TR200003789T2 - İkameli triazolo-piridazin türevi ve bundan yapılan farmasötik bileşimler. - Google Patents

İkameli triazolo-piridazin türevi ve bundan yapılan farmasötik bileşimler.

Info

Publication number
TR200003789T2
TR200003789T2 TR2000/03789T TR200003789T TR200003789T2 TR 200003789 T2 TR200003789 T2 TR 200003789T2 TR 2000/03789 T TR2000/03789 T TR 2000/03789T TR 200003789 T TR200003789 T TR 200003789T TR 200003789 T2 TR200003789 T2 TR 200003789T2
Authority
TR
Turkey
Prior art keywords
pharmaceutical compositions
made therefrom
compositions made
pyridazine derivative
substituted triazolo
Prior art date
Application number
TR2000/03789T
Other languages
English (en)
Inventor
Robert Carling William
Luis Castro Pineiro Jose
John Cowden Cameron
John Davies Antony
Madin Andrew
Francis Mccabe James
Edward Stephen Pearce Gareth
Joseph Street Leslie
Original Assignee
Merck Sharp & Dohme Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited
Publication of TR200003789T2 publication Critical patent/TR200003789T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

7-(1,1-Dimetiletil)-6- (2-etil-2H-1,2,4-triazol-3-ilmetoksi) -3-(2-flüorofenil) -1,2,4-triazolo[4,3-b] piridazin ve bunun farmasötik açidan kabul edilen tuzlari olup, GABAA reseptörleri için, özellikle alfa2 ve/veya alfa3 alt ünitesi için yüksek uyum gösteren seçici ligantlardir ve buna uygun olarak, anksiyete ve konvülsiyonu da içeren merkezi sinir sistemi hastaliklarinin tedavisi ve/veya önlenmesinde yararlidir.
TR2000/03789T 1998-06-24 1999-06-15 İkameli triazolo-piridazin türevi ve bundan yapılan farmasötik bileşimler. TR200003789T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9813576.7A GB9813576D0 (en) 1998-06-24 1998-06-24 Therapeutic agents

Publications (1)

Publication Number Publication Date
TR200003789T2 true TR200003789T2 (tr) 2001-04-20

Family

ID=10834265

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03789T TR200003789T2 (tr) 1998-06-24 1999-06-15 İkameli triazolo-piridazin türevi ve bundan yapılan farmasötik bileşimler.

Country Status (35)

Country Link
US (1) US6630471B1 (tr)
EP (1) EP1090004B1 (tr)
JP (1) JP4749545B2 (tr)
KR (1) KR100604108B1 (tr)
CN (1) CN1138779C (tr)
AR (1) AR018925A1 (tr)
AT (1) ATE239730T1 (tr)
AU (1) AU757315B2 (tr)
BG (1) BG64989B1 (tr)
BR (1) BR9911563A (tr)
CA (1) CA2335328C (tr)
CO (1) CO5031239A1 (tr)
CZ (1) CZ291409B6 (tr)
DE (1) DE69907675T2 (tr)
EA (1) EA003332B1 (tr)
EE (1) EE200000767A (tr)
ES (1) ES2196824T3 (tr)
GB (1) GB9813576D0 (tr)
GE (1) GEP20033143B (tr)
HR (1) HRP20000879A2 (tr)
HU (1) HUP0102894A3 (tr)
ID (1) ID27771A (tr)
IL (2) IL139775A0 (tr)
IS (1) IS2258B (tr)
MY (1) MY124341A (tr)
NO (1) NO317992B1 (tr)
NZ (1) NZ508290A (tr)
PE (1) PE20000710A1 (tr)
PL (1) PL204650B1 (tr)
RS (1) RS49746B (tr)
SK (1) SK285307B6 (tr)
TR (1) TR200003789T2 (tr)
TW (1) TWI222449B (tr)
WO (1) WO1999067245A1 (tr)
ZA (1) ZA200007485B (tr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) * 2001-05-08 2001-06-27 Merck Sharp & Dohme Therapeutic agents
KR101075812B1 (ko) * 2002-12-18 2011-10-25 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서의 트리아졸로피리다진
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
US8501738B2 (en) 2009-06-23 2013-08-06 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
EP2456311A4 (en) * 2009-07-24 2013-01-23 Concert Pharmaceuticals Inc SUBSTITUTED IMIDASOTRIAZINES
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
SG182297A1 (en) 2009-12-31 2012-08-30 Ct Nac Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) * 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
JP6042438B2 (ja) 2011-09-27 2016-12-14 ジェンフィットＧｅｎｆｉｔ Ｒｅｖ−ｅｒｂアゴニストとしての６−置換トリアゾロピリダジン類の誘導体
UA125463C2 (uk) 2016-01-27 2022-03-16 Універсітет Цюріх ЗАСТОСУВАННЯ МОДУЛЯТОРІВ GABA<sub>A</sub>-РЕЦЕПТОРА ДЛЯ ЛІКУВАННЯ СВЕРБЕЖУ
AU2019255282B2 (en) * 2018-04-18 2024-08-08 Neurocycle Therapeutics, Inc. Gabaa positive allosteric modulator compounds, methods of making, and uses thereof
HUE060943T2 (hu) * 2018-09-13 2023-04-28 Saniona As A gaba A receptor ligandum
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
WO2021191837A1 (en) 2020-03-26 2021-09-30 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE236904T1 (de) * 1996-07-25 2003-04-15 Merck Sharp & Dohme Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren

