Withdrawn EP0941086A4 (en) | 1996-11-01 | 1997-10-31 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0941086A4 (en) |
JP (1) | JP2001504457A (en) |
AU (1) | AU722480B2 (en) |
CA (1) | CA2270118A1 (en) |
WO (1) | WO1998019672A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
EP1535611A3 (en) * | 1997-06-23 | 2009-09-16 | Strakan International Limited | Microdose therapy of vascular conditions by no donors |
CA2305394C (en) * | 1997-10-28 | 2006-12-12 | Vivus, Incorporated | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
US6200591B1 (en) | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
CN1149983C (en) * | 1998-12-14 | 2004-05-19 | 赛勒吉药物股份有限公司 | Compositions and methods for treatment of anorectal disorders |
US6627632B2 (en) | 1998-12-14 | 2003-09-30 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
US6476037B1 (en) * | 2000-03-23 | 2002-11-05 | The Regents Of The University Of California | L-arginine and phosphodiesterase (PDE) inhibitor synergism |
AU2000270300A1 (en) * | 2000-09-13 | 2002-03-26 | Isis Innovation Limited | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders |
CA2446064A1 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
PL367205A1 (en) * | 2001-06-15 | 2005-02-21 | Yamanouchi Pharmaceutical Co, Ltd. | Phenylpyridine carbonyl piperazine derivative |
EP1448205B1 (en) | 2001-10-05 | 2011-03-23 | Zalicus Inc. | Combinations for the treatment of immunoinflammatory disorders |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
US7875268B2 (en) | 2004-04-06 | 2011-01-25 | L'oreal S.A. | Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith |
US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
ATE462703T1 (en) | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | BICYCLONONE DERIVATIVES AS RENIN INHIBITORS |
US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
KR100963455B1 (en) | 2005-05-27 | 2010-06-18 | 액테리온 파마슈티칼 리미티드 | Novel piperidine carboxylic acid amide derivatives |
WO2007016677A2 (en) | 2005-08-02 | 2007-02-08 | Nitromed, Inc. | Nitric oxide enhancing antimicrobial compounds, compositions and methods of use |
US7968720B2 (en) | 2006-02-02 | 2011-06-28 | Actelion Pharmaceuticals Ltd. | Secondary amines as renin inhibitors |
CA2647859C (en) | 2006-03-29 | 2016-01-05 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
CA2722734C (en) | 2008-05-05 | 2013-11-05 | Merck Frosst Canada Ltd. | 3,4-substituted piperidine derivatives as renin inhibitors |
NO2440239T3 (en) | 2009-06-09 | 2018-02-10 | ||
KR102670626B1 (en) * | 2017-05-22 | 2024-05-29 | 토파두르 파마 아게 | Novel dual mode of action of soluble guanylate cyclase activator and phosphodiesterase inhibitor and use thereof |
WO2022022669A1 (en) * | 2020-07-30 | 2022-02-03 | Biofront Therapeutics (Beijing) Co., Ltd. | Dual-functional compounds and methods of use |
JP7425925B2 (en) * | 2020-07-30 | 2024-01-31 | バイオフロント セラピューティクス (ベイジン) カンパニー リミテッド | Bifunctional compounds and methods of use |
WO2023005180A1 (en) * | 2021-07-30 | 2023-02-02 | Biofront Therapeutics (Beijing) Co., Ltd. | Dual-functional compounds and methods of use |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0252721A1 (en) * | 1986-07-07 | 1988-01-13 | Ortho Pharmaceutical Corporation | 4-Nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties |
EP0352960A2 (en) * | 1988-07-25 | 1990-01-31 | Smith Kline & French Laboratories Limited | Purine compounds, process for their preparation and pharmaceutical compositions |
EP0442204A2 (en) * | 1989-12-15 | 1991-08-21 | Smith Kline & French Laboratories Limited | Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
EP0463756A1 (en) * | 1990-06-20 | 1992-01-02 | Pfizer Limited | Pyrazolopyrimidinone antianginal agents |
EP0506194A1 (en) * | 1991-03-25 | 1992-09-30 | Akzo Nobel N.V. | 4-aryl-thiazole or imidazole derivatives |
WO1993012068A1 (en) * | 1991-12-11 | 1993-06-24 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
WO1995009636A1 (en) * | 1993-10-04 | 1995-04-13 | The Trustees Of Columbia University In The City Ofnew York | Method of inducing vasorelaxation to treat pulmonary hypertension |
WO1996025184A1 (en) * | 1995-02-16 | 1996-08-22 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
WO1997034871A1 (en) * | 1996-03-22 | 1997-09-25 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
WO1997039760A1 (en) * | 1996-04-23 | 1997-10-30 | Queen's University At Kingston | Combination therapy for treatment of erectile dysfunction |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU179019B (en) * | 1978-11-01 | 1982-08-28 | Gyogyszekutato Intezet | Process for preparing 4-//3,4-dialkoxy-phenyl/-alkyl/- 2imidazolidinone derivatives |
