CO5650165A2 - Procedimientos para la preparacion de derivados de benzoimidazol - Google Patents
Procedimientos para la preparacion de derivados de benzoimidazolInfo
- Publication number
- CO5650165A2 CO5650165A2 CO05127734A CO05127734A CO5650165A2 CO 5650165 A2 CO5650165 A2 CO 5650165A2 CO 05127734 A CO05127734 A CO 05127734A CO 05127734 A CO05127734 A CO 05127734A CO 5650165 A2 CO5650165 A2 CO 5650165A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- cycloalkyl
- independently selected
- group
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
1.- Un procedimiento para preparar un compuesto de fórmula I o una sal, profármaco, hidrato o solvato farmacéuticamente aceptable del mismo; en el que cada R1, R2 y R3 se selecciona independientemente del grupo constituido por H, alquilo(C1-C6), cicloalquilo(C3-C6), halo, ciano, CF3, difluorometoxi, trifluorometoxi, -O-alquilo(C1-C6), -O-cicloalquilo(C3-C6), y -NR12R13; en la que R4 es -(CR5R6)mH o un grupo -(CR7R8)n heterociclo (de 4 a 10 miembros) aromático o no aromático conteniendo uno o más heteroátomos seleccionados cada uno de O, S y N, en la que m es un número entero variando de 1 a 5, en la que n es un número entero variando de 0 a 5, en la que dicho grupo heterocíclico de 4 a 10 miembros cuando es aromático está sustituido opcionalmente con 1 a 3 sustituyentes R9, y en la que dicho grupo heterocíclico de 4 a 10 miembros cuando no es aromático está sustituido opcionalmente con 1 a 3 sustituyentes R11 en cualquier posición no adyacente a o directamente unida a un heteroátomo; en la que cada R5, R6, R7 y R8 se seleccionan independientemente del grupo constituido por H y alquilo(C1-C6); en la que cada R9 se selecciona independientemente de H, alquilo(C1-C6), cicloalquilo(C3-C6), halo, ciano, CF3, difluorometoxi, trifluorometoxi, -O-alquilo(C1-C6), -O-cicloalquilo(C3-C6), y -NR14R15; en la que cada R10 se selecciona independientemente de H, alquilo(C1-C6), y cicloalquilo(C3-C6); en la que cada R11 se selecciona independientemente de halo, ciano, CF3, difluorometoxi, trifluorometoxi, -O-alquilo(C1-C6), -O-cicloalquilo(C3-C6), y NR16R17; en la que R12, R13, R14, R15, R16 y R17 se seleccionan independientemente del grupo constituido por H, alquilo(C1-C6), y cicloalquilo(C3-C6); en la que cada uno de los mencionados sustituyentes alquilo(C1-C6), cicloalquilo(C3-C6), -O-alquilo(C1-C6), y -O-cicloalquilo(C3-C6) dondequiera que se encuentren pueden estar opcionalmente sustituidos independientemente con uno a tres sustituyentes seleccionados independientemente del grupo constituido por halo, ciano, amino, alquilamino(C1-C6), [alquil(C1-C6)]2-amino, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48217603P | 2003-06-24 | 2003-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5650165A2 true CO5650165A2 (es) | 2006-06-30 |
Family
ID=33539339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05127734A CO5650165A2 (es) | 2003-06-24 | 2005-12-20 | Procedimientos para la preparacion de derivados de benzoimidazol |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7183414B2 (es) |
| EP (1) | EP1641780B1 (es) |
| JP (1) | JP2007516168A (es) |
| KR (2) | KR100787649B1 (es) |
| CN (1) | CN100404530C (es) |
| AR (1) | AR044849A1 (es) |
| AT (1) | ATE414077T1 (es) |
| AU (1) | AU2004249511B2 (es) |
| BR (1) | BRPI0411794A (es) |
| CA (1) | CA2529032C (es) |
| CL (1) | CL2004001470A1 (es) |
| CO (1) | CO5650165A2 (es) |
| DE (1) | DE602004017731D1 (es) |
| DK (1) | DK1641780T3 (es) |
| ES (1) | ES2315663T3 (es) |
| HK (1) | HK1089170A1 (es) |
| IL (1) | IL172064A (es) |
| MX (1) | MXPA05014203A (es) |
| NO (1) | NO20060376L (es) |
| NZ (2) | NZ571898A (es) |
| RU (1) | RU2323214C2 (es) |
| SG (1) | SG161745A1 (es) |
| TW (1) | TWI294425B (es) |
| WO (1) | WO2004113322A1 (es) |
| ZA (1) | ZA200509253B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| WO2006038111A1 (en) * | 2004-10-07 | 2006-04-13 | Pfizer Products Inc. | Benzoimidazole derivatives useful as antiproliferative agents |
