MXPA04004018A - Metodos de separacion por exclusion para toxicidad de compuestos de prueba. - Google Patents
Metodos de separacion por exclusion para toxicidad de compuestos de prueba.Info
- Publication number
- MXPA04004018A MXPA04004018A MXPA04004018A MXPA04004018A MXPA04004018A MX PA04004018 A MXPA04004018 A MX PA04004018A MX PA04004018 A MXPA04004018 A MX PA04004018A MX PA04004018 A MXPA04004018 A MX PA04004018A MX PA04004018 A MXPA04004018 A MX PA04004018A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- test compounds
- toxicity
- screening
- determining
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invencion se refiere a metodos de separacion por exclusion de candidatos a farmaco para efectos toxicos en celulas humanas. La invencion proporciona metodos para determinar la toxicidad idiosincratica de los compuestos de prueba.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33650901P | 2001-10-31 | 2001-10-31 | |
PCT/US2002/034894 WO2003050297A1 (en) | 2001-10-31 | 2002-10-31 | Methods of screening for toxicity of test compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04004018A true MXPA04004018A (es) | 2004-07-23 |
Family
ID=23316423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04004018A MXPA04004018A (es) | 2001-10-31 | 2002-10-31 | Metodos de separacion por exclusion para toxicidad de compuestos de prueba. |
Country Status (8)
Country | Link |
---|---|
US (1) | US7041501B2 (es) |
EP (1) | EP1446497A4 (es) |
JP (1) | JP2005511093A (es) |
AU (1) | AU2002364692B2 (es) |
CA (1) | CA2465262A1 (es) |
IL (1) | IL161300A0 (es) |
MX (1) | MXPA04004018A (es) |
WO (1) | WO2003050297A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7759113B2 (en) * | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
US7776021B2 (en) | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
ATE439039T1 (de) * | 2003-01-16 | 2009-08-15 | Gen Hospital Corp | Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen |
EP1636351A4 (en) | 2003-05-21 | 2007-04-04 | Gen Hospital Corp | MICROFABRICATED COMPOSITIONS AND METHOD FOR CONSTRUCTING TISSUES WITH MULTIPLE CELL TYPES |
US7452678B2 (en) * | 2003-06-24 | 2008-11-18 | Bristol-Myers Squibb Company | Identification of biomarkers for liver toxicity |
US7235353B2 (en) * | 2003-07-18 | 2007-06-26 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
US20050014217A1 (en) * | 2003-07-18 | 2005-01-20 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
EP2029766A4 (en) * | 2006-06-08 | 2010-02-10 | Univ North Carolina | PULSES OF BILIARY COMPARTMENTS IN HEPATOCYTES CULTIVATED IN SANDWICH |
WO2012031057A1 (en) | 2010-09-01 | 2012-03-08 | Bristol-Myers Squibb Company | Bms- 582949 for the treatment of resistant rheumatic disease |
JP2017035081A (ja) * | 2015-08-13 | 2017-02-16 | サントリーホールディングス株式会社 | 動物細胞毒性又は抗酸化能の試験方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164313A (en) | 1987-06-05 | 1992-11-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant vaccinia virus encoding cytochromes P-450 |
US5356806A (en) * | 1987-06-05 | 1994-10-18 | The United States Of America As Represented By The Department Of Health And Human Services | Immortalized human cell lines containing exogenous cytochrome P450 |
US5506131A (en) * | 1987-06-05 | 1996-04-09 | The United States Of America As Represented By The Department Of Health And Human Services | Immortalized human cell lines containing exogenous cytochrome P450 genes |
US5665589A (en) * | 1988-12-14 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Human liver epithelial cell lines |
EP0449950A4 (en) * | 1988-12-14 | 1991-10-16 | Us Health | Cell culture medium for human liver epithelial cell line |
US5529920A (en) * | 1988-12-14 | 1996-06-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human liver epithelial cell line and culture media therefor |
JPH0749923B2 (ja) * | 1989-05-31 | 1995-05-31 | 大日本スクリーン製造株式会社 | レーザ測長器のための単位変換装置 |
US5457187A (en) * | 1993-12-08 | 1995-10-10 | Board Of Regents University Of Nebraska | Oligonucleotides containing 5-fluorouracil |
US5759782A (en) * | 1995-06-07 | 1998-06-02 | The United States Of America | Cellular apoptosis susceptibility protein (CSP) and antisense CSP |
US5869243A (en) * | 1996-03-05 | 1999-02-09 | Rhode Island Hospital | Immortalized hepatocytes |
TW471968B (en) * | 1999-08-25 | 2002-01-11 | Committee On Chinese Medicine | Solamargine pharmaceutical composition for killing cancer cells |
US6852845B1 (en) * | 1999-11-22 | 2005-02-08 | Curagen Corporation | Method of identifying toxic agents using NSAID-induced differential gene expression in liver |
US7700822B2 (en) * | 2002-07-12 | 2010-04-20 | Cancer Research Technology Limited | Modulation of cytochrome P450 reductase activity |
-
2002
- 2002-10-31 CA CA002465262A patent/CA2465262A1/en not_active Abandoned
- 2002-10-31 MX MXPA04004018A patent/MXPA04004018A/es unknown
- 2002-10-31 WO PCT/US2002/034894 patent/WO2003050297A1/en not_active Application Discontinuation
- 2002-10-31 JP JP2003551318A patent/JP2005511093A/ja active Pending
- 2002-10-31 EP EP02804681A patent/EP1446497A4/en not_active Withdrawn
- 2002-10-31 US US10/285,093 patent/US7041501B2/en not_active Expired - Lifetime
- 2002-10-31 IL IL16130002A patent/IL161300A0/xx unknown
- 2002-10-31 AU AU2002364692A patent/AU2002364692B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2465262A1 (en) | 2003-06-19 |
IL161300A0 (en) | 2004-09-27 |
WO2003050297A1 (en) | 2003-06-19 |
US20030113708A1 (en) | 2003-06-19 |
AU2002364692A1 (en) | 2003-06-23 |
JP2005511093A (ja) | 2005-04-28 |
US7041501B2 (en) | 2006-05-09 |
EP1446497A1 (en) | 2004-08-18 |
AU2002364692B2 (en) | 2006-11-23 |
EP1446497A4 (en) | 2004-12-29 |
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