DE60307462D1 - 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren - Google Patents
8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptorenInfo
- Publication number
- DE60307462D1 DE60307462D1 DE60307462T DE60307462T DE60307462D1 DE 60307462 D1 DE60307462 D1 DE 60307462D1 DE 60307462 T DE60307462 T DE 60307462T DE 60307462 T DE60307462 T DE 60307462T DE 60307462 D1 DE60307462 D1 DE 60307462D1
- Authority
- DE
- Germany
- Prior art keywords
- ligands
- fluorimidazo
- pyridine derivative
- gaba receptors
- sub
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ITBDFOMJMRICLZ-UHFFFAOYSA-N 8-fluoroimidazo[1,2-a]pyridine Chemical class FC1=CC=CN2C=CN=C12 ITBDFOMJMRICLZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0212049 | 2002-05-24 | ||
| GBGB0212049.1A GB0212049D0 (en) | 2002-05-24 | 2002-05-24 | Therapeutic agents |
| PCT/GB2003/002250 WO2003099817A1 (en) | 2002-05-24 | 2003-05-23 | 8-fluorimidazo`1,2-a!pyridine derivatives as ligands for gaba receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60307462D1 true DE60307462D1 (de) | 2006-09-21 |
| DE60307462T2 DE60307462T2 (de) | 2007-08-02 |
Family
ID=9937397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60307462T Expired - Fee Related DE60307462T2 (de) | 2002-05-24 | 2003-05-23 | 8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7226926B2 (de) |
| EP (1) | EP1511748B1 (de) |
| JP (1) | JP2005535598A (de) |
| AT (1) | ATE335741T1 (de) |
| AU (1) | AU2003239687B2 (de) |
| CA (1) | CA2486753A1 (de) |
| DE (1) | DE60307462T2 (de) |
| ES (1) | ES2270044T3 (de) |
| GB (1) | GB0212049D0 (de) |
| WO (1) | WO2003099817A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006135705A1 (en) * | 2005-06-09 | 2006-12-21 | Michigan State University | Process for producing cyano substituted arene boranes and compounds |
| US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
| US7425556B2 (en) | 2005-12-20 | 2008-09-16 | Astrazeneca Ab | Compounds and uses thereof |
| JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| CA2672172C (en) | 2006-12-22 | 2016-05-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| JP5640005B2 (ja) | 2008-07-14 | 2014-12-10 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物 |
| US8344018B2 (en) | 2008-07-14 | 2013-01-01 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| EP2303881A2 (de) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Kondensierte heterocyclische hemmer von histondeacetylase und/oder cyclin-abhängigen kinasen |
| NZ590747A (en) | 2008-07-28 | 2012-11-30 | Gilead Sciences Inc | Cycloalkylidene and heterocycloalkylidene hdac inhibitor compounds |
| WO2010108074A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Inhibitors of pi3 kinase |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| AU2010259042A1 (en) | 2009-06-08 | 2011-12-15 | Gilead Sciences, Inc. | Cycloalkylcarbamate benzamide aniline HDAC inhibitor compounds |
| US8258316B2 (en) | 2009-06-08 | 2012-09-04 | Gilead Sciences, Inc. | Alkanoylamino benzamide aniline HDAC inhibitor compounds |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| KR20200116481A (ko) | 2018-01-29 | 2020-10-12 | 메르크 파텐트 게엠베하 | Gcn2 억제제 및 이의 용도 |
| CN111867581B (zh) | 2018-01-29 | 2023-12-26 | 默克专利股份有限公司 | Gcn2抑制剂及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9927687D0 (en) * | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
| US6642229B2 (en) * | 2000-05-24 | 2003-11-04 | Merck Sharp & Dohme Ltd. | 3-Phenyl-imidazo-pyrimidine derivatives as ligands for GABA receptors |
| ATE338758T1 (de) * | 2001-03-23 | 2006-09-15 | Merck Sharp & Dohme | Imidazopyrimidin-derivate als liganden für gaba- rezeptoren |
| DE60309848T2 (de) * | 2002-03-05 | 2007-05-16 | Eli Lilly And Co., Indianapolis | Purinderivate als kinaseinhibitoren |
| GB0212048D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
-
2002
- 2002-05-24 GB GBGB0212049.1A patent/GB0212049D0/en not_active Ceased
-
2003
- 2003-05-23 DE DE60307462T patent/DE60307462T2/de not_active Expired - Fee Related
- 2003-05-23 ES ES03732655T patent/ES2270044T3/es not_active Expired - Lifetime
- 2003-05-23 EP EP03732655A patent/EP1511748B1/de not_active Expired - Lifetime
- 2003-05-23 JP JP2004507474A patent/JP2005535598A/ja active Pending
- 2003-05-23 AT AT03732655T patent/ATE335741T1/de not_active IP Right Cessation
- 2003-05-23 WO PCT/GB2003/002250 patent/WO2003099817A1/en active IP Right Grant
- 2003-05-23 CA CA002486753A patent/CA2486753A1/en not_active Abandoned
- 2003-05-23 AU AU2003239687A patent/AU2003239687B2/en not_active Ceased
- 2003-05-23 US US10/515,165 patent/US7226926B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7226926B2 (en) | 2007-06-05 |
| EP1511748A1 (de) | 2005-03-09 |
| GB0212049D0 (en) | 2002-07-03 |
| EP1511748B1 (de) | 2006-08-09 |
| AU2003239687A1 (en) | 2003-12-12 |
| ATE335741T1 (de) | 2006-09-15 |
| DE60307462T2 (de) | 2007-08-02 |
| ES2270044T3 (es) | 2007-04-01 |
| AU2003239687B2 (en) | 2009-01-29 |
| WO2003099817A1 (en) | 2003-12-04 |
| JP2005535598A (ja) | 2005-11-24 |
| US20060052385A1 (en) | 2006-03-09 |
| CA2486753A1 (en) | 2003-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |