DE69936998D1 - Pyrazolotriazinderivate als gaba-rezeptorliganden - Google Patents

Pyrazolotriazinderivate als gaba-rezeptorliganden

Info

Publication number
DE69936998D1
DE69936998D1 DE69936998T DE69936998T DE69936998D1 DE 69936998 D1 DE69936998 D1 DE 69936998D1 DE 69936998 T DE69936998 T DE 69936998T DE 69936998 T DE69936998 T DE 69936998T DE 69936998 D1 DE69936998 D1 DE 69936998D1
Authority
DE
Germany
Prior art keywords
receptor ligands
gaba receptor
pyrazolotriazine
derivatives
pyrazolotriazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69936998T
Other languages
English (en)
Other versions
DE69936998T2 (de
Inventor
William Robert Carling
Andrew Mitchinson
Kevin William Moore
Michael Geoffrey Neil Russell
Gayle Scott
Leslie Joseph Street
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9822716.8A external-priority patent/GB9822716D0/en
Priority claimed from GBGB9920092.5A external-priority patent/GB9920092D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of DE69936998D1 publication Critical patent/DE69936998D1/de
Publication of DE69936998T2 publication Critical patent/DE69936998T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69936998T 1998-10-16 1999-10-13 Pyrazolotriazinderivate als gaba-rezeptorliganden Expired - Fee Related DE69936998T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9822716.8A GB9822716D0 (en) 1998-10-16 1998-10-16 Therapeutic agents
GB9822716 1998-10-16
GBGB9920092.5A GB9920092D0 (en) 1999-08-25 1999-08-25 Therapeutic agents
GB9920092 1999-08-25
PCT/GB1999/003401 WO2000023449A1 (en) 1998-10-16 1999-10-13 Pyrazolo-triazine derivatives as ligands for gaba receptors

Publications (2)

Publication Number Publication Date
DE69936998D1 true DE69936998D1 (de) 2007-10-11
DE69936998T2 DE69936998T2 (de) 2008-05-21

Family

ID=26314533

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936998T Expired - Fee Related DE69936998T2 (de) 1998-10-16 1999-10-13 Pyrazolotriazinderivate als gaba-rezeptorliganden

Country Status (9)

Country Link
US (1) US6476030B1 (de)
EP (1) EP1121361B1 (de)
JP (1) JP2002527519A (de)
AT (1) ATE371659T1 (de)
AU (1) AU760688B2 (de)
CA (1) CA2346289A1 (de)
DE (1) DE69936998T2 (de)
ES (1) ES2291043T3 (de)
WO (1) WO2000023449A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9919957D0 (en) 1999-08-23 1999-10-27 Merck Sharp & Dohme Therapeutic agents
US6355638B1 (en) * 1999-11-25 2002-03-12 Merck Sharp & Dohme Ltd. Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB0008696D0 (en) 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic agents
GB0210127D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0210124D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (de) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
EP2026813A2 (de) 2006-05-09 2009-02-25 Braincells, Inc. 5-ht-rezeptor-vermittelte neurogenese
US7998971B2 (en) * 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
CN102558001B (zh) * 2007-05-22 2015-09-23 惠氏有限责任公司 制造酰肼的改良方法
WO2009132135A1 (en) 2008-04-23 2009-10-29 Gilead Sciences, Inc. 1' -substituted carba-nucleoside analogs for antiviral treatment
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
DK2480559T3 (da) 2009-09-21 2013-08-05 Gilead Sciences Inc Fremgangsmåder og mellemprodukter til fremstillingen af 1'-cyano-carbanukleosid-analoger
BR112013001267A2 (pt) 2010-07-19 2016-05-17 Gilead Sciences Inc métodos para a preparação de pró-fármacos de fosforamidato diasteromericamente puro
CR20170278A (es) 2010-07-22 2017-09-29 Gilead Sciences Inc Métodos y compuestos para tratar infecciones virales por paramyxoviridae
JP5919291B2 (ja) * 2010-11-09 2016-05-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｇａｂａ受容体リガンドとしてのトリアゾール誘導体
JP6106603B2 (ja) 2011-01-11 2017-04-05 スノビオン プハルマセウトイカルス インコーポレイテッド ヘテロアリール化合物及びその使用方法
US20150374705A1 (en) * 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
TWI740546B (zh) 2014-10-29 2021-09-21 美商基利科學股份有限公司 製備核糖苷的方法
SG10202001878WA (en) 2015-09-16 2020-04-29 Gilead Sciences Inc Methods for treating arenaviridae and coronaviridae virus infections
CN107344938B (zh) * 2016-05-06 2022-05-06 上海赛默罗生物科技有限公司 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
KR102460968B1 (ko) 2017-03-14 2022-11-01 길리애드 사이언시즈, 인코포레이티드 고양이 코로나바이러스 감염의 치료 방법
WO2018204198A1 (en) 2017-05-01 2018-11-08 Gilead Sciences, Inc. Crystalline forms of (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
CA3077489A1 (en) 2017-07-11 2019-01-17 Gilead Sciences, Inc. Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
CN112608316B (zh) * 2019-07-30 2022-10-21 厦门宝太生物科技股份有限公司 一种吡唑并三嗪类腺苷受体拮抗剂
EP4010333A1 (de) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasmakallikreininhibitoren
CA3163424A1 (en) 2020-01-27 2021-08-05 Gilead Sciences, Inc. Methods for treating sars cov-2 infections
JP2023516087A (ja) 2020-03-12 2023-04-17 ギリアード サイエンシーズ， インコーポレイテッド １’－シアノヌクレオシドを調製する方法
KR20220164784A (ko) 2020-04-06 2022-12-13 길리애드 사이언시즈, 인코포레이티드 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형
TW202203941A (zh) 2020-05-29 2022-02-01 美商基利科學股份有限公司 瑞德西韋之治療方法
CR20220675A (es) 2020-06-24 2023-02-15 Gilead Sciences Inc Análogos de nucleósido de 1´- ciano y usos de los mismos
KR20230057411A (ko) 2020-08-27 2023-04-28 길리애드 사이언시즈, 인코포레이티드 바이러스 감염 치료를 위한 화합물 및 방법
TW202400185A (zh) 2022-03-02 2024-01-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9321162D0 (en) * 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents
SK9399A3 (en) 1996-07-25 2000-04-10 Merck Sharp & Dohme Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
AU724076B2 (en) 1996-07-25 2000-09-14 Merck Sharp & Dohme Limited Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAalpha5 receptor subtype
GB9713707D0 (en) 1997-06-27 1997-09-03 Merck Sharp & Dohme Therapeutic agents
US6303597B1 (en) 1998-01-14 2001-10-16 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors

Also Published As

Publication number Publication date
DE69936998T2 (de) 2008-05-21
US6476030B1 (en) 2002-11-05
ES2291043T3 (es) 2008-02-16
ATE371659T1 (de) 2007-09-15
EP1121361A1 (de) 2001-08-08
CA2346289A1 (en) 2000-04-27
EP1121361B1 (de) 2007-08-29
WO2000023449A1 (en) 2000-04-27
JP2002527519A (ja) 2002-08-27
AU760688B2 (en) 2003-05-22
AU6219999A (en) 2000-05-08

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Legal Events

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8339 Ceased/non-payment of the annual fee