DE602005003803D1 - Verfahren zur herstellung von pyrrolidinoximen - Google Patents

Verfahren zur herstellung von pyrrolidinoximen

Info

Publication number
DE602005003803D1
DE602005003803D1 DE602005003803T DE602005003803T DE602005003803D1 DE 602005003803 D1 DE602005003803 D1 DE 602005003803D1 DE 602005003803 T DE602005003803 T DE 602005003803T DE 602005003803 T DE602005003803 T DE 602005003803T DE 602005003803 D1 DE602005003803 D1 DE 602005003803D1
Authority
DE
Germany
Prior art keywords
production
oximes
pyrrolidine oximes
pyrrolidine
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602005003803T
Other languages
English (en)
Other versions
DE602005003803T2 (de
Inventor
William Nadler
Doris Pupowicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Laboratoires Serono SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono SA filed Critical Laboratoires Serono SA
Publication of DE602005003803D1 publication Critical patent/DE602005003803D1/de
Application granted granted Critical
Publication of DE602005003803T2 publication Critical patent/DE602005003803T2/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602005003803T 2004-02-26 2005-02-28 Verfahren zur herstellung von pyrrolidinoximen Expired - Fee Related DE602005003803T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04100773 2004-02-26
EP04100773 2004-02-26
PCT/EP2005/050852 WO2005082848A2 (en) 2004-02-26 2005-02-28 Method for preparing pyrrolidine oximes

Publications (2)

Publication Number Publication Date
DE602005003803D1 true DE602005003803D1 (de) 2008-01-24
DE602005003803T2 DE602005003803T2 (de) 2008-12-24

Family

ID=34896105

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005003803T Expired - Fee Related DE602005003803T2 (de) 2004-02-26 2005-02-28 Verfahren zur herstellung von pyrrolidinoximen

Country Status (21)

Country Link
US (1) US20070197794A1 (de)
EP (1) EP1725526B1 (de)
JP (1) JP2007524702A (de)
KR (1) KR20060124775A (de)
CN (1) CN1946686A (de)
AT (1) ATE380792T1 (de)
AU (1) AU2005217153A1 (de)
BR (1) BRPI0508059A (de)
CA (1) CA2554767A1 (de)
CY (1) CY1107139T1 (de)
DE (1) DE602005003803T2 (de)
DK (1) DK1725526T3 (de)
EA (1) EA011026B1 (de)
ES (1) ES2296137T3 (de)
IL (1) IL177388A0 (de)
NO (1) NO20064352L (de)
PL (1) PL1725526T3 (de)
PT (1) PT1725526E (de)
SI (1) SI1725526T1 (de)
UA (1) UA86226C2 (de)
WO (1) WO2005082848A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2845850A1 (de) * 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidinderivate als Oxytocin/Vasopressin-V1a-Rezeptorantagonisten
EP2886107A1 (de) 2013-12-17 2015-06-24 ObsEva S.A. Orale Formulierungen von Pyrrolydinderivaten
EP3753921A1 (de) 2014-07-02 2020-12-23 ObsEva S.A. Kristallines (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-on-o-methyloxim und verfahren zur verwendung davon
WO2021165927A1 (en) * 2020-02-21 2021-08-26 Wockhardt Bio Ag 2-cyanopyrroldines, -piperidines or -dazepines as hyperglycemic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329418B1 (en) * 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
MXPA02009382A (es) * 2000-03-27 2003-01-28 Applied Research Systems Derivados de pirrolidina farmaceuticamente activos.
BR0211030A (pt) * 2001-06-18 2004-06-22 Applied Research Systems Derivado de pirrolidina oxadiazole, uso de um derivado de pirrolidina oxadiazole, composição farmacêutica contendo pelo menos um derivado de pirrolidina oxadiazole, método para preparação de um composto de pirrolidina oxadiazole

Also Published As

Publication number Publication date
EP1725526A2 (de) 2006-11-29
EA200601456A1 (ru) 2007-02-27
EP1725526B1 (de) 2007-12-12
UA86226C2 (en) 2009-04-10
ATE380792T1 (de) 2007-12-15
US20070197794A1 (en) 2007-08-23
JP2007524702A (ja) 2007-08-30
WO2005082848A3 (en) 2005-12-01
CN1946686A (zh) 2007-04-11
KR20060124775A (ko) 2006-12-05
PT1725526E (pt) 2007-12-27
IL177388A0 (en) 2006-12-10
BRPI0508059A (pt) 2007-07-17
NO20064352L (no) 2006-09-26
PL1725526T3 (pl) 2008-03-31
CY1107139T1 (el) 2012-10-24
AU2005217153A1 (en) 2005-09-09
DK1725526T3 (da) 2008-03-03
DE602005003803T2 (de) 2008-12-24
WO2005082848A2 (en) 2005-09-09
CA2554767A1 (en) 2005-09-09
ES2296137T3 (es) 2008-04-16
EA011026B1 (ru) 2008-12-30
SI1725526T1 (sl) 2008-04-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee