TW200637830A - Erastin and erastin binding proteins, and uses thereof - Google Patents

Erastin and erastin binding proteins, and uses thereof

Info

Publication number
TW200637830A
TW200637830A TW095102803A TW95102803A TW200637830A TW 200637830 A TW200637830 A TW 200637830A TW 095102803 A TW095102803 A TW 095102803A TW 95102803 A TW95102803 A TW 95102803A TW 200637830 A TW200637830 A TW 200637830A
Authority
TW
Taiwan
Prior art keywords
erastin
binding proteins
methods
binding partners
vdacs
Prior art date
Application number
TW095102803A
Other languages
Chinese (zh)
Other versions
TWI389892B (en
Inventor
Sudhir Sahasrabudhe
Robert R Becklin
Cindy Lou Chepanoske
John M Peltier
Paul B Robbins
Robert Selliah
Keith Simmons
Brent R Stockwell
Rechenberg Moritz Von
Yuejun Zhen
Raj Gopal Venkat
Longwu Qi
Original Assignee
Prolexys Pharmaceuticals Inc
Whitehead Biomedical Inst
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolexys Pharmaceuticals Inc, Whitehead Biomedical Inst, Univ Columbia filed Critical Prolexys Pharmaceuticals Inc
Publication of TW200637830A publication Critical patent/TW200637830A/en
Application granted granted Critical
Publication of TWI389892B publication Critical patent/TWI389892B/en

Links

Abstract

The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
TW95102803A 2005-01-25 2006-01-25 Erastin and erastin binding proteins, and uses thereof TWI389892B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64730305P 2005-01-25 2005-01-25

Publications (2)

Publication Number Publication Date
TW200637830A true TW200637830A (en) 2006-11-01
TWI389892B TWI389892B (en) 2013-03-21

Family

ID=39624238

Family Applications (1)

Application Number Title Priority Date Filing Date
TW95102803A TWI389892B (en) 2005-01-25 2006-01-25 Erastin and erastin binding proteins, and uses thereof

Country Status (2)

Country Link
CN (1) CN101218211A (en)
TW (1) TWI389892B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101602737B (en) * 2009-06-11 2011-09-14 浙江大学 Benzenesulfonyl quinoxaline compound and preparation method and application thereof
CN103193722B (en) * 2012-01-10 2016-02-24 北京师范大学 Novel quinazoline quinoline nitrogen mustards compound and preparation method thereof and cancer therapeutic applications
CN103360327B (en) * 2012-12-13 2016-04-20 中山大学 A kind of phenonaphthazine derivative and its preparation method and application
CN103450096B (en) * 2013-04-27 2015-04-29 北京师范大学 Two nitrogen mustard derivatives, as well as preparation method and application therefore in tumor treatment
CN107400094B (en) * 2017-09-08 2020-04-03 贾玉庆 Quinazolinyl carboxylic ester compound and application thereof
CN112494477A (en) * 2020-12-28 2021-03-16 福建省立医院 Erastin-Tax-DOX liposome preparation and preparation method and application thereof

Also Published As

Publication number Publication date
CN101218211A (en) 2008-07-09
TWI389892B (en) 2013-03-21

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees