DE602004017731D1 - Verfahren zur herstellung von 1-ä(benzimidazol-1-yl)chinolin-8-ylüpiperidin-4-ylaminderivaten - Google Patents
Verfahren zur herstellung von 1-ä(benzimidazol-1-yl)chinolin-8-ylüpiperidin-4-ylaminderivatenInfo
- Publication number
- DE602004017731D1 DE602004017731D1 DE602004017731T DE602004017731T DE602004017731D1 DE 602004017731 D1 DE602004017731 D1 DE 602004017731D1 DE 602004017731 T DE602004017731 T DE 602004017731T DE 602004017731 T DE602004017731 T DE 602004017731T DE 602004017731 D1 DE602004017731 D1 DE 602004017731D1
- Authority
- DE
- Germany
- Prior art keywords
- ylipiperidin
- chinolin
- benzimidazol
- preparation
- ylamine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48217603P | 2003-06-24 | 2003-06-24 | |
| PCT/IB2004/001983 WO2004113322A1 (en) | 2003-06-24 | 2004-06-14 | Processes for the preparation of 1-[(benzoimidazole-1yl) quinolin-8-yl] piperidin-4-ylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004017731D1 true DE602004017731D1 (de) | 2008-12-24 |
Family
ID=33539339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004017731T Active DE602004017731D1 (de) | 2003-06-24 | 2004-06-14 | Verfahren zur herstellung von 1-ä(benzimidazol-1-yl)chinolin-8-ylüpiperidin-4-ylaminderivaten |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7183414B2 (de) |
| EP (1) | EP1641780B1 (de) |
| JP (1) | JP2007516168A (de) |
| KR (2) | KR20070092333A (de) |
| CN (1) | CN100404530C (de) |
| AR (1) | AR044849A1 (de) |
| AT (1) | ATE414077T1 (de) |
| AU (1) | AU2004249511B2 (de) |
| BR (1) | BRPI0411794A (de) |
| CA (1) | CA2529032C (de) |
| CL (1) | CL2004001470A1 (de) |
| CO (1) | CO5650165A2 (de) |
| DE (1) | DE602004017731D1 (de) |
| DK (1) | DK1641780T3 (de) |
| ES (1) | ES2315663T3 (de) |
| HK (1) | HK1089170A1 (de) |
| IL (1) | IL172064A (de) |
| MX (1) | MXPA05014203A (de) |
| NO (1) | NO20060376L (de) |
| NZ (2) | NZ571898A (de) |
| RU (1) | RU2323214C2 (de) |
| SG (1) | SG161745A1 (de) |
| TW (1) | TWI294425B (de) |
| WO (1) | WO2004113322A1 (de) |
| ZA (1) | ZA200509253B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| US20100016353A1 (en) * | 2004-10-07 | 2010-01-21 | Kirk Russell Henne | Benzoimidazole derivatives useful as antiproliferative agents |
| MX2007012393A (es) * | 2005-04-05 | 2008-02-22 | Pharmacopeia Inc | Derivados de purina e imidazopiridina para la inmunosupresion. |
| US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
| JP5576370B2 (ja) | 2008-08-06 | 2014-08-20 | ファイザー・インク | Ｃｈｋ−１阻害剤としての６置換２−ヘテロシクリルアミノピラジン化合物 |
| EP2379543A2 (de) | 2008-12-18 | 2011-10-26 | F. Hoffmann-La Roche AG | Thiazolyl-benzimidazole |
| CN101993416B (zh) * | 2009-08-27 | 2013-09-11 | 中国科学院上海药物研究所 | 喹啉类化合物、其制备方法、包含该化合物的药物组合物及该化合物的用途 |
| TWI569799B (zh) | 2012-09-21 | 2017-02-11 | 安羅格製藥股份有限公司 | 抑制組成型活性磷酸化ｆｌｔ３激酶的方法 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| TWI599356B (zh) | 2012-09-26 | 2017-09-21 | 安羅格製藥有限責任公司 | 抑制突變型ｃ－ｋｉｔ的方法 |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| EP3359155A4 (de) | 2016-11-02 | 2019-05-22 | Arog Pharmaceuticals, Inc. | Crenolanib zur behandlung von mutationen im zusammenhang mit flt3-mutierten proliferativen erkrankungen |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| CN109678849A (zh) * | 2019-01-16 | 2019-04-26 | 北京悦康科创医药科技股份有限公司 | 一种抗癌药物的制备方法 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN117447376A (zh) * | 2019-12-09 | 2024-01-26 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| US11713310B2 (en) * | 2020-07-20 | 2023-08-01 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| US20220079934A1 (en) * | 2020-09-17 | 2022-03-17 | Arog Pharmaceuticals, Inc. | Crenolanib for treating pain |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2300119T3 (es) * | 1997-02-27 | 2008-06-01 | Takeda Pharmaceutical Company Limited | Compuestos de amina, su produccion y su uso como inhibidores de la produccion de beta-amiloide. |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| EP1245390A4 (de) * | 1999-12-10 | 2009-04-01 | Fujifilm Corp | Tintenstrahldruckkopf und drucker |
| EP1321454A4 (de) * | 2000-09-14 | 2005-11-02 | Kaneka Corp | Verfahren zur abtrennung von nitrobenzenesulfonyl |
| PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
-
2004
- 2004-06-14 BR BRPI0411794-8A patent/BRPI0411794A/pt not_active IP Right Cessation
- 2004-06-14 NZ NZ571898A patent/NZ571898A/en not_active IP Right Cessation
- 2004-06-14 KR KR1020077019713A patent/KR20070092333A/ko not_active Application Discontinuation
- 2004-06-14 NZ NZ543714A patent/NZ543714A/en not_active IP Right Cessation
- 2004-06-14 KR KR1020057024593A patent/KR100787649B1/ko active IP Right Grant
- 2004-06-14 MX MXPA05014203A patent/MXPA05014203A/es active IP Right Grant
- 2004-06-14 CN CNB2004800175706A patent/CN100404530C/zh active Active
- 2004-06-14 ES ES04736779T patent/ES2315663T3/es active Active
- 2004-06-14 AU AU2004249511A patent/AU2004249511B2/en not_active Ceased
- 2004-06-14 AT AT04736779T patent/ATE414077T1/de not_active IP Right Cessation
- 2004-06-14 SG SG200700254-6A patent/SG161745A1/en unknown
- 2004-06-14 DE DE602004017731T patent/DE602004017731D1/de active Active
- 2004-06-14 DK DK04736779T patent/DK1641780T3/da active
- 2004-06-14 EP EP04736779A patent/EP1641780B1/de active Active
- 2004-06-14 CA CA002529032A patent/CA2529032C/en active Active
- 2004-06-14 JP JP2006516552A patent/JP2007516168A/ja active Pending
- 2004-06-14 WO PCT/IB2004/001983 patent/WO2004113322A1/en active Application Filing
- 2004-06-14 CL CL200401470A patent/CL2004001470A1/es unknown
- 2004-06-14 RU RU2005138367/04A patent/RU2323214C2/ru active
- 2004-06-22 AR ARP040102160A patent/AR044849A1/es unknown
- 2004-06-23 TW TW093118112A patent/TWI294425B/zh not_active IP Right Cessation
- 2004-06-23 US US10/875,030 patent/US7183414B2/en active Active
-
2005
- 2005-11-15 ZA ZA200509253A patent/ZA200509253B/en unknown
- 2005-11-20 IL IL172064A patent/IL172064A/en active IP Right Grant
- 2005-12-20 CO CO05127734A patent/CO5650165A2/es active IP Right Grant
-
2006
- 2006-01-24 NO NO20060376A patent/NO20060376L/no not_active Application Discontinuation
- 2006-08-28 HK HK06109559A patent/HK1089170A1/xx not_active IP Right Cessation
- 2006-12-05 US US11/567,071 patent/US20070088032A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |