ES2067022T3 - Complejos estabilizados de oxido nitrico y aminas primarias utiles como agentes cardiovasculares. - Google Patents

Complejos estabilizados de oxido nitrico y aminas primarias utiles como agentes cardiovasculares.

Info

Publication number
ES2067022T3
ES2067022T3 ES90904147T ES90904147T ES2067022T3 ES 2067022 T3 ES2067022 T3 ES 2067022T3 ES 90904147 T ES90904147 T ES 90904147T ES 90904147 T ES90904147 T ES 90904147T ES 2067022 T3 ES2067022 T3 ES 2067022T3
Authority
ES
Spain
Prior art keywords
nitric oxide
primary amines
cardiovascular agents
amines useful
biologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90904147T
Other languages
English (en)
Inventor
Larry Kay Keefer
David Anderson Wink
Tambra Marie Dunams
Joseph Anthony Hrabie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of ES2067022T3 publication Critical patent/ES2067022T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

UN METODO PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES EN UN MAMIFERO MEDIANTE LA ADMINISTRACION A DICHO MAMIFERO DE UNA CANTIDAD EFICAZ DE UN COMPUESTO DE LA FORMULA: [R N(H)N(NO)O ILALQUILO, O CICLOALQUILO, CUALQUIERA DE DICHOS GRUPOS R PUEDE SUSTITUIRSE OPCIONALMENTE POR UNO O TRES SUSTITUYENTES SELECCIONADOS DEL GRUPO QUE CONSISTE EN: HALO, HIDROXILO, ALCOXI, AMINO, AMIDO, CARBONILO, CARBOXILO, O NITRO; Y DONDE X ES UN CATION BIOLOGICAMENTE ACEPTABLE, UN CENTRO METALICO BIOLOGICAMENTE ACEPTABLE, O UN GRUPO ORGANICO BIOLOGICAMENTE ACEPTABLE SELECCIONADO DE ALQUILO INFERIOR, ACILO O AMIDO, Y Y ES DE 1 A 3 CONSISTENTE CON LA VALENCIA DE X. SE DESCRIBEN TAMBIEN COMPOSICIONES FARMACEUTICAS COMPRENDIENDO LOS COMPUESTOS.
ES90904147T 1989-02-28 1990-02-27 Complejos estabilizados de oxido nitrico y aminas primarias utiles como agentes cardiovasculares. Expired - Lifetime ES2067022T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/316,958 US4954526A (en) 1989-02-28 1989-02-28 Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents

Publications (1)

Publication Number Publication Date
ES2067022T3 true ES2067022T3 (es) 1995-03-16

Family

ID=23231459

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90904147T Expired - Lifetime ES2067022T3 (es) 1989-02-28 1990-02-27 Complejos estabilizados de oxido nitrico y aminas primarias utiles como agentes cardiovasculares.

Country Status (11)

Country Link
US (1) US4954526A (es)
EP (1) EP0495776B1 (es)
JP (1) JPH07108855B2 (es)
AT (1) ATE117894T1 (es)
AU (1) AU621470B2 (es)
CA (1) CA2046910C (es)
DE (1) DE69016667T2 (es)
DK (1) DK0495776T3 (es)
ES (1) ES2067022T3 (es)
IL (1) IL93556A (es)
WO (1) WO1990009785A1 (es)

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AU5192290A (en) 1990-09-26
JPH04505317A (ja) 1992-09-17
IL93556A0 (en) 1990-11-29
EP0495776A4 (en) 1992-02-10
US4954526A (en) 1990-09-04
JPH07108855B2 (ja) 1995-11-22
WO1990009785A1 (en) 1990-09-07
CA2046910C (en) 1995-04-04
EP0495776B1 (en) 1995-02-01
IL93556A (en) 1996-10-16
EP0495776A1 (en) 1992-07-29
DE69016667T2 (de) 1995-06-01
DK0495776T3 (da) 1995-07-03
DE69016667D1 (de) 1995-03-16
ATE117894T1 (de) 1995-02-15
AU621470B2 (en) 1992-03-12

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