AR042632A1 - Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas - Google Patents

Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas

Info

Publication number
AR042632A1
AR042632A1 ARP030104752A ARP030104752A AR042632A1 AR 042632 A1 AR042632 A1 AR 042632A1 AR P030104752 A ARP030104752 A AR P030104752A AR P030104752 A ARP030104752 A AR P030104752A AR 042632 A1 AR042632 A1 AR 042632A1
Authority
AR
Argentina
Prior art keywords
disorders
pharmaceutical compositions
oxoetoxi
etoxipropanoic
lipids
Prior art date
Application number
ARP030104752A
Other languages
English (en)
Inventor
Lanna Li
Christina Olsson
Eva-Lotte Alstermark
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR042632A1 publication Critical patent/AR042632A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

El enantiómero S de un compuesto de fórmula (1), donde R1 representa cloro, trifluorometilo o trifluorometoxi; R2 representa H o fluoro y R3 representa un grupo alquilo C2-4, así como sales aceptables para uso farmacéutico, solvatos y profármacos del mismo; procesos para preparar dichos compuestos; su utilidad en el tratamiento de trastornos clínicos, por ejemplo de trastornos lipídicos (dislipidemias) relacionados o no relacionados con al resistencia a la insulina; métodos para su uso terapéutico y composiciones farmacéuticas que lo contienen, solo o en combinación con un inhibidor de IBAT.
ARP030104752A 2002-12-21 2003-12-19 Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas AR042632A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0229931.1A GB0229931D0 (en) 2002-12-21 2002-12-21 Therapeutic agents

Publications (1)

Publication Number Publication Date
AR042632A1 true AR042632A1 (es) 2005-06-29

Family

ID=9950253

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104752A AR042632A1 (es) 2002-12-21 2003-12-19 Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas

Country Status (21)

Country Link
US (1) US7462644B2 (es)
EP (1) EP1572626A1 (es)
JP (2) JP3786945B2 (es)
KR (1) KR20050089065A (es)
CN (1) CN1308291C (es)
AR (1) AR042632A1 (es)
AU (1) AU2003290309B2 (es)
BR (1) BR0317458A (es)
CA (1) CA2508851A1 (es)
CL (1) CL2003002683A1 (es)
CO (1) CO5580820A2 (es)
GB (1) GB0229931D0 (es)
IS (1) IS7946A (es)
MX (1) MXPA05006812A (es)
NO (1) NO20052914L (es)
PL (1) PL377144A1 (es)
RU (1) RU2005117792A (es)
TW (1) TW200508180A (es)
UA (1) UA80729C2 (es)
WO (1) WO2004056748A1 (es)
ZA (1) ZA200504730B (es)

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Also Published As

Publication number Publication date
RU2005117792A (ru) 2006-01-27
WO2004056748A1 (en) 2004-07-08
CA2508851A1 (en) 2004-07-08
PL377144A1 (pl) 2006-01-23
US20050131068A1 (en) 2005-06-16
CN1753862A (zh) 2006-03-29
GB0229931D0 (en) 2003-01-29
EP1572626A1 (en) 2005-09-14
JP3786945B2 (ja) 2006-06-21
TW200508180A (en) 2005-03-01
NO20052914D0 (no) 2005-06-15
CO5580820A2 (es) 2005-11-30
MXPA05006812A (es) 2005-09-08
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US7462644B2 (en) 2008-12-09
IS7946A (is) 2005-07-19
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UA80729C2 (en) 2007-10-25
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