AR043268A1 - PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A STEROID DERIVATIVE 9, 11-EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A DELTA-4,5, STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY COMPOUNDS AND COMPOSITE SUBSTRATES OBTAINED - Google Patents

PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A STEROID DERIVATIVE 9, 11-EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A DELTA-4,5, STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY COMPOUNDS AND COMPOSITE SUBSTRATES OBTAINED

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Publication number
AR043268A1
AR043268A1 ARP980102772A AR043268A1 AR 043268 A1 AR043268 A1 AR 043268A1 AR P980102772 A ARP980102772 A AR P980102772A AR 043268 A1 AR043268 A1 AR 043268A1
Authority
AR
Argentina
Prior art keywords
group
derivative
steroid
compound
intermediary
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Ng S John
Liu Chin
Joseph Wieczorek
Ping Wang
Edward YONAN
Richard M Weier
Thomas Kowar
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of AR043268A1 publication Critical patent/AR043268A1/en

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  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso para la preparación de un compuesto, intermediario en la síntesis de un derivado de un esteroide 9-11 epoxi, donde dicho compuesto es de la fórmula (1), donde: -A-A- representa el grupo -CHR4-CHR5 o -CR4=R5-; R3, R4 y R5 se seleccionan independientemente del grupo formado por oxígeno, halo, hidroxi, alquilo inferior, alcoxi inferior, hidroxialquilo, alcoxialquilo, hidroxi carbonilo, ciano y ariloxi; R1 representa un radical alcoxicarbonilo o hidroxicarbonilo inferior alfa-orientado; -B-B- representa el grupo -CHR6-CHR7- o un grupo alfa o beta orientado de la fórmula (2), donde R6 y R7 se seleccionan independientemente del grupo formado por hidrógeno, halo, alcoxi inferior, acilo, hidroxialquilo, alcoxialquilo, hidroxicarbonilo, alquilo, alcoxicarbonilo, aciloxialquilo, ciano y ariloxi; y R8 y R9 se seleccionan independientemente del grupo formado por hidrógeno, hidroxi, halo, alcoxi inferior, acilo, hidroxialquilo, alcoxialquilo, hidroxicarbonilo, alquilo, alcoxicarbonilo, aciloxialquilo, ciano y ariloxi, o R8 y R9 juntos constituyen una estructura de anillo carbocíclico o heterocíclico, o R8 o R9 junto con R6 o R7 comprenden una estructura de anillo carbocíclico o heterocíclico fusionado al anillo pentacíclico D; en el cual dicho proceso comprende: eliminar un grupo saliente 11a de un compuesto de fórmula (3), donde R2 es un grupo saliente 11a cuya abstracción es eficaz para generar una doble ligadura C9-11. Estos procesos son útiles en la fabricación de epoximexrenona y de intermediarios útiles para su fabricación. Se describen asimismo los compuestos que se obtienen por dichos procesos así como también los intermediarios y sustratos de los mismos.A process for the preparation of a compound, intermediate in the synthesis of a derivative of a 9-11 epoxy steroid, wherein said compound is of the formula (1), where: -AA- represents the group -CHR4-CHR5 or -CR4 = R5-; R3, R4 and R5 are independently selected from the group consisting of oxygen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano and aryloxy; R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxycarbonyl radical; -BB- represents the group -CHR6-CHR7- or an alpha or beta oriented group of the formula (2), where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl , alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; and R8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together constitute a carbocyclic ring structure or heterocyclic, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic ring D; wherein said process comprises: removing a leaving group 11a from a compound of formula (3), where R2 is a leaving group 11a whose abstraction is effective to generate a double C9-11 ligature. These processes are useful in the manufacture of epoxymexrenone and intermediates useful for its manufacture. The compounds obtained by said processes as well as the intermediates and substrates thereof are also described.

ARP980102772 1997-06-11 1998-06-11 PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A STEROID DERIVATIVE 9, 11-EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A DELTA-4,5, STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY COMPOUNDS AND COMPOSITE SUBSTRATES OBTAINED AR043268A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4938897P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
AR043268A1 true AR043268A1 (en) 2005-07-27

Family

ID=21959557

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP980102772 AR043268A1 (en) 1997-06-11 1998-06-11 PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A STEROID DERIVATIVE 9, 11-EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A DELTA-4,5, STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY COMPOUNDS AND COMPOSITE SUBSTRATES OBTAINED
ARP070101746A AR060624A2 (en) 1997-06-11 2007-04-23 PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A DERIVATIVE OF A STEROID 9-11EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A (DELTA) -4.5 STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY AND SUBSTRATE COMPOUNDS AND COMPUTERS OBTAINED

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP070101746A AR060624A2 (en) 1997-06-11 2007-04-23 PROCESS FOR THE PREPARATION OF AN INTERMEDIARY COMPOUND IN THE SYNTHESIS OF A DERIVATIVE OF A STEROID 9-11EPOXI; FROM A DERIVATIVE OF MEXRENONA; OF A (DELTA) -4.5 STEROID REPLACED WITH 3-CETO-7 ALFA ALCOXICARBONILO AND OTHER INTERMEDIARY AND SUBSTRATE COMPOUNDS AND COMPUTERS OBTAINED

Country Status (4)

Country Link
AR (2) AR043268A1 (en)
PL (1) PL189757B1 (en)
TW (2) TWI248443B (en)
ZA (1) ZA985088B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112723321A (en) * 2021-01-26 2021-04-30 呼伦贝尔驰宏矿业有限公司 Acid cross-linking system and acid cross-linking process for industrial sulfuric acid preparation purification section

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114456952B (en) * 2022-02-22 2023-04-14 昆明理工大学 Chrysosporium and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112723321A (en) * 2021-01-26 2021-04-30 呼伦贝尔驰宏矿业有限公司 Acid cross-linking system and acid cross-linking process for industrial sulfuric acid preparation purification section

Also Published As

Publication number Publication date
TWI277620B (en) 2007-04-01
AR060624A2 (en) 2008-07-02
ZA985088B (en) 1999-06-11
PL189757B1 (en) 2005-09-30
TWI248443B (en) 2006-02-01
TW200606174A (en) 2006-02-16

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