MX9707472A - Diaminas radiosensibilizadoras y sus preparaciones farmaceuticas. - Google Patents

Diaminas radiosensibilizadoras y sus preparaciones farmaceuticas.

Info

Publication number
MX9707472A
MX9707472A MX9707472A MX9707472A MX9707472A MX 9707472 A MX9707472 A MX 9707472A MX 9707472 A MX9707472 A MX 9707472A MX 9707472 A MX9707472 A MX 9707472A MX 9707472 A MX9707472 A MX 9707472A
Authority
MX
Mexico
Prior art keywords
radiosensitizing
diamines
chain
pharmaceutical preparations
carbons
Prior art date
Application number
MX9707472A
Other languages
English (en)
Inventor
Kurt G Hofer
Li-Xi Yang
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of MX9707472A publication Critical patent/MX9707472A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se provee un compuesto que comprende una diamina que contiene de 2 a 4 grupos funcionales radiosensibilizadores electron-afínicos, o una sal del mismo; en una modalidad preferida, el compuesto tiene la formula (I): en donde A comprende una cadena de carbono que tiene de aproximadamente 2 a 10 átomos de carbono en la cadena, R1, R2, R3, y R4 son H o T, T es en donde A' comprende una cadena de carbono que tiene de aproximadamente 1-8 átomos de carbono en la cadena, R5 es H, alquilo inferior o halogeno, y R6 es H, alquilo inferior, halogeno o nitro, siempre que por lo menos uno de R1 y R2, y por lo menos uno de R3 y R4 sea T; también se proveen intermediarios para composiciones farmacéuticas que contienen dichos compuestos, métodos para hacerlos y métodos para usar dichos compuestos para radiosensibilizar y matar células tumorales hipoxicas.
MX9707472A 1995-03-31 1996-01-03 Diaminas radiosensibilizadoras y sus preparaciones farmaceuticas. MX9707472A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/414,272 US5700825A (en) 1995-03-31 1995-03-31 Radiosensitizing diamines and their pharmaceutical preparations
PCT/US1996/000222 WO1996030365A1 (en) 1995-03-31 1996-01-03 Radiosensitizing diamines and their pharmaceutical preparations

Publications (1)

Publication Number Publication Date
MX9707472A true MX9707472A (es) 1998-03-31

Family

ID=23640730

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707472A MX9707472A (es) 1995-03-31 1996-01-03 Diaminas radiosensibilizadoras y sus preparaciones farmaceuticas.

Country Status (9)

Country Link
US (1) US5700825A (es)
EP (1) EP0830357A4 (es)
JP (1) JPH11502835A (es)
KR (1) KR19980703489A (es)
CN (1) CN1081637C (es)
AU (1) AU706494B2 (es)
CA (1) CA2216381A1 (es)
MX (1) MX9707472A (es)
WO (1) WO1996030365A1 (es)

Families Citing this family (19)

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US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
MXPA06014684A (es) 2004-06-18 2007-02-12 Ambrx Inc Novedosos polipeptidos de enlace antigeno y sus usos.
US8541459B2 (en) * 2007-01-26 2013-09-24 Pola Pharma Inc. Pharmaceutical composition
WO2009039192A2 (en) 2007-09-17 2009-03-26 The Regents Of The University Of Californina Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
FI3383920T3 (fi) 2015-11-30 2024-04-10 Univ California Kasvainspesifinen hyötyaineen antaminen ja immuuniaktivointi käyttämällä erittäin spesifiseen kasvainsolun pinta-antigeeniin kohdentuvaa ihmisen vasta-ainetta
CN105541727B (zh) * 2016-01-15 2018-01-30 徐州医学院 一种具放疗增敏功能的脂质分子、其制备方法及其在肿瘤放射治疗药物中的应用
CA3043277A1 (en) 2016-11-11 2018-05-17 The Regents Of The University Of California Anti-cd46 antibodies and methods of use
KR102630499B1 (ko) 2018-12-21 2024-01-30 어비디티 바이오사이언시스 인크. 항트랜스페린 수용체 항체 및 이의 용도
EP4121063A4 (en) 2020-03-19 2024-07-03 Avidity Biosciences Inc COMPOSITIONS AND METHODS FOR TREATING FACIO-SCAPULO-HUMERAL MUSCULAR DYSTROPHY
KR20220161378A (ko) 2020-03-27 2022-12-06 어비디티 바이오사이언시스 인크. 근이영양증의 치료용 조성물 및 방법
US11484604B2 (en) 2020-08-07 2022-11-01 Fortis Therapeutics, Inc. Immunoconjugates targeting CD46 and methods of use thereof
WO2023043953A1 (en) 2021-09-16 2023-03-23 Avidity Biosciences, Inc. Compositions and methods of treating facioscapulohumeral muscular dystrophy

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
CA519633A (en) * 1955-12-20 E. Carpenter Joseph Cationic surface active agents
CA784711A (en) * 1968-05-07 Carlo Erba S.P.A. Imidazole-derivatives and process for their preparation
US4282232A (en) * 1979-04-26 1981-08-04 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US4371540A (en) * 1979-09-14 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells
DE2948884A1 (de) * 1979-12-05 1981-06-11 Basf Ag, 6700 Ludwigshafen 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
GB2131020B (en) * 1982-11-25 1986-10-01 Gerald Edward Adams Improvements relating to compounds useful in radiotherapy or chemotherapy
US5215738A (en) * 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
US4665191A (en) * 1985-05-06 1987-05-12 Texaco Inc. Mannich condensates
CA1339133C (en) * 1987-03-13 1997-07-29 Rikuo Nasu Imidazole compounds and biocidal composition comprising the same for controlling harmful organisms
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JP2627441B2 (ja) * 1989-01-19 1997-07-09 大鵬薬品工業株式会社 １―アセトキシム―２―ニトロイミダゾール誘導体
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KR927003539A (ko) * 1990-01-26 1992-12-18 스즈끼 쯔네시 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
IL103353A (en) * 1991-10-29 1999-01-26 Bracco Int Bv His metal bracelet ligand is a diagnostic product and processes for its preparation
US5389661A (en) * 1991-12-05 1995-02-14 Warner-Lambert Company Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
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JPH06345728A (ja) * 1993-06-11 1994-12-20 Nissan Chem Ind Ltd Ｎ−置換アゾール誘導体の製造方法

Also Published As

Publication number Publication date
AU4748396A (en) 1996-10-16
EP0830357A1 (en) 1998-03-25
AU706494B2 (en) 1999-06-17
US5700825A (en) 1997-12-23
EP0830357A4 (en) 2000-01-19
WO1996030365A1 (en) 1996-10-03
CA2216381A1 (en) 1996-10-03
KR19980703489A (ko) 1998-11-05
CN1081637C (zh) 2002-03-27
CN1183097A (zh) 1998-05-27
JPH11502835A (ja) 1999-03-09

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees