NO20003730L - Triazolo-pyridazinderivater som ligander for GABA reseptorer - Google Patents

Triazolo-pyridazinderivater som ligander for GABA reseptorer

Info

Publication number
NO20003730L
NO20003730L NO20003730A NO20003730A NO20003730L NO 20003730 L NO20003730 L NO 20003730L NO 20003730 A NO20003730 A NO 20003730A NO 20003730 A NO20003730 A NO 20003730A NO 20003730 L NO20003730 L NO 20003730L
Authority
NO
Norway
Prior art keywords
triazolo
ligands
pyridazine derivatives
gaba receptors
gaba
Prior art date
Application number
NO20003730A
Other languages
English (en)
Other versions
NO315516B1 (no
NO20003730D0 (no
Inventor
William Robert Carling
Jose Luis Castro Pineiro
Ian James Collins
Alexander Richard Guiblin
Timothy Harrison
Andrew Madin
Kevin William Moore
Michael Geoffrey Neil Russell
Gayle Scott
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohne Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801233.9A external-priority patent/GB9801233D0/en
Priority claimed from GBGB9821517.1A external-priority patent/GB9821517D0/en
Application filed by Merck Sharp & Dohne Ltd filed Critical Merck Sharp & Dohne Ltd
Publication of NO20003730D0 publication Critical patent/NO20003730D0/no
Publication of NO20003730L publication Critical patent/NO20003730L/no
Publication of NO315516B1 publication Critical patent/NO315516B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20003730A 1998-01-21 2000-07-20 Triazolo-pyridazinderivater som ligander for GABA-reseptorer NO315516B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9801233.9A GB9801233D0 (en) 1998-01-21 1998-01-21 Therapeutic agents
GBGB9821517.1A GB9821517D0 (en) 1998-10-02 1998-10-02 Therapeutic agents
PCT/GB1999/000103 WO1999037644A1 (en) 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (3)

Publication Number Publication Date
NO20003730D0 NO20003730D0 (no) 2000-07-20
NO20003730L true NO20003730L (no) 2000-09-20
NO315516B1 NO315516B1 (no) 2003-09-15

Family

ID=26312988

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003730A NO315516B1 (no) 1998-01-21 2000-07-20 Triazolo-pyridazinderivater som ligander for GABA-reseptorer

Country Status (24)

Country Link
US (2) US6579875B1 (no)
EP (1) EP1049696A1 (no)
JP (1) JP2002501066A (no)
KR (1) KR20010034257A (no)
CN (1) CN1110498C (no)
AU (1) AU748737B2 (no)
BG (1) BG104671A (no)
BR (1) BR9906905A (no)
CA (1) CA2315763A1 (no)
CZ (1) CZ290883B6 (no)
EA (1) EA002755B1 (no)
EE (1) EE200000430A (no)
GE (1) GEP20032868B (no)
HR (1) HRP20000492A2 (no)
HU (1) HUP0100575A3 (no)
IL (1) IL136442A0 (no)
IS (1) IS5540A (no)
MX (1) MXPA00007135A (no)
NO (1) NO315516B1 (no)
NZ (1) NZ504870A (no)
PL (1) PL341652A1 (no)
SK (1) SK10922000A3 (no)
WO (1) WO1999037644A1 (no)
YU (1) YU43800A (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037644A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9929685D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0017543D0 (en) * 2000-07-17 2000-09-06 Merck Sharp & Dohme Therapeutic agents
WO2005058860A1 (ja) * 2003-12-19 2005-06-30 Ube Industries, Ltd. ４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AP3433A (en) * 2005-12-21 2015-10-31 Janssen Pharmaceutica Nv Triazolopyridazines as tyrosine kinase modultors
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2123619A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma AG Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung
EA020071B1 (ru) * 2008-08-29 2014-08-29 Консерт Фармасьютикалс Инк. Замещенные производные триазолопиридазина
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2012531419A (ja) * 2009-06-23 2012-12-10 コンサート ファーマシューティカルズ インコーポレイテッド Ｇａｂａ−ａ受容体修飾物質としての重水素修飾されたトリアゾロピリダジン誘導体
DK2464645T3 (en) 2009-07-27 2017-10-23 Gilead Sciences Inc CONDENSED, HETEROCYCLIC COMPOUNDS AS IRON CHANNEL MODULATORS
WO2012050907A2 (en) 2010-09-28 2012-04-19 The Regents Of The University Of California Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes
AU2012253653A1 (en) 2011-05-10 2013-05-02 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
NO3175985T3 (no) 2011-07-01 2018-04-28
UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
GB201321745D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2017151617A1 (en) 2016-02-29 2017-09-08 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
US11325955B2 (en) 2017-07-19 2022-05-10 Dana-Farber Cancer Institute, Inc. Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4230705A (en) 1976-09-22 1980-10-28 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
US4112095A (en) * 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
PH12424A (en) * 1976-10-26 1979-02-15 American Cyanamid Co Method of treating anxiety in mammals
US4260755A (en) 1979-10-31 1981-04-07 American Cyanamid Company Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines
US4260756A (en) 1979-11-15 1981-04-07 American Cyanamid Company 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4654343A (en) 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
US6255305B1 (en) 1996-07-25 2001-07-03 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
WO1999037644A1 (en) 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
EA002755B1 (ru) 2002-08-29
WO1999037644A1 (en) 1999-07-29
AU2065799A (en) 1999-08-09
SK10922000A3 (sk) 2001-03-12
NZ504870A (en) 2002-11-26
EP1049696A1 (en) 2000-11-08
AU748737B2 (en) 2002-06-13
US20040063714A1 (en) 2004-04-01
MXPA00007135A (es) 2002-11-07
CN1110498C (zh) 2003-06-04
BR9906905A (pt) 2000-10-10
KR20010034257A (ko) 2001-04-25
CA2315763A1 (en) 1999-07-29
CZ290883B6 (cs) 2002-11-13
NO315516B1 (no) 2003-09-15
JP2002501066A (ja) 2002-01-15
HRP20000492A2 (en) 2000-12-31
PL341652A1 (en) 2001-04-23
HUP0100575A2 (hu) 2001-09-28
IS5540A (is) 2000-06-16
EE200000430A (et) 2001-12-17
US6828322B2 (en) 2004-12-07
US6579875B1 (en) 2003-06-17
IL136442A0 (en) 2001-06-14
GEP20032868B (en) 2003-01-27
BG104671A (en) 2001-05-31
CN1288465A (zh) 2001-03-21
EA200000783A1 (ru) 2000-12-25
NO20003730D0 (no) 2000-07-20
YU43800A (sh) 2002-12-10
HUP0100575A3 (en) 2003-03-28
CZ20002691A3 (cs) 2000-12-13

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