TW200606174A - Processes for preparation of 9,11-epoxy steroids and intermediates useful therein - Google Patents

Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Info

Publication number
TW200606174A
TW200606174A TW094131840A TW94131840A TW200606174A TW 200606174 A TW200606174 A TW 200606174A TW 094131840 A TW094131840 A TW 094131840A TW 94131840 A TW94131840 A TW 94131840A TW 200606174 A TW200606174 A TW 200606174A
Authority
TW
Taiwan
Prior art keywords
group
hydroxyalkyl
hydroxycarbonyl
alkoxyalkyl
aryloxy
Prior art date
Application number
TW094131840A
Other languages
Chinese (zh)
Other versions
TWI277620B (en
Inventor
John S Ng
Chin Liu
Dennis K Anderson
Jon P Lawson
Joseph J Wieczorek
A Kunda Sastry
J Letendre Leo
J Pozzo Mark
L Sing Yuen-Lung
T Wang Ping
Yonan Edward
M Weier Richard
R Kowar Thomas
A Baez Julio
Erb Bernhard
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of TW200606174A publication Critical patent/TW200606174A/en
Application granted granted Critical
Publication of TWI277620B publication Critical patent/TWI277620B/en

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  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I, wherein: -A-A- represents the group -CHR4-CHR5- or -CR4=CR5-R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy; R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical; -B-B- represents the group -CHR6-CHR7- or an alpha- or beta-oriented group: where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; and R8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
TW94131840A 1997-06-11 1998-09-03 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein TWI277620B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4938897P 1997-06-11 1997-06-11

Publications (2)

Publication Number Publication Date
TW200606174A true TW200606174A (en) 2006-02-16
TWI277620B TWI277620B (en) 2007-04-01

Family

ID=21959557

Family Applications (2)

Application Number Title Priority Date Filing Date
TW87109305A TWI248443B (en) 1997-06-11 1998-09-03 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
TW94131840A TWI277620B (en) 1997-06-11 1998-09-03 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TW87109305A TWI248443B (en) 1997-06-11 1998-09-03 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Country Status (4)

Country Link
AR (2) AR043268A1 (en)
PL (1) PL189757B1 (en)
TW (2) TWI248443B (en)
ZA (1) ZA985088B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112723321A (en) * 2021-01-26 2021-04-30 呼伦贝尔驰宏矿业有限公司 Acid cross-linking system and acid cross-linking process for industrial sulfuric acid preparation purification section
CN114456952B (en) * 2022-02-22 2023-04-14 昆明理工大学 Chrysosporium and application thereof

Also Published As

Publication number Publication date
PL189757B1 (en) 2005-09-30
TWI248443B (en) 2006-02-01
ZA985088B (en) 1999-06-11
TWI277620B (en) 2007-04-01
AR060624A2 (en) 2008-07-02
AR043268A1 (en) 2005-07-27

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Legal Events

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MM4A Annulment or lapse of patent due to non-payment of fees