US5459145A (en) * | 1988-01-19 | 1995-10-17 | Pfizer Inc. | Calcium independent camp phosphodiesterase inhibitor antidepressant |
GB8929208D0 (en) * | 1989-12-27 | 1990-02-28 | Almirall Lab | New xanthine derivatives |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9212693D0 (en) * | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
EP0706513B1 (en) * | 1993-07-02 | 2002-05-15 | Byk Gulden Lomberg Chemische Fabrik GmbH | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
-
1997
- 1997-10-31 CA CA002270118A patent/CA2270118A1/en not_active Abandoned
- 1997-10-31 JP JP52161698A patent/JP2001504457A/en not_active Ceased
- 1997-10-31 EP EP97946871A patent/EP0941086A4/en not_active Withdrawn
- 1997-10-31 WO PCT/US1997/019870 patent/WO1998019672A1/en active Application Filing
- 1997-10-31 AU AU51962/98A patent/AU722480B2/en not_active Ceased
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0252721A1 (en) * | 1986-07-07 | 1988-01-13 | Ortho Pharmaceutical Corporation | 4-Nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties |
EP0352960A2 (en) * | 1988-07-25 | 1990-01-31 | Smith Kline & French Laboratories Limited | Purine compounds, process for their preparation and pharmaceutical compositions |
EP0442204A2 (en) * | 1989-12-15 | 1991-08-21 | Smith Kline & French Laboratories Limited | Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
EP0463756A1 (en) * | 1990-06-20 | 1992-01-02 | Pfizer Limited | Pyrazolopyrimidinone antianginal agents |
EP0506194A1 (en) * | 1991-03-25 | 1992-09-30 | Akzo Nobel N.V. | 4-aryl-thiazole or imidazole derivatives |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
WO1993012068A1 (en) * | 1991-12-11 | 1993-06-24 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
WO1995009636A1 (en) * | 1993-10-04 | 1995-04-13 | The Trustees Of Columbia University In The City Ofnew York | Method of inducing vasorelaxation to treat pulmonary hypertension |
WO1996025184A1 (en) * | 1995-02-16 | 1996-08-22 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
WO1997034871A1 (en) * | 1996-03-22 | 1997-09-25 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
WO1997039760A1 (en) * | 1996-04-23 | 1997-10-30 | Queen's University At Kingston | Combination therapy for treatment of erectile dysfunction |
Non-Patent Citations (15)
Title |
---|
A.J.M. BARBIER ET AL., BR. J. PHARMACOL., vol. 111, no. 4, 1994, pages 1280 - 1286 * |
AM. J. PHYSIOL., vol. 265, no. 3(1), 1993, pages G418 - G422 * |
BOOLELL M ET AL: "SILDENAFIL, A NOVEL EFFECTIVE ORAL THERAPY FOR MALE ERECTILE DYSFUNCTION", BRITISH JOURNAL OF UROLOGY,GB,EDINBURGH, vol. 78, no. 2, 1996, pages 257-261, XP000853934 * |
CHEMICAL ABSTRACTS, vol. 116, no. 1, 6 January 1992, Columbus, Ohio, US; abstract no. 4477, XP002127110 * |
CHEMICAL ABSTRACTS, vol. 120, no. 1, 3 January 1994, Columbus, Ohio, US; abstract no. 5451d, XP002107375 * |
CHEMICAL ABSTRACTS, vol. 120, no. 25, 20 June 1994, Columbus, Ohio, US; abstract no. 315630, XP002127108 * |
CHEMICAL ABSTRACTS, vol. 121, no. 7, 15 August 1994, Columbus, Ohio, US; abstract no. 73410, XP002127109 * |
CHEMICAL ABSTRACTS, vol. 123, no. 1, 3 July 1995, Columbus, Ohio, US; abstract no. 574, XP002127107 * |
CHEMICAL ABSTRACTS, vol. 125, no. 15, 7 October 1996, Columbus, Ohio, US; abstract no. 191382, XP002127106 * |
F. ICHINOSE ET AL., J. APPL. PHYSIOL., vol. 78, no. 4, 1995, pages 1288 - 1295 * |
J. DE VENTE ET AL., J. CHEM. NEUROANAT., vol. 10, no. 3,4, 1996, pages 241 - 248 * |
M.W. RADOMSKI ET AL., CANCER RES., vol. 51, no. 22, 1991, pages 6073 - 6078 * |
MARTEL A M ET AL: "Sildenafil", DRUGS OF THE FUTURE,ES,BARCELONA, vol. 22, no. 2, 1997, pages 138-143, XP002090616, ISSN: 0377-8282 * |
N.A. ALLEN ET AL., BR. J. PHARMACOL., vol. 112, no. 2, 1994, pages 423 - 428 * |
See also references of WO9819672A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0941086A1 (en) | 1999-09-15 |
AU722480B2 (en) | 2000-08-03 |
WO1998019672A1 (en) | 1998-05-14 |
JP2001504457A (en) | 2001-04-03 |
CA2270118A1 (en) | 1998-05-14 |
AU5196298A (en) | 1998-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19990428 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/165 A, 7A 61K 31/38 B, 7A 61K 31/40 B, 7A 61K 31/415 B, 7A 61K 31/425 B, 7A 61K 31/44 B, 7A 61K 31/47 B, 7A 61K 31/50 B, 7A 61K 31/505 B, 7C 07D 207/24 B, 7A 61K 31/52 B, 7C 07D 473/30 B, 7C 07D 487/04 B, 7C 07D 405/14 B, 7C 07D 487/04 J, 7C 07D 239:00 J, 7C 07D 239:00 J |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20000525 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20010122 |
|
17Q | First examination report despatched |
Effective date: 20010122 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20100504 |