ATE310721T1 - Aromatische c16-c20-substituierte tetrahydro- prostaglandinen verwendbar wie fp agoniste - Google Patents

Aromatische c16-c20-substituierte tetrahydro- prostaglandinen verwendbar wie fp agoniste

Info

Publication number
ATE310721T1
ATE310721T1 AT98944720T AT98944720T ATE310721T1 AT E310721 T1 ATE310721 T1 AT E310721T1 AT 98944720 T AT98944720 T AT 98944720T AT 98944720 T AT98944720 T AT 98944720T AT E310721 T1 ATE310721 T1 AT E310721T1
Authority
AT
Austria
Prior art keywords
prostaglandins
agonists
usable
aromatic
substituted tetrahydro
Prior art date
Application number
AT98944720T
Other languages
English (en)
Inventor
John August Wos
Mitchell Anthony Delong
Jack S Amburgey Jr
Biswanath De
Haiyan George Dai
Cynthia J Miley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of ATE310721T1 publication Critical patent/ATE310721T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT98944720T 1997-09-09 1998-09-04 Aromatische c16-c20-substituierte tetrahydro- prostaglandinen verwendbar wie fp agoniste ATE310721T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5824697P 1997-09-09 1997-09-09
PCT/US1998/018340 WO1999012896A1 (en) 1997-09-09 1998-09-04 Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists

Publications (1)

Publication Number Publication Date
ATE310721T1 true ATE310721T1 (de) 2005-12-15

Family

ID=22015602

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98944720T ATE310721T1 (de) 1997-09-09 1998-09-04 Aromatische c16-c20-substituierte tetrahydro- prostaglandinen verwendbar wie fp agoniste

Country Status (23)

Country Link
US (1) US6107338A (de)
EP (1) EP1021402B1 (de)
JP (1) JP2001515883A (de)
KR (1) KR20010023837A (de)
CN (1) CN1269785A (de)
AR (1) AR017077A1 (de)
AT (1) ATE310721T1 (de)
AU (1) AU741014B2 (de)
BR (1) BR9811779A (de)
CA (1) CA2303763C (de)
CO (1) CO4970730A1 (de)
DE (1) DE69832513T2 (de)
ES (1) ES2253826T3 (de)
HU (1) HUP0004436A3 (de)
IL (1) IL134792A0 (de)
NO (1) NO20001142L (de)
NZ (1) NZ503736A (de)
PE (1) PE123199A1 (de)
PL (1) PL339213A1 (de)
SK (1) SK3362000A3 (de)
TR (1) TR200000670T2 (de)
WO (1) WO1999012896A1 (de)
ZA (1) ZA988231B (de)

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KR20010074981A (ko) * 1998-09-14 2001-08-09 우에노 도시오 ω치환된 페닐프로스타그란딘 Ｅ 유도체 및 그 유도체를유효 성분으로 하는 약제
KR20010108316A (ko) 1999-03-05 2001-12-07 데이비드 엠 모이어 Ｃ16 불포화된 ｆｐ-선택적 프로스타글란딘 유사체
WO2001010873A1 (en) * 1999-08-04 2001-02-15 The Procter & Gamble Company Novel 2-decarboxy-2-phosphinico prostaglandin f analogs
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US6586462B2 (en) 2000-10-20 2003-07-01 Allergan, Inc. ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6376533B1 (en) * 2000-10-20 2002-04-23 Allergan Sales, Inc. Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
US7590997B2 (en) 2004-07-30 2009-09-15 Broadband Itv, Inc. System and method for managing, converting and displaying video content on a video-on-demand platform, including ads used for drill-down navigation and consumer-generated classified ads
US7631336B2 (en) 2004-07-30 2009-12-08 Broadband Itv, Inc. Method for converting, navigating and displaying video content uploaded from the internet to a digital TV video-on-demand platform
JP2008517941A (ja) * 2004-10-21 2008-05-29 デューク・ユニバーシティー 眼科用薬剤
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
CA2739571A1 (en) 2008-10-29 2010-08-26 Aerie Pharmaceuticals, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
EP3354643B1 (de) 2009-05-01 2020-10-28 Aerie Pharmaceuticals, Inc. Hemmer mit doppelmechanismus zur behandlung von erkrankungen
WO2013059215A1 (en) 2011-10-17 2013-04-25 Biotheryx, Inc. Substituted biaryl alkyl amides
US20140275160A1 (en) 2013-03-15 2014-09-18 Aerie Pharmaceuticals, Inc. Combination therapy
CN104140410B (zh) * 2013-05-09 2017-12-15 江苏豪森药业集团有限公司 鲁比前列酮的制备方法
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102568079B1 (ko) 2016-08-31 2023-08-17 에어리 파마슈티컬즈, 인코포레이티드 안과용 조성물
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
WO2020056345A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

