ATE328593T1 - Umwandlung von cox-inhibierenden, nicht cox-2 selektiven inhibitoren in derivate von cox-2 selektiven inhibitoren - Google Patents
Umwandlung von cox-inhibierenden, nicht cox-2 selektiven inhibitoren in derivate von cox-2 selektiven inhibitorenInfo
- Publication number
- ATE328593T1 ATE328593T1 AT99967416T AT99967416T ATE328593T1 AT E328593 T1 ATE328593 T1 AT E328593T1 AT 99967416 T AT99967416 T AT 99967416T AT 99967416 T AT99967416 T AT 99967416T AT E328593 T1 ATE328593 T1 AT E328593T1
- Authority
- AT
- Austria
- Prior art keywords
- cox
- selective inhibitors
- derivatives
- conversion
- inhibiting non
- Prior art date
Links
- 229940111134 coxibs Drugs 0.000 title 2
- 238000006243 chemical reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- -1 indomethacin Chemical class 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003334 secondary amides Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11509099P | 1999-01-07 | 1999-01-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE328593T1 true ATE328593T1 (de) | 2006-06-15 |
Family
ID=22359275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99967416T ATE328593T1 (de) | 1999-01-07 | 1999-12-16 | Umwandlung von cox-inhibierenden, nicht cox-2 selektiven inhibitoren in derivate von cox-2 selektiven inhibitoren |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1148783B1 (de) |
| JP (1) | JP2002534361A (de) |
| CN (1) | CN1227008C (de) |
| AT (1) | ATE328593T1 (de) |
| AU (1) | AU772705B2 (de) |
| BR (1) | BR9917001A (de) |
| CA (1) | CA2358241A1 (de) |
| DE (1) | DE69931814T2 (de) |
| ES (1) | ES2270634T3 (de) |
| IL (1) | IL144126A0 (de) |
| WO (1) | WO2000040087A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE283048T1 (de) | 1999-12-08 | 2004-12-15 | Pharmacia Corp | Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt |
| AR030346A1 (es) | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
| AU2002247284A1 (en) | 2001-04-02 | 2002-10-15 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac |
| FR2835433B1 (fr) * | 2002-02-01 | 2006-02-17 | Richard Lab M | Utilisation de la 1-(-4-chlorobenzoyl)-5methoxy-2-methyl-1h- indole-3acetic 4-(acetylamino)phenylester pour la fabrication d'un medicament destine a inhiber exclusivement la cox2 |
| EP1745791B1 (de) | 2003-05-07 | 2013-06-26 | Osteologix A/S | Behandlung von Knorpel/Knochen-Erkrankungen mit wasserlöslichen Strontiumsalzen |
| JP2007527397A (ja) * | 2003-07-01 | 2007-09-27 | マイクロバイア インコーポレイテッド | Ｃｏｘ−２及びｆａａｈ阻害剤 |
| EP1744747A4 (de) | 2004-04-26 | 2009-12-02 | Univ Vanderbilt | Indolessigsäure und indolessigsäurederivate als therapeutische wirkstoffe mit verminderter gastrointestinaler toxizität |
| US7736624B2 (en) | 2006-06-19 | 2010-06-15 | Univ Vanderbilt | Methods and compositions for diagnostic and therapeutic targeting of COX-2 |
| WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
| CN118221668A (zh) * | 2024-03-19 | 2024-06-21 | 华南农业大学 | 一种含2-氨基-1,3,4-噻二唑的吲哚美辛衍生物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3285908A (en) * | 1963-04-30 | 1966-11-15 | Merck & Co Inc | Indolyl acid amides |
| US3336194A (en) * | 1963-04-30 | 1967-08-15 | Merck & Co Inc | Indolyl acid amides |
| FR2358145A1 (fr) | 1976-03-29 | 1978-02-10 | Richard Sa Laboratoire M | Nouveau medicament anti-inflammatoire, analgesique et antipyretique a base de (p-chlorobenzoyl-1 methyl-2 methoxy-5)-indole-3 acetate de p-acetamidophenol |
| JPS596287B2 (ja) * | 1980-11-28 | 1984-02-10 | 日東電工株式会社 | 医薬製剤 |
| JPS5872560A (ja) * | 1981-10-27 | 1983-04-30 | Teikoku Chem Ind Corp Ltd | インドメタシンフエニルエステル誘導体 |
| JPS58177966A (ja) * | 1982-04-09 | 1983-10-18 | Ss Pharmaceut Co Ltd | 新規なインド−ル酢酸エステル誘導体及びその製造法 |
| JPS60152462A (ja) * | 1984-01-20 | 1985-08-10 | Terumo Corp | インド−ル酢酸アミド誘導体の製造方法 |
| US5510368A (en) * | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
-
1999
- 1999-12-16 ES ES99967416T patent/ES2270634T3/es not_active Expired - Lifetime
- 1999-12-16 DE DE69931814T patent/DE69931814T2/de not_active Expired - Lifetime
- 1999-12-16 AU AU23697/00A patent/AU772705B2/en not_active Ceased
- 1999-12-16 CN CNB998164526A patent/CN1227008C/zh not_active Expired - Fee Related
- 1999-12-16 BR BR9917001-9A patent/BR9917001A/pt not_active Application Discontinuation
- 1999-12-16 AT AT99967416T patent/ATE328593T1/de not_active IP Right Cessation
- 1999-12-16 WO PCT/US1999/030219 patent/WO2000040087A1/en not_active Ceased
- 1999-12-16 EP EP99967416A patent/EP1148783B1/de not_active Expired - Lifetime
- 1999-12-16 CA CA002358241A patent/CA2358241A1/en not_active Abandoned
- 1999-12-16 IL IL14412699A patent/IL144126A0/xx not_active IP Right Cessation
- 1999-12-16 JP JP2000591861A patent/JP2002534361A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1148783A4 (de) | 2003-05-21 |
| CN1227008C (zh) | 2005-11-16 |
| EP1148783B1 (de) | 2006-06-07 |
| AU772705B2 (en) | 2004-05-06 |
| BR9917001A (pt) | 2001-11-13 |
| CN1337851A (zh) | 2002-02-27 |
| WO2000040087A1 (en) | 2000-07-13 |
| DE69931814D1 (de) | 2006-07-20 |
| EP1148783A1 (de) | 2001-10-31 |
| IL144126A0 (en) | 2002-05-23 |
| DE69931814T2 (de) | 2007-01-04 |
| JP2002534361A (ja) | 2002-10-15 |
| ES2270634T3 (es) | 2007-04-01 |
| CA2358241A1 (en) | 2000-07-13 |
| AU2369700A (en) | 2000-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |