ATE249457T1 - Indolderivate und ihre verwendung als serotoninrezeptor-liganden - Google Patents
Indolderivate und ihre verwendung als serotoninrezeptor-ligandenInfo
- Publication number
- ATE249457T1 ATE249457T1 AT99972634T AT99972634T ATE249457T1 AT E249457 T1 ATE249457 T1 AT E249457T1 AT 99972634 T AT99972634 T AT 99972634T AT 99972634 T AT99972634 T AT 99972634T AT E249457 T1 ATE249457 T1 AT E249457T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- receptor ligands
- serotonin receptor
- indole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9825413.9A GB9825413D0 (en) | 1998-11-19 | 1998-11-19 | Pharmaceutical compounds |
| PCT/GB1999/003836 WO2000031074A2 (en) | 1998-11-19 | 1999-11-18 | Indole derivatives and their use as serotonin receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE249457T1 true ATE249457T1 (de) | 2003-09-15 |
Family
ID=10842732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99972634T ATE249457T1 (de) | 1998-11-19 | 1999-11-18 | Indolderivate und ihre verwendung als serotoninrezeptor-liganden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6329366B1 (de) |
| EP (1) | EP1131321B1 (de) |
| JP (1) | JP2002530405A (de) |
| AT (1) | ATE249457T1 (de) |
| AU (1) | AU1170300A (de) |
| CA (1) | CA2351526A1 (de) |
| DE (1) | DE69911238T2 (de) |
| ES (1) | ES2207344T3 (de) |
| GB (1) | GB9825413D0 (de) |
| WO (1) | WO2000031074A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844338B2 (en) | 2000-05-18 | 2005-01-18 | Eli Lilly And Company | Piperidyindoles as serotonin receptor ligands |
| GB2362381A (en) * | 2000-05-18 | 2001-11-21 | Lilly Co Eli | Pharmaceutically active indolyl-piperidines |
| IL153234A0 (en) * | 2000-06-14 | 2003-07-06 | Lundbeck & Co As H | Indole derivatives useful for the treatment of cns disorders |
| AR028685A1 (es) * | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
| EP1468996B1 (de) * | 2000-06-14 | 2007-09-26 | H. Lundbeck A/S | Indolderivate zur Behandlung von Erkrankungen des Zentralnervensystems |
| HUP0400343A2 (hu) | 2001-03-29 | 2004-09-28 | Bristol-Myers Squibb Co. | Ciklopropil-indol-származékok mint szelektív szerotonin-újrafelvétel inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| DE10157673A1 (de) * | 2001-11-24 | 2003-06-05 | Merck Patent Gmbh | Verwendung von N-(Indolcarbonyl-)piperazinderivaten |
| TWI391387B (zh) | 2004-05-12 | 2013-04-01 | Eisai R&D Man Co Ltd | 具有哌啶環之吲哚衍生物 |
| JPWO2006082872A1 (ja) * | 2005-02-04 | 2008-06-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | １−（ピペリジン−４−イル）−１ｈ−インドール誘導体 |
| US20080227815A1 (en) * | 2005-05-11 | 2008-09-18 | Takahisa Sakaguchi | Crystal of Indole Derivative Having Piperidine Ring and Process for Production Thereof |
| JP4932717B2 (ja) * | 2005-05-11 | 2012-05-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピペリジン環を有するインドール誘導体の製造方法 |
| CA2607907C (en) * | 2005-05-11 | 2012-09-18 | Eisai R & D Management Co., Ltd. | Method for producing indole derivative having piperidine ring |
| KR20080007649A (ko) * | 2005-05-11 | 2008-01-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피페리딘환을 가지는 인돌 유도체의 결정 및 그의 제조방법 |
| US7718652B2 (en) | 2006-12-12 | 2010-05-18 | Wyeth Llc | Substituted benzothiadiazinedioxide derivatives and methods of their use |
| CL2007003590A1 (es) * | 2006-12-12 | 2008-02-29 | Wyeth Corp | Compuestos derivados de aril sulfamida; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en prevencion y tratamiento de sintomas vasomotrices, disfuncion sexual, transtornos gastrointestinales, transt |
| PL392436A1 (pl) * | 2010-09-17 | 2012-03-26 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Pochodne arylosulfonamidów do leczenia chorób odśrodkowego układu nerwowego |
| CN109896984A (zh) * | 2019-03-27 | 2019-06-18 | 南通宝凯化工有限公司 | 一种二甲氨基磺酰氯的生产工艺 |
| CN115093368A (zh) * | 2022-07-18 | 2022-09-23 | 湖南警察学院 | 铜催化α-溴羰基炔环化/氧化切断制备喹啉-2,4-二酮衍生物的方法 |
| CN115109060A (zh) * | 2022-07-18 | 2022-09-27 | 湖南警察学院 | 铜催化α-溴羰基炔和马来酰亚胺串联环化选择性合成喹啉-2-酮的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4359468A (en) | 1981-02-25 | 1982-11-16 | Boehringer Ingelheim Ltd. | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
| DE19500689A1 (de) * | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
| GB9700895D0 (en) * | 1997-01-17 | 1997-03-05 | Lilly Co Eli | Pharmaceutical compounds |
| AU8743098A (en) | 1997-08-22 | 1999-03-16 | Eli Lilly And Company Limited | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands |
| GB9810886D0 (en) | 1998-05-13 | 1998-07-22 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1998
- 1998-11-19 GB GBGB9825413.9A patent/GB9825413D0/en not_active Ceased
-
1999
- 1999-11-18 ES ES99972634T patent/ES2207344T3/es not_active Expired - Lifetime
- 1999-11-18 US US09/442,904 patent/US6329366B1/en not_active Expired - Fee Related
- 1999-11-18 CA CA002351526A patent/CA2351526A1/en not_active Abandoned
- 1999-11-18 WO PCT/GB1999/003836 patent/WO2000031074A2/en active IP Right Grant
- 1999-11-18 AT AT99972634T patent/ATE249457T1/de not_active IP Right Cessation
- 1999-11-18 EP EP99972634A patent/EP1131321B1/de not_active Expired - Lifetime
- 1999-11-18 DE DE69911238T patent/DE69911238T2/de not_active Expired - Fee Related
- 1999-11-18 JP JP2000583902A patent/JP2002530405A/ja active Pending
- 1999-11-18 AU AU11703/00A patent/AU1170300A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002530405A (ja) | 2002-09-17 |
| ES2207344T3 (es) | 2004-05-16 |
| EP1131321A2 (de) | 2001-09-12 |
| EP1131321B1 (de) | 2003-09-10 |
| CA2351526A1 (en) | 2000-06-02 |
| US6329366B1 (en) | 2001-12-11 |
| WO2000031074A2 (en) | 2000-06-02 |
| WO2000031074A3 (en) | 2000-09-14 |
| DE69911238T2 (de) | 2004-07-01 |
| GB9825413D0 (en) | 1999-01-13 |
| AU1170300A (en) | 2000-06-13 |
| DE69911238D1 (de) | 2003-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |