AR038046A1 - Derivados de acidos 3-fenil-2-arilalquiltiopropionicos moduladores de ppar alfa - Google Patents

Derivados de acidos 3-fenil-2-arilalquiltiopropionicos moduladores de ppar alfa

Info

Publication number
AR038046A1
AR038046A1 ARP020105003A ARP020105003A AR038046A1 AR 038046 A1 AR038046 A1 AR 038046A1 AR P020105003 A ARP020105003 A AR P020105003A AR P020105003 A ARP020105003 A AR P020105003A AR 038046 A1 AR038046 A1 AR 038046A1
Authority
AR
Argentina
Prior art keywords
moduladores
arilalquiltiopropionicos
fenil
acid derivatives
ppar alfa
Prior art date
Application number
ARP020105003A
Other languages
English (en)
Inventor
Maria Boije
Patrik Holm
Lindstedt Eva-Lotte Alstermark
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR038046A1 publication Critical patent/AR038046A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Un compuesto de fórmula (1) donde R1 representa Cl, F o hidroxilo, así como isómeros ópticos y racematos del mismo, así como sales, prodrogas, solvatos y formas cristalinas del mismo aceptables para uso farmacéutico, procesos para preparar tales compuestos, su utilidad para tratar condiciones clínicas que incluyen trastornos en los lípidos (dislipidemias), asociados o no con la resistencia a la insulina con métodos para su uso terapéutico y con composiciones farmacéuticas que los contienen.
ARP020105003A 2001-12-19 2002-12-19 Derivados de acidos 3-fenil-2-arilalquiltiopropionicos moduladores de ppar alfa AR038046A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0104333A SE0104333D0 (sv) 2001-12-19 2001-12-19 Therapeutic agents

Publications (1)

Publication Number Publication Date
AR038046A1 true AR038046A1 (es) 2004-12-22

Family

ID=20286432

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020105003A AR038046A1 (es) 2001-12-19 2002-12-19 Derivados de acidos 3-fenil-2-arilalquiltiopropionicos moduladores de ppar alfa

Country Status (27)

Country Link
US (1) US7276539B2 (es)
EP (1) EP1458677B1 (es)
JP (2) JP3810770B2 (es)
KR (1) KR20040068589A (es)
CN (1) CN100343229C (es)
AR (1) AR038046A1 (es)
AT (1) ATE428691T1 (es)
AU (1) AU2002352426A1 (es)
BR (1) BR0215090A (es)
CA (1) CA2470066C (es)
CO (1) CO5590908A2 (es)
DE (1) DE60232018D1 (es)
ES (1) ES2324025T3 (es)
HK (1) HK1068866A1 (es)
HU (1) HUP0402093A3 (es)
IL (1) IL162378A0 (es)
IS (1) IS7303A (es)
MX (1) MXPA04005992A (es)
NO (1) NO20043084L (es)
NZ (1) NZ533365A (es)
PL (1) PL370623A1 (es)
RU (1) RU2004117776A (es)
SE (1) SE0104333D0 (es)
TW (1) TW200410678A (es)
UA (1) UA80407C2 (es)
WO (1) WO2003051826A1 (es)
ZA (1) ZA200404585B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1517883B8 (en) 2002-06-20 2008-05-21 AstraZeneca AB Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
GB0314131D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314130D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314075D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314134D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314260D0 (en) * 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0427524D0 (en) * 2004-12-16 2005-01-19 Astrazeneca Ab Chemical process
GB0427701D0 (en) * 2004-12-17 2005-01-19 Astrazeneca Ab Therapeutic agents
RU2480453C2 (ru) 2007-03-08 2013-04-27 Альбирео Аб Новые соединения

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
US5232945A (en) * 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
WO1999029640A2 (en) 1997-12-05 1999-06-17 Eisai Co., Ltd. Compositions and methods for modulating the activity of fibroblast growth factor
KR100620337B1 (ko) * 1998-03-10 2006-09-13 오노 야꾸힝 고교 가부시키가이샤 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제
SE9801990D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl propionic acid derivatives and analogs
MA26634A1 (fr) 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE9801992D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
GB9822473D0 (en) * 1998-10-16 1998-12-09 Glaxo Group Ltd Chemical compounds
EP1177187B1 (en) 1999-04-28 2007-07-25 Sanofi-Aventis Deutschland GmbH Di-aryl acid derivatives as ppar receptor ligands
TWI262185B (en) * 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
SE9904421D0 (sv) 1999-12-03 1999-12-03 Astra Ab New compounds
TW574193B (en) 1999-12-03 2004-02-01 Astrazeneca Ab Novel phenalkyloxy-phenyl derivatives, pharmaceutical composition containing the same and their uses
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
KR20020081424A (ko) 2000-03-09 2002-10-26 아벤티스 파마 도이칠란트 게엠베하 Ｐｐａｒ 매개인자의 치료학적 용도
SE0003766D0 (sv) 2000-10-18 2000-10-18 Astrazeneca Ab Novel formulation
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
SE0101978D0 (sv) 2001-06-01 2001-06-01 Astrazeneca Ab New compounds
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) * 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
CN1582151A (zh) 2001-09-08 2005-02-16 阿斯特拉曾尼卡有限公司 用于治疗高脂血症、具有回肠胆汁酸转运(ibat)抑制活性的苯并硫氮杂䓬和苯并硫杂二氮杂䓬衍生物
SE0104334D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
GB0229931D0 (en) 2002-12-21 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
SE0201936D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
SE0201937D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
EP1517883B8 (en) 2002-06-20 2008-05-21 AstraZeneca AB Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
GB0314136D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314078D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314129D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314131D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314130D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314075D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314260D0 (en) 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents

