EA199900326A1 - Промежуточные соединения и способ получения оланзапина - Google Patents

Промежуточные соединения и способ получения оланзапина

Info

Publication number
EA199900326A1
EA199900326A1 EA199900326A EA199900326A EA199900326A1 EA 199900326 A1 EA199900326 A1 EA 199900326A1 EA 199900326 A EA199900326 A EA 199900326A EA 199900326 A EA199900326 A EA 199900326A EA 199900326 A1 EA199900326 A1 EA 199900326A1
Authority
EA
Eurasian Patent Office
Prior art keywords
intermediate compounds
olanzapine
obtaining
obtaining olanzapine
international
Prior art date
Application number
EA199900326A
Other languages
English (en)
Other versions
EA001642B1 (ru
Inventor
Чарльз А. Баннелл
Сэмюель Д. Ларсен
Джон Р. Николс
Сюзн М. Рётзель
Грегори А. Стефенсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199900326(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900326A1 publication Critical patent/EA199900326A1/ru
Publication of EA001642B1 publication Critical patent/EA001642B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к способу получения оланзапина и к промежуточным соединениям.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900326A 1996-09-23 1997-09-18 Промежуточные соединения и способ получения оланзапина EA001642B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23
PCT/US1997/016499 WO1998012199A1 (en) 1996-09-23 1997-09-18 Intermediates and process for preparing olanzapine

Publications (2)

Publication Number Publication Date
EA199900326A1 true EA199900326A1 (ru) 1999-08-26
EA001642B1 EA001642B1 (ru) 2001-06-25

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900326A EA001642B1 (ru) 1996-09-23 1997-09-18 Промежуточные соединения и способ получения оланзапина

Country Status (36)

Country Link
US (1) US6020487A (ru)
EP (1) EP0831098B1 (ru)
JP (2) JP2001500877A (ru)
KR (1) KR100560015B1 (ru)
CN (1) CN1122036C (ru)
AR (1) AR013838A1 (ru)
AT (1) ATE209208T1 (ru)
AU (1) AU719441B2 (ru)
BR (1) BR9712100A (ru)
CA (1) CA2265712C (ru)
CO (1) CO4910140A1 (ru)
CZ (1) CZ299248B6 (ru)
DE (1) DE69708428T2 (ru)
DK (1) DK0831098T3 (ru)
EA (1) EA001642B1 (ru)
EG (1) EG23861A (ru)
ES (1) ES2166051T3 (ru)
HK (1) HK1009807A1 (ru)
HU (1) HU226484B1 (ru)
ID (1) ID27275A (ru)
IL (1) IL128962A (ru)
IN (1) IN187156B (ru)
MY (1) MY125565A (ru)
NO (1) NO323980B1 (ru)
NZ (1) NZ334448A (ru)
PE (1) PE110398A1 (ru)
PL (3) PL194565B1 (ru)
PT (1) PT831098E (ru)
RS (1) RS49598B (ru)
SI (1) SI0831098T1 (ru)
SV (1) SV1997000081A (ru)
TR (1) TR199900640T2 (ru)
TW (1) TW470746B (ru)
UA (1) UA59371C2 (ru)
WO (1) WO1998012199A1 (ru)
ZA (1) ZA978515B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1313742A1 (en) * 2000-08-31 2003-05-28 Dr. Reddy's Laboratories Ltd. Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
WO2003037903A1 (en) * 2001-10-29 2003-05-08 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
EP1470130A2 (en) 2001-12-24 2004-10-27 Sun Pharmaceuticals Industries Ltd. Crystalline form i of 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno 2,3-b 1,5 benzodiazepine
WO2003091260A1 (en) * 2002-04-23 2003-11-06 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
ATE500258T1 (de) * 2002-05-31 2011-03-15 Sandoz Ag Verfahren zur herstellung von olanzapin form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
AU2003300324A1 (en) * 2002-12-24 2004-07-22 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
WO2005049090A2 (en) * 2003-11-18 2005-06-02 3M Innovative Properties Company Olanzapine containing transdermal drug delivery compositions
PT1611139E (pt) * 2003-12-22 2008-07-17 Teva Pharma Métodos de preparação de olanzapina
ATE504588T1 (de) 2004-01-27 2011-04-15 Synthon Bv Stabile salze von olanzapin
US20070072845A1 (en) * 2004-02-19 2007-03-29 Davuluri Rammohan Rao Process for the preparation of olanzapine form 1 useful as antipsychotic drug
ES2289974T1 (es) * 2004-07-14 2008-02-16 Shasun Chemicals And Drugs Limited Metodo mejorado para producir la forma i de la olanzapina.
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
ES2303462B1 (es) 2004-09-06 2009-06-05 Shasun Chemicals And Drugs Limited Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura.
KR20130030305A (ko) * 2004-11-16 2013-03-26 엘란 파마 인터내셔널 리미티드 주사가능한 나노입자형 올란자핀 제형
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
NZ247703A (en) * 1992-05-29 1995-07-26 Lilly Industries Ltd Thienobenzdiazepine derivatives and medicaments thereof
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
BR9711541A (pt) * 1996-09-23 1999-08-24 Lilly Co Eli Dihidrato d de olanzapina

Also Published As

Publication number Publication date
IN187156B (ru) 2002-02-16
CZ299248B6 (cs) 2008-05-28
DE69708428T2 (de) 2002-07-04
YU15599A (sh) 2001-12-26
US6020487A (en) 2000-02-01
PL332482A1 (en) 1999-09-13
ES2166051T3 (es) 2002-04-01
PT831098E (pt) 2002-04-29
MY125565A (en) 2006-08-30
AU719441B2 (en) 2000-05-11
CZ99099A3 (cs) 1999-11-17
KR100560015B1 (ko) 2006-03-15
ID27275A (id) 2001-03-22
CN1122036C (zh) 2003-09-24
SI0831098T1 (en) 2002-04-30
EP0831098A3 (en) 1998-04-29
CN1234802A (zh) 1999-11-10
KR20000048520A (ko) 2000-07-25
CA2265712A1 (en) 1998-03-26
BR9712100A (pt) 1999-08-31
DK0831098T3 (da) 2002-05-21
EP0831098A2 (en) 1998-03-25
HUP0000066A3 (en) 2000-11-28
JP2001500877A (ja) 2001-01-23
IL128962A0 (en) 2000-02-17
JP2009242407A (ja) 2009-10-22
ZA978515B (en) 1999-03-23
CA2265712C (en) 2006-10-31
PE110398A1 (es) 1999-01-14
WO1998012199A1 (en) 1998-03-26
CO4910140A1 (es) 2000-04-24
HUP0000066A2 (hu) 2000-06-28
RS49598B (sr) 2007-06-04
NZ334448A (en) 2000-08-25
SV1997000081A (es) 1999-01-14
NO991382D0 (no) 1999-03-22
TR199900640T2 (xx) 1999-06-21
NO991382L (no) 1999-03-22
NO323980B1 (no) 2007-07-30
PL196068B1 (pl) 2007-12-31
UA59371C2 (ru) 2003-09-15
TW470746B (en) 2002-01-01
PL196069B1 (pl) 2007-12-31
HU226484B1 (en) 2009-03-02
EP0831098B1 (en) 2001-11-21
PL194565B1 (pl) 2007-06-29
AU4484197A (en) 1998-04-14
HK1009807A1 (en) 1999-06-11
DE69708428D1 (de) 2002-01-03
IL128962A (en) 2003-01-12
EA001642B1 (ru) 2001-06-25
ATE209208T1 (de) 2001-12-15
AR013838A1 (es) 2001-01-31
EG23861A (en) 2007-11-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): RU