| EP1874772A1 (en) * | 2005-04-05 | 2008-01-09 | Pharmacopeia, Inc. | Purine and imidazopyridine derivatives for immunosuppression |
| US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
| ES2378513T3 (es) | 2008-08-06 | 2012-04-13 | Pfizer Inc. | Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1 |
| JP2012512223A (ja) | 2008-12-18 | 2012-05-31 | エフ．ホフマン−ラ ロシュ アーゲー | チアゾリル−ベンズイミダゾール類 |
| CN101993416B (zh) * | 2009-08-27 | 2013-09-11 | 中国科学院上海药物研究所 | 喹啉类化合物、其制备方法、包含该化合物的药物组合物及该化合物的用途 |
| KR101738063B1 (ko) | 2012-09-21 | 2017-05-19 | 아로그 파마슈티칼스, 인코퍼레이티드 | 구조적으로 활성인 인산화된 ｆｌｔ３ 키나제의 억제 방법 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| KR20140040594A (ko) | 2012-09-26 | 2014-04-03 | 아로그 파마슈티칼스, 엘엘씨 | 돌연변이체 c-kit의 억제 방법 |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| JP2019532011A (ja) | 2016-11-02 | 2019-11-07 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| CN109678849A (zh) * | 2019-01-16 | 2019-04-26 | 北京悦康科创医药科技股份有限公司 | 一种抗癌药物的制备方法 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN114702428B (zh) * | 2019-12-09 | 2023-11-28 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| US11713310B2 (en) * | 2020-07-20 | 2023-08-01 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| US20220079934A1 (en) * | 2020-09-17 | 2022-03-17 | Arog Pharmaceuticals, Inc. | Crenolanib for treating pain |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT971878E (pt) * | 1997-02-27 | 2008-07-08 | Takeda Pharmaceutical | Compostos de amina, sua produção e utilização como inibidores da produção de amilóide beta |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| EP1245390A4 (en) * | 1999-12-10 | 2009-04-01 | Fujifilm Corp | INK JET HEAD AND PRINTER |
| EP1321454A4 (en) * | 2000-09-14 | 2005-11-02 | Kaneka Corp | PROCESS FOR EXTRACTING NITROBENZENESULFONYL |
| PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
-
2004
- 2004-06-14 KR KR1020057024593A patent/KR100787649B1/ko active IP Right Grant
- 2004-06-14 CA CA002529032A patent/CA2529032C/en active Active
- 2004-06-14 ES ES04736779T patent/ES2315663T3/es active Active
- 2004-06-14 JP JP2006516552A patent/JP2007516168A/ja active Pending
- 2004-06-14 MX MXPA05014203A patent/MXPA05014203A/es active IP Right Grant
- 2004-06-14 BR BRPI0411794-8A patent/BRPI0411794A/pt not_active IP Right Cessation
- 2004-06-14 CN CNB2004800175706A patent/CN100404530C/zh active Active
- 2004-06-14 NZ NZ571898A patent/NZ571898A/en not_active IP Right Cessation
- 2004-06-14 DE DE602004017731T patent/DE602004017731D1/de active Active
- 2004-06-14 SG SG200700254-6A patent/SG161745A1/en unknown
- 2004-06-14 KR KR1020077019713A patent/KR20070092333A/ko not_active Application Discontinuation
- 2004-06-14 EP EP04736779A patent/EP1641780B1/en active Active
- 2004-06-14 RU RU2005138367/04A patent/RU2323214C2/ru active
- 2004-06-14 WO PCT/IB2004/001983 patent/WO2004113322A1/en active Application Filing
- 2004-06-14 NZ NZ543714A patent/NZ543714A/en not_active IP Right Cessation
- 2004-06-14 AU AU2004249511A patent/AU2004249511B2/en not_active Ceased
- 2004-06-14 DK DK04736779T patent/DK1641780T3/da active
- 2004-06-14 CL CL200401470A patent/CL2004001470A1/es unknown
- 2004-06-14 AT AT04736779T patent/ATE414077T1/de not_active IP Right Cessation
- 2004-06-22 AR ARP040102160A patent/AR044849A1/es unknown
- 2004-06-23 TW TW093118112A patent/TWI294425B/zh not_active IP Right Cessation
- 2004-06-23 US US10/875,030 patent/US7183414B2/en active Active
-
2005
- 2005-11-15 ZA ZA200509253A patent/ZA200509253B/en unknown
- 2005-11-20 IL IL172064A patent/IL172064A/en active IP Right Grant
- 2005-12-20 CO CO05127734A patent/CO5650165A2/es active IP Right Grant
-
2006
- 2006-01-24 NO NO20060376A patent/NO20060376L/no not_active Application Discontinuation
- 2006-08-28 HK HK06109559A patent/HK1089170A1/xx not_active IP Right Cessation
- 2006-12-05 US US11/567,071 patent/US20070088032A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |