EA200000783A1 - Производные триазолопиридазина в качестве лигандов для гамк рецепторов - Google Patents

Производные триазолопиридазина в качестве лигандов для гамк рецепторов

Info

Publication number
EA200000783A1
EA200000783A1 EA200000783A EA200000783A EA200000783A1 EA 200000783 A1 EA200000783 A1 EA 200000783A1 EA 200000783 A EA200000783 A EA 200000783A EA 200000783 A EA200000783 A EA 200000783A EA 200000783 A1 EA200000783 A1 EA 200000783A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ligands
derivatives
gaba receptors
triazolopiridazin
substituted
Prior art date
Application number
EA200000783A
Other languages
English (en)
Other versions
EA002755B1 (ru
Inventor
Вилльям Роберт Карлинг
Хосе Луис Кастро Пинейро
Ян Джеймс Коллинз
Александер Ричард Гвиблин
Тимоти Харрисон
Эндрю Мэйдин
Кевин Вилльям Мур
Майкл Джеффри Нейл Расселл
Гейл Скотт
Лесли Джозеф Стрит
Original Assignee
Мерк Шарп Энд Домэ Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801233.9A external-priority patent/GB9801233D0/en
Priority claimed from GBGB9821517.1A external-priority patent/GB9821517D0/en
Application filed by Мерк Шарп Энд Домэ Лимитед filed Critical Мерк Шарп Энд Домэ Лимитед
Publication of EA200000783A1 publication Critical patent/EA200000783A1/ru
Publication of EA002755B1 publication Critical patent/EA002755B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

(57) Класс замещенных производных 1,2,4-триазоло[4,3-b]пиридазина, имеющих фторзамещенное фенильное кольцо в положении 3 и гетероарилметоксигруппу в положении 6, являющихся селективными лигандами для ГАМКрецепторов, в частности, имеющих высокое сродство к их субъединицам α2 и/или α3, в соответствии с этим благотворно действующих при лечении и/или профилактике расстройств центральной нервной системы, включая состояния тревоги и судороги.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000783A 1998-01-21 1999-01-13 Производные триазолопиридазина в качестве лигандов для гамк рецепторов EA002755B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9801233.9A GB9801233D0 (en) 1998-01-21 1998-01-21 Therapeutic agents
GBGB9821517.1A GB9821517D0 (en) 1998-10-02 1998-10-02 Therapeutic agents
PCT/GB1999/000103 WO1999037644A1 (en) 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (2)

Publication Number Publication Date
EA200000783A1 true EA200000783A1 (ru) 2000-12-25
EA002755B1 EA002755B1 (ru) 2002-08-29

Family

ID=26312988

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000783A EA002755B1 (ru) 1998-01-21 1999-01-13 Производные триазолопиридазина в качестве лигандов для гамк рецепторов

Country Status (24)

Country Link
US (2) US6579875B1 (ru)
EP (1) EP1049696A1 (ru)
JP (1) JP2002501066A (ru)
KR (1) KR20010034257A (ru)
CN (1) CN1110498C (ru)
AU (1) AU748737B2 (ru)
BG (1) BG104671A (ru)
BR (1) BR9906905A (ru)
CA (1) CA2315763A1 (ru)
CZ (1) CZ290883B6 (ru)
EA (1) EA002755B1 (ru)
EE (1) EE200000430A (ru)
GE (1) GEP20032868B (ru)
HR (1) HRP20000492A2 (ru)
HU (1) HUP0100575A3 (ru)
IL (1) IL136442A0 (ru)
IS (1) IS5540A (ru)
MX (1) MXPA00007135A (ru)
NO (1) NO315516B1 (ru)
NZ (1) NZ504870A (ru)
PL (1) PL341652A1 (ru)
SK (1) SK10922000A3 (ru)
WO (1) WO1999037644A1 (ru)
YU (1) YU43800A (ru)

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NZ504870A (en) * 1998-01-21 2002-11-26 Merck Sharp & Dohme Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9929685D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0017543D0 (en) 2000-07-17 2000-09-06 Merck Sharp & Dohme Therapeutic agents
WO2005058860A1 (ja) * 2003-12-19 2005-06-30 Ube Industries, Ltd. ４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
BRPI0620292B1 (pt) * 2005-12-21 2021-08-24 Janssen Pharmaceutica N. V. Compostos de triazolopiridazinas como moduladores da cinase, composição, uso, combinação e processo de preparo do referido composto
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2123619A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma AG Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung
CA2735549A1 (en) * 2008-08-29 2010-03-04 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011005520A1 (en) 2009-06-23 2011-01-13 Concert Pharmaceuticals, Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
DK2464645T3 (en) 2009-07-27 2017-10-23 Gilead Sciences Inc CONDENSED, HETEROCYCLIC COMPOUNDS AS IRON CHANNEL MODULATORS
CN103228142A (zh) 2010-09-28 2013-07-31 加利福尼亚大学董事会 治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合
WO2012154760A1 (en) 2011-05-10 2012-11-15 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
TWI549944B (zh) 2011-07-01 2016-09-21 吉李德科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (ru) 2011-07-01 2018-04-28
GB201321745D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
JP7105696B2 (ja) 2016-02-29 2022-07-25 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
WO2019018499A2 (en) 2017-07-19 2019-01-24 Dana-Farber Cancer Institute, Inc. ANTIMICROBIAL PEPTIDES STABILIZED FOR THE TREATMENT OF ANTIBIOTIC-RESISTANT BACTERIAL INFECTIONS

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US4230705A (en) * 1976-09-22 1980-10-28 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4112095A (en) * 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
PH12424A (en) 1976-10-26 1979-02-15 American Cyanamid Co Method of treating anxiety in mammals
US4260755A (en) * 1979-10-31 1981-04-07 American Cyanamid Company Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines
US4260756A (en) 1979-11-15 1981-04-07 American Cyanamid Company 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
IT1194310B (it) 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
WO1998004559A2 (en) * 1996-07-25 1998-02-05 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
NZ504870A (en) * 1998-01-21 2002-11-26 Merck Sharp & Dohme Triazolo-pyridazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
MXPA00007135A (es) 2002-11-07
NO20003730L (no) 2000-09-20
AU748737B2 (en) 2002-06-13
GEP20032868B (en) 2003-01-27
CN1288465A (zh) 2001-03-21
HRP20000492A2 (en) 2000-12-31
NO20003730D0 (no) 2000-07-20
JP2002501066A (ja) 2002-01-15
BG104671A (en) 2001-05-31
EE200000430A (et) 2001-12-17
US6579875B1 (en) 2003-06-17
AU2065799A (en) 1999-08-09
HUP0100575A3 (en) 2003-03-28
EA002755B1 (ru) 2002-08-29
CZ290883B6 (cs) 2002-11-13
WO1999037644A1 (en) 1999-07-29
NO315516B1 (no) 2003-09-15
HUP0100575A2 (hu) 2001-09-28
CA2315763A1 (en) 1999-07-29
NZ504870A (en) 2002-11-26
CN1110498C (zh) 2003-06-04
EP1049696A1 (en) 2000-11-08
IS5540A (is) 2000-06-16
CZ20002691A3 (cs) 2000-12-13
SK10922000A3 (sk) 2001-03-12
PL341652A1 (en) 2001-04-23
IL136442A0 (en) 2001-06-14
KR20010034257A (ko) 2001-04-25
BR9906905A (pt) 2000-10-10
US20040063714A1 (en) 2004-04-01
YU43800A (sh) 2002-12-10
US6828322B2 (en) 2004-12-07

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU