ATE344259T1 - Verfahren und zwischenprodukte für die herstellung von emtricitabin - Google Patents
Verfahren und zwischenprodukte für die herstellung von emtricitabinInfo
- Publication number
- ATE344259T1 ATE344259T1 AT04721969T AT04721969T ATE344259T1 AT E344259 T1 ATE344259 T1 AT E344259T1 AT 04721969 T AT04721969 T AT 04721969T AT 04721969 T AT04721969 T AT 04721969T AT E344259 T1 ATE344259 T1 AT E344259T1
- Authority
- AT
- Austria
- Prior art keywords
- emtricitabine
- production
- intermediate products
- preparing
- preparing emtricitabine
- Prior art date
Links
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 title abstract 3
- 229960000366 emtricitabine Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000013067 intermediate product Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000578A ITMI20030578A1 (it) | 2003-03-24 | 2003-03-24 | Processo ed intermedi per la preparazione di emtricitabina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE344259T1 true ATE344259T1 (de) | 2006-11-15 |
Family
ID=33042697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04721969T ATE344259T1 (de) | 2003-03-24 | 2004-03-19 | Verfahren und zwischenprodukte für die herstellung von emtricitabin |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7534885B2 (de) |
| EP (1) | EP1608644B8 (de) |
| JP (1) | JP5255765B2 (de) |
| KR (1) | KR101099824B1 (de) |
| AT (1) | ATE344259T1 (de) |
| DE (1) | DE602004003037T2 (de) |
| ES (1) | ES2279356T3 (de) |
| IT (1) | ITMI20030578A1 (de) |
| WO (1) | WO2004085432A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
| WO2007077505A2 (en) * | 2005-12-30 | 2007-07-12 | Ranbaxy Laboratories Limited | Crystalline l-menthyl (2r, 5s)-5-(4-amino-5-fluoro-2-oxo-2h-pyrimidin-1-yl)[1, 3]oxathiolan-2-carboxylate and process for preparation thereof |
| WO2010082128A1 (en) | 2009-01-19 | 2010-07-22 | Aurobindo Pharma Limited | Process for the preparation of cis-nucleoside derivative |
| CN102167696B (zh) * | 2010-02-25 | 2013-09-18 | 南京正大天晴制药有限公司 | 拉米夫定草酸盐及其制备方法 |
| TW201131192A (en) * | 2010-03-01 | 2011-09-16 | Univ Nat Central | A co-crystal compound of optical devices |
| US8748604B2 (en) * | 2010-03-04 | 2014-06-10 | Ranbaxy Laboratories Limited | Process for stereoselective synthesis of 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
| EP2377862A1 (de) | 2010-03-29 | 2011-10-19 | Esteve Química, S.A. | Verfahren zur Gewinnung von Emtricitabin |
| WO2012131541A1 (en) * | 2011-03-25 | 2012-10-04 | Piramal Healthcare Limited | A process for the isolation of emtricitabine |
| CN103833741A (zh) * | 2012-11-22 | 2014-06-04 | 上海医药工业研究院 | 一种恩曲他滨水杨酸盐及其制备方法和用途 |
| GB201610327D0 (en) * | 2016-06-14 | 2016-07-27 | Univ Nelson Mandela Metropolitan | Process for producing Lamivudine and Entricitabine |
| CN119350115A (zh) * | 2024-10-24 | 2025-01-24 | 浙江外国语学院 | 一种从含有β和α两种异构体的CME溶液中回收β异构体的方法 |
| CN119350314A (zh) * | 2024-10-24 | 2025-01-24 | 浙江外国语学院 | 一种拉米夫定中间体的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827727A (en) | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
| US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| US5276151A (en) | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| IL100965A (en) * | 1991-02-22 | 1999-12-31 | Univ Emory | 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it |
| ZA923640B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9116601D0 (en) | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
| IL113432A (en) | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
| ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
-
2003
- 2003-03-24 IT IT000578A patent/ITMI20030578A1/it unknown
-
2004
- 2004-03-19 WO PCT/IB2004/000924 patent/WO2004085432A1/en not_active Ceased
- 2004-03-19 ES ES04721969T patent/ES2279356T3/es not_active Expired - Lifetime
- 2004-03-19 KR KR1020057017744A patent/KR101099824B1/ko not_active Expired - Fee Related
- 2004-03-19 EP EP04721969A patent/EP1608644B8/de not_active Expired - Lifetime
- 2004-03-19 US US10/550,718 patent/US7534885B2/en not_active Expired - Fee Related
- 2004-03-19 AT AT04721969T patent/ATE344259T1/de not_active IP Right Cessation
- 2004-03-19 DE DE602004003037T patent/DE602004003037T2/de not_active Expired - Lifetime
- 2004-03-19 JP JP2006506397A patent/JP5255765B2/ja not_active Expired - Fee Related
-
2009
- 2009-04-06 US US12/419,050 patent/US7939660B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2279356T3 (es) | 2007-08-16 |
| EP1608644A1 (de) | 2005-12-28 |
| JP2006521350A (ja) | 2006-09-21 |
| DE602004003037T2 (de) | 2007-05-31 |
| ITMI20030578A1 (it) | 2004-09-25 |
| KR20050115292A (ko) | 2005-12-07 |
| DE602004003037D1 (de) | 2006-12-14 |
| US7939660B2 (en) | 2011-05-10 |
| WO2004085432A1 (en) | 2004-10-07 |
| US20060189805A1 (en) | 2006-08-24 |
| US20090192310A1 (en) | 2009-07-30 |
| EP1608644B1 (de) | 2006-11-02 |
| JP5255765B2 (ja) | 2013-08-07 |
| US7534885B2 (en) | 2009-05-19 |
| KR101099824B1 (ko) | 2011-12-27 |
| EP1608644B8 (de) | 2006-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |