DE60316152D1 - Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen - Google Patents

Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen

Info

Publication number
DE60316152D1
DE60316152D1 DE60316152T DE60316152T DE60316152D1 DE 60316152 D1 DE60316152 D1 DE 60316152D1 DE 60316152 T DE60316152 T DE 60316152T DE 60316152 T DE60316152 T DE 60316152T DE 60316152 D1 DE60316152 D1 DE 60316152D1
Authority
DE
Germany
Prior art keywords
production
via different
intermediate levels
different intermediate
pioglitazone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60316152T
Other languages
English (en)
Inventor
Bipin Cadila Pandey
Vidya Bhushan Lohray
Braj Bhushan Lohray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Application granted granted Critical
Publication of DE60316152D1 publication Critical patent/DE60316152D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Epoxy Compounds (AREA)
DE60316152T 2002-07-16 2003-07-15 Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen Expired - Lifetime DE60316152D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN648MU2002 2002-07-16
PCT/IN2003/000241 WO2004007490A2 (en) 2002-07-16 2003-07-15 A process to prepare pioglitazone via several intermediates.

Publications (1)

Publication Number Publication Date
DE60316152D1 true DE60316152D1 (de) 2007-10-18

Family

ID=30012270

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60316152T Expired - Lifetime DE60316152D1 (de) 2002-07-16 2003-07-15 Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen

Country Status (6)

Country Link
US (5) US7465801B2 (de)
EP (1) EP1521753B1 (de)
AT (1) ATE372336T1 (de)
AU (1) AU2003272072A1 (de)
DE (1) DE60316152D1 (de)
WO (1) WO2004007490A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993773B2 (en) 2002-07-16 2015-03-31 Cadila Healthcare Limited Process to prepare pioglitazone via several novel intermediates
US7465801B2 (en) * 2002-07-16 2008-12-16 Cadila Healthcare Limited Process to prepare pioglitazone via several novel intermediates
CZ297266B6 (cs) * 2004-09-10 2006-10-11 Zentiva, A. S. Zpusob prípravy rosiglitazonu
WO2008075380A2 (en) * 2006-12-21 2008-06-26 Ind-Swift Laboratories Limited Process for the preparation of thiazolidine derivatives
US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US20080318870A1 (en) 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JOP20180077A1 (ar) 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
US8067450B2 (en) 2007-09-14 2011-11-29 Metabolic Solutions Development Company Thiazolidinedione analogues for the treatment of metabolic diseases
US8304441B2 (en) 2007-09-14 2012-11-06 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues for the treatment of metabolic diseases
US8024889B2 (en) * 2008-06-25 2011-09-27 Brett Bunker Pest control method and apparatus
WO2010105048A1 (en) * 2009-03-12 2010-09-16 Metabolic Solutions Development Company Thiazolidinedione analogues
HUE038042T2 (hu) 2009-12-15 2018-09-28 Cirius Therapeutics Inc PPAR helyettesítõ tiazolidindion sók metabolikus betegségek kezelésére
JP2013514371A (ja) * 2009-12-15 2013-04-25 メタボリック ソリューションズ ディベロップメント カンパニー， エルエルシー 肥満および他の代謝性疾患の処置のためのＰＰＡＲγ温存チアゾリジンジオンならびに組み合わせ物
KR101164429B1 (ko) 2010-05-25 2012-07-12 (주)부흥산업사 환상 아민 중간체를 이용한 피오글리타존 염산염의 제조 방법
US8596663B2 (en) * 2011-03-29 2013-12-03 Shimano Inc. Fluid flow control structure
WO2012153312A1 (en) 2011-05-11 2012-11-15 Ranbaxy Laboratories Limited Process for the purification of pioglitazone
WO2015109037A1 (en) 2014-01-15 2015-07-23 Deuterx, Llc Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
CN109020790B (zh) * 2018-08-16 2021-07-27 苏州大学 一种4-环烷基苯乙酮衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4444179A (en) * 1981-03-02 1984-04-24 Trippi Anthony C Orthopedic tongs
NL8402765A (nl) * 1984-09-11 1986-04-01 Philips Nv Manipulator met zes vrijheidsgraden.
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4812570A (en) 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
WO1993022445A1 (en) 1992-05-05 1993-11-11 The Upjohn Company A process for producing pioglitazone metabolite
KR100366617B1 (ko) * 2000-03-13 2003-01-09 삼성전자 주식회사 자기 정렬 콘택홀 제조 방법
WO2002088120A1 (en) * 2001-04-26 2002-11-07 Léciva, a.s. Method for obtaining pioglitazone as an antidiabetic agent
US7465801B2 (en) 2002-07-16 2008-12-16 Cadila Healthcare Limited Process to prepare pioglitazone via several novel intermediates

