CY1116082T1 - Μεθοδος παρασκευης ενωσεων βενζαζεπινης ή αλατων τους - Google Patents

Μεθοδος παρασκευης ενωσεων βενζαζεπινης ή αλατων τους

Info

Publication number
CY1116082T1
CY1116082T1 CY20151100219T CY151100219T CY1116082T1 CY 1116082 T1 CY1116082 T1 CY 1116082T1 CY 20151100219 T CY20151100219 T CY 20151100219T CY 151100219 T CY151100219 T CY 151100219T CY 1116082 T1 CY1116082 T1 CY 1116082T1
Authority
CY
Cyprus
Prior art keywords
salts
venzazepin
union
preparation
preparing
Prior art date
Application number
CY20151100219T
Other languages
English (en)
Inventor
Yasuhiro Torisawa
Kaoru Abe
Yasuaki Muguruma
Shigekazu Fujita
Hidenori Ogawa
Naoto Utsumi
Masahiro Miyake
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37398782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116082(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of CY1116082T1 publication Critical patent/CY1116082T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Αυτή η εφεύρεση παρέχει μια μέθοδο για την παρασκευή ενώσεων βενζαζεπίνης του τύπου (1): όπου το Χ1 είναι άτομο αλογόνου, τα R1 και R2 είναι ομάδα κατωτέρου αλκυλίου, ή αλάτων τους καθώς και ενδιάμεσων ενώσεων βενζοϊκού οξέος με υψηλή απόδοση και υψηλή καθαρότητα επί βιομηχανικής κλίμακας, οι οποίες είναι χρήσιμες ως ενδιάμεσο για την παρασκευή μιας φαρμακευτικώς δραστικής ένωσης 2,3,4,5-τετραϋδρο-1Η-1-βενζαζεπίνης η οποία έχει ανταγωνιστική δράση αγγειοπρεσσίνης.
CY20151100219T 2005-09-02 2015-03-03 Μεθοδος παρασκευης ενωσεων βενζαζεπινης ή αλατων τους CY1116082T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005254744 2005-09-02
EP10174000.9A EP2261215B1 (en) 2005-09-02 2006-09-01 Process for preparing benzazepine compounds or salts thereof

Publications (1)

Publication Number Publication Date
CY1116082T1 true CY1116082T1 (el) 2017-02-08

Family

ID=37398782

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20111100323T CY1111788T1 (el) 2005-09-02 2011-03-24 Μεθοδος παρασκευης ενωσεων βενζαζεπινης ή αλατων τους
CY20121100279T CY1112496T1 (el) 2005-09-02 2012-03-15 Μεθοδος παρασκευης παραγωγων βενζοϊκου οξεος
CY20151100219T CY1116082T1 (el) 2005-09-02 2015-03-03 Μεθοδος παρασκευης ενωσεων βενζαζεπινης ή αλατων τους

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20111100323T CY1111788T1 (el) 2005-09-02 2011-03-24 Μεθοδος παρασκευης ενωσεων βενζαζεπινης ή αλατων τους
CY20121100279T CY1112496T1 (el) 2005-09-02 2012-03-15 Μεθοδος παρασκευης παραγωγων βενζοϊκου οξεος

Country Status (16)

Country Link
US (2) US8273735B2 (el)
EP (3) EP2251319B1 (el)
JP (6) JP5046587B2 (el)
KR (4) KR101077329B1 (el)
CN (4) CN101967107B (el)
AT (2) ATE496895T1 (el)
CY (3) CY1111788T1 (el)
DE (1) DE602006019882D1 (el)
DK (3) DK2251319T3 (el)
ES (3) ES2379153T3 (el)
HK (5) HK1124318A1 (el)
IL (5) IL189481A (el)
PL (3) PL2261215T3 (el)
PT (3) PT2261215E (el)
SI (3) SI2261215T1 (el)
WO (1) WO2007026971A2 (el)