Also Published As

Publication number Publication date
UA80407C2 (en) 2007-09-25
JP2006241162A (ja) 2006-09-14
CN100343229C (zh) 2007-10-17
US20050215630A1 (en) 2005-09-29
PL370623A1 (en) 2005-05-30
WO2003051826A1 (en) 2003-06-26
EP1458677B1 (en) 2009-04-15
CA2470066A1 (en) 2003-06-26
EP1458677A1 (en) 2004-09-22
KR20040068589A (ko) 2004-07-31
CN1620430A (zh) 2005-05-25
DE60232018D1 (de) 2009-05-28
HK1068866A1 (en) 2005-05-06
CA2470066C (en) 2007-04-10
HUP0402093A2 (hu) 2005-02-28
ES2324025T3 (es) 2009-07-29
SE0104333D0 (sv) 2001-12-19
NZ533365A (en) 2006-05-26
MXPA04005992A (es) 2004-09-27
AU2002352426A1 (en) 2003-06-30
JP3810770B2 (ja) 2006-08-16
CO5590908A2 (es) 2005-12-30
IL162378A0 (en) 2005-11-20
US7276539B2 (en) 2007-10-02
HUP0402093A3 (en) 2008-08-28
JP2005511785A (ja) 2005-04-28
IS7303A (is) 2004-06-08
NO20043084L (no) 2004-07-16
ATE428691T1 (de) 2009-05-15
BR0215090A (pt) 2004-11-16
TW200410678A (en) 2004-07-01
ZA200404585B (en) 2005-10-26
RU2004117776A (ru) 2006-01-10

Similar Documents

Publication Publication Date Title
AR038047A1 (es) Agentes terapeuticos
CO5650227A2 (es) Derivados del acido propionico utiles en desordenes lipidicos
CO5580820A2 (es) Derivados novedosos de acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico procesos para su preparacion y composiciones farmaceuticas que los contienen
AR039063A1 (es) Derivados de diarilcicloalquilo, procedimiento para su preparacion, medicamento, un proceso para su preparacion, utilizacion de dichos derivados para la preparacion de un medicamento
PA8621901A1 (es) Derivados de sulfonamida para el tratamiento de enfermedades
UY28339A1 (es) Derivados de 2-amino-piridina utiles para el tratamiento de enfermedades
ES2095824T3 (es) Procedimiento para la obtencion de derivados de n-2'-(aminofenil)-benzamida y su empleo para la lucha contra las enfermedades neoplasticas.
NI201000085A (es) Derivados bis - (sulfonilamino) en terapia 066.
UY31468A1 (es) Derivados bis-(sulfonilamino) en terapia 065
ECSP088323A (es) Derivados de fenil-[1,2,4]-oxadiazol-5-ona con grupo fenilo, procedimientos para su preparación y su uso como productos farmacéuticos
AR081337A1 (es) Derivados de 1,4-benzotiazepinas, composiciones farmaceuticas que los comprenden y su uso en la preparacion de un medicamento para el tratamiento de trastornos metabolicos
UY31546A1 (es) Derivados bis-(sulfonilamino) en terapia 205
ECSP056164A (es) Compuestos utiles para el tratamiento de enfermedades
ECSP066730A (es) Compuestos y procedimientos para uso
DOP2013000191A (es) Derivados de heteroarilo como modulares de nachr alfa 7
UY28343A1 (es) Derivados de 2-amino-piridina utiles para el tratamiento de enfermedades
GT200100196A (es) Nuevos tiadiazoles y oxadiazoles y su uso como inhibidores de fosfodiesterasa-7.
AR038046A1 (es) Derivados de acidos 3-fenil-2-arilalquiltiopropionicos moduladores de ppar alfa
ECSP066964A (es) Nuevos beta-agonistas, procedimiento para su preparación y su uso como medicamentos
AR043430A1 (es) Derivados de diarilcicloalquilo, procesos para su preparacion y su uso como agentes farmaceuticos
ECSP044994A (es) Derivados de diarilcicloalquilo, procedimientos para su preparacion y su utilización como agentes activadores del ppar
UY29883A1 (es) Nuevos beta-agonistas que contienen indol, procedimientos para prepararlos, y su empleo como medicamentos
AR001769A1 (es) Benzamida enterocinética composiciones farmacéuticas que las contienen procedimiento para la preparación de dichas composiciones farmacéuticas el uso de dichos compuestos para la manufactura de medicamentos y un procedimiento para su preparación
UY25175A1 (es) 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocin-10-oles sustituidos, procedimientos para su preparación, y empleo de los mismos como medicamentos.
PA8529801A1 (es) Un nuevo compuesto derivado de la triptamina y sus analogos

Legal Events

Date Code Title Description
FA Abandonment or withdrawal