Also Published As

Publication number Publication date
US8173816B2 (en) 2012-05-08
US20110021576A1 (en) 2011-01-27
AU2003272072A8 (en) 2004-02-02
US7863300B2 (en) 2011-01-04
ATE372336T1 (de) 2007-09-15
US20080300282A1 (en) 2008-12-04
WO2004007490A2 (en) 2004-01-22
AU2003272072A1 (en) 2004-02-02
US7671207B2 (en) 2010-03-02
US20120077848A1 (en) 2012-03-29
US20080004446A1 (en) 2008-01-03
US8445685B2 (en) 2013-05-21
US20060167061A1 (en) 2006-07-27
WO2004007490A3 (en) 2004-03-25
EP1521753A2 (de) 2005-04-13
EP1521753B1 (de) 2007-09-05
US7465801B2 (en) 2008-12-16

Similar Documents

Publication Publication Date Title
DE60316152D1 (de) Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen
HK1089444A1 (en) Dihydropteridinones, method for the production and use thereof in the form of drugs
MXPA05012362A (es) Yodopirazolilcarboxanilidas.
SE0200920D0 (sv) Novel compounds
CO5611065A2 (es) Difluorometiltiazolilcarboxanilidas
TNSN04199A1 (en) Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
AU2003202585A1 (en) Disubstituted thiazolyl carboxanilides and their use as microbicides
MX2007003031A (es) Compuestos heteroarilo para uso como betamimeticos en el tratamiento de enfermedades de vias respiratorias.
SE0401762D0 (sv) Novel compounds
DE60108042D1 (de) Prozesse zur Herstellung von pulverförmigen Schlagzäh-Modifizierern
DE60202958D1 (de) Stabiles polymorph von flibanserin, industrielles verfahren zu dessen herstellung und dessen verwendung zur herstellung von medikamenten
ATE430160T1 (de) Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
ATE359285T1 (de) Verwendung von scopinester derivaten zur herstellung von arzneimitteln
DE60204464D1 (de) Verfahren zur herstellung von ethern, vorzugsweise von thf
DE60210778D1 (de) Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen
ATE344259T1 (de) Verfahren und zwischenprodukte für die herstellung von emtricitabin
DE602004011730D1 (de) Verfahren zur Herstellung von Valsartan
DE60318444D1 (de) Verfahren zur herstellung von nevirapin
DE60236303D1 (de) Verfahren zur herstellung von 14-beta-hydroxybaccatin-iii-1,14-carbonat
DE602004031727D1 (de) Neues verfahren und zwischenprodukte zur herstellung von 19-nor-steroiden
ATE537160T1 (de) Verfahren zur herstellung von 14beta- hydroxybaccatin-iii-1,14-carbonat
DE50312447D1 (de) Verfahren zur herstellung von 4,6-dichlor-5-fluorpyrimidin
UA84150C2 (ru) Йодопиразолилкарбоксанилиды, способ их получения, производные йодопиразолилкарбоновой кислоты и средство для борьбы с нежелательными микроорганизмами
DE50203529D1 (de) Verfahren zur herstellung von desclarithromycin, sowie zwischenprodukte
DE60327567D1 (de) Verfahren zur herstellung von 3,3',4,4'-tetraaminobiphenyl

Legal Events

Date Code Title Description
8332 No legal effect for de