TR200000670T2 - FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler. - Google Patents

FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler.

Info

Publication number
TR200000670T2
TR200000670T2 TR2000/00670T TR200000670T TR200000670T2 TR 200000670 T2 TR200000670 T2 TR 200000670T2 TR 2000/00670 T TR2000/00670 T TR 2000/00670T TR 200000670 T TR200000670 T TR 200000670T TR 200000670 T2 TR200000670 T2 TR 200000670T2
Authority
TR
Turkey
Prior art keywords
compounds
formula
agonists
aromatic
substituted tetrahydro
Prior art date
Application number
TR2000/00670T
Other languages
English (en)
Inventor
August Wos John
Anthony Delong Mitchell
Jack S. Amburgey, Jr.
De Biswanath
George Dai Haiyan
J. Miley Cynthia
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Publication of TR200000670T2 publication Critical patent/TR200000670T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

(Formül(I)); Bulus yeni PGF analoglari sunmaktadir. Özellikle bu bulus bir formül (I) yapisini haiz bilesiklere iliskindir: burada R1, R2, R3, R4, X, Y ve Z tanimlandigi gibidir. Bu bulus ayrica adi geçen formülün optik izomerlerini, diastereomerlerini ve enantiomerlerini ve farmasötik olarak kabul edilebilir tuzlarini, biyohidrolize edilebilir amitlerini, esterlerini ve imitlerini kapsamaktadir. Bu bulusun bilesikleri kemik bozukluklari ve glokom gibi çesitli hastaliklarin ve durumlarin tedavisi için yararlidir. Bu nedenle bulus ayrica bu bilesikleri içeren farmasötik bilesimleri sunmaktadir. Bulus ayrica bu bilesikleri veya bunlari içeren bilesimleri kullanarak kemik bozukluklarini ve glokomu tedavi etmek için yöntemler sunmaktadir.
TR2000/00670T 1997-09-09 1998-09-04 FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler. TR200000670T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5824697P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
TR200000670T2 true TR200000670T2 (tr) 2000-11-21

Family

ID=22015602

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00670T TR200000670T2 (tr) 1997-09-09 1998-09-04 FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler.

Country Status (23)

Country Link
US (1) US6107338A (tr)
EP (1) EP1021402B1 (tr)
JP (1) JP2001515883A (tr)
KR (1) KR20010023837A (tr)
CN (1) CN1269785A (tr)
AR (1) AR017077A1 (tr)
AT (1) ATE310721T1 (tr)
AU (1) AU741014B2 (tr)
BR (1) BR9811779A (tr)
CA (1) CA2303763C (tr)
CO (1) CO4970730A1 (tr)
DE (1) DE69832513T2 (tr)
ES (1) ES2253826T3 (tr)
HU (1) HUP0004436A3 (tr)
IL (1) IL134792A0 (tr)
NO (1) NO20001142L (tr)
NZ (1) NZ503736A (tr)
PE (1) PE123199A1 (tr)
PL (1) PL339213A1 (tr)
SK (1) SK3362000A3 (tr)
TR (1) TR200000670T2 (tr)
WO (1) WO1999012896A1 (tr)
ZA (1) ZA988231B (tr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015608A1 (en) * 1998-09-14 2000-03-23 Ono Pharmaceutical Co., Ltd. φ-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
ES2232434T3 (es) * 1999-03-05 2005-06-01 Duke University Analogos de prostaglandinas c-16 fp selectivas insaturadas.
EP1202999B1 (en) * 1999-08-04 2003-06-18 The Procter & Gamble Company Novel 2-decarboxy-2-phosphinico prostaglandin f analogs
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US6376533B1 (en) * 2000-10-20 2002-04-23 Allergan Sales, Inc. Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6586462B2 (en) 2000-10-20 2003-07-01 Allergan, Inc. ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
US7631336B2 (en) 2004-07-30 2009-12-08 Broadband Itv, Inc. Method for converting, navigating and displaying video content uploaded from the internet to a digital TV video-on-demand platform
US7590997B2 (en) 2004-07-30 2009-09-15 Broadband Itv, Inc. System and method for managing, converting and displaying video content on a video-on-demand platform, including ads used for drill-down navigation and consumer-generated classified ads
US20060135609A1 (en) 2004-10-21 2006-06-22 Duke University Ophthamological drugs
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
AU2009340420A1 (en) 2008-10-29 2010-08-26 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
EP3053913B1 (en) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
CA2850987C (en) 2011-10-17 2019-10-15 Biotheryx, Inc. Substituted biaryl alkyl amides
CN109528721B (zh) 2013-03-15 2021-10-01 爱瑞制药公司 联合治疗
CN104140410B (zh) * 2013-05-09 2017-12-15 江苏豪森药业集团有限公司 鲁比前列酮的制备方法
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
CA3035566A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
CN110506037A (zh) 2017-03-31 2019-11-26 爱瑞制药公司 芳基环丙基-氨基-异喹啉酰胺化合物
US11427563B2 (en) 2018-09-14 2022-08-30 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
IL43571A (en) * 1972-11-08 1977-08-31 Pfizer Omega-pentanorprostaglandins and their preparation
JPS5720305B2 (tr) * 1973-02-28 1982-04-27
DE2365101A1 (de) * 1973-12-21 1975-07-10 Schering Ag Neue prostansaeurederivate und verfahren zu ihrer herstellung
DE2460990A1 (de) * 1974-12-21 1976-07-01 Hoechst Ag Neue prostaglandin-analoga und verfahren zu ihrer herstellung
DE2737808A1 (de) * 1976-08-27 1978-03-16 Pfizer 2-substituierte aryl-heterocyclische omega-pentanorprostaglandine
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US6169111B1 (en) * 1995-06-07 2001-01-02 Alcon Laboratories, Inc. Conformationally rigid aryl prostaglandins for use in glaucoma therapy
WO1997023225A1 (en) * 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5703108A (en) * 1996-02-28 1997-12-30 Pfizer Inc. Bone deposition by certain prostaglandin agonists
US5741810A (en) * 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
DE69714698T2 (de) * 1996-06-10 2002-12-05 Sucampo Ag Endothelin-antagonisten
DE69714274T3 (de) * 1996-09-17 2006-06-01 Asahi Glass Co., Ltd. Fluorierte prostaglandinderivate und medikamente
AU5436198A (en) * 1996-11-12 1998-06-03 Alcon Laboratories, Inc. 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
AU5258698A (en) * 1996-11-12 1998-06-03 Alcon Laboratories, Inc. 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension
AU725677B2 (en) * 1997-05-09 2000-10-19 Mount Sinai School Of Medicine Of The City University Of New York, The 8-iso-prostaglandins for glaucoma therapy

