ATE284403T1 - Triazolopyridazinderivate als liganden für gaba- rezeptoren - Google Patents
Triazolopyridazinderivate als liganden für gaba- rezeptorenInfo
- Publication number
- ATE284403T1 ATE284403T1 AT00900748T AT00900748T ATE284403T1 AT E284403 T1 ATE284403 T1 AT E284403T1 AT 00900748 T AT00900748 T AT 00900748T AT 00900748 T AT00900748 T AT 00900748T AT E284403 T1 ATE284403 T1 AT E284403T1
- Authority
- AT
- Austria
- Prior art keywords
- ligands
- gaba receptors
- triazolopyridazine derivatives
- derivatives
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9901743.6A GB9901743D0 (en) | 1999-01-27 | 1999-01-27 | Therapeutic agents |
GBGB9901744.4A GB9901744D0 (en) | 1999-01-27 | 1999-01-27 | Therapeutic agents |
GBGB9912429.9A GB9912429D0 (en) | 1999-05-27 | 1999-05-27 | Therapeutic agents |
PCT/GB2000/000183 WO2000044752A1 (en) | 1999-01-27 | 2000-01-19 | Triazolo-pyridazine derivatives as ligands for gaba receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE284403T1 true ATE284403T1 (de) | 2004-12-15 |
Family
ID=27269629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00900748T ATE284403T1 (de) | 1999-01-27 | 2000-01-19 | Triazolopyridazinderivate als liganden für gaba- rezeptoren |
Country Status (9)
Country | Link |
---|---|
US (2) | US6500828B1 (de) |
EP (1) | EP1149102B1 (de) |
JP (1) | JP2002535407A (de) |
AT (1) | ATE284403T1 (de) |
AU (1) | AU772947B2 (de) |
CA (1) | CA2359008C (de) |
DE (1) | DE60016566T2 (de) |
ES (1) | ES2232416T3 (de) |
WO (1) | WO2000044752A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0000564D0 (en) * | 2000-01-11 | 2000-03-01 | Merck Sharp & Dohme | Therapeutic agents |
AU2002251266A1 (en) | 2001-04-10 | 2002-10-28 | Merck Sharp And Dohme Limited | Inhibitors of akt activity |
WO2002083139A1 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
US6958334B2 (en) | 2001-04-10 | 2005-10-25 | Merck & Co., Inc. | Inhibitors of Akt activity |
ATE371193T1 (de) * | 2002-11-28 | 2007-09-15 | Neurosearch As | Verfahren zum screening für verbindungen mit sedativer oder anxiolytischer potenz |
WO2006061428A2 (en) * | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (de) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenese mittels angiotensin-modulation |
EP2068872A1 (de) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
DK2328414T3 (en) * | 2008-08-29 | 2014-03-10 | Concert Pharmaceuticals Inc | Substituted triazolopyridazine derivatives |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2011005520A1 (en) | 2009-06-23 | 2011-01-13 | Concert Pharmaceuticals, Inc. | Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators |
US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
WO2013170241A1 (en) * | 2012-05-11 | 2013-11-14 | Concert Pharmaceuticals, Inc. | Polymorphs of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolol[4,3b]pyridazine |
US20150099753A1 (en) * | 2012-05-11 | 2015-04-09 | Concert Pharmaceuticals Inc. | Form 5 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine |
JP2015516440A (ja) * | 2012-05-11 | 2015-06-11 | コンサート ファーマシューティカルズ インコーポレイテッド | 7−(tert−ブチル−d9)−3−(2,5−ジフルオロフェニル)−6−((1−メチル−1H−1,2,4−トリアゾール−5−イル)メトキシ)−[1,2,4]トリアゾロ[4,3−b]ピリダジンの2型多形 |
WO2015095549A1 (en) * | 2013-12-18 | 2015-06-25 | Concert Pharmaceuticals, Inc. | Dosage regimen for gabaa receptor subtype selective drug |
ES2935705T3 (es) | 2018-09-13 | 2023-03-09 | Saniona As | Un ligando del receptor GABA A |
WO2023205722A1 (en) * | 2022-04-20 | 2023-10-26 | Engrail Therapeutics, Inc. | Gabaa receptor modulator salts, particles, and uses thereof |
