NO992825D0 - FremgangsmÕter for fremstilling av 9,11-epoksysteroider og derved brukbare mellomprodukter - Google Patents

FremgangsmÕter for fremstilling av 9,11-epoksysteroider og derved brukbare mellomprodukter

Info

Publication number
NO992825D0
NO992825D0 NO992825A NO992825A NO992825D0 NO 992825 D0 NO992825 D0 NO 992825D0 NO 992825 A NO992825 A NO 992825A NO 992825 A NO992825 A NO 992825A NO 992825 D0 NO992825 D0 NO 992825D0
Authority
NO
Norway
Prior art keywords
group
hydroxyalkyl
alkoxyalkyl
aryloxy
halo
Prior art date
Application number
NO992825A
Other languages
English (en)
Other versions
NO314149B1 (no
NO992825L (no
Inventor
John S Ng
Chin Liu
Dennis K Anderson
Jon P Lawson
Joseph Wieczorek
Sastry A Kunda
Leo J Letendre
Mark J Pozzo
Yuen-Lung L Sing
Ping T Wang
Edward E Yonan
Richard M Weier
Thomas R Kowar
Julio A Baez
Bernhard Erb
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26709541&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO992825(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Searle & Co filed Critical Searle & Co
Publication of NO992825D0 publication Critical patent/NO992825D0/no
Publication of NO992825L publication Critical patent/NO992825L/no
Publication of NO314149B1 publication Critical patent/NO314149B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO19992825A 1996-12-11 1999-06-10 Fremgangsmåter for fremstilling av 9,11-epoksysteroider og mellomproduktertil bruk ved fremgangsmåtene NO314149B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3331596P 1996-12-11 1996-12-11
US4938897P 1997-06-11 1997-06-11
PCT/US1997/023090 WO1998025948A2 (en) 1996-12-11 1997-12-11 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Publications (3)

Publication Number Publication Date
NO992825D0 true NO992825D0 (no) 1999-06-10
NO992825L NO992825L (no) 1999-07-29
NO314149B1 NO314149B1 (no) 2003-02-03

Family

ID=26709541

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19992825A NO314149B1 (no) 1996-12-11 1999-06-10 Fremgangsmåter for fremstilling av 9,11-epoksysteroider og mellomproduktertil bruk ved fremgangsmåtene

Country Status (21)

Country Link
US (1) US6610844B2 (no)
EP (1) EP0944644B1 (no)
JP (1) JP2001509792A (no)
KR (1) KR100523409B1 (no)
CN (1) CN100369927C (no)
AT (2) ATE375992T1 (no)
AU (1) AU733559B2 (no)
BR (1) BR9714510A (no)
CA (1) CA2273343C (no)
DE (2) DE69716116T2 (no)
DK (1) DK0944644T3 (no)
ES (2) ES2293944T3 (no)
HK (1) HK1043370B (no)
IL (1) IL130182A0 (no)
NO (1) NO314149B1 (no)
NZ (1) NZ336004A (no)
PL (1) PL189459B1 (no)
PT (1) PT944644E (no)
RO (1) RO120710B1 (no)
RU (1) RU2005121439A (no)
WO (1) WO1998025948A2 (no)

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KR100607923B1 (ko) * 1999-12-08 2006-08-04 파마시아 코포레이션 증가된 용해 속도를 나타내는 결정형 에플레레논
EP1580193A3 (en) * 1999-12-08 2010-06-23 Pharmacia Corporation Eplerenone crystalline form
CA2362845A1 (en) * 1999-12-08 2001-06-14 Pharmacia Corporation Eplerenone crystalline form
EP1505072A3 (en) * 1999-12-08 2006-06-21 Pharmacia Corporation Eplerenone crystalline form exhiniting enhanced dissolution rate
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
CA2419256A1 (en) * 2000-08-28 2002-03-07 Kenton N. Fedde Use of an aldosterone receptor antagonist to improve cognitive function
BR0115245A (pt) 2000-10-30 2005-05-10 Pharmacia Corp 11 alfa-hidroxilase e óxido redutase de aspergillus ochraceus
RS90504A (en) * 2002-03-22 2006-10-27 Pharmacia Corporation C-17 spirolactonization and 6,7 oxidation of steroids
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
JP3814284B2 (ja) 2002-11-06 2006-08-23 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ７−カルボキシ置換ステロイドの製造方法
WO2004043986A1 (en) * 2002-11-07 2004-05-27 Pharmacia & Upjohn Company Llc Processes for preparing c-7 substituted 5-androstenes
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CA2525205C (en) * 2004-11-08 2013-06-25 Ecolab Inc. Foam cleaning and brightening composition, and methods
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CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
ES2566934T3 (es) 2010-05-10 2016-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina
JP6180930B2 (ja) 2010-06-16 2017-08-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 創傷治癒過程における再上皮化を刺激するための方法及び組成物
CN104844681B (zh) * 2014-02-13 2016-06-01 合肥久诺医药科技有限公司 一种l晶型依普利酮的精制方法
EP3009443B1 (en) 2014-10-17 2018-09-12 INDUSTRIALE CHIMICA S.r.l. Process for the preparation of 7alfa-(methoxycarbonyl)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
WO2017055248A1 (en) 2015-09-28 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of heart failure
WO2017064121A1 (en) 2015-10-13 2017-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
CN105541960A (zh) * 2016-02-22 2016-05-04 浙江仙琚制药股份有限公司 17α-羟基-3-氧代-γ-内酯-孕甾-4-烯-（7α，9α）-二羧酸内酯的制备方法
WO2018019843A1 (en) 2016-07-26 2018-02-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
CN106349326A (zh) * 2016-07-29 2017-01-25 北京万全德众医药生物技术有限公司 依普利酮杂质a的制备方法
CN107602652A (zh) * 2017-10-11 2018-01-19 浙江仙琚制药股份有限公司 制备6β‑甲基泼尼松龙的方法
CN108445236B (zh) * 2018-02-07 2021-04-20 深圳市新产业生物医学工程股份有限公司 甾体类衍生物和其保存液以及其应用
CN110698529A (zh) * 2019-11-19 2020-01-17 湖南新合新生物医药有限公司 一种依普利酮中间体△9,11烯酯的制备方法
EP4395785A1 (en) 2021-08-31 2024-07-10 Inserm (Institut National de la Santé et de la Recherche Scientifique) Methods for the treatment of ocular rosacea
CN115433252A (zh) * 2022-08-24 2022-12-06 浙江亚瑟医药有限公司 一种δ9(11)-坎利酮的制备方法

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Also Published As

Publication number Publication date
CA2273343C (en) 2006-10-10
RO120710B1 (ro) 2006-06-30
EP0944644B1 (en) 2002-10-02
HK1043370B (zh) 2008-08-01
NZ336004A (en) 2001-04-27
PL334084A1 (en) 2000-01-31
DE69738225T2 (de) 2008-07-17
DK0944644T3 (da) 2003-02-03
ES2293944T3 (es) 2008-04-01
NO314149B1 (no) 2003-02-03
ATE375992T1 (de) 2007-11-15
DE69738225D1 (de) 2007-11-29
PL189459B1 (pl) 2005-08-31
CA2273343A1 (en) 1998-06-18
ES2186017T3 (es) 2003-05-01
DE69716116T2 (de) 2003-09-04
KR20050009765A (ko) 2005-01-25
WO1998025948A2 (en) 1998-06-18
BR9714510A (pt) 2000-11-28
AU5798398A (en) 1998-07-03
CN1253564A (zh) 2000-05-17
AU733559B2 (en) 2001-05-17
WO1998025948A3 (en) 1998-10-15
NO992825L (no) 1999-07-29
RU2005121439A (ru) 2007-01-20
JP2001509792A (ja) 2001-07-24
DE69716116D1 (de) 2002-11-07
IL130182A0 (en) 2000-06-01
EP0944644A2 (en) 1999-09-29
US6610844B2 (en) 2003-08-26
HK1043370A1 (en) 2002-09-13
PT944644E (pt) 2003-02-28
US20030055274A1 (en) 2003-03-20
CN100369927C (zh) 2008-02-20
ATE225367T1 (de) 2002-10-15
KR100523409B1 (ko) 2005-10-24

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