EP0941086A4 - Nitrosierte und nitrosylierte phosphodiesterase hemmende verbindungen, zusammensetzungen und ihre verwendungen - Google Patents

Nitrosierte und nitrosylierte phosphodiesterase hemmende verbindungen, zusammensetzungen und ihre verwendungen

Info

Publication number
EP0941086A4
EP0941086A4 EP97946871A EP97946871A EP0941086A4 EP 0941086 A4 EP0941086 A4 EP 0941086A4 EP 97946871 A EP97946871 A EP 97946871A EP 97946871 A EP97946871 A EP 97946871A EP 0941086 A4 EP0941086 A4 EP 0941086A4
Authority
EP
European Patent Office
Prior art keywords
nitrosated
compositions
inhibitor compounds
phosphodiesterase inhibitor
nitrosylated phosphodiesterase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97946871A
Other languages
English (en)
French (fr)
Other versions
EP0941086A1 (de
Inventor
David S Garvey
De Tejada Inigo Saenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitromed Inc
Original Assignee
Nitromed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/740,764 external-priority patent/US5874437A/en
Application filed by Nitromed Inc filed Critical Nitromed Inc
Publication of EP0941086A1 publication Critical patent/EP0941086A1/de
Publication of EP0941086A4 publication Critical patent/EP0941086A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Paper (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP97946871A 1996-11-01 1997-10-31 Nitrosierte und nitrosylierte phosphodiesterase hemmende verbindungen, zusammensetzungen und ihre verwendungen Withdrawn EP0941086A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/740,764 US5874437A (en) 1996-11-01 1996-11-01 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US740764 1996-11-01
PCT/US1997/019870 WO1998019672A1 (en) 1996-11-01 1997-10-31 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses

Publications (2)

Publication Number Publication Date
EP0941086A1 EP0941086A1 (de) 1999-09-15
EP0941086A4 true EP0941086A4 (de) 2000-07-12

Family

ID=26792881

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97946871A Withdrawn EP0941086A4 (de) 1996-11-01 1997-10-31 Nitrosierte und nitrosylierte phosphodiesterase hemmende verbindungen, zusammensetzungen und ihre verwendungen

Country Status (5)

Country Link
EP (1) EP0941086A4 (de)
JP (1) JP2001504457A (de)
AU (1) AU722480B2 (de)
CA (1) CA2270118A1 (de)
WO (1) WO1998019672A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
EP1535611A3 (de) * 1997-06-23 2009-09-16 Strakan International Limited Microdosistherapie von Gefässbedingten Erscheinungen durch NO-Donoren
JP2003525845A (ja) * 1997-10-28 2003-09-02 ヴィヴァス・インコーポレイテッド 勃起機能不全の処置のためのホスホジエステラーゼインヒビターの局所投与
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
US6627632B2 (en) 1998-12-14 2003-09-30 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
JP2002542147A (ja) * 1998-12-14 2002-12-10 セレジィ ファーマシューティカルス， インコーポレイテッド 肛門直腸障害の処置のための組成物および方法
US6476037B1 (en) * 2000-03-23 2002-11-05 The Regents Of The University Of California L-arginine and phosphodiesterase (PDE) inhibitor synergism
AU2000270300A1 (en) * 2000-09-13 2002-03-26 Isis Innovation Limited Use of phosphodiesterase inhibitors for the treatment of anorectal disorders
JP2004528337A (ja) 2001-05-02 2004-09-16 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法
WO2002102778A1 (fr) * 2001-06-15 2002-12-27 Yamanouchi Pharmaceutical Co., Ltd. Derive de phenylpyridinecarbonylpiperazine
US7253155B2 (en) 2001-10-05 2007-08-07 Combinatorx, Inc. Combinations for the treatment of immunoinflammatory disorders
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US7875268B2 (en) 2004-04-06 2011-01-25 L'oreal S.A. Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith
US7067659B2 (en) * 2004-04-23 2006-06-27 Duke University Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
EP1786814B1 (de) 2004-08-25 2010-03-31 Actelion Pharmaceuticals Ltd. Bicyclononen-derivate als renin-inhibitoren
WO2006041855A2 (en) 2004-10-04 2006-04-20 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
BRPI0609890A2 (pt) 2005-05-27 2010-05-04 Actelion Pharmaceuticals Ltd composto, composição farmacêutica, e, uso de um composto
US20090018091A1 (en) 2005-08-02 2009-01-15 Nitromed, Inc. Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use
NZ570828A (en) 2006-02-02 2011-07-29 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
WO2007126609A1 (en) 2006-03-29 2007-11-08 Nitromed, Inc. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
AU2009243875B2 (en) 2008-05-05 2011-12-01 Idorsia Pharmaceuticals Ltd 3, 4 - substituted piperidine derivatives as renin inhibitors
RU2589254C2 (ru) 2009-06-09 2016-07-10 ПРОЛОНГ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Композиции гемоглобина
MX2019013626A (es) * 2017-05-22 2020-01-13 Topadur Pharma Ag Modo de accion dual novedoso de activadores de guanilato ciclasa solubles e inhibidores de fosfodiesterasa y usos de los mismos.
WO2022022669A1 (en) * 2020-07-30 2022-02-03 Biofront Therapeutics (Beijing) Co., Ltd. Dual-functional compounds and methods of use
EP4175943A4 (de) * 2020-07-30 2023-11-15 Biofront Therapeutics (Beijing) Co., Ltd. Bifunktionelle verbindungen und verfahren zu ihrer verwendung
WO2023005180A1 (en) * 2021-07-30 2023-02-02 Biofront Therapeutics (Beijing) Co., Ltd. Dual-functional compounds and methods of use

