BR9913526A - Métodos de tratamento da osteoartrite com inibidores de sintase de óxido nìtrico induzìvel - Google Patents

Métodos de tratamento da osteoartrite com inibidores de sintase de óxido nìtrico induzìvel

Info

Publication number
BR9913526A
BR9913526A BR9913526-4A BR9913526A BR9913526A BR 9913526 A BR9913526 A BR 9913526A BR 9913526 A BR9913526 A BR 9913526A BR 9913526 A BR9913526 A BR 9913526A
Authority
BR
Brazil
Prior art keywords
methods
nitric oxide
treating osteoarthritis
oxide synthase
synthase inhibitors
Prior art date
Application number
BR9913526-4A
Other languages
English (en)
Inventor
Pamela T Manning
Jean Pierre Pelletier
Johanne Martel Pelletier
Jane R Connor
Mark G Currie
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of BR9913526A publication Critical patent/BR9913526A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"MéTODOS DE TRATAMENTO DA OSTEOARTRITE COM INIBIDORES DE SìNTESE DE óXIDO NìTRICO INDUZìVEL"<D>. Métodos de tratar a osteoartrite administrando-se uma quantidade terapeuticamente eficaz de inibidor NOS são fornecidos.
BR9913526-4A 1998-09-08 1999-09-07 Métodos de tratamento da osteoartrite com inibidores de sintase de óxido nìtrico induzìvel BR9913526A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9941298P 1998-09-08 1998-09-08
PCT/US1999/020545 WO2000013709A2 (en) 1998-09-08 1999-09-07 Methods of treating osteoarthritis with inducible nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
BR9913526A true BR9913526A (pt) 2001-06-05

Family

ID=22274881

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913526-4A BR9913526A (pt) 1998-09-08 1999-09-07 Métodos de tratamento da osteoartrite com inibidores de sintase de óxido nìtrico induzìvel

Country Status (12)

Country Link
US (2) US6653350B1 (pt)
EP (1) EP1112068A2 (pt)
JP (1) JP2002524424A (pt)
KR (1) KR20010086383A (pt)
CN (1) CN1420769A (pt)
AU (1) AU1704100A (pt)
BR (1) BR9913526A (pt)
CA (1) CA2342349A1 (pt)
IL (1) IL141809A0 (pt)
NO (1) NO20011158L (pt)
PL (1) PL346860A1 (pt)
WO (1) WO2000013709A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9913526A (pt) * 1998-09-08 2001-06-05 Monsanto Co Métodos de tratamento da osteoartrite com inibidores de sintase de óxido nìtrico induzìvel
WO2000051624A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Methods and compositions useful in inhibiting apoptosis
GB0004153D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
EP2323638B1 (en) * 2008-07-18 2014-05-07 Hill's Pet Nutrition, Inc. Compositions and methods for treating osteoarthritis
WO2012025910A1 (en) * 2010-08-26 2012-03-01 Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional METHODS OF DIAGNOSIS AND TREATMENT OF OSTEOARTHRITIS AT EARLY STAGES USING INTERLEUKIN IL-1ß AS EARLY BIOMARKER OF THE DISEASE
EP3245290A4 (en) * 2015-01-16 2018-11-07 University of Iowa Research Foundation Methods to prevent or treat periodontitis or peri-implantitis
US11904006B2 (en) 2019-12-11 2024-02-20 University Of Iowa Research Foundation Poly(diaminosulfide) particle-based vaccine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1273380A (en) 1989-07-24 1990-08-28 Frank Van Oirschot Inline venturi for pneumatic conveying systems
US5268465A (en) 1991-01-18 1993-12-07 The Johns Hopkins University Purification and molecular cloning of nitric oxide synthase
US5358969A (en) 1991-12-16 1994-10-25 Washington University Method of inhibiting nitric oxide formation
US5246970A (en) 1991-12-16 1993-09-21 Washington University Method of inhibiting nitric oxide formation
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
US5449688A (en) 1993-03-30 1995-09-12 The United States Of America As Represented By The Department Of Health And Human Services Method of treating chronic inflammatory diseases
JPH09508891A (ja) 1993-11-17 1997-09-09 デューク ユニバーシティ メディカル センター 自己免疫疾患の治療におけるナイトリックオキサイドシンターゼ阻害剤の使用
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
WO1996016648A1 (en) 1994-11-29 1996-06-06 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Method for regulating metalloproteinase activity
US5929063A (en) 1995-03-24 1999-07-27 Children's Hospital Medical Center Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
US5759836A (en) * 1995-03-27 1998-06-02 Hospital For Joint Diseases Osteoarthritis-associated inducable isoform of nitric oxide synthetase
BR9610988A (pt) * 1995-10-17 1999-04-06 Astra Pharma Prod Composto uso do mesmo fomulação farmacêutica e processo para produção do composto
BR9913526A (pt) * 1998-09-08 2001-06-05 Monsanto Co Métodos de tratamento da osteoartrite com inibidores de sintase de óxido nìtrico induzìvel

Also Published As

Publication number Publication date
EP1112068A2 (en) 2001-07-04
IL141809A0 (en) 2002-03-10
PL346860A1 (en) 2002-03-11
CN1420769A (zh) 2003-05-28
JP2002524424A (ja) 2002-08-06
CA2342349A1 (en) 2000-03-16
WO2000013709A2 (en) 2000-03-16
NO20011158D0 (no) 2001-03-07
NO20011158L (no) 2001-05-08
KR20010086383A (ko) 2001-09-10
WO2000013709A3 (en) 2000-09-14
US6653350B1 (en) 2003-11-25
AU1704100A (en) 2000-03-27
US20040143017A1 (en) 2004-07-22

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]