PT84091B - Processo para a preparacao de novos derivados da decahidroquinolina e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de novos derivados da decahidroquinolina e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT84091B PT84091B PT84091A PT8409187A PT84091B PT 84091 B PT84091 B PT 84091B PT 84091 A PT84091 A PT 84091A PT 8409187 A PT8409187 A PT 8409187A PT 84091 B PT84091 B PT 84091B
- Authority
- PT
- Portugal
- Prior art keywords
- group
- decahydrodebin
- preparation
- same
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8600354A FR2592879B1 (fr) | 1986-01-13 | 1986-01-13 | Nouveaux derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT84091A PT84091A (fr) | 1987-02-01 |
| PT84091B true PT84091B (pt) | 1989-07-31 |
Family
ID=9331031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT84091A PT84091B (pt) | 1986-01-13 | 1987-01-12 | Processo para a preparacao de novos derivados da decahidroquinolina e de composicoes farmaceuticas que os contem |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4816465A (pt) |
| EP (1) | EP0233793B1 (pt) |
| JP (1) | JPH07116156B2 (pt) |
| AT (1) | ATE74352T1 (pt) |
| AU (1) | AU597326B2 (pt) |
| CA (1) | CA1282784C (pt) |
| DE (1) | DE3777852D1 (pt) |
| DK (1) | DK168068B1 (pt) |
| ES (1) | ES2037098T3 (pt) |
| FR (1) | FR2592879B1 (pt) |
| GR (1) | GR3004250T3 (pt) |
| HU (1) | HU196593B (pt) |
| IE (1) | IE59794B1 (pt) |
| PT (1) | PT84091B (pt) |
| SU (1) | SU1598874A3 (pt) |
| ZA (1) | ZA8742B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3770726D1 (de) * | 1986-08-12 | 1991-07-18 | Roussel Uclaf | Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen. |
| FR2617481B1 (fr) * | 1987-07-03 | 1989-11-10 | Roussel Uclaf | Nouveaux derives de la tetrahydropyridine, leur procede de preparation et les intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| GB8804014D0 (en) * | 1988-02-23 | 1988-03-23 | Humphreys & Glasgow Ltd | Synthesis gas production |
| EP0330468A3 (en) * | 1988-02-23 | 1991-04-03 | Glaxo Group Limited | Use of heterocyclic derivatives as kappa-opioid receptor agonists in the treatment of cerebral ischaemia |
| DK247789A (da) * | 1988-05-23 | 1989-11-24 | Glaxo Group Ltd | Piperazinderivater |
| GB8824400D0 (en) * | 1988-10-18 | 1988-11-23 | Glaxo Group Ltd | Chemical compounds |
| TW234124B (pt) * | 1992-07-15 | 1994-11-11 | Sumitomo Chemical Co | |
| US5474673A (en) * | 1994-07-05 | 1995-12-12 | Ludlow; David J. | Top mounted biological filtration system for an aquarium |
| US6750216B2 (en) | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| USRE38133E1 (en) * | 1996-03-08 | 2003-06-03 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| AU2001238690A1 (en) * | 2000-03-14 | 2001-09-24 | Sepracor, Inc. | 3-substituted piperidines comprising urea functionality, and methods of use thereof |
| US7135484B2 (en) | 2002-08-14 | 2006-11-14 | Abbott Laboratories | Azabicyclic compounds are central nervous system active agents |
| CA2495589A1 (en) * | 2002-08-14 | 2004-02-26 | Abbott Laboratories | Azabicyclic compounds are central nervous system active agents |
| US11091497B2 (en) * | 2017-12-08 | 2021-08-17 | The Rockefeller University | Pyrano[3,4-b]pyrazine kappa opioid receptor ligands for treating addiction, pruritus, pain, and inflammation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3056792A (en) * | 1958-06-04 | 1962-10-02 | Geschickter Fund Med Res | Unsymmetrical 1, 3-diamino-2-propanols |
