PE20030432A1 - Derivados de imidazol-triazina como ligandos de los receptores gaba - Google Patents

Derivados de imidazol-triazina como ligandos de los receptores gaba

Info

Publication number
PE20030432A1
PE20030432A1 PE2002000616A PE2002000616A PE20030432A1 PE 20030432 A1 PE20030432 A1 PE 20030432A1 PE 2002000616 A PE2002000616 A PE 2002000616A PE 2002000616 A PE2002000616 A PE 2002000616A PE 20030432 A1 PE20030432 A1 PE 20030432A1
Authority
PE
Peru
Prior art keywords
triazine derivatives
ligands
imidazole
gaba receptors
phenylimidazo
Prior art date
Application number
PE2002000616A
Other languages
English (en)
Inventor
William Robert Carling
Leslie Joseph Street
Michael Geoffrey Neil Russell
David James Hallett
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20030432A1 publication Critical patent/PE20030432A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A DERIVADOS DE IMIDAZOL-TRIAZINA DE FORMULA I DONDE X1 ES H, F; R11 ES H, ALQUILO C1-C6, , HALO(ALQUILO C1-C6), (ALCOXI C2-C6)CARBONILO O -CR4=NOR5, ENTRE OTROS; R6 ES F; R4 ES H, ALQUILO C1-6; R5 ES H, ALQUILO C1-6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4,2'-DIFLUORO-5´-[3-(1-FLUORO-1-METILETIL)IMIDAZO[1,2-b][1,2,4]TRIAZIN-7-IL]BIFENIL-2-CARBONITRILO; 5,2´-DIFLUORO-5´-(3-TRIFLUOROMETILIMIDAZO[1,2-b][1,2,4]TRIAZIN-7-IL)-BIFENIL-2-CARBONITRILO, 6,2´-DIFLUORO-5´-(3-(1-HIDROXI-1-METILETIL)IMIDAZO[1,2-b][1,2,4]TRIAZIN-7-IL)-BIFENIL-2-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA . LOS COMPUESTOS MENCIONADOS SON LIGANDOS DE LOS RECEPTORES GABA Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL
PE2002000616A 2001-07-16 2002-07-10 Derivados de imidazol-triazina como ligandos de los receptores gaba PE20030432A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0117277.4A GB0117277D0 (en) 2001-07-16 2001-07-16 Therapeutic agents

Publications (1)

Publication Number Publication Date
PE20030432A1 true PE20030432A1 (es) 2003-05-17

Family

ID=9918561

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000616A PE20030432A1 (es) 2001-07-16 2002-07-10 Derivados de imidazol-triazina como ligandos de los receptores gaba

Country Status (11)

Country Link
US (2) US6617326B2 (es)
EP (1) EP1409488B1 (es)
JP (1) JP4373780B2 (es)
AT (1) ATE310002T1 (es)
AU (1) AU2002317957B2 (es)
CA (1) CA2451445A1 (es)
DE (1) DE60207416T2 (es)
ES (1) ES2249598T3 (es)
GB (1) GB0117277D0 (es)
PE (1) PE20030432A1 (es)
WO (1) WO2003008418A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4302980B2 (ja) * 2000-11-10 2009-07-29 メルク シャープ エンド ドーム リミテッド Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
GB0210124D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0210127D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
WO2005023256A1 (en) * 2003-09-10 2005-03-17 Merck Sharp & Dohme Limited Use of gabaa receptor agonists for the treatment of hearing, vestibular and attention disorders, intention tremor and restless leg syndrome
WO2005087735A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP1942879A1 (en) * 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP1991212A1 (en) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
JP2009536667A (ja) * 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
BRPI0716604A2 (pt) 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20080103165A1 (en) * 2006-09-19 2008-05-01 Braincells, Inc. Ppar mediated modulation of neurogenesis
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
UA112028C2 (uk) 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
WO2015189744A1 (en) 2014-06-12 2015-12-17 Pfizer Limited Imidazopyridazine derivatives as modulators of the gabaa receptor activity.
US10079661B2 (en) 2015-09-16 2018-09-18 At&T Intellectual Property I, L.P. Method and apparatus for use with a radio distributed antenna system having a clock reference
KR102482200B1 (ko) 2016-01-27 2022-12-27 우니페르지타에트 취리히 가려움증 치료를 위한 ｇａｂａａ 수용체 조절인자의 용도
SG11202010220QA (en) * 2018-04-18 2020-11-27 Neurocycle Therapeutics Inc Gabaa positive allosteric modulator compounds, methods of making, and uses thereof
AU2020241731B2 (en) * 2019-03-18 2023-09-07 Neurocycle Therapeutics, Inc. Use of GABAA receptor modulators for treatment of pain
US20230017378A1 (en) * 2019-10-22 2023-01-19 Neurocycle Therapeutics, Inc. Gabaa positive allosteric modulator compounds, methods of making, and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422194A (en) * 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
GB9702524D0 (en) 1997-02-07 1997-03-26 Merck Sharp & Dohme Therapeutic agents
DE60025604T2 (de) * 1999-06-22 2006-07-27 Neurosearch A/S Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen
GB9921150D0 (en) 1999-09-07 1999-11-10 Merck Sharp & Dohme Therapeutic agents
GB9927687D0 (en) 1999-11-23 2000-01-19 Merck Sharp & Dohme Therapeutic agents
CA2410037C (en) 2000-05-24 2009-11-03 Merck Sharp & Dohme Limited 3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
GB0018473D0 (en) 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
GB0027561D0 (en) 2000-11-10 2000-12-27 Merck Sharp & Dohme Therapeutic agents
JP4302980B2 (ja) 2000-11-10 2009-07-29 メルク シャープ エンド ドーム リミテッド Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体
TWI248936B (en) 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors

Also Published As

Publication number Publication date
US20030216395A1 (en) 2003-11-20
EP1409488A1 (en) 2004-04-21
EP1409488B1 (en) 2005-11-16
CA2451445A1 (en) 2003-01-30
ES2249598T3 (es) 2006-04-01
WO2003008418A1 (en) 2003-01-30
JP4373780B2 (ja) 2009-11-25
JP2004536862A (ja) 2004-12-09
DE60207416T2 (de) 2006-08-03
GB0117277D0 (en) 2001-09-05
US20030055060A1 (en) 2003-03-20
ATE310002T1 (de) 2005-12-15
US6617326B2 (en) 2003-09-09
US6696444B2 (en) 2004-02-24
AU2002317957B2 (en) 2007-10-25
DE60207416D1 (de) 2005-12-22

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