AR060624A2 - PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A DERIVATIVE OF A STEROID 9-11EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A (DELTA) -4.5 STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY AND SUBSTRATE COMPOUNDS AND COMPUTERS OBTAINED - Google Patents
PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A DERIVATIVE OF A STEROID 9-11EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A (DELTA) -4.5 STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY AND SUBSTRATE COMPOUNDS AND COMPUTERS OBTAINEDInfo
- Publication number
- AR060624A2 AR060624A2 ARP070101746A ARP070101746A AR060624A2 AR 060624 A2 AR060624 A2 AR 060624A2 AR P070101746 A ARP070101746 A AR P070101746A AR P070101746 A ARP070101746 A AR P070101746A AR 060624 A2 AR060624 A2 AR 060624A2
- Authority
- AR
- Argentina
- Prior art keywords
- derivative
- group
- steroid
- intermediary
- compound
- Prior art date
Links
Landscapes
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Un proceso para la preparacion de un compuesto, intermediario en la síntesis de un derivado de un esteroide 9-11 epoxi, donde dicho compuesto es de la formula 1 donde -A-A- representa el grupo -CHR4-CHR5- o -CR4=CR5-; R3, R4 y R5 se seleccionan independientemente del grupo formado por hidrogeno, halo, hidroxi, alquilo inferior, alcoxi inferior, hidroxialquilo, alcoxialquilo, hidroxi carbonilo, ciano y ariloxi; R1 representa un radical alcoxicarbonilo o hidroxicarbonilo inferior alfa-orientado; -B-B- representa el grupo -CHR6-CHR7- o un grupo alfa o beta orientado de formula (2) donde R6 y R7 se seleccionan independientemente del grupo formado por hidrogeno, halo, alcoxi inferior, acilo, hidroxialquilo, alcoxialquilo, hidroxicarbonilo, alquilo, alcoxicarbonilo, aciloxialquilo, ciano y ariloxi; y R8 y R9 se seleccionan independientemente del grupo formado por hidrogeno, hidroxi, halo, alcoxi inferior, acilo, hidroxialquilo, alcoxialquilo, hidroxicarbonilo, alquilo, alcoxicarbonilo, aciloxialquilo, ciano y ariloxi, o R8 y R9 juntos constituyen una estructura de anillo carbocíclico o heterocíclico, o R8 o R9 junto con R6 o R7 comprenden una estructura de anillo carbocíclico o heterocíclico fusionada al anillo pentacíclico D; en el cual dicho proceso comprende: eliminar un grupo saliente 11 alfa de un compuesto de formula 4: donde R2 es un grupo saliente 11 alfa cuya abstraccion es eficaz para generar una doble ligadura entre los átomos de carbono 9 y11.Claim 1: A process for the preparation of a compound, intermediate in the synthesis of a derivative of a 9-11 epoxy steroid, wherein said compound is of the formula 1 wherein -AA- represents the group -CHR4-CHR5- or -CR4 = CR5-; R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxy carbonyl, cyano and aryloxy; R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxycarbonyl radical; -BB- represents the group -CHR6-CHR7- or an alpha or beta oriented group of formula (2) where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl , alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; and R8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together constitute a carbocyclic ring structure or heterocyclic, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic ring D; wherein said process comprises: removing a leaving group 11 alpha from a compound of formula 4: where R2 is a leaving group 11 alpha whose abstraction is effective to generate a double bond between carbon atoms 9 and 11.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4938897P | 1997-06-11 | 1997-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060624A2 true AR060624A2 (en) | 2008-07-02 |
Family
ID=21959557
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102772 AR043268A1 (en) | 1997-06-11 | 1998-06-11 | PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A STEROID DERIVATIVE 9, 11-EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A DELTA-4,5, STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY COMPOUNDS AND COMPOSITE SUBSTRATES OBTAINED |
| ARP070101746A AR060624A2 (en) | 1997-06-11 | 2007-04-23 | PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A DERIVATIVE OF A STEROID 9-11EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A (DELTA) -4.5 STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY AND SUBSTRATE COMPOUNDS AND COMPUTERS OBTAINED |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102772 AR043268A1 (en) | 1997-06-11 | 1998-06-11 | PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A STEROID DERIVATIVE 9, 11-EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A DELTA-4,5, STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY COMPOUNDS AND COMPOSITE SUBSTRATES OBTAINED |
Country Status (4)
| Country | Link |
|---|---|
| AR (2) | AR043268A1 (en) |
| PL (1) | PL189757B1 (en) |
| TW (2) | TWI248443B (en) |
| ZA (1) | ZA985088B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112723321A (en) * | 2021-01-26 | 2021-04-30 | 呼伦贝尔驰宏矿业有限公司 | Acid cross-linking system and acid cross-linking process for industrial sulfuric acid preparation purification section |
| CN114456952B (en) * | 2022-02-22 | 2023-04-14 | 昆明理工大学 | Chrysosporium and application thereof |
-
1997
- 1997-12-11 PL PL97368692A patent/PL189757B1/en not_active IP Right Cessation
-
1998
- 1998-06-11 ZA ZA985088A patent/ZA985088B/en unknown
- 1998-06-11 AR ARP980102772 patent/AR043268A1/en unknown
- 1998-09-03 TW TW87109305A patent/TWI248443B/en not_active IP Right Cessation
- 1998-09-03 TW TW94131840A patent/TWI277620B/en not_active IP Right Cessation
-
2007
- 2007-04-23 AR ARP070101746A patent/AR060624A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200606174A (en) | 2006-02-16 |
| TWI277620B (en) | 2007-04-01 |
| PL189757B1 (en) | 2005-09-30 |
| AR043268A1 (en) | 2005-07-27 |
| TWI248443B (en) | 2006-02-01 |
| ZA985088B (en) | 1999-06-11 |
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