| GB1463582A (en) * | 1974-03-05 | 1977-02-02 | Wyeth John & Brother Ltd | Pyridine derivatives |
| US4173636A (en) * | 1975-12-16 | 1979-11-06 | Labaz | Decahydroquinolines, pharmaceutical compositions and methods of use |
| GB1515540A (en) * | 1975-12-16 | 1978-06-28 | Labaz | 4-amino-trans-decahydroquinoline derivatives |
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| US4098904A (en) * | 1976-11-12 | 1978-07-04 | The Upjohn Company | Analgesic n-(2-aminocycloaliphatic)benzamides |
| US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
| DE3770726D1 (de) * | 1986-08-12 | 1991-07-18 | Roussel Uclaf | Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen. |
| DE3633977A1 (de) * | 1986-10-06 | 1988-04-07 | Cassella Ag | Tetrahydrochinolinderivate, ein verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen |
| FR2617164B1 (fr) * | 1987-06-25 | 1989-11-10 | Roussel Uclaf | Nouveaux derives de la decahydroquinoleine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| JPH094481A (ja) * | 1996-07-18 | 1997-01-07 | Yanmar Agricult Equip Co Ltd | 走行作業機におけるエンジン出力制御装置 |
-
1986
- 1986-01-13 FR FR8600354A patent/FR2592879B1/fr not_active Expired
-
1987
- 1987-01-05 ZA ZA8742A patent/ZA8742B/xx unknown
- 1987-01-09 AT AT87400033T patent/ATE74352T1/de not_active IP Right Cessation
- 1987-01-09 DE DE8787400033T patent/DE3777852D1/de not_active Expired - Fee Related
- 1987-01-09 EP EP87400033A patent/EP0233793B1/fr not_active Expired - Lifetime
- 1987-01-09 ES ES198787400033T patent/ES2037098T3/es not_active Expired - Lifetime
- 1987-01-12 AU AU67476/87A patent/AU597326B2/en not_active Ceased
- 1987-01-12 IE IE6887A patent/IE59794B1/en not_active IP Right Cessation
- 1987-01-12 DK DK012087A patent/DK168068B1/da not_active IP Right Cessation
- 1987-01-12 PT PT84091A patent/PT84091B/pt not_active IP Right Cessation
- 1987-01-12 JP JP62003424A patent/JPH07116156B2/ja not_active Expired - Lifetime
- 1987-01-12 SU SU874028897A patent/SU1598874A3/ru active
- 1987-01-13 US US07/002,778 patent/US4816465A/en not_active Expired - Fee Related
- 1987-01-13 HU HU8799A patent/HU196593B/hu not_active IP Right Cessation
- 1987-01-13 CA CA000527242A patent/CA1282784C/fr not_active Expired - Fee Related
-
1988
- 1988-07-11 US US07/217,834 patent/US4968700A/en not_active Expired - Fee Related
-
1992
- 1992-04-02 GR GR910402210T patent/GR3004250T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1282784C (fr) | 1991-04-09 |
| SU1598874A3 (ru) | 1990-10-07 |
| ATE74352T1 (de) | 1992-04-15 |
| FR2592879B1 (fr) | 1988-04-29 |
| EP0233793A3 (en) | 1989-04-19 |
| US4816465A (en) | 1989-03-28 |
| DK12087D0 (da) | 1987-01-12 |
| DK168068B1 (da) | 1994-01-31 |
| IE870068L (en) | 1987-07-13 |
| HUT43570A (en) | 1987-11-30 |
| GR3004250T3 (pt) | 1993-03-31 |
| JPH07116156B2 (ja) | 1995-12-13 |
| US4968700A (en) | 1990-11-06 |
| FR2592879A1 (fr) | 1987-07-17 |
| EP0233793B1 (fr) | 1992-04-01 |
| AU6747687A (en) | 1987-07-16 |
| EP0233793A2 (fr) | 1987-08-26 |
| DE3777852D1 (de) | 1992-05-07 |
| ZA8742B (en) | 1988-03-30 |
| JPS62167767A (ja) | 1987-07-24 |
| DK12087A (da) | 1987-07-14 |
| ES2037098T3 (es) | 1993-06-16 |
| PT84091A (fr) | 1987-02-01 |
| IE59794B1 (en) | 1994-04-06 |
| AU597326B2 (en) | 1990-05-31 |
| HU196593B (en) | 1988-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19980731 |