TR200002971T2 - İkameli pirolidin hidroksamat metaloproteaz inhibitörleri - Google Patents

İkameli pirolidin hidroksamat metaloproteaz inhibitörleri

Info

Publication number
TR200002971T2
TR200002971T2 TR2000/02971T TR200002971T TR200002971T2 TR 200002971 T2 TR200002971 T2 TR 200002971T2 TR 2000/02971 T TR2000/02971 T TR 2000/02971T TR 200002971 T TR200002971 T TR 200002971T TR 200002971 T2 TR200002971 T2 TR 200002971T2
Authority
TR
Turkey
Prior art keywords
compounds
provides
substituted pyrrolidine
metalloprotease inhibitors
formula
Prior art date
Application number
TR2000/02971T
Other languages
English (en)
Inventor
Cheng Menyan
George Natchus Michael
De Biswanath
Gregory Almstead Neil
Olabisi Taiwo Yetunde
Pikul Stanislaw
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Publication of TR200002971T2 publication Critical patent/TR200002971T2/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Bulus, metaloproteazlarin etkili inhibitörleri olan ve bu enzimlerin asiri aktivitesi ile iliskili hastaliklarin tedavi edilmesinde etkili olan bilesikler saglar. Özel olarak, bu bulus, Formül (I)'e uygun bir yapiya sahip bilesik saglar: buradaki R1,R2,X,Z,m ve n, asagida tanimlanmistir. Bu bulus, ayrica formül (I)'in optik izomerlerini, diyastereomerlerini ve enantiyomerlerini ve bunlarin farmasötik olarak kabul edilebilir tuzlarini, biyolojik olarak hidrolize olabilir amidlerini,esterlerini ve imidlerini de içerir. Bu bulusun bilesikleri, istenmeyen metaloproteaz aktivitesiyle iliskili hastaliklarin ve durumlarin tedavisinde faydalidirlar. Buna göre, bulus, bu bilesikleri içeren farmasötik bilesimler saglar. Bulus ayrica bu bilesikleri ve bunlari içeren farmasötik bilesimleri kullanarak metaloproteaz ile iliskili hastaliklarin tedavisi için yöntemler de saglar.
TR2000/02971T 1998-04-14 1999-04-09 İkameli pirolidin hidroksamat metaloproteaz inhibitörleri TR200002971T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8166798P 1998-04-14 1998-04-14

Publications (1)

Publication Number Publication Date
TR200002971T2 true TR200002971T2 (tr) 2001-02-21

Family

ID=22165611

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02971T TR200002971T2 (tr) 1998-04-14 1999-04-09 İkameli pirolidin hidroksamat metaloproteaz inhibitörleri

Country Status (21)

Country Link
US (1) US6329418B1 (tr)
EP (1) EP1073635A1 (tr)
JP (1) JP2002511448A (tr)
KR (1) KR100400507B1 (tr)
CN (1) CN1297436A (tr)
AR (1) AR029145A1 (tr)
AU (1) AU753048B2 (tr)
BR (1) BR9909620A (tr)
CA (1) CA2328211A1 (tr)
CO (1) CO5011039A1 (tr)
HU (1) HUP0102195A3 (tr)
ID (1) ID26925A (tr)
IL (1) IL138738A0 (tr)
NO (1) NO20005196L (tr)
NZ (1) NZ507076A (tr)
PE (1) PE20000425A1 (tr)
PL (1) PL343529A1 (tr)
SK (1) SK15462000A3 (tr)
TR (1) TR200002971T2 (tr)
WO (1) WO1999052868A1 (tr)
ZA (1) ZA200005047B (tr)

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GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
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JP2017519015A (ja) 2014-07-02 2017-07-13 オブセヴァ エス．エー． Ｏｔ−ｒ活性に関する疾患を治療するための方法に有用な結晶質の（３ｚ，５ｓ）−５−（ヒドロキシメチル）−１−［（２’−メチル−１，１’−ビフェニル−４−イル）カルボニル］ピロリジン−３−オン о−メチルオキシム

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Also Published As

Publication number Publication date
NO20005196L (no) 2000-12-14
PE20000425A1 (es) 2000-07-13
WO1999052868A1 (en) 1999-10-21
PL343529A1 (en) 2001-08-27
NZ507076A (en) 2003-04-29
NO20005196D0 (no) 2000-10-16
KR20010042694A (ko) 2001-05-25
ZA200005047B (en) 2001-06-06
SK15462000A3 (sk) 2001-06-11
CA2328211A1 (en) 1999-10-21
KR100400507B1 (ko) 2003-10-08
HUP0102195A3 (en) 2001-12-28
ID26925A (id) 2001-02-22
IL138738A0 (en) 2001-10-31
US6329418B1 (en) 2001-12-11
EP1073635A1 (en) 2001-02-07
JP2002511448A (ja) 2002-04-16
HUP0102195A2 (hu) 2001-11-28
AU753048B2 (en) 2002-10-03
CN1297436A (zh) 2001-05-30
AR029145A1 (es) 2003-06-18
CO5011039A1 (es) 2001-02-28
BR9909620A (pt) 2000-12-19
AU3552299A (en) 1999-11-01

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