Also Published As

Publication number Publication date
AU9219498A (en) 1999-03-29
CA2303763A1 (en) 1999-03-18
EP1021402B1 (en) 2005-11-23
ES2253826T3 (es) 2006-06-01
IL134792A0 (en) 2001-04-30
WO1999012896A1 (en) 1999-03-18
DE69832513D1 (de) 2005-12-29
DE69832513T2 (de) 2006-07-13
NZ503736A (en) 2002-06-28
SK3362000A3 (en) 2000-10-09
CO4970730A1 (es) 2000-11-07
ZA988231B (en) 1999-03-09
NO20001142L (no) 2000-05-04
HUP0004436A3 (en) 2001-09-28
EP1021402A1 (en) 2000-07-26
US6107338A (en) 2000-08-22
KR20010023837A (ko) 2001-03-26
BR9811779A (pt) 2000-09-12
CN1269785A (zh) 2000-10-11
ATE310721T1 (de) 2005-12-15
AR017077A1 (es) 2001-08-22
AU741014B2 (en) 2001-11-22
PE123199A1 (es) 2000-02-02
CA2303763C (en) 2007-04-24
PL339213A1 (en) 2000-12-04
JP2001515883A (ja) 2001-09-25
NO20001142D0 (no) 2000-03-06
HUP0004436A2 (hu) 2001-05-28

Similar Documents

Publication Publication Date Title
TR200000671T2 (tr) FP agonistleri olarak yararlı aromatik C16-C20-ikameli tetrahidro prostaglandinler.
TR200000670T2 (tr) FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler.
TR200000673T2 (tr) FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler.
ES542323A0 (es) Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
EA200100135A1 (ru) Алкинилзамещенные производные хинолин-2-она, полезные в качестве противораковых агентов
EA200100553A1 (ru) Замещенные бициклические производные, полезные в качестве противораковых агентов
PT896533E (pt) Pentafluorobenzenosulfonamidas e analogos
UY23657A1 (es) Procedimiento para la preparacion de derivados de indol
TR200002971T2 (tr) İkameli pirolidin hidroksamat metaloproteaz inhibitörleri
TR199901468T2 (tr) Alfa-2 adrenoseptör agonistleri olarak yararli guanidinil heterosikl bilesikleri.
HK1076107A1 (en) Pyrrolidine derivatives as oxytocin antagonists
ES2202156T3 (es) Nuevos analogos de 2-descarboxi-2-fosfinico prostaglandina f.
NO20014241L (no) C16-umettede FP-selektive prostaglandinanaloger
BR0008778A (pt) Análogos de prostaglandinas seletivos para fpc16 insaturados
TR200002808T2 (tr) İlaç olarak yararlı C11 oksimil ve hidroksilamino prostaglandinleri
TR199901486T2 (tr) Alfa-2 adrenoseptör agonistleri olarak yararli 2-imidazolinilamino-benzoksazol bilesikleri.
CA2324590A1 (en) C11 oxymyl and hydroxylamino prostaglandins useful as fp agonists
FI910159A0 (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 9a-hydroxi-3-oxo-4,24(25)-stigmastadien-26 -syraderivat.
HUT53103A (en) Process for the preparation of new 20,21-dinor-eburnamenine derivatives, new intermediates thereof, as well as pharmaceutical compositions containing said compounds as active ingredients
TR199901467T2 (tr) Alfa-2 adrenoseptör agonistleri olarak yararli guanidinilamino heterosikl bilesikleri.
TR199901542T2 (tr) Alfa-2 adrenoseptör agonistleri olarak yararli 2-imidazolinilaminoindazol bilesikleri.