DE69327330T2 - Verfahren zum bekämpfen der pneumocystis carinii pneumonie und dafür verwendbare verbindungen - Google Patents
Verfahren zum bekämpfen der pneumocystis carinii pneumonie und dafür verwendbare verbindungenInfo
- Publication number
- DE69327330T2 DE69327330T2 DE69327330T DE69327330T DE69327330T2 DE 69327330 T2 DE69327330 T2 DE 69327330T2 DE 69327330 T DE69327330 T DE 69327330T DE 69327330 T DE69327330 T DE 69327330T DE 69327330 T2 DE69327330 T2 DE 69327330T2
- Authority
- DE
- Germany
- Prior art keywords
- combating
- pneumocystis carinii
- compounds
- pneumonie
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/958,696 US5428051A (en) | 1992-10-13 | 1992-10-13 | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
PCT/US1993/009477 WO1994008580A1 (en) | 1992-10-13 | 1993-10-04 | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69327330D1 DE69327330D1 (de) | 2000-01-20 |
DE69327330T2 true DE69327330T2 (de) | 2000-08-24 |
Family
ID=25501203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69327330T Expired - Fee Related DE69327330T2 (de) | 1992-10-13 | 1993-10-04 | Verfahren zum bekämpfen der pneumocystis carinii pneumonie und dafür verwendbare verbindungen |
Country Status (10)
Country | Link |
---|---|
US (2) | US5428051A (de) |
EP (1) | EP0664703B1 (de) |
JP (1) | JP2888453B2 (de) |
AT (1) | ATE187641T1 (de) |
AU (1) | AU675092B2 (de) |
BR (1) | BR9307235A (de) |
CA (1) | CA2104196C (de) |
DE (1) | DE69327330T2 (de) |
NZ (1) | NZ257001A (de) |
WO (1) | WO1994008580A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
IL111011A0 (en) * | 1993-09-22 | 1994-11-28 | Wellcome Found | Bisbenzimidazole compounds, their preparation and pharmaceutical compositions containing them |
US6815461B1 (en) * | 1994-01-20 | 2004-11-09 | The University Of North Carolina At Chapel Hill | Method of inhibiting retroviral integrase |
US5629348A (en) * | 1994-11-14 | 1997-05-13 | Nzym, Inc. | Methods and compositions for treating septoria infections |
WO1996015104A2 (en) * | 1994-11-14 | 1996-05-23 | Nzym, Inc. | Methods and compositions for treating phytopathogenic fungi infections |
US5637621A (en) * | 1994-11-14 | 1997-06-10 | Nzym, Inc. | Methods and compositions for treating Botrytis infections |
US6562854B2 (en) | 1994-12-14 | 2003-05-13 | Axys Pharmaceuticals, Inc. | Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders |
US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
US5723495A (en) * | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
US5935982A (en) * | 1997-02-28 | 1999-08-10 | The University Of North Carolina At Chapel Hill | Methods of treating retroviral infection and compounds useful therefor |
US6150379A (en) * | 1997-11-26 | 2000-11-21 | Axys Pharmaceuticals, Inc. | Compounds and compositions as anticoagulants |
US6635668B1 (en) * | 1998-07-22 | 2003-10-21 | The University Of North Carolina At Chapel Hill | Imidazoline receptor binding compounds |
ES2275362T3 (es) | 1998-09-17 | 2007-06-01 | The University Of North Carolina At Chapel Hill | Actividad antifungica de moleculas dicationicas. |
WO2000075117A1 (en) | 1999-06-04 | 2000-12-14 | Elan Pharma International Ltd. | Compositions and methods for inhibiting cell death |
US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
JP2005504053A (ja) * | 2001-08-31 | 2005-02-10 | ニューロケム (インターナショナル) リミテッド | アミロイドーシス治療のためのアミジン誘導体 |
WO2004002430A2 (en) * | 2002-06-28 | 2004-01-08 | Combinatorx Incorporated | Combinations for the treatment of fungal infections |
US20050054708A1 (en) * | 2003-07-28 | 2005-03-10 | Nichols Matthew James | Combinations of drugs for the treatment of neoplasms |
WO2005020913A2 (en) * | 2003-08-25 | 2005-03-10 | Combinatorx, Incorporated | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms |
US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
US20050100508A1 (en) * | 2003-11-12 | 2005-05-12 | Nichols M. J. | Methods for identifying drug combinations for the treatment of proliferative diseases |
US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
JP2008500965A (ja) * | 2004-03-17 | 2008-01-17 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 細菌の排出ポンプ阻害剤の使用および投与 |
US7994225B2 (en) * | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
DE102004031656A1 (de) * | 2004-06-30 | 2006-01-19 | Merck Patent Gmbh | Tetrahydrochinoline |
DE102007013854A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Tetrahydrochinoline |
DE102007013855A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydrochinoline |
DE102007013856A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydropyrrolochinoline |
EP2194981B1 (de) * | 2007-10-05 | 2011-11-23 | Université de Mons-Hainaut | Bisbenzimidazole und mittel gegen malaria |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4933347A (en) * | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
AU626033B2 (en) * | 1988-10-25 | 1992-07-23 | Government Of The United States Of America, As Represented By The Secretary Of The Army, The | Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods |
US4963589A (en) * | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
-
1992
- 1992-10-13 US US07/958,696 patent/US5428051A/en not_active Expired - Fee Related
-
1993
- 1993-08-16 CA CA002104196A patent/CA2104196C/en not_active Expired - Fee Related
- 1993-10-04 DE DE69327330T patent/DE69327330T2/de not_active Expired - Fee Related
- 1993-10-04 WO PCT/US1993/009477 patent/WO1994008580A1/en active IP Right Grant
- 1993-10-04 NZ NZ257001A patent/NZ257001A/en unknown
- 1993-10-04 EP EP93923239A patent/EP0664703B1/de not_active Expired - Lifetime
- 1993-10-04 AU AU52995/93A patent/AU675092B2/en not_active Ceased
- 1993-10-04 BR BR9307235A patent/BR9307235A/pt not_active Application Discontinuation
- 1993-10-04 JP JP6510083A patent/JP2888453B2/ja not_active Expired - Fee Related
- 1993-10-04 AT AT93923239T patent/ATE187641T1/de not_active IP Right Cessation
-
1995
- 1995-04-24 US US08/427,597 patent/US5578631A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5578631A (en) | 1996-11-26 |
CA2104196C (en) | 2001-03-27 |
BR9307235A (pt) | 1999-08-24 |
AU5299593A (en) | 1994-05-09 |
NZ257001A (en) | 1997-06-24 |
US5428051A (en) | 1995-06-27 |
CA2104196A1 (en) | 1994-04-14 |
EP0664703A4 (de) | 1997-05-21 |
AU675092B2 (en) | 1997-01-23 |
EP0664703B1 (de) | 1999-12-15 |
JPH08502294A (ja) | 1996-03-12 |
JP2888453B2 (ja) | 1999-05-10 |
WO1994008580A1 (en) | 1994-04-28 |
DE69327330D1 (de) | 2000-01-20 |
ATE187641T1 (de) | 2000-01-15 |
EP0664703A1 (de) | 1995-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |