AR010768A1 - PROCESS FOR THE PREPARATION OF A DELTA -4,5-STEROID REPLACED WITH 3-CETO-7 ALPHA-ALCOXICARBONILO, COMPOUNDS OBTAINED, SYNTHESIS INTERMEDIARIES AND PROCESSES TO OBTAIN SUCH INTERMEDIARIES. - Google Patents
PROCESS FOR THE PREPARATION OF A DELTA -4,5-STEROID REPLACED WITH 3-CETO-7 ALPHA-ALCOXICARBONILO, COMPOUNDS OBTAINED, SYNTHESIS INTERMEDIARIES AND PROCESSES TO OBTAIN SUCH INTERMEDIARIES.Info
- Publication number
- AR010768A1 AR010768A1 ARP970105848A AR010768A1 AR 010768 A1 AR010768 A1 AR 010768A1 AR P970105848 A ARP970105848 A AR P970105848A AR 010768 A1 AR010768 A1 AR 010768A1
- Authority
- AR
- Argentina
- Prior art keywords
- intermediaries
- group
- alpha
- hydroxyalkyl
- synthesis
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describen multiples esquemas de reaccion, para la síntesis de epoximexrenona y otros compuestos de formula (I) donde: -A-A- representa elgrupo -CHR4-CHR5- o -CR4=CR5-, R3, R4 Y R5 se seleccionan independientemente del grupo formado p orhidrogeno, halo, hidroxi, alquilo inferior, alcoxiinferior, hidroxialquilo, alcoxialquilo, hidroxicarbonilo, ciano, ariloxi, R1 representa un radical carbonilo o hidroxialquilo alcoxi inferior alfa-orientado, -B-B representa el grupo -CHR6- CHR7- oun grupo alfa-o beta- orientado: (III) donde R6 y R7 se seleccionan independientemente del grupoformado por hidrogeno, halo, alcoxi inferior, acilo, hidroxialquilo, alcoxialquilo, hidroxicarbonilo, alquilo, alcoxicarbonilo, acil oxialquilo,ciano,ariloxi, y R8 y R9 se seleccionan independientemente del grupo formado por hidrogeno, halo, alcoxi inferior, acilo, hidroxialquilo, alcoxialquilo,hidroxicarbonilo, alquilo, alcoxicarbonilo, aciloxialquilo, ciano, ariloxi, o R6 y R9 comprenden enconjunto una estructura de anillo carbocíclico oheteracíclico, o R6 o R9 junto con R6 o R7 comprenden una estructura de anillo carbocíclico o heterocíclico fusionado al anillo pentacíclico D.Multiple reaction schemes are described, for the synthesis of epoxymexrenone and other compounds of formula (I) where: -AA- represents the group -CHR4-CHR5- or -CR4 = CR5-, R3, R4 and R5 are independently selected from the group formed p orhydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, R1 represents an alpha-oriented carbonyl or hydroxyalkyl radical, -BB represents the group -CHR6-CHR7- or an alpha-o group beta -oriented: (III) where R6 and R7 are independently selected from the group by hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyl oxyalkyl, cyano, aryloxy, and R8 and R9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R6 and R9 together comprise a structure Heterocyclic carbocyclic ring ra, or R6 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to pentacyclic ring D.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3331596P | 1996-12-11 | 1996-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010768A1 true AR010768A1 (en) | 2000-07-12 |
Family
ID=21869706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105848 AR010768A1 (en) | 1996-12-11 | 1997-12-11 | PROCESS FOR THE PREPARATION OF A DELTA -4,5-STEROID REPLACED WITH 3-CETO-7 ALPHA-ALCOXICARBONILO, COMPOUNDS OBTAINED, SYNTHESIS INTERMEDIARIES AND PROCESSES TO OBTAIN SUCH INTERMEDIARIES. |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR010768A1 (en) |
| RU (1) | RU2261865C2 (en) |
| TW (2) | TWI244483B (en) |
| ZA (1) | ZA9711038B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111471668B (en) * | 2020-02-28 | 2022-05-24 | 浙江工业大学 | Nitrilase mutant and application thereof in preparation of 1-cyanocyclohexylacetic acid |
| CN114456952B (en) * | 2022-02-22 | 2023-04-14 | 昆明理工大学 | Chrysosporium and application thereof |
-
1997
- 1997-12-09 ZA ZA9711038A patent/ZA9711038B/en unknown
- 1997-12-11 TW TW92125191A patent/TWI244483B/en not_active IP Right Cessation
- 1997-12-11 TW TW86118698A patent/TW593305B/en not_active IP Right Cessation
- 1997-12-11 RU RU99114851/04A patent/RU2261865C2/en active
- 1997-12-11 AR ARP970105848 patent/AR010768A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9711038B (en) | 1999-01-25 |
| RU2261865C2 (en) | 2005-10-10 |
| TWI244483B (en) | 2005-12-01 |
| TW200400956A (en) | 2004-01-16 |
| TW593305B (en) | 2004-06-21 |
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