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US8273735B2 (en) * 2005-09-02 2012-09-25 Otsuka Pharmaceutical Co., Ltd. Process for preparing benzazepine compounds or salts thereof
JP2009035513A (ja) * 2007-08-02 2009-02-19 Ube Ind Ltd ４−ｎ−（メチルベンゾイル）アミノ−２−メチル安息香酸の製法
CN102020609A (zh) * 2009-09-17 2011-04-20 北京本草天源药物研究院 托伐普坦晶体或无定形物及其制备方法
CN101817783B (zh) * 2010-05-12 2012-02-22 天津泰普药品科技发展有限公司 一种托伐普坦中间体的制备方法
EP2624693B1 (en) 2010-10-05 2019-03-06 Hetero Research Foundation Process for preparing tolvaptan intermediates
CN102093247B (zh) * 2010-12-15 2014-03-12 天津药物研究院 一种2-甲基-4-n-(2-甲基苯甲酰)苯甲酸的制备方法
CN102060769B (zh) * 2010-12-20 2013-09-18 天津药物研究院 一种托伐普坦的制备方法
CN102093293B (zh) * 2011-03-02 2012-06-13 宁波人健药业集团有限公司 一种制备7-氯-2,3,4,5-四氢-1h-1-苯并氮杂卓-5-酮的方法
CN102558051B (zh) * 2011-07-15 2016-08-10 天津泰普药品科技发展有限公司 一种托伐普坦晶体及其药物组合物
CN102382053B (zh) * 2011-08-31 2016-06-01 浙江华海药业股份有限公司 一种制备托伐普坦中间体的方法
CN102329268B (zh) * 2011-10-25 2014-03-12 天津药物研究院 7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN103159641A (zh) * 2011-12-14 2013-06-19 天津泰普药品科技发展有限公司 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
CN102690211B (zh) * 2012-06-05 2015-12-09 郑州明泽医药科技有限公司 托伐普坦中间体的制备方法
CN103012265B (zh) * 2012-11-23 2014-10-15 天津药物研究院 一种7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN103012266B (zh) * 2012-11-23 2014-07-23 天津药物研究院 一种7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN104418803A (zh) * 2013-08-21 2015-03-18 上海天慈生物谷生物工程有限公司 一种托伐普坦的制备方法
IN2013MU03296A (el) 2013-10-21 2015-07-17 Rpg Life Sciences Ltd
CN103880747B (zh) * 2014-03-20 2015-08-26 成都百裕科技制药有限公司 无定形托伐普坦的制备方法
CN106883175A (zh) * 2015-12-16 2017-06-23 天津泰普制药有限公司 一种托伐普坦的制备方法
ITUB20160256A1 (it) * 2016-01-15 2017-07-15 Olon Spa Derivati idrossibenzazepinici esterificati e loro impiego nella sintesi di tolvaptan
CN107663171A (zh) * 2017-10-10 2018-02-06 常州市阳光药业有限公司 高纯度托伐普坦的制备方法
CN113004202B (zh) * 2019-12-20 2023-10-24 成都倍特药业股份有限公司 一种高纯度托伐普坦的制备方法
CN113717070A (zh) * 2020-05-25 2021-11-30 南京正大天晴制药有限公司 一种升压素v2受体拮抗剂的中间体的制备方法
WO2022256378A1 (en) 2021-06-02 2022-12-08 Esperion Therapeutics, Inc. Compositions containing and therapies using bempedoic acid and tolvaptan

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Also Published As

Publication number Publication date
JP2012197295A (ja) 2012-10-18
EP1919874B1 (en) 2011-01-26
JP2007091738A (ja) 2007-04-12
DK1919874T3 (da) 2011-02-21
CN101967107A (zh) 2011-02-09
US8273735B2 (en) 2012-09-25
CN102746229B (zh) 2015-04-08
IL189481A0 (en) 2008-08-07
ATE544744T1 (de) 2012-02-15
ES2358217T3 (es) 2011-05-06
PT2261215E (pt) 2015-02-13
WO2007026971A2 (en) 2007-03-08
JP2014205699A (ja) 2014-10-30
KR20110029184A (ko) 2011-03-22
CN102219741B (zh) 2013-05-15
CN101273017B (zh) 2011-09-14
EP2251319A2 (en) 2010-11-17
PL1919874T3 (pl) 2011-06-30
HK1148999A1 (en) 2011-09-23
HK1172329A1 (en) 2013-04-19
PL2251319T3 (pl) 2012-07-31
HK1124318A1 (en) 2009-07-10
IL217446A (en) 2016-08-31
CN102219741A (zh) 2011-10-19
CN102746229A (zh) 2012-10-24
DK2251319T3 (da) 2012-03-05
KR20100132087A (ko) 2010-12-16
ES2379153T3 (es) 2012-04-23
IL217444A (en) 2013-05-30
IL217444A0 (en) 2012-02-29
KR20100133028A (ko) 2010-12-20
EP2251319A3 (en) 2011-03-09
DE602006019882D1 (de) 2011-03-10
KR101077329B1 (ko) 2011-10-26
IL217445A (en) 2013-11-28
ATE496895T1 (de) 2011-02-15
DK2261215T3 (en) 2015-02-02
EP1919874A2 (en) 2008-05-14
KR20080039459A (ko) 2008-05-07
SI1919874T1 (sl) 2011-04-29
US20120226034A1 (en) 2012-09-06
SI2251319T1 (sl) 2012-05-31
HK1144932A1 (en) 2011-03-18
IL217446A0 (en) 2012-02-29
IL217445A0 (en) 2012-02-29
EP2261215B1 (en) 2014-12-31
WO2007026971A3 (en) 2007-07-05
KR101019363B1 (ko) 2011-03-07
US8501730B2 (en) 2013-08-06
JP5784164B2 (ja) 2015-09-24
IL222396A (en) 2014-05-28
CN101273017A (zh) 2008-09-24
JP5893083B2 (ja) 2016-03-23
JP2014139203A (ja) 2014-07-31
JP2012197296A (ja) 2012-10-18
ES2527794T3 (es) 2015-01-29
US20090306369A1 (en) 2009-12-10
JP5583172B2 (ja) 2014-09-03
SI2261215T1 (sl) 2015-02-27
JP2012176979A (ja) 2012-09-13
HK1145835A1 (en) 2011-05-06
JP5046587B2 (ja) 2012-10-10
CN101967107B (zh) 2012-12-12
CY1111788T1 (el) 2015-10-07
IL189481A (en) 2013-08-29
CY1112496T1 (el) 2015-12-09
PT1919874E (pt) 2011-03-14
PT2251319E (pt) 2012-03-05
PL2261215T3 (pl) 2015-06-30
KR101119732B1 (ko) 2012-03-22
EP2261215A1 (en) 2010-12-15
EP2251319B1 (en) 2012-02-08

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