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252721A1 (de) * 1986-07-07 1988-01-13 Ortho Pharmaceutical Corporation In 4-Stellung durch Stickstoff substituierte Isochinolinolverbindungen mit cardiotonischen, die Wirkung von Phosphodiesterase-Fraktion-III inhibierenden und/oder renal vasodilatierenden Eigenschaften
EP0352960A2 (de) * 1988-07-25 1990-01-31 Smith Kline & French Laboratories Limited Purinverbindungen, Verfahren zu ihrer Herstellung und pharmazeutische Präparate
EP0442204A2 (de) * 1989-12-15 1991-08-21 Smith Kline & French Laboratories Limited Pyrimidopyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0463756A1 (de) * 1990-06-20 1992-01-02 Pfizer Limited Pyrazolopyrimidone als Wirkstoffe gegen Angina
EP0506194A1 (de) * 1991-03-25 1992-09-30 Akzo Nobel N.V. 4-Aryl-thiazole oder imidazolederivate
WO1993012068A1 (en) * 1991-12-11 1993-06-24 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
WO1995009636A1 (en) * 1993-10-04 1995-04-13 The Trustees Of Columbia University In The City Ofnew York Method of inducing vasorelaxation to treat pulmonary hypertension
WO1996025184A1 (en) * 1995-02-16 1996-08-22 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
WO1997034871A1 (en) * 1996-03-22 1997-09-25 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
WO1997039760A1 (en) * 1996-04-23 1997-10-30 Queen's University At Kingston Combination therapy for treatment of erectile dysfunction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179019B (en) * 1978-11-01 1982-08-28 Gyogyszekutato Intezet Process for preparing 4-//3,4-dialkoxy-phenyl/-alkyl/- 2imidazolidinone derivatives
US5459145A (en) * 1988-01-19 1995-10-17 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9212693D0 (en) * 1992-06-15 1992-07-29 Celltech Ltd Chemical compounds
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
AU687087B2 (en) * 1993-07-02 1998-02-19 Takeda Gmbh Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252721A1 (de) * 1986-07-07 1988-01-13 Ortho Pharmaceutical Corporation In 4-Stellung durch Stickstoff substituierte Isochinolinolverbindungen mit cardiotonischen, die Wirkung von Phosphodiesterase-Fraktion-III inhibierenden und/oder renal vasodilatierenden Eigenschaften
EP0352960A2 (de) * 1988-07-25 1990-01-31 Smith Kline & French Laboratories Limited Purinverbindungen, Verfahren zu ihrer Herstellung und pharmazeutische Präparate
EP0442204A2 (de) * 1989-12-15 1991-08-21 Smith Kline & French Laboratories Limited Pyrimidopyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0463756A1 (de) * 1990-06-20 1992-01-02 Pfizer Limited Pyrazolopyrimidone als Wirkstoffe gegen Angina
EP0506194A1 (de) * 1991-03-25 1992-09-30 Akzo Nobel N.V. 4-Aryl-thiazole oder imidazolederivate
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
WO1993012068A1 (en) * 1991-12-11 1993-06-24 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
WO1995009636A1 (en) * 1993-10-04 1995-04-13 The Trustees Of Columbia University In The City Ofnew York Method of inducing vasorelaxation to treat pulmonary hypertension
WO1996025184A1 (en) * 1995-02-16 1996-08-22 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
WO1997034871A1 (en) * 1996-03-22 1997-09-25 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
WO1997039760A1 (en) * 1996-04-23 1997-10-30 Queen's University At Kingston Combination therapy for treatment of erectile dysfunction

