PE110398A1 - Productos intermedios y proceso para preparar olanzapina - Google Patents
Productos intermedios y proceso para preparar olanzapinaInfo
- Publication number
- PE110398A1 PE110398A1 PE1997000855A PE00085597A PE110398A1 PE 110398 A1 PE110398 A1 PE 110398A1 PE 1997000855 A PE1997000855 A PE 1997000855A PE 00085597 A PE00085597 A PE 00085597A PE 110398 A1 PE110398 A1 PE 110398A1
- Authority
- PE
- Peru
- Prior art keywords
- olanzapine
- polymorph
- methyl
- refers
- intermediate products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE AL PROCEDIMIENTO DE PREPARACION DEL 2-METIL-4-(4-METIL-1-PIPERAZINIL)-1OH-TIENO[2,3-b][1,5]BENZODIAZEPINA (OLANZAPINA) DE FORMA II, QUE COMPRENDE: DESHIDRATAR UN DIHIDRATO DE OLANZAPINA EN UN VACUOHORNO A UNA TEMPERATURA ENTRE 40�C a 70�C. ESTE PROCESO PERMITE LA OBTENCION DE LA FORMA II (FORMA ANHIDRA MAS ESTABLE DE OLANZAPINA) SUSTANCIALMENTE PURA, QUE TENDRA APROXIMADAMENTE MENOS DE 0,5% DE IMPUREZAS QUIMICAS O SOLVENTES RESIDUALES INDESABLES. TAMBIEN SE REFIERE A LOS POLIMORFOS "B" Y "E" DEL DIHIDRATO DE OLANZAPINA; EN DONDE EL POLIMORFO "B" SE CARACTERIZA POR EL SIGUIENTE PATRON DE DIFRACCION DE RAYOS X: 9,9045 6,9985 6,763 6,4079 6,1548 6,0611 5,8933 5,6987 5,4395 5,1983 5,0843 4,9478 4,7941 4,696 4,5272 4,4351 4,3474 4,2657 4,1954 4,0555 3,9903 3,9244 3,8561 3,8137 3,7671 3,6989 3,6527 3,5665 3,4879 3,3911 3,3289 3,2316 3,1982 3,1393 3,0824 2,9899 2,9484 2,9081 2,8551 2,8324 2,751 2,7323 2,6787 2,6424 2,5937; Y EL POLIMORFO "E" SE CARACTERIZA POR EL SIGUIENTE PATRON DE DIFRACCION DE RAYOS X: 9,871 9,5514 6,9575 6,141 6,0644 5,9896 5,8774 4,7721 4,6673 4,5171 4,4193 4,354 4,2539 4,2369 4,0537 4,0129 3,8555 3,7974 3,6846 3,5541 3,4844 3,474 3,4637 3,3771 3,1245 2,9403. LA OLANZAPINA ES USADA EN EL TRATAMIENTO ANTIPSICOTICO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2648796P | 1996-09-23 | 1996-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE110398A1 true PE110398A1 (es) | 1999-01-14 |
Family
ID=21832120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000855A PE110398A1 (es) | 1996-09-23 | 1997-09-23 | Productos intermedios y proceso para preparar olanzapina |
Country Status (36)
Country | Link |
---|---|
US (1) | US6020487A (es) |
EP (1) | EP0831098B1 (es) |
JP (2) | JP2001500877A (es) |
KR (1) | KR100560015B1 (es) |
CN (1) | CN1122036C (es) |
AR (1) | AR013838A1 (es) |
AT (1) | ATE209208T1 (es) |
AU (1) | AU719441B2 (es) |
BR (1) | BR9712100A (es) |
CA (1) | CA2265712C (es) |
CO (1) | CO4910140A1 (es) |
CZ (1) | CZ299248B6 (es) |
DE (1) | DE69708428T2 (es) |
DK (1) | DK0831098T3 (es) |
EA (1) | EA001642B1 (es) |
EG (1) | EG23861A (es) |
ES (1) | ES2166051T3 (es) |
HK (1) | HK1009807A1 (es) |
HU (1) | HU226484B1 (es) |
ID (1) | ID27275A (es) |
IL (1) | IL128962A (es) |
IN (1) | IN187156B (es) |
MY (1) | MY125565A (es) |
NO (1) | NO323980B1 (es) |
NZ (1) | NZ334448A (es) |
PE (1) | PE110398A1 (es) |
PL (3) | PL196069B1 (es) |
PT (1) | PT831098E (es) |
RS (1) | RS49598B (es) |
SI (1) | SI0831098T1 (es) |
SV (1) | SV1997000081A (es) |
TR (1) | TR199900640T2 (es) |
TW (1) | TW470746B (es) |
UA (1) | UA59371C2 (es) |
WO (1) | WO1998012199A1 (es) |
ZA (1) | ZA978515B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2420987A1 (en) * | 2000-08-31 | 2002-03-07 | Dr. Reddy's Laboratories Ltd. | Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine |
