ES2037783T3 - Procedimiento para la obtencion de 3-aminosidnoniminas substituidas. - Google Patents
Procedimiento para la obtencion de 3-aminosidnoniminas substituidas.Info
- Publication number
- ES2037783T3 ES2037783T3 ES198888115165T ES88115165T ES2037783T3 ES 2037783 T3 ES2037783 T3 ES 2037783T3 ES 198888115165 T ES198888115165 T ES 198888115165T ES 88115165 T ES88115165 T ES 88115165T ES 2037783 T3 ES2037783 T3 ES 2037783T3
- Authority
- ES
- Spain
- Prior art keywords
- denotes
- atoms
- formula
- image
- aminosidnonimines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
LAS 3-AMINOSIDNONIMINAS SUSTITUIDAS DE LA FORMULA I Y SUS SALES DE ACIDOADICION FARMACOLOGICAMENTE ACEPTABLES, DONDE A ES, POR EJEMPLO, - CH2 -, R1 ES HIDROGENO O EL RESTO - COR7, R2, R3, R4, R5 SON ALQUILO CON ENTRE 1 Y 4 ATOMOS DE CARBONO, R7 ES, POR EJEMPLO, UN RESTO ALIFATICO CON ENTRE 1 Y 4 ATOMOS DE CARBONO, SE OBTIENEN MEDIANTE CICLIZACION DE UN COMPUESTO DE LA FORMULA II Y, DADO EL CASO, ACZILACION POSTERIOR, Y POSEEN VALIOSAS PROPIEDADES FARMACOLOGICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873732174 DE3732174A1 (de) | 1987-09-24 | 1987-09-24 | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2037783T3 true ES2037783T3 (es) | 1993-07-01 |
Family
ID=6336771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198888115165T Expired - Lifetime ES2037783T3 (es) | 1987-09-24 | 1988-09-16 | Procedimiento para la obtencion de 3-aminosidnoniminas substituidas. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4937244A (es) |
EP (1) | EP0312773B1 (es) |
JP (1) | JPH01106881A (es) |
KR (1) | KR890005094A (es) |
AT (1) | ATE70838T1 (es) |
DE (2) | DE3732174A1 (es) |
DK (1) | DK479688A (es) |
ES (1) | ES2037783T3 (es) |
HU (1) | HU203749B (es) |
IL (1) | IL87796A0 (es) |
PT (1) | PT88569B (es) |
ZA (1) | ZA887086B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5221680A (en) * | 1988-01-14 | 1993-06-22 | Cassella Aktiengesellschaft | Substituted 3-aminosydnonimines |
DE4015236A1 (de) * | 1990-05-13 | 1991-11-14 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3921460A1 (de) * | 1989-06-30 | 1991-01-03 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3921796A1 (de) * | 1989-07-03 | 1991-01-17 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DK0429751T3 (da) * | 1989-11-30 | 1993-12-13 | Cassella Farbwerke Mainkur Ag | Substituerede 3-aminosydnoniminer, fremgangsmåde til deres fremstilling og deres anvendelse |
DE4031373A1 (de) * | 1990-10-04 | 1992-04-09 | Cassella Ag | 3-piperazino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1695897C3 (de) * | 1966-07-04 | 1979-02-15 | Takeda Chemical Industries Ltd | N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US3833580A (en) * | 1966-08-09 | 1974-09-03 | Boehringer Sohn Ingelheim | 3-morpholino-n6-cyclohexylcarbonyl sydnonimine |
CH507276A (de) * | 1966-09-29 | 1971-05-15 | Takeda Chemical Industries Ltd | Verfahren zur Herstellung von Sydnoniminderivaten |
US3833589A (en) * | 1972-07-31 | 1974-09-03 | Sandoz Ag | Substituted sydnonimine nitrate esters |