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US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
IL43571A (en) * 1972-11-08 1977-08-31 Pfizer Omega-pentanorprostaglandins and their preparation
JPS5720305B2 (de) * 1973-02-28 1982-04-27
DE2365101A1 (de) * 1973-12-21 1975-07-10 Schering Ag Neue prostansaeurederivate und verfahren zu ihrer herstellung
DE2460990A1 (de) * 1974-12-21 1976-07-01 Hoechst Ag Neue prostaglandin-analoga und verfahren zu ihrer herstellung
DE2737808A1 (de) * 1976-08-27 1978-03-16 Pfizer 2-substituierte aryl-heterocyclische omega-pentanorprostaglandine
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US6169111B1 (en) * 1995-06-07 2001-01-02 Alcon Laboratories, Inc. Conformationally rigid aryl prostaglandins for use in glaucoma therapy
WO1997023225A1 (en) * 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5703108A (en) * 1996-02-28 1997-12-30 Pfizer Inc. Bone deposition by certain prostaglandin agonists
US5741810A (en) * 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
CN102126998B (zh) * 1996-06-10 2013-06-12 苏坎波公司 内皮素拮抗剂
DE69714274T3 (de) * 1996-09-17 2006-06-01 Asahi Glass Co., Ltd. Fluorierte prostaglandinderivate und medikamente
US6353000B1 (en) * 1996-11-12 2002-03-05 Alcon Laboratories, Inc. 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
AU5258698A (en) * 1996-11-12 1998-06-03 Alcon Laboratories, Inc. 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension
EP1007028A4 (de) * 1997-05-09 2002-06-05 Behandlung von glaukom mit 8-iso-prostaglandinen

Also Published As

Publication number Publication date
DE69832513D1 (de) 2005-12-29
BR9811779A (pt) 2000-09-12
HUP0004436A3 (en) 2001-09-28
CA2303763A1 (en) 1999-03-18
EP1021402B1 (de) 2005-11-23
IL134792A0 (en) 2001-04-30
US6107338A (en) 2000-08-22
SK3362000A3 (en) 2000-10-09
AR017077A1 (es) 2001-08-22
NO20001142L (no) 2000-05-04
ES2253826T3 (es) 2006-06-01
TR200000670T2 (tr) 2000-11-21
HUP0004436A2 (hu) 2001-05-28
KR20010023837A (ko) 2001-03-26
PL339213A1 (en) 2000-12-04
ZA988231B (en) 1999-03-09
CN1269785A (zh) 2000-10-11
AU9219498A (en) 1999-03-29
CO4970730A1 (es) 2000-11-07
NO20001142D0 (no) 2000-03-06
NZ503736A (en) 2002-06-28
AU741014B2 (en) 2001-11-22
CA2303763C (en) 2007-04-24
DE69832513T2 (de) 2006-07-13
PE123199A1 (es) 2000-02-02
WO1999012896A1 (en) 1999-03-18
EP1021402A1 (de) 2000-07-26
JP2001515883A (ja) 2001-09-25

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