US6740753B2 (en) * | 2001-01-04 | 2004-05-25 | Geneva Pharmaceuticals, Inc. | Olanzapine crystal modification |
CA2464306A1 (en) * | 2001-10-29 | 2003-05-08 | Dr. Reddy's Laboratories Ltd. | Olanzapine dihydrate-ii a process for its preparation and use thereof |
JP4530664B2 (ja) | 2001-12-24 | 2010-08-25 | サン・ファーマシューティカル・インダストリーズ・リミテッド | 2−メチル−4−(4−メチル−1−ピペラジニル)−10H−チエノ[2,3−b][1,5]ベンゾジアゼピンの結晶形I、この結晶形Iの製造方法、及び医薬組成物 |
WO2003091260A1 (en) * | 2002-04-23 | 2003-11-06 | Dr. Reddy's Laboratories Limited | Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof |
AU2003237305A1 (en) | 2002-05-31 | 2003-12-19 | Geneva Pharmaceuticals, Inc. | Process of preparation of olanzapine form i |
SI21270A (sl) | 2002-07-15 | 2004-02-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Kristalne oblike olanzapina in postopki za njihovo pripravo |
AU2003300324A1 (en) | 2002-12-24 | 2004-07-22 | Teva Pharmaceutical Industries Ltd. | Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms |
CA2546200A1 (en) * | 2003-11-18 | 2005-06-02 | 3M Innovative Properties Company | Olanzapine containing transdermal drug delivery compositions |
ATE397611T1 (de) * | 2003-12-22 | 2008-06-15 | Teva Pharma | Verfahren zur herstellung von olanzapin |
ATE504588T1 (de) | 2004-01-27 | 2011-04-15 | Synthon Bv | Stabile salze von olanzapin |
US20070072845A1 (en) * | 2004-02-19 | 2007-03-29 | Davuluri Rammohan Rao | Process for the preparation of olanzapine form 1 useful as antipsychotic drug |
DE05783995T1 (de) * | 2004-07-14 | 2007-10-11 | Shasun Chemicals and Drugs Ltd., Chennai | Verbessertes verfahren zur herstellung von form i aus olanzapin |
ES2253091B1 (es) | 2004-07-27 | 2007-02-01 | Inke, S.A. | Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo. |
ES2303462B1 (es) | 2004-09-06 | 2009-06-05 | Shasun Chemicals And Drugs Limited | Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura. |
ES2526092T3 (es) * | 2004-11-16 | 2015-01-05 | Alkermes Pharma Ireland Limited | Formulaciones de olanzapina en nanopartículas inyectables |
US7834176B2 (en) | 2006-01-26 | 2010-11-16 | Sandoz Ag | Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E |
CA2591644A1 (en) * | 2007-06-14 | 2008-12-14 | Apotex Pharmachem Inc. | Novel processes to form-i of olanzapine |
EP2486913A1 (en) | 2011-02-14 | 2012-08-15 | Labtec GmbH | Rapidly disintegrating oral film formulation for Olanzapin |
JP6008734B2 (ja) * | 2012-12-20 | 2016-10-19 | 株式会社トクヤマ | オランザピンii型結晶の製造方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5302716A (en) * | 1986-01-16 | 1994-04-12 | Schering Corporation | Fused benzazepines |
CA2002596A1 (en) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates of b-lactam antibiotic |
GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
US5229382A (en) * | 1990-04-25 | 1993-07-20 | Lilly Industries Limited | 2-methyl-thieno-benzodiazepine |
NO305125B1 (no) * | 1992-05-29 | 1999-04-06 | Lilly Industries Ltd | Farmas°ytiske forbindelser |
US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
US5602124A (en) * | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
US5637584A (en) * | 1995-03-24 | 1997-06-10 | Eli Lilly And Company | Solvate of olanzapine |
