ATE310002T1 - Imidazotriazin-derivate als gaba-rezeptor- liganden - Google Patents
Imidazotriazin-derivate als gaba-rezeptor- ligandenInfo
- Publication number
- ATE310002T1 ATE310002T1 AT02747567T AT02747567T ATE310002T1 AT E310002 T1 ATE310002 T1 AT E310002T1 AT 02747567 T AT02747567 T AT 02747567T AT 02747567 T AT02747567 T AT 02747567T AT E310002 T1 ATE310002 T1 AT E310002T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor ligands
- gaba receptor
- derivatives
- imidazotriazine
- imidazotriazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0117277.4A GB0117277D0 (en) | 2001-07-16 | 2001-07-16 | Therapeutic agents |
PCT/GB2002/003114 WO2003008418A1 (en) | 2001-07-16 | 2002-07-08 | Imidazo-triazine derivatives as ligands for gaba receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE310002T1 true ATE310002T1 (de) | 2005-12-15 |
Family
ID=9918561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02747567T ATE310002T1 (de) | 2001-07-16 | 2002-07-08 | Imidazotriazin-derivate als gaba-rezeptor- liganden |
Country Status (11)
Country | Link |
---|---|
US (2) | US6617326B2 (de) |
EP (1) | EP1409488B1 (de) |
JP (1) | JP4373780B2 (de) |
AT (1) | ATE310002T1 (de) |
AU (1) | AU2002317957B2 (de) |
CA (1) | CA2451445A1 (de) |
DE (1) | DE60207416T2 (de) |
ES (1) | ES2249598T3 (de) |
GB (1) | GB0117277D0 (de) |
PE (1) | PE20030432A1 (de) |
WO (1) | WO2003008418A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6936608B2 (en) * | 2000-11-10 | 2005-08-30 | Merck Sharp & Dohme Ltd. | Imidazo-triazine derivatives as ligands for GABA receptors |
GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
GB0210127D0 (en) * | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
GB0210124D0 (en) * | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
WO2005023256A1 (en) * | 2003-09-10 | 2005-03-17 | Merck Sharp & Dohme Limited | Use of gabaa receptor agonists for the treatment of hearing, vestibular and attention disorders, intention tremor and restless leg syndrome |
US7456199B2 (en) * | 2004-03-11 | 2008-11-25 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
CA2625210A1 (en) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007223036A1 (en) * | 2006-03-08 | 2007-09-13 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2026813A2 (de) * | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5-ht-rezeptor-vermittelte neurogenese |
US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
EP2066355A2 (de) * | 2006-09-19 | 2009-06-10 | Braincells, Inc. | Kombination aus einem durch einen peroxisom-proliferator aktivierten rezeptor-mittel und einem zweiten neurogenen mittel zur behandlung von erkrankungen des nervensystems sowie zur förderung von neuraler differenzierung und neurogenese |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
UA112028C2 (uk) | 2012-12-14 | 2016-07-11 | Пфайзер Лімітед | Похідні імідазопіридазину як модулятори гамка-рецептора |
WO2015189744A1 (en) | 2014-06-12 | 2015-12-17 | Pfizer Limited | Imidazopyridazine derivatives as modulators of the gabaa receptor activity. |
US10079661B2 (en) | 2015-09-16 | 2018-09-18 | At&T Intellectual Property I, L.P. | Method and apparatus for use with a radio distributed antenna system having a clock reference |
MX2018009252A (es) | 2016-01-27 | 2019-01-21 | Univ Zuerich | Uso de moduladores de receptores de gabaa para el tratamiento de picor. |
JP7449272B2 (ja) * | 2018-04-18 | 2024-03-13 | ニューロサイクル・セラピューティクス・インコーポレイテッド | Gabaa陽性アロステリックモジュレーター化合物、その作製の方法および使用 |
WO2020191047A1 (en) * | 2019-03-18 | 2020-09-24 | Neurocycle Therapeutics, Inc. | Use of gabaa receptor modulators for treatment of pain |
CA3154222A1 (en) * | 2019-10-22 | 2021-04-29 | Matthew TOCZKO | Gabaa positive allosteric modulator compounds, methods of making, and uses thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3422194A (en) * | 1967-08-15 | 1969-01-14 | Smithkline Corp | The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof |
GB9702524D0 (en) | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
WO2000078728A1 (en) * | 1999-06-22 | 2000-12-28 | Neurosearch A/S | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
GB9921150D0 (en) | 1999-09-07 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
GB9927687D0 (en) | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
AU783521B2 (en) | 2000-05-24 | 2005-11-03 | Merck Sharp & Dohme Limited | 3-phenyl-imidazo-pyrimidine derivatives as ligands for GABA receptors |
GB0018473D0 (en) | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
US6936608B2 (en) | 2000-11-10 | 2005-08-30 | Merck Sharp & Dohme Ltd. | Imidazo-triazine derivatives as ligands for GABA receptors |
GB0027561D0 (en) | 2000-11-10 | 2000-12-27 | Merck Sharp & Dohme | Therapeutic agents |
TWI248936B (en) | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
-
2001
- 2001-07-16 GB GBGB0117277.4A patent/GB0117277D0/en not_active Ceased
-
2002
- 2002-07-08 EP EP02747567A patent/EP1409488B1/de not_active Expired - Lifetime
- 2002-07-08 AT AT02747567T patent/ATE310002T1/de not_active IP Right Cessation
- 2002-07-08 WO PCT/GB2002/003114 patent/WO2003008418A1/en active IP Right Grant
- 2002-07-08 DE DE60207416T patent/DE60207416T2/de not_active Expired - Fee Related
- 2002-07-08 JP JP2003513977A patent/JP4373780B2/ja not_active Expired - Fee Related
- 2002-07-08 ES ES02747567T patent/ES2249598T3/es not_active Expired - Lifetime
- 2002-07-08 AU AU2002317957A patent/AU2002317957B2/en not_active Ceased
- 2002-07-08 CA CA002451445A patent/CA2451445A1/en not_active Abandoned
- 2002-07-10 PE PE2002000616A patent/PE20030432A1/es not_active Application Discontinuation
- 2002-07-15 US US10/195,274 patent/US6617326B2/en not_active Expired - Fee Related
-
2003
- 2003-06-17 US US10/463,025 patent/US6696444B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2004536862A (ja) | 2004-12-09 |
ES2249598T3 (es) | 2006-04-01 |
PE20030432A1 (es) | 2003-05-17 |
DE60207416D1 (de) | 2005-12-22 |
JP4373780B2 (ja) | 2009-11-25 |
DE60207416T2 (de) | 2006-08-03 |
GB0117277D0 (en) | 2001-09-05 |
US6617326B2 (en) | 2003-09-09 |
WO2003008418A1 (en) | 2003-01-30 |
US20030216395A1 (en) | 2003-11-20 |
US6696444B2 (en) | 2004-02-24 |
US20030055060A1 (en) | 2003-03-20 |
EP1409488B1 (de) | 2005-11-16 |
EP1409488A1 (de) | 2004-04-21 |
CA2451445A1 (en) | 2003-01-30 |
AU2002317957B2 (en) | 2007-10-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |