ES8405033A1 - Procedimiento para la obtencion de esteroides dihalogenados. - Google Patents

Procedimiento para la obtencion de esteroides dihalogenados.

Info

Publication number
ES8405033A1
ES8405033A1 ES516712A ES516712A ES8405033A1 ES 8405033 A1 ES8405033 A1 ES 8405033A1 ES 516712 A ES516712 A ES 516712A ES 516712 A ES516712 A ES 516712A ES 8405033 A1 ES8405033 A1 ES 8405033A1
Authority
ES
Spain
Prior art keywords
dihalogenated
steroids
activity
inflammatory
cortocosteroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516712A
Other languages
English (en)
Other versions
ES516712A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8405033A1 publication Critical patent/ES8405033A1/es
Publication of ES516712A0 publication Critical patent/ES516712A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTEROIDES DIHALOGENADOS, DE FORMULA (I), EN LA QUE X ES METILENO O METILO A-ORIENTADO E HIDROGENO; R ES ALQUILO C1-6; Y LA LINEA DISCONTINUA ES UN ENLACE ADICIONAL.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE RO ES UN GRUPO SUSTITUIBLE POR UN ATOMO DE CLORO; Y R Y X TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN COMPUESTO CAPAZ DE SUSTITUIR EL GRUPO RO POR CLORO, TAL COMO CLORURO DE METAL ALCALINO, DE TRIHIDROCARBIL-SILILO O DE TRIFENILMETILO. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE.
ES516712A 1981-10-23 1982-10-21 Procedimiento para la obtencion de esteroides dihalogenados. Granted ES516712A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH679081 1981-10-23

Publications (2)

Publication Number Publication Date
ES8405033A1 true ES8405033A1 (es) 1984-05-16
ES516712A0 ES516712A0 (es) 1984-05-16

Family

ID=4315071

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516712A Granted ES516712A0 (es) 1981-10-23 1982-10-21 Procedimiento para la obtencion de esteroides dihalogenados.

Country Status (12)

Country Link
EP (1) EP0078235A3 (es)
JP (1) JPS5879998A (es)
AU (1) AU8970182A (es)
DK (1) DK469482A (es)
ES (1) ES516712A0 (es)
FI (1) FI823586L (es)
GB (1) GB2108504A (es)
GR (1) GR76767B (es)
IL (1) IL67048A0 (es)
NO (1) NO823515L (es)
PT (1) PT75718B (es)
ZA (1) ZA827737B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110603A (en) * 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives
US7184535B1 (en) 1999-02-26 2007-02-27 Bellsouth Intellectual Property Corporation Methods and systems for releasing a voice mail system from a communication and further processing the communication

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3629242A (en) * 1969-03-03 1971-12-21 Syntex Corp 6-gem-difluoro steroids
US3832366A (en) * 1973-07-30 1974-08-27 Squibb & Sons Inc Process for preparing 21-chloro-17-acyloxy-20-ketosteroids
DE2655570A1 (de) * 1975-12-12 1977-06-16 Ciba Geigy Ag Neue polyhalogensteroide und verfahren zu ihrer herstellung
US4361558A (en) * 1980-04-29 1982-11-30 Ciba-Geigy Corporation Halogenated steroids

Also Published As

Publication number Publication date
PT75718B (de) 1985-12-03
NO823515L (no) 1983-04-25
DK469482A (da) 1983-04-24
EP0078235A2 (de) 1983-05-04
FI823586A0 (fi) 1982-10-20
JPS5879998A (ja) 1983-05-13
PT75718A (de) 1982-11-01
EP0078235A3 (de) 1983-06-29
AU8970182A (en) 1983-05-12
IL67048A0 (en) 1983-02-23
ZA827737B (en) 1983-08-31
GB2108504A (en) 1983-05-18
ES516712A0 (es) 1984-05-16
GR76767B (es) 1984-09-03
FI823586L (fi) 1983-04-24

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