ES2062927B1 - ANTAGONISTS OF ENDOTHELIN RECEPTORS AND PROCEDURE FOR THEIR PREPARATION. - Google Patents

ANTAGONISTS OF ENDOTHELIN RECEPTORS AND PROCEDURE FOR THEIR PREPARATION.

Info

Publication number
ES2062927B1
ES2062927B1 ES9202548A ES9202548A ES2062927B1 ES 2062927 B1 ES2062927 B1 ES 2062927B1 ES 9202548 A ES9202548 A ES 9202548A ES 9202548 A ES9202548 A ES 9202548A ES 2062927 B1 ES2062927 B1 ES 2062927B1
Authority
ES
Spain
Prior art keywords
antagonists
procedure
preparation
endothelin receptors
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9202548A
Other languages
Spanish (es)
Other versions
ES2062927A1 (en
Inventor
Russell Donavan Cousins
John Duncan Elliott
Maria Amparo Lago
Jack Dale Leber
Catherine E Peishoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to ES9202548A priority Critical patent/ES2062927B1/en
Publication of ES2062927A1 publication Critical patent/ES2062927A1/en
Application granted granted Critical
Publication of ES2062927B1 publication Critical patent/ES2062927B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

ANTAGONISTAS DE LOS RECEPTORES DE ENDOTELINA, Y PROCEDIMIENTO PARA SU PREPARACION; TIENE LA FORMULA (I) **FORMULA** EN DONDE R1, R2, R1, P1, P2, X, Z1, Z2 Y Z3 REPRESENTAN DIVERSOS RADICALES ORGANICOS O INORGANICOS. ESTOS COMPUESTOS SE PREPARAN POR REACCION DE UN DERIVADO DE INDANO CON UN COMPUESTO DE ORGANOMAGNESIO Y POSTERIOR REDUCCION. LOS COMPUESTOS SE UTILIZAN COMO ANTAGONISTAS DE RECEPTORES DE ENDOTELINA.ANTAGONISTS OF ENDOTHELIN RECEPTORS, AND PROCEDURE FOR THEIR PREPARATION; IT HAS THE FORMULA (I) ** FORMULA ** WHERE R1, R2, R1, P1, P2, X, Z1, Z2 AND Z3 REPRESENT VARIOUS ORGANIC OR INORGANIC RADICALS. THESE COMPOUNDS ARE PREPARED BY REACTION OF AN INDANO DERIVATIVE WITH AN ORGANOMAGNESIUM COMPOUND AND SUBSEQUENT REDUCTION. THE COMPOUNDS ARE USED AS ENDOTHELIN RECEPTOR ANTAGONISTS.

ES9202548A 1992-12-17 1992-12-17 ANTAGONISTS OF ENDOTHELIN RECEPTORS AND PROCEDURE FOR THEIR PREPARATION. Expired - Fee Related ES2062927B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202548A ES2062927B1 (en) 1992-12-17 1992-12-17 ANTAGONISTS OF ENDOTHELIN RECEPTORS AND PROCEDURE FOR THEIR PREPARATION.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202548A ES2062927B1 (en) 1992-12-17 1992-12-17 ANTAGONISTS OF ENDOTHELIN RECEPTORS AND PROCEDURE FOR THEIR PREPARATION.

Publications (2)

Publication Number Publication Date
ES2062927A1 ES2062927A1 (en) 1994-12-16
ES2062927B1 true ES2062927B1 (en) 1995-07-01

Family

ID=8279128

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202548A Expired - Fee Related ES2062927B1 (en) 1992-12-17 1992-12-17 ANTAGONISTS OF ENDOTHELIN RECEPTORS AND PROCEDURE FOR THEIR PREPARATION.

Country Status (1)

Country Link
ES (1) ES2062927B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2667294B2 (en) * 1991-11-05 1997-10-27 スミスクライン・ビーチャム・コーポレイション Endothelin receptor antagonist

Also Published As

Publication number Publication date
ES2062927A1 (en) 1994-12-16

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Effective date: 20180806