EG24221A (en) * | 1995-03-24 | 2008-11-10 | Lilly Co Eli | Process for preparing olanzapine |
US5631250A (en) * | 1995-03-24 | 1997-05-20 | Eli Lilly And Company | Process and solvate of 2-methyl-thieno-benzodiazepine |
EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
NZ334346A (en) * | 1996-09-23 | 2000-05-26 | Lilly Co Eli | Olanzapine dihydrate D comprising 2-methyl-4-(4-methyl-1-piperazinyl)-1OH-thieno[2,3-b][1,5]benzodiazepine and a formulation for use in treating central nervous system disorders |
-
1997
- 1997-09-02 ZA ZA978515A patent/ZA978515B/xx unknown
- 1997-09-18 PL PL381478A patent/PL196069B1/pl unknown
- 1997-09-18 KR KR1019997002424A patent/KR100560015B1/ko not_active IP Right Cessation
- 1997-09-18 RS YUP-155/99A patent/RS49598B/sr unknown
- 1997-09-18 ID IDW990058D patent/ID27275A/id unknown
- 1997-09-18 WO PCT/US1997/016499 patent/WO1998012199A1/en not_active Application Discontinuation
- 1997-09-18 UA UA99031635A patent/UA59371C2/uk unknown
- 1997-09-18 JP JP10514842A patent/JP2001500877A/ja not_active Withdrawn
- 1997-09-18 PL PL381479A patent/PL196068B1/pl unknown
- 1997-09-18 BR BR9712100-2A patent/BR9712100A/pt not_active Application Discontinuation
- 1997-09-18 EA EA199900326A patent/EA001642B1/ru not_active IP Right Cessation
- 1997-09-18 TR TR1999/00640T patent/TR199900640T2/xx unknown
- 1997-09-18 NZ NZ334448A patent/NZ334448A/en not_active IP Right Cessation
- 1997-09-18 IL IL12896297A patent/IL128962A/xx not_active IP Right Cessation
- 1997-09-18 CZ CZ0099099A patent/CZ299248B6/cs not_active IP Right Cessation
- 1997-09-18 PL PL97332482A patent/PL194565B1/pl unknown
- 1997-09-18 AU AU44841/97A patent/AU719441B2/en not_active Expired
- 1997-09-18 CA CA002265712A patent/CA2265712C/en not_active Expired - Lifetime
- 1997-09-18 CN CN97198137A patent/CN1122036C/zh not_active Expired - Lifetime
- 1997-09-18 HU HU0000066A patent/HU226484B1/hu unknown
- 1997-09-19 IN IN1736CA1997 patent/IN187156B/en unknown
- 1997-09-22 SI SI9730288T patent/SI0831098T1/xx unknown
- 1997-09-22 PT PT97307383T patent/PT831098E/pt unknown
- 1997-09-22 EP EP97307383A patent/EP0831098B1/en not_active Expired - Lifetime
- 1997-09-22 SV SV1997000081A patent/SV1997000081A/es not_active Application Discontinuation
- 1997-09-22 DE DE69708428T patent/DE69708428T2/de not_active Expired - Lifetime
- 1997-09-22 AT AT97307383T patent/ATE209208T1/de active
- 1997-09-22 ES ES97307383T patent/ES2166051T3/es not_active Expired - Lifetime
- 1997-09-22 CO CO97055061A patent/CO4910140A1/es unknown
- 1997-09-22 MY MYPI97004392A patent/MY125565A/en unknown
- 1997-09-22 DK DK97307383T patent/DK0831098T3/da active
- 1997-09-23 US US08/935,884 patent/US6020487A/en not_active Expired - Lifetime
- 1997-09-23 AR ARP970104362A patent/AR013838A1/es not_active Application Discontinuation
- 1997-09-23 PE PE1997000855A patent/PE110398A1/es active IP Right Grant
- 1997-09-23 EG EG98697A patent/EG23861A/xx active
-
1998
- 1998-02-27 TW TW086113832A patent/TW470746B/zh not_active IP Right Cessation
- 1998-09-21 HK HK98110796A patent/HK1009807A1/xx not_active IP Right Cessation
-
1999
- 1999-03-22 NO NO19991382A patent/NO323980B1/no not_active IP Right Cessation
-
2009
- 2009-06-05 JP JP2009135901A patent/JP2009242407A/ja active Pending
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