DE602004031727D1 - Neues verfahren und zwischenprodukte zur herstellung von 19-nor-steroiden - Google Patents

Neues verfahren und zwischenprodukte zur herstellung von 19-nor-steroiden

Info

Publication number
DE602004031727D1
DE602004031727D1 DE602004031727T DE602004031727T DE602004031727D1 DE 602004031727 D1 DE602004031727 D1 DE 602004031727D1 DE 602004031727 T DE602004031727 T DE 602004031727T DE 602004031727 T DE602004031727 T DE 602004031727T DE 602004031727 D1 DE602004031727 D1 DE 602004031727D1
Authority
DE
Germany
Prior art keywords
steroids
preparation
new method
intermediate products
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004031727T
Other languages
English (en)
Inventor
Denis Prat
Christian Moratille
Francoise Benedetti
Lahlou Nait-Bouda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE602004031727D1 publication Critical patent/DE602004031727D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
DE602004031727T 2003-04-29 2004-04-27 Neues verfahren und zwischenprodukte zur herstellung von 19-nor-steroiden Expired - Lifetime DE602004031727D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0305221A FR2854402B1 (fr) 2003-04-29 2003-04-29 Nouveau procede et intermediaires de preparation de composes 19-nor-steroides
PCT/FR2004/001010 WO2004096828A2 (fr) 2003-04-29 2004-04-27 Nouveau procede et intermediaires de preparation de composes 19-nor-steroïdes

Publications (1)

Publication Number Publication Date
DE602004031727D1 true DE602004031727D1 (de) 2011-04-21

Family

ID=33155512

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031727T Expired - Lifetime DE602004031727D1 (de) 2003-04-29 2004-04-27 Neues verfahren und zwischenprodukte zur herstellung von 19-nor-steroiden

Country Status (7)

Country Link
US (2) US20040229853A1 (de)
EP (1) EP1622925B1 (de)
JP (1) JP4755083B2 (de)
AT (1) ATE501162T1 (de)
DE (1) DE602004031727D1 (de)
FR (1) FR2854402B1 (de)
WO (1) WO2004096828A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854403B1 (fr) * 2003-04-29 2008-07-11 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides 17-halogenes
US10385093B2 (en) 2012-12-10 2019-08-20 Northeastern University Estrogen receptor imaging agents
CA2933590C (en) 2013-12-11 2023-10-03 Sloan-Kettering Institute For Cancer Research Glucocorticoid inhibitors for treatment of prostate cancer
CN105566432B (zh) * 2016-02-19 2017-11-03 常州四药制药有限公司 一种醋酸乌利司他的杂质及其制备和检测方法
CN105566431B (zh) * 2016-02-19 2017-11-24 常州市第四制药厂有限公司 一种醋酸乌利司他的杂质及其制备和检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3264327A (en) 1962-07-27 1966-08-02 Syntex Corp 17alpha-fluoro-, 17beta-chlorofluoroacetoxy- and 17beta-methyl-delta4-and delta5-androstene derivatives
FR1550974A (de) 1967-03-20 1968-12-27
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
FR2701262B1 (fr) 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
FR2757519B1 (fr) 1996-12-23 1999-06-11 Hoechst Marion Roussel Inc Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
FR2761992B1 (fr) 1997-04-09 1999-06-11 Hoechst Marion Roussel Inc Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2771096B1 (fr) * 1997-11-17 2000-08-11 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides, substitues en position 11beta, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant
FR2780060B1 (fr) 1998-06-23 2000-08-04 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant
FR2826004B1 (fr) * 2001-06-13 2008-03-28 Aventis Pharma Sa Procede de preparation de derives estrogenes
FR2854403B1 (fr) * 2003-04-29 2008-07-11 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides 17-halogenes

Also Published As

Publication number Publication date
US8258328B2 (en) 2012-09-04
ATE501162T1 (de) 2011-03-15
WO2004096828A2 (fr) 2004-11-11
JP4755083B2 (ja) 2011-08-24
EP1622925B1 (de) 2011-03-09
FR2854402A1 (fr) 2004-11-05
US20110046402A1 (en) 2011-02-24
EP1622925A2 (de) 2006-02-08
US20040229853A1 (en) 2004-11-18
WO2004096828A3 (fr) 2004-12-29
JP2006524671A (ja) 2006-11-02
FR2854402B1 (fr) 2008-07-04

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