ES2141347T3 - Amidino-derivados utiles como inhibidores de oxido nitrico sintasa. - Google Patents

Amidino-derivados utiles como inhibidores de oxido nitrico sintasa.

Info

Publication number
ES2141347T3
ES2141347T3 ES95914809T ES95914809T ES2141347T3 ES 2141347 T3 ES2141347 T3 ES 2141347T3 ES 95914809 T ES95914809 T ES 95914809T ES 95914809 T ES95914809 T ES 95914809T ES 2141347 T3 ES2141347 T3 ES 2141347T3
Authority
ES
Spain
Prior art keywords
alkyl
amino
alkoxy
hydroxy
nitric oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95914809T
Other languages
English (en)
Inventor
Mark G Currie
Keith Webber
Foe S Tjoeng
Kam F Fok
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2141347T3 publication Critical patent/ES2141347T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBEN DERIVADOS DE AMIDINO DE FORMULA (I), COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS DERIVADOS, Y SU USO EN TERAPIA, EN PARTICULAR SU USO COMO INHIBIDORES DE SINTASA OXIDO NITRICO EN DONDE: X ES ALQUILO, ALQUENILO, ALQUINILO, (CH{SUB,2}){SUB,K}Q(CH{SUB,2})L- DONDE K ES 2 O 3, L ES 1 O 2 Y Q ES 0, SESIY{SUB,2} DONDE Y ES ALQUILO, S(O){SUB,Z} DONDE Z ES 0,1 O 2, NR DONDE R ES HIDROGENO O ALQUILO, O (CH{SUB,2}){SUB,M}A(CH{SUB,2}){SUB,N}- DONDE M ES 0,1, O 2, N ES 0, 1, O 2, A ES UN RADICAL HIDROCARBURO AROMATICO DE 3 A 6 MIEMBROS O UN RADICAL HETEROCICLICO DE 3 A 6 MIEMBROS EN DONDE DE 1 A 3 HETEROATOMOS SON OXIGENO, AZUFRE, O NITROGENO Y EN DONDE TODOS LOS RADICALES DICHOS PUEDEN SER OPCIONALMENTE SUSTITUIDOS POR UNO O MAS SUSTITUYENTES COMO ALQUILO, ALCOXI, HIDROXI, HALOGENO, NITRO, CIANO, TRIFLUOROALQUILO Y AMINO;R{SUB,1} PUEDE SER UN ENLACE A X O HIDROGENO (CUANDO Q ES SE), HIDROXIALQUILO, ALQUILO, ALQUENILO, ALQUINILO, O HALOALQUILO Y EN DONDE TODOS LOS RADICALES DICHOS PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS POR UNO O MAS SUSTITUYENTES COMO ALQUILO, ALCOXI, HIDROXI, HALOGENO, NITRO, CIANO, TRIFLUOROALQUILO Y AMINO; R{SUB,2} ES ALQUILO, ALQUENILO, ALQUINILO, UN RADICAL HIDROCARBURO AROMATICO, HALOALQUILO, HIDROXILAMINA O UN RADICAL HETEROCICLICO EN DONDE DE 1 A 3 HETEROATOMOS SON OXIGENO, AZUFRE, O NITROGENO Y EN DONDE TODOS LOS RADICALES DICHOS PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS POR UNO O MAS SUSTITUYENTES COMO ALQUILO, ALCOXI, HIDROXI, HALOGENO, NITRO, CIANO, TRIFLUOROALQUILO Y AMINO; Y R{SUB,3} ES AMINO, ALQUILAMINA, AMINOACIDO, HIDROXI, ALCOXI, TETRAZOL O TETRAZOLAMINA.
ES95914809T 1994-03-24 1995-03-24 Amidino-derivados utiles como inhibidores de oxido nitrico sintasa. Expired - Lifetime ES2141347T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21816094A 1994-03-24 1994-03-24

Publications (1)

Publication Number Publication Date
ES2141347T3 true ES2141347T3 (es) 2000-03-16

Family

ID=22813994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95914809T Expired - Lifetime ES2141347T3 (es) 1994-03-24 1995-03-24 Amidino-derivados utiles como inhibidores de oxido nitrico sintasa.

Country Status (9)

Country Link
EP (1) EP0751930B1 (es)
AT (1) ATE188467T1 (es)
AU (1) AU2190895A (es)
DE (1) DE69514341T2 (es)
DK (1) DK0751930T3 (es)
ES (1) ES2141347T3 (es)
GR (1) GR3032365T3 (es)
PT (1) PT751930E (es)
WO (1) WO1995025717A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
EP1067926A2 (en) * 1998-04-06 2001-01-17 Fujisawa Pharmaceutical Co., Ltd. Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus or cyclosporins
US6552052B2 (en) 1998-06-10 2003-04-22 Monsanto/G.D. Searle Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors
WO2000026195A1 (en) * 1998-10-30 2000-05-11 G.D. Searle & Co. Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors
AU2847200A (en) * 1999-01-27 2000-08-18 G.D. Searle & Co. Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors
WO2000063195A1 (en) * 1999-04-19 2000-10-26 G.D. Searle & Co. Novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors
WO2001005748A1 (en) * 1999-07-15 2001-01-25 Monsanto Company Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors
MY135721A (en) 2000-03-24 2008-06-30 Pharmacia Corp Amidino compounds useful as nitric oxide synthase inhibitors
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR034120A1 (es) * 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
AR032318A1 (es) * 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US6956131B2 (en) 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
MY131964A (en) * 2000-09-15 2007-09-28 Pharmacia Corp 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
AR031608A1 (es) 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR035585A1 (es) * 2000-09-15 2004-06-16 Pharmacia Corp Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
AR031609A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
AR031129A1 (es) 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20040127569A1 (en) * 2002-08-02 2004-07-01 Manning Pamela T. Methods for treatment and prevention of gastrointestinal conditions
TWI340133B (en) 2002-08-23 2011-04-11 Pharmacia Corp Crystalline solid form of (2s,5z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid.
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof

Also Published As

Publication number Publication date
EP0751930B1 (en) 2000-01-05
GR3032365T3 (en) 2000-04-27
PT751930E (pt) 2000-04-28
ATE188467T1 (de) 2000-01-15
EP0751930A1 (en) 1997-01-08
AU2190895A (en) 1995-10-09
DE69514341T2 (de) 2000-05-18
DK0751930T3 (da) 2000-04-17
DE69514341D1 (en) 2000-02-10
WO1995025717A1 (en) 1995-09-28

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