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
A.J.M. BARBIER ET AL., BR. J. PHARMACOL., vol. 111, no. 4, 1994, pages 1280 - 1286 *
AM. J. PHYSIOL., vol. 265, no. 3(1), 1993, pages G418 - G422 *
BOOLELL M ET AL: "SILDENAFIL, A NOVEL EFFECTIVE ORAL THERAPY FOR MALE ERECTILE DYSFUNCTION", BRITISH JOURNAL OF UROLOGY,GB,EDINBURGH, vol. 78, no. 2, 1996, pages 257-261, XP000853934 *
CHEMICAL ABSTRACTS, vol. 116, no. 1, 6 January 1992, Columbus, Ohio, US; abstract no. 4477, XP002127110 *
CHEMICAL ABSTRACTS, vol. 120, no. 1, 3 January 1994, Columbus, Ohio, US; abstract no. 5451d, XP002107375 *
CHEMICAL ABSTRACTS, vol. 120, no. 25, 20 June 1994, Columbus, Ohio, US; abstract no. 315630, XP002127108 *
CHEMICAL ABSTRACTS, vol. 121, no. 7, 15 August 1994, Columbus, Ohio, US; abstract no. 73410, XP002127109 *
CHEMICAL ABSTRACTS, vol. 123, no. 1, 3 July 1995, Columbus, Ohio, US; abstract no. 574, XP002127107 *
CHEMICAL ABSTRACTS, vol. 125, no. 15, 7 October 1996, Columbus, Ohio, US; abstract no. 191382, XP002127106 *
F. ICHINOSE ET AL., J. APPL. PHYSIOL., vol. 78, no. 4, 1995, pages 1288 - 1295 *
J. DE VENTE ET AL., J. CHEM. NEUROANAT., vol. 10, no. 3,4, 1996, pages 241 - 248 *
M.W. RADOMSKI ET AL., CANCER RES., vol. 51, no. 22, 1991, pages 6073 - 6078 *
MARTEL A M ET AL: "Sildenafil", DRUGS OF THE FUTURE,ES,BARCELONA, vol. 22, no. 2, 1997, pages 138-143, XP002090616, ISSN: 0377-8282 *
N.A. ALLEN ET AL., BR. J. PHARMACOL., vol. 112, no. 2, 1994, pages 423 - 428 *
See also references of WO9819672A1 *

Also Published As

Publication number Publication date
JP2001504457A (ja) 2001-04-03
AU722480B2 (en) 2000-08-03
WO1998019672A1 (en) 1998-05-14
CA2270118A1 (en) 1998-05-14
EP0941086A1 (de) 1999-09-15
AU5196298A (en) 1998-05-29

Similar Documents

Publication Publication Date Title
EP0941086A4 (de) Nitrosierte und nitrosylierte phosphodiesterase hemmende verbindungen, zusammensetzungen und ihre verwendungen
EP1109543A4 (de) Nitroso- und nitrosylverbindungen als phosphodiesterase inhibitoren, zusammenstellungen und verwendungsmethoden
GB2346877B (en) 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
IL150368A0 (en) Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
EP1126838A4 (de) Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden
EP0710195A4 (de) Thermit-zusammensetzungen zur verwendung als gaserzeugende körper
EP0659715A3 (de) Gaserzeugende Zusammenasetzungen.
EP0928230A4 (de) Federfutter
GB9721094D0 (en) Autophobic hairspray compositions
AU5652698A (en) (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
DE69704919D1 (de) Grundierzusammensetzung
GR3031669T3 (en) Rectal compositions
AUPO371096A0 (en) Corrosion inhibiting composition
AU1470497A (en) Triazine containing compounds useful as antiviral agents
DE69700553D1 (de) Lackzusammensetzung
HUP0000701A3 (en) Chemical linker compositions
GB9811079D0 (en) Vice accessory
GB9326418D0 (en) Multi-purpose clip
GB9406179D0 (en) Chemical compositions
AU3419097A (en) Triazine containing compounds useful as antiviral agents
GB9702112D0 (en) Compounds,compositions and their use
GB9714537D0 (en) Compounds, compositions and their use
GB9617302D0 (en) Chemical compositions
GB9623943D0 (en) Chemical compositions
PL316514A1 (en) Novel disazo compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990428

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/165 A, 7A 61K 31/38 B, 7A 61K 31/40 B, 7A 61K 31/415 B, 7A 61K 31/425 B, 7A 61K 31/44 B, 7A 61K 31/47 B, 7A 61K 31/50 B, 7A 61K 31/505 B, 7C 07D 207/24 B, 7A 61K 31/52 B, 7C 07D 473/30 B, 7C 07D 487/04 B, 7C 07D 405/14 B, 7C 07D 487/04 J, 7C 07D 239:00 J, 7C 07D 239:00 J

A4 Supplementary search report drawn up and despatched

Effective date: 20000525

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 20010122

17Q First examination report despatched

Effective date: 20010122

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100504