Also Published As

Publication number Publication date
JP2002518501A (ja) 2002-06-25
CA2335328C (en) 2007-11-27
CN1138779C (zh) 2004-02-18
HUP0102894A2 (hu) 2001-11-28
NZ508290A (en) 2003-09-26
DE69907675D1 (de) 2003-06-12
TWI222449B (en) 2004-10-21
CO5031239A1 (es) 2001-04-27
CZ20004872A3 (cs) 2001-07-11
SK19552000A3 (sk) 2001-08-06
EP1090004B1 (en) 2003-05-07
NO317992B1 (no) 2005-01-17
WO1999067245A1 (en) 1999-12-29
YU77800A (sh) 2003-10-31
AU4630199A (en) 2000-01-10
ID27771A (id) 2001-04-26
ES2196824T3 (es) 2003-12-16
RS49746B (sr) 2008-04-04
MY124341A (en) 2006-06-30
ATE239730T1 (de) 2003-05-15
BR9911563A (pt) 2001-03-20
KR20010053136A (ko) 2001-06-25
JP4749545B2 (ja) 2011-08-17
DE69907675T2 (de) 2004-03-04
AR018925A1 (es) 2001-12-12
CN1307579A (zh) 2001-08-08
BG105152A (en) 2001-10-31
PL204650B1 (pl) 2010-01-29
EA003332B1 (ru) 2003-04-24
NO20006576D0 (no) 2000-12-21
NO20006576L (no) 2001-02-14
ZA200007485B (en) 2002-01-07
EA200100071A1 (ru) 2001-06-25
AU757315B2 (en) 2003-02-13
HUP0102894A3 (en) 2003-03-28
EE200000767A (et) 2002-06-17
IS2258B (is) 2007-06-15
EP1090004A1 (en) 2001-04-11
HRP20000879A2 (en) 2001-06-30
IL139775A (en) 2007-02-11
IL139775A0 (en) 2002-02-10
GEP20033143B (en) 2003-12-25
GB9813576D0 (en) 1998-08-19
BG64989B1 (bg) 2006-11-30
PE20000710A1 (es) 2000-08-14
SK285307B6 (sk) 2006-10-05
US6630471B1 (en) 2003-10-07
CA2335328A1 (en) 1999-12-29
IS5730A (is) 2000-11-24
KR100604108B1 (ko) 2006-07-26
PL345332A1 (en) 2001-12-17
CZ291409B6 (cs) 2003-03-12

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