CN115837022B (zh) * | 2023-02-20 | 2023-04-25 | 中山大学附属第八医院(深圳福田) | 1,2,4三唑并4,3-b哒嗪衍生物在制备抗衰老药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA002436B1 (ru) | 1996-07-25 | 2002-04-25 | Мерк Шарп Энд Домэ Лимитед | Замещенные производные триазоло-пиридазина в качестве лигандов рецепторов гамк |
-
2000
- 2000-01-19 WO PCT/GB2000/000183 patent/WO2000044752A1/en active IP Right Grant
- 2000-01-19 ES ES00900748T patent/ES2232416T3/es not_active Expired - Lifetime
- 2000-01-19 DE DE60016566T patent/DE60016566T2/de not_active Expired - Fee Related
- 2000-01-19 JP JP2000596008A patent/JP2002535407A/ja not_active Withdrawn
- 2000-01-19 CA CA002359008A patent/CA2359008C/en not_active Expired - Fee Related
- 2000-01-19 EP EP00900748A patent/EP1149102B1/de not_active Expired - Lifetime
- 2000-01-19 AU AU30669/00A patent/AU772947B2/en not_active Ceased
- 2000-01-19 AT AT00900748T patent/ATE284403T1/de not_active IP Right Cessation
- 2000-01-19 US US09/890,000 patent/US6500828B1/en not_active Expired - Fee Related
-
2002
- 2002-12-20 US US10/324,968 patent/US20030158203A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60016566D1 (de) | 2005-01-13 |
AU3066900A (en) | 2000-08-18 |
CA2359008A1 (en) | 2000-08-03 |
AU772947B2 (en) | 2004-05-13 |
US20030158203A1 (en) | 2003-08-21 |
DE60016566T2 (de) | 2005-12-15 |
CA2359008C (en) | 2008-05-20 |
US6500828B1 (en) | 2002-12-31 |
JP2002535407A (ja) | 2002-10-22 |
ES2232416T3 (es) | 2005-06-01 |
EP1149102B1 (de) | 2004-12-08 |
WO2000044752A1 (en) | 2000-08-03 |
EP1149102A1 (de) | 2001-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60016566D1 (de) | Triazolopyridazinderivate als liganden für gaba-rezeptoren | |
BG104671A (en) | Triazolo-pyridazine derivatives as ligands for gaba receptors | |
ATE270672T1 (de) | Imidazopyridinderivate als liganden für gaba- rezeptoren | |
YU2899A (sh) | Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore | |
PE20030432A1 (es) | Derivados de imidazol-triazina como ligandos de los receptores gaba | |
ATE253066T1 (de) | Imidazotriazinderivate als gaba rezeptor-liganden | |
DE60214532D1 (de) | Imidazopyrimidin-derivate als liganden für gaba-rezeptoren | |
ATE310740T1 (de) | Imidazotriazin-derivate als liganden für gaba- rezeptoren | |
DE69911374D1 (de) | Triazolopiridazinederivate als gaba rezeptor-liganden | |
ATE255109T1 (de) | Imidazopyridinderivate als gaba rezeptor liganden | |
GB0212048D0 (en) | Therapeutic agents | |
BG108166A (en) | Imidazo-pyrimidine derivatives as liigands for gaba receptors | |
DE69936998D1 (de) | Pyrazolotriazinderivate als gaba-rezeptorliganden | |
WO2002002557A3 (en) | 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands | |
DE60307462D1 (de) | 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren | |
BG105152A (en) | A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom | |
DE60325865D1 (de) | Phenylpyridazin derivative als liganden für gaba-rezeptoren | |
PE44299A1 (es) | Derivados sustituidos de triazolo-piridacina como ligandos para receptores gaba | |
TR200002100T2 (tr) | GABA reseptörleri için ligandlar olarak triazolo-piridazin türevleri | |
CA2260774A1 (en) | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors | |
JO2312B1 (en) | Imidazo-pyrimidine derivatives as associative groups of JABA receptors | |
ATE252103T1 (de) | 6-substituierte 1,2,4a,5a,8a,8b-hexahydro- und 1, 2,3,4,4a,5a,8a,8b-oktahydro-6h-pyrrolo(3',4':4, 5)furo(3,2-b)pyrid-8(7h)-on derivate und ihre verwendung zur bekämpfung von endoparasiten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |