ES2527794T3 - Procedimiento para preparar compuestos de benzazepina o sus sales - Google Patents

Procedimiento para preparar compuestos de benzazepina o sus sales Download PDF

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Publication number
ES2527794T3
ES2527794T3 ES10174000.9T ES10174000T ES2527794T3 ES 2527794 T3 ES2527794 T3 ES 2527794T3 ES 10174000 T ES10174000 T ES 10174000T ES 2527794 T3 ES2527794 T3 ES 2527794T3
Authority
ES
Spain
Prior art keywords
salts
preparing
procedure
benzazepine compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10174000.9T
Other languages
English (en)
Inventor
Yasuhiro Torisawa
Kaoru Abe
Yasuaki Muguruma
Shigekazu Fujita
Hidenori Ogawa
Naoto Utsumi
Masahiro Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37398782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2527794(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2527794T3 publication Critical patent/ES2527794T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un procedimiento para producir un compuesto de benzazepina de fórmula (1):**Fórmula** donde X1 es un átomo de halógeno y R1 y R2 son independientemente un grupo alquilo de 1 a 6 átomos de carbono, o sus sales, que consiste en hacer reaccionar un compuesto de benzazepina de fórmula (2):**Fórmula** donde X1 es como se ha definido anteriormente, o una sal del mismo, con un compuesto de amida de fórmula (3):**Fórmula** donde R1 y R2 son como se ha definido anteriormente y X2 es un átomo de halógeno, o una sal del mismo, en presencia de un agente carbonilante

Description

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Claims (1)

  1. imagen1
ES10174000.9T 2005-09-02 2006-09-01 Procedimiento para preparar compuestos de benzazepina o sus sales Active ES2527794T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005254744 2005-09-02
JP2005254744 2005-09-02

Publications (1)

Publication Number Publication Date
ES2527794T3 true ES2527794T3 (es) 2015-01-29

Family

ID=37398782

Family Applications (3)

Application Number Title Priority Date Filing Date
ES06797660T Active ES2358217T3 (es) 2005-09-02 2006-09-01 Proceso para preparar compuestos de benzazepina o sales de los mismos.
ES10174006T Active ES2379153T3 (es) 2005-09-02 2006-09-01 Proceso para preparar derivados del ácido benzoico
ES10174000.9T Active ES2527794T3 (es) 2005-09-02 2006-09-01 Procedimiento para preparar compuestos de benzazepina o sus sales

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES06797660T Active ES2358217T3 (es) 2005-09-02 2006-09-01 Proceso para preparar compuestos de benzazepina o sales de los mismos.
ES10174006T Active ES2379153T3 (es) 2005-09-02 2006-09-01 Proceso para preparar derivados del ácido benzoico

Country Status (16)

Country Link
US (2) US8273735B2 (es)
EP (3) EP1919874B1 (es)
JP (6) JP5046587B2 (es)
KR (4) KR101077329B1 (es)
CN (4) CN102219741B (es)
AT (2) ATE544744T1 (es)
CY (3) CY1111788T1 (es)
DE (1) DE602006019882D1 (es)
DK (3) DK2251319T3 (es)
ES (3) ES2358217T3 (es)
HK (5) HK1148999A1 (es)
IL (5) IL189481A (es)
PL (3) PL2261215T3 (es)
PT (3) PT1919874E (es)
SI (3) SI1919874T1 (es)
WO (1) WO2007026971A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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DK2251319T3 (da) * 2005-09-02 2012-03-05 Otsuka Pharma Co Ltd Fremgangsmåde til fremstilling af derivater af benzoesyre
JP2009035513A (ja) * 2007-08-02 2009-02-19 Ube Ind Ltd ４−ｎ−（メチルベンゾイル）アミノ−２−メチル安息香酸の製法
CN102020609A (zh) * 2009-09-17 2011-04-20 北京本草天源药物研究院 托伐普坦晶体或无定形物及其制备方法
CN101817783B (zh) * 2010-05-12 2012-02-22 天津泰普药品科技发展有限公司 一种托伐普坦中间体的制备方法
US9024015B2 (en) 2010-10-05 2015-05-05 Hetero Research Foundation Process for preparing tolvaptan intermediates
CN102093247B (zh) * 2010-12-15 2014-03-12 天津药物研究院 一种2-甲基-4-n-(2-甲基苯甲酰)苯甲酸的制备方法
CN102060769B (zh) * 2010-12-20 2013-09-18 天津药物研究院 一种托伐普坦的制备方法
CN102093293B (zh) * 2011-03-02 2012-06-13 宁波人健药业集团有限公司 一种制备7-氯-2,3,4,5-四氢-1h-1-苯并氮杂卓-5-酮的方法
CN102558051B (zh) * 2011-07-15 2016-08-10 天津泰普药品科技发展有限公司 一种托伐普坦晶体及其药物组合物
CN102382053B (zh) * 2011-08-31 2016-06-01 浙江华海药业股份有限公司 一种制备托伐普坦中间体的方法
CN102329268B (zh) * 2011-10-25 2014-03-12 天津药物研究院 7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN103159641A (zh) * 2011-12-14 2013-06-19 天津泰普药品科技发展有限公司 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
CN102690211B (zh) * 2012-06-05 2015-12-09 郑州明泽医药科技有限公司 托伐普坦中间体的制备方法
CN103012265B (zh) * 2012-11-23 2014-10-15 天津药物研究院 一种7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN103012266B (zh) * 2012-11-23 2014-07-23 天津药物研究院 一种7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN104418803A (zh) * 2013-08-21 2015-03-18 上海天慈生物谷生物工程有限公司 一种托伐普坦的制备方法
IN2013MU03296A (es) 2013-10-21 2015-07-17 Rpg Life Sciences Ltd
CN103880747B (zh) * 2014-03-20 2015-08-26 成都百裕科技制药有限公司 无定形托伐普坦的制备方法
CN106883175A (zh) * 2015-12-16 2017-06-23 天津泰普制药有限公司 一种托伐普坦的制备方法
ITUB20160256A1 (it) * 2016-01-15 2017-07-15 Olon Spa Derivati idrossibenzazepinici esterificati e loro impiego nella sintesi di tolvaptan
CN107663171A (zh) * 2017-10-10 2018-02-06 常州市阳光药业有限公司 高纯度托伐普坦的制备方法
CN113004202B (zh) * 2019-12-20 2023-10-24 成都倍特药业股份有限公司 一种高纯度托伐普坦的制备方法
CN113717070A (zh) * 2020-05-25 2021-11-30 南京正大天晴制药有限公司 一种升压素v2受体拮抗剂的中间体的制备方法
JP2024521354A (ja) 2021-06-02 2024-05-31 エスペリオン・セラピューティクス・インコーポレイテッド ベンペド酸とトルバブタンを含む組成物及びそれらを用いた治療方法

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Also Published As

Publication number Publication date
HK1124318A1 (en) 2009-07-10
CN101967107A (zh) 2011-02-09
DE602006019882D1 (de) 2011-03-10
CN101273017B (zh) 2011-09-14
HK1172329A1 (en) 2013-04-19
JP5893083B2 (ja) 2016-03-23
KR101077329B1 (ko) 2011-10-26
CN101967107B (zh) 2012-12-12
SI2251319T1 (sl) 2012-05-31
IL189481A (en) 2013-08-29
CN102219741A (zh) 2011-10-19
ES2379153T3 (es) 2012-04-23
IL189481A0 (en) 2008-08-07
WO2007026971A2 (en) 2007-03-08
EP2261215A1 (en) 2010-12-15
PT2261215E (pt) 2015-02-13
EP2261215B1 (en) 2014-12-31
IL217446A (en) 2016-08-31
ES2358217T3 (es) 2011-05-06
JP2007091738A (ja) 2007-04-12
IL217445A (en) 2013-11-28
US20090306369A1 (en) 2009-12-10
JP2012176979A (ja) 2012-09-13
EP2251319A2 (en) 2010-11-17
SI1919874T1 (sl) 2011-04-29
CN101273017A (zh) 2008-09-24
EP2251319A3 (en) 2011-03-09
CY1111788T1 (el) 2015-10-07
DK2261215T3 (en) 2015-02-02
WO2007026971A3 (en) 2007-07-05
ATE544744T1 (de) 2012-02-15
JP2012197295A (ja) 2012-10-18
HK1145835A1 (en) 2011-05-06
CY1112496T1 (el) 2015-12-09
IL222396A (en) 2014-05-28
JP2014205699A (ja) 2014-10-30
US8273735B2 (en) 2012-09-25
PT2251319E (pt) 2012-03-05
HK1144932A1 (en) 2011-03-18
PL1919874T3 (pl) 2011-06-30
JP2012197296A (ja) 2012-10-18
PL2251319T3 (pl) 2012-07-31
CN102219741B (zh) 2013-05-15
US20120226034A1 (en) 2012-09-06
KR101019363B1 (ko) 2011-03-07
KR20100132087A (ko) 2010-12-16
HK1148999A1 (en) 2011-09-23
SI2261215T1 (sl) 2015-02-27
IL217444A (en) 2013-05-30
PT1919874E (pt) 2011-03-14
JP5784164B2 (ja) 2015-09-24
PL2261215T3 (pl) 2015-06-30
ATE496895T1 (de) 2011-02-15
US8501730B2 (en) 2013-08-06
KR20110029184A (ko) 2011-03-22
JP2014139203A (ja) 2014-07-31
KR20080039459A (ko) 2008-05-07
IL217446A0 (en) 2012-02-29
EP1919874B1 (en) 2011-01-26
KR101119732B1 (ko) 2012-03-22
DK2251319T3 (da) 2012-03-05
DK1919874T3 (da) 2011-02-21
KR20100133028A (ko) 2010-12-20
CN102746229A (zh) 2012-10-24
CY1116082T1 (el) 2017-02-08
CN102746229B (zh) 2015-04-08
IL217444A0 (en) 2012-02-29
EP2251319B1 (en) 2012-02-08
JP5583172B2 (ja) 2014-09-03
IL217445A0 (en) 2012-02-29
JP5046587B2 (ja) 2012-10-10
EP1919874A2 (en) 2008-05-14

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