US4245100A (en) * | 1977-11-28 | 1981-01-13 | Vsesojuzny Nauchno-Issledovatelsky Khimikofarmatsevtichesky Institut Imeni S. Ordzhonikidze | Sydnonimine N-acyl derivatives and method for preparing same |
DE2930736A1 (de) * | 1979-07-28 | 1981-02-12 | Cassella Ag | Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
US4277609A (en) * | 1979-08-31 | 1981-07-07 | American Home Products Corporation | Sydnone imines |
US4446322A (en) * | 1980-07-29 | 1984-05-01 | American Home Products Corporation | Hydroxyl protected 3-(2-hydroxy-2-phenylethyl)-N-[(phenylamino)carbonyl]sydnone imine intermediates |
US4324897A (en) * | 1980-10-02 | 1982-04-13 | American Home Products Corporation | 1,2,3 Oxadiazolium salts |
US4301285A (en) * | 1980-10-02 | 1981-11-17 | American Home Products Corporation | Sydnonimine CNS stimulants |
US4289885A (en) * | 1980-10-02 | 1981-09-15 | American Home Products Corporation | 3-[2-(Dimethylamino)-2-phenylethyl]N-[phenylamino)carbonyl]sydnone imine, a new central nervous system stimulant |
US4371697A (en) * | 1980-10-06 | 1983-02-01 | American Home Products Corporation | 3-[1-(Hydroxymethyl)-2-phenylethyl]-N-[(phenylamino)-carbonyl]sydnone imine |
DE3107933A1 (de) * | 1981-03-02 | 1982-09-16 | Cassella Ag, 6000 Frankfurt | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
US4371539A (en) * | 1981-04-27 | 1983-02-01 | American Home Products Corporation | CNS Stimulants |
JPS5832870A (ja) * | 1981-08-24 | 1983-02-25 | Hiroyoshi Hidaka | 新規なシドノンイミン誘導体及びその製法 |
JPS5859977A (ja) * | 1981-10-06 | 1983-04-09 | Banyu Pharmaceut Co Ltd | 新規なn−アシルシドノンイミン誘導体およびその製法 |
-
1987
- 1987-09-24 DE DE19873732174 patent/DE3732174A1/de not_active Withdrawn
-
1988
- 1988-08-03 US US07/238,456 patent/US4937244A/en not_active Expired - Fee Related
- 1988-08-26 DK DK479688A patent/DK479688A/da not_active Application Discontinuation
- 1988-09-16 ES ES198888115165T patent/ES2037783T3/es not_active Expired - Lifetime
- 1988-09-16 EP EP88115165A patent/EP0312773B1/de not_active Expired - Lifetime
- 1988-09-16 DE DE8888115165T patent/DE3867205D1/de not_active Expired - Fee Related
- 1988-09-16 AT AT88115165T patent/ATE70838T1/de not_active IP Right Cessation
- 1988-09-19 IL IL87796A patent/IL87796A0/xx unknown
- 1988-09-22 ZA ZA887086A patent/ZA887086B/xx unknown
- 1988-09-22 PT PT88569A patent/PT88569B/pt not_active IP Right Cessation
- 1988-09-22 JP JP63236665A patent/JPH01106881A/ja active Pending
- 1988-09-23 KR KR1019880012291A patent/KR890005094A/ko not_active Application Discontinuation
- 1988-09-23 HU HU884988A patent/HU203749B/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA887086B (en) | 1989-06-28 |
EP0312773A2 (de) | 1989-04-26 |
IL87796A0 (en) | 1989-03-31 |
JPH01106881A (ja) | 1989-04-24 |
US4937244A (en) | 1990-06-26 |
HUT51618A (en) | 1990-05-28 |
DE3732174A1 (de) | 1989-04-06 |
HU203749B (en) | 1991-09-30 |
DK479688D0 (da) | 1988-08-26 |
DE3867205D1 (de) | 1992-02-06 |
KR890005094A (ko) | 1989-05-11 |
EP0312773A3 (en) | 1990-05-09 |
PT88569A (pt) | 1988-10-01 |
PT88569B (pt) | 1992-11-30 |
DK479688A (da) | 1989-03-25 |
ATE70838T1 (de) | 1992-01-15 |
EP0312773B1 (de) | 1991-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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