DK1641780T3 - Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater - Google Patents
Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivaterInfo
- Publication number
- DK1641780T3 DK1641780T3 DK04736779T DK04736779T DK1641780T3 DK 1641780 T3 DK1641780 T3 DK 1641780T3 DK 04736779 T DK04736779 T DK 04736779T DK 04736779 T DK04736779 T DK 04736779T DK 1641780 T3 DK1641780 T3 DK 1641780T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzimidazol
- quinolin
- piperidin
- preparation
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48217603P | 2003-06-24 | 2003-06-24 | |
| PCT/IB2004/001983 WO2004113322A1 (en) | 2003-06-24 | 2004-06-14 | Processes for the preparation of 1-[(benzoimidazole-1yl) quinolin-8-yl] piperidin-4-ylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1641780T3 true DK1641780T3 (da) | 2009-02-02 |
Family
ID=33539339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04736779T DK1641780T3 (da) | 2003-06-24 | 2004-06-14 | Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7183414B2 (da) |
| EP (1) | EP1641780B1 (da) |
| JP (1) | JP2007516168A (da) |
| KR (2) | KR100787649B1 (da) |
| CN (1) | CN100404530C (da) |
| AR (1) | AR044849A1 (da) |
| AT (1) | ATE414077T1 (da) |
| AU (1) | AU2004249511B2 (da) |
| BR (1) | BRPI0411794A (da) |
| CA (1) | CA2529032C (da) |
| CL (1) | CL2004001470A1 (da) |
| CO (1) | CO5650165A2 (da) |
| DE (1) | DE602004017731D1 (da) |
| DK (1) | DK1641780T3 (da) |
| ES (1) | ES2315663T3 (da) |
| HK (1) | HK1089170A1 (da) |
| IL (1) | IL172064A (da) |
| MX (1) | MXPA05014203A (da) |
| NO (1) | NO20060376L (da) |
| NZ (2) | NZ571898A (da) |
| RU (1) | RU2323214C2 (da) |
| SG (1) | SG161745A1 (da) |
| TW (1) | TWI294425B (da) |
| WO (1) | WO2004113322A1 (da) |
| ZA (1) | ZA200509253B (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| CA2582479C (en) * | 2004-10-07 | 2011-07-12 | Pfizer Products Inc. | Benzoimidazole derivatives useful as antiproliferative agents |
| CA2604161A1 (en) * | 2005-04-05 | 2006-10-12 | Pharmacopeia, Inc. | Purine and imidazopyridine derivatives for immunosuppression |
| US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
| EP2328890B1 (en) | 2008-08-06 | 2012-01-25 | Pfizer Inc. | 6 substituted 2-heterocyclylamino pyrazine compounds as chk-1 inhibitors |
| CN102256972A (zh) | 2008-12-18 | 2011-11-23 | 霍夫曼-拉罗奇有限公司 | 噻唑基-苯并咪唑类 |
| CN101993416B (zh) * | 2009-08-27 | 2013-09-11 | 中国科学院上海药物研究所 | 喹啉类化合物、其制备方法、包含该化合物的药物组合物及该化合物的用途 |
| KR101738063B1 (ko) | 2012-09-21 | 2017-05-19 | 아로그 파마슈티칼스, 인코퍼레이티드 | 구조적으로 활성인 인산화된 ｆｌｔ３ 키나제의 억제 방법 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| JP6042157B2 (ja) | 2012-09-26 | 2016-12-14 | アログ・ファーマシューティカルズ・リミテッド・ライアビリティ・カンパニーＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，ＬＬＣ | 変異型ｃ−ｋｉｔの阻害方法 |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| AU2017353925A1 (en) | 2016-11-02 | 2018-09-27 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| CN109678849A (zh) * | 2019-01-16 | 2019-04-26 | 北京悦康科创医药科技股份有限公司 | 一种抗癌药物的制备方法 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN114702428B (zh) * | 2019-12-09 | 2023-11-28 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| JP2023506768A (ja) | 2019-12-12 | 2023-02-20 | ティン セラピューティックス エルエルシー | 聴覚損失の予防及び治療のための組成物及び方法 |
| US11713310B2 (en) * | 2020-07-20 | 2023-08-01 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| US20220079934A1 (en) * | 2020-09-17 | 2022-03-17 | Arog Pharmaceuticals, Inc. | Crenolanib for treating pain |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT971878E (pt) * | 1997-02-27 | 2008-07-08 | Takeda Pharmaceutical | Compostos de amina, sua produção e utilização como inibidores da produção de amilóide beta |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| KR100481900B1 (ko) * | 1999-12-10 | 2005-04-11 | 후지 샤신 필름 가부시기가이샤 | 잉크젯 헤드 및 인쇄 장치 |
| WO2002022549A1 (fr) * | 2000-09-14 | 2002-03-21 | Kaneka Corporation | Procede d'extraction de nitrobenzenesulfonyle |
| PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
-
2004
- 2004-06-14 BR BRPI0411794-8A patent/BRPI0411794A/pt not_active IP Right Cessation
- 2004-06-14 NZ NZ571898A patent/NZ571898A/en not_active IP Right Cessation
- 2004-06-14 DK DK04736779T patent/DK1641780T3/da active
- 2004-06-14 CL CL200401470A patent/CL2004001470A1/es unknown
- 2004-06-14 KR KR1020057024593A patent/KR100787649B1/ko active IP Right Grant
- 2004-06-14 NZ NZ543714A patent/NZ543714A/en not_active IP Right Cessation
- 2004-06-14 CN CNB2004800175706A patent/CN100404530C/zh not_active Expired - Lifetime
- 2004-06-14 JP JP2006516552A patent/JP2007516168A/ja active Pending
- 2004-06-14 DE DE602004017731T patent/DE602004017731D1/de not_active Expired - Lifetime
- 2004-06-14 CA CA002529032A patent/CA2529032C/en not_active Expired - Lifetime
- 2004-06-14 AU AU2004249511A patent/AU2004249511B2/en not_active Ceased
- 2004-06-14 SG SG200700254-6A patent/SG161745A1/en unknown
- 2004-06-14 EP EP04736779A patent/EP1641780B1/en not_active Expired - Lifetime
- 2004-06-14 MX MXPA05014203A patent/MXPA05014203A/es active IP Right Grant
- 2004-06-14 WO PCT/IB2004/001983 patent/WO2004113322A1/en active Application Filing
- 2004-06-14 AT AT04736779T patent/ATE414077T1/de not_active IP Right Cessation
- 2004-06-14 ES ES04736779T patent/ES2315663T3/es not_active Expired - Lifetime
- 2004-06-14 RU RU2005138367/04A patent/RU2323214C2/ru active
- 2004-06-14 KR KR1020077019713A patent/KR20070092333A/ko not_active Application Discontinuation
- 2004-06-22 AR ARP040102160A patent/AR044849A1/es unknown
- 2004-06-23 US US10/875,030 patent/US7183414B2/en active Active
- 2004-06-23 TW TW093118112A patent/TWI294425B/zh not_active IP Right Cessation
-
2005
- 2005-11-15 ZA ZA200509253A patent/ZA200509253B/en unknown
- 2005-11-20 IL IL172064A patent/IL172064A/en active IP Right Grant
- 2005-12-20 CO CO05127734A patent/CO5650165A2/es active IP Right Grant
-
2006
- 2006-01-24 NO NO20060376A patent/NO20060376L/no not_active Application Discontinuation
- 2006-08-28 HK HK06109559A patent/HK1089170A1/xx not_active IP Right Cessation
- 2006-12-05 US US11/567,071 patent/US20070088032A1/en not_active Abandoned
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