BRPI0508059A - método para preparação de pirrolidina oximas - Google Patents

método para preparação de pirrolidina oximas

Info

Publication number
BRPI0508059A
BRPI0508059A BRPI0508059-2A BRPI0508059A BRPI0508059A BR PI0508059 A BRPI0508059 A BR PI0508059A BR PI0508059 A BRPI0508059 A BR PI0508059A BR PI0508059 A BRPI0508059 A BR PI0508059A
Authority
BR
Brazil
Prior art keywords
preparation
oximes
pyrrolidine oximes
pyrrolidine
formula
Prior art date
Application number
BRPI0508059-2A
Other languages
English (en)
Inventor
William Nadler
Doris Pupowicz
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BRPI0508059A publication Critical patent/BRPI0508059A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

MéTODO PARA PREPARAçãO DE PIRROLIDINA OXIMAS. A presente invenção refere-se a uma nova síntese para preparação de pirrolidina oximas de fórmula geral (I). Os compostos de fórmula (I) são úteis no tratamento e/ou prevenção de trabalho de parto espontâneo, parto prematuro e dismenorréia.
BRPI0508059-2A 2004-02-26 2005-02-28 método para preparação de pirrolidina oximas BRPI0508059A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100773 2004-02-26
PCT/EP2005/050852 WO2005082848A2 (en) 2004-02-26 2005-02-28 Method for preparing pyrrolidine oximes

Publications (1)

Publication Number Publication Date
BRPI0508059A true BRPI0508059A (pt) 2007-07-17

Family

ID=34896105

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508059-2A BRPI0508059A (pt) 2004-02-26 2005-02-28 método para preparação de pirrolidina oximas

Country Status (21)

Country Link
US (1) US20070197794A1 (pt)
EP (1) EP1725526B1 (pt)
JP (1) JP2007524702A (pt)
KR (1) KR20060124775A (pt)
CN (1) CN1946686A (pt)
AT (1) ATE380792T1 (pt)
AU (1) AU2005217153A1 (pt)
BR (1) BRPI0508059A (pt)
CA (1) CA2554767A1 (pt)
CY (1) CY1107139T1 (pt)
DE (1) DE602005003803T2 (pt)
DK (1) DK1725526T3 (pt)
EA (1) EA011026B1 (pt)
ES (1) ES2296137T3 (pt)
IL (1) IL177388A0 (pt)
NO (1) NO20064352L (pt)
PL (1) PL1725526T3 (pt)
PT (1) PT1725526E (pt)
SI (1) SI1725526T1 (pt)
UA (1) UA86226C2 (pt)
WO (1) WO2005082848A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
UA122210C2 (uk) 2014-07-02 2020-10-12 Обсева С.А. Кристалічний о-метилоксим (3z,5s)-5-(гідроксиметил)-1-[(2'-метил-1,1'-біфеніл-4-іл)карбоніл]піролідин-3-oну, корисний у способах лікування станів, пов'язаних з активністю ot-r
WO2021165927A1 (en) * 2020-02-21 2021-08-26 Wockhardt Bio Ag 2-cyanopyrroldines, -piperidines or -dazepines as hyperglycemic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329418B1 (en) * 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
DE60120940T2 (de) * 2000-03-27 2007-01-25 Applied Research Systems Ars Holding N.V. Pyrrolidin-derivate verwendbar als bax-inhibitoren
IL159219A0 (en) * 2001-06-18 2004-06-01 Applied Research Systems Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP1725526A2 (en) 2006-11-29
NO20064352L (no) 2006-09-26
CY1107139T1 (el) 2012-10-24
DK1725526T3 (da) 2008-03-03
DE602005003803D1 (de) 2008-01-24
PT1725526E (pt) 2007-12-27
DE602005003803T2 (de) 2008-12-24
EA011026B1 (ru) 2008-12-30
KR20060124775A (ko) 2006-12-05
EP1725526B1 (en) 2007-12-12
JP2007524702A (ja) 2007-08-30
ATE380792T1 (de) 2007-12-15
UA86226C2 (en) 2009-04-10
EA200601456A1 (ru) 2007-02-27
CA2554767A1 (en) 2005-09-09
WO2005082848A3 (en) 2005-12-01
US20070197794A1 (en) 2007-08-23
SI1725526T1 (sl) 2008-04-30
AU2005217153A1 (en) 2005-09-09
CN1946686A (zh) 2007-04-11
WO2005082848A2 (en) 2005-09-09
PL1725526T3 (pl) 2008-03-31
IL177388A0 (en) 2006-12-10
ES2296137T3 (es) 2008-04-16

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: LABORATOIRES SERONO S.A. (CH)

Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.