AR013838A1 - Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos - Google Patents
Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratosInfo
- Publication number
- AR013838A1 AR013838A1 ARP970104362A ARP970104362A AR013838A1 AR 013838 A1 AR013838 A1 AR 013838A1 AR P970104362 A ARP970104362 A AR P970104362A AR P970104362 A ARP970104362 A AR P970104362A AR 013838 A1 AR013838 A1 AR 013838A1
- Authority
- AR
- Argentina
- Prior art keywords
- olanzapine
- dihydrates
- methyl
- substantially pure
- piperazinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un proceso para preparar 2-metil-4-(metil-1-piperazinil)-1OH-tieno[2,3-b] 1,5 benzodiacepina (denominada en la presente olanzapina y ciertosintermediarios dihidratos. La olanzapina resulta util en el tratamiento de pacientes psicoticos, yactu almente se está investigando dicha aplicacion. Lossolicitantes han descubierto que la olanzapina forma II es la forma anhidro más estable de olanzapina, y proporciona una formulacion anhidro estable concaracterísticas farmacéuticamentedeseables. (Ve r patente europea 733635). Se requiere condiciones de preparacion controladas para asegurar una olanzapina deForma II sustancialmente pura ( denominada en la presente Forma II); sin embargo los solicitantes han descubierto unproceso para prepar ar la Forma IIdeseada utilizando un intermedio olanzapina dihidrato en condiciones acuosas. En ciertas situaciones, la Formula II que ha sido preparada a partir de unsolvente acuoso puede resultar particularmente ventajosa.Dicho material Forma II resulte sustancialmente libre de todos los residuos de solvente orgánico.Este proceso puede proporcionar unmétodo ecologico especialmente deseado para proporcionar la Forma II en cuestion. La invencion que sereivindicaproporcion olazapina dihidra to que resulta especialmente util como intermedio para la preparacion de olazapina Forma II. La forma cristalina puede serespecialmente ventajosa. Un proceso para preparar la Forma II sustancialmente puraque consiste en secar una olanzapina dihi drato hasta que se prepara laForma II deseada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2648796P | 1996-09-23 | 1996-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013838A1 true AR013838A1 (es) | 2001-01-31 |
Family
ID=21832120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104362A AR013838A1 (es) | 1996-09-23 | 1997-09-23 | Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6020487A (es) |
| EP (1) | EP0831098B1 (es) |
| JP (2) | JP2001500877A (es) |
| KR (1) | KR100560015B1 (es) |
| CN (1) | CN1122036C (es) |
| AR (1) | AR013838A1 (es) |
| AT (1) | ATE209208T1 (es) |
| AU (1) | AU719441B2 (es) |
| BR (1) | BR9712100A (es) |
| CA (1) | CA2265712C (es) |
| CO (1) | CO4910140A1 (es) |
| CZ (1) | CZ299248B6 (es) |
| DE (1) | DE69708428T2 (es) |
| DK (1) | DK0831098T3 (es) |
| EA (1) | EA001642B1 (es) |
| EG (1) | EG23861A (es) |
| ES (1) | ES2166051T3 (es) |
| HK (1) | HK1009807A1 (es) |
| HU (1) | HU226484B1 (es) |
| ID (1) | ID27275A (es) |
| IL (1) | IL128962A (es) |
| IN (1) | IN187156B (es) |
| MY (1) | MY125565A (es) |
| NO (1) | NO323980B1 (es) |
| NZ (1) | NZ334448A (es) |
| PE (1) | PE110398A1 (es) |
| PL (3) | PL194565B1 (es) |
| PT (1) | PT831098E (es) |
| RS (1) | RS49598B (es) |
| SI (1) | SI0831098T1 (es) |
| SV (1) | SV1997000081A (es) |
| TR (1) | TR199900640T2 (es) |
| TW (1) | TW470746B (es) |
| UA (1) | UA59371C2 (es) |
| WO (1) | WO1998012199A1 (es) |
| ZA (1) | ZA978515B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1313742A1 (en) * | 2000-08-31 | 2003-05-28 | Dr. Reddy's Laboratories Ltd. | Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine |
| US6740753B2 (en) | 2001-01-04 | 2004-05-25 | Geneva Pharmaceuticals, Inc. | Olanzapine crystal modification |
| WO2003037903A1 (en) * | 2001-10-29 | 2003-05-08 | Dr. Reddy's Laboratories Ltd. | Olanzapine dihydrate-ii a process for its preparation and use thereof |
| EP1470130A2 (en) | 2001-12-24 | 2004-10-27 | Sun Pharmaceuticals Industries Ltd. | Crystalline form i of 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno 2,3-b 1,5 benzodiazepine |
| WO2003091260A1 (en) * | 2002-04-23 | 2003-11-06 | Dr. Reddy's Laboratories Limited | Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof |
| ATE500258T1 (de) * | 2002-05-31 | 2011-03-15 | Sandoz Ag | Verfahren zur herstellung von olanzapin form i |
| SI21270A (sl) | 2002-07-15 | 2004-02-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Kristalne oblike olanzapina in postopki za njihovo pripravo |
| AU2003300324A1 (en) * | 2002-12-24 | 2004-07-22 | Teva Pharmaceutical Industries Ltd. | Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms |
| WO2005049090A2 (en) * | 2003-11-18 | 2005-06-02 | 3M Innovative Properties Company | Olanzapine containing transdermal drug delivery compositions |
| PT1611139E (pt) * | 2003-12-22 | 2008-07-17 | Teva Pharma | Métodos de preparação de olanzapina |
| ATE504588T1 (de) | 2004-01-27 | 2011-04-15 | Synthon Bv | Stabile salze von olanzapin |
| US20070072845A1 (en) * | 2004-02-19 | 2007-03-29 | Davuluri Rammohan Rao | Process for the preparation of olanzapine form 1 useful as antipsychotic drug |
| ES2289974T1 (es) * | 2004-07-14 | 2008-02-16 | Shasun Chemicals And Drugs Limited | Metodo mejorado para producir la forma i de la olanzapina. |
| ES2253091B1 (es) | 2004-07-27 | 2007-02-01 | Inke, S.A. | Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo. |
| ES2303462B1 (es) | 2004-09-06 | 2009-06-05 | Shasun Chemicals And Drugs Limited | Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura. |
| KR20130030305A (ko) * | 2004-11-16 | 2013-03-26 | 엘란 파마 인터내셔널 리미티드 | 주사가능한 나노입자형 올란자핀 제형 |
| US7834176B2 (en) | 2006-01-26 | 2010-11-16 | Sandoz Ag | Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E |
| CA2591644A1 (en) * | 2007-06-14 | 2008-12-14 | Apotex Pharmachem Inc. | Novel processes to form-i of olanzapine |
| EP2486913A1 (en) | 2011-02-14 | 2012-08-15 | Labtec GmbH | Rapidly disintegrating oral film formulation for Olanzapin |
| JP6008734B2 (ja) * | 2012-12-20 | 2016-10-19 | 株式会社トクヤマ | オランザピンｉｉ型結晶の製造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5302716A (en) * | 1986-01-16 | 1994-04-12 | Schering Corporation | Fused benzazepines |
| CA2002596A1 (en) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates of b-lactam antibiotic |
| US5229382A (en) * | 1990-04-25 | 1993-07-20 | Lilly Industries Limited | 2-methyl-thieno-benzodiazepine |
| GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
| NZ247703A (en) * | 1992-05-29 | 1995-07-26 | Lilly Industries Ltd | Thienobenzdiazepine derivatives and medicaments thereof |
| US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
| US5602124A (en) * | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
| EG24221A (en) * | 1995-03-24 | 2008-11-10 | Lilly Co Eli | Process for preparing olanzapine |
| EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
| US5637584A (en) * | 1995-03-24 | 1997-06-10 | Eli Lilly And Company | Solvate of olanzapine |
| US5631250A (en) * | 1995-03-24 | 1997-05-20 | Eli Lilly And Company | Process and solvate of 2-methyl-thieno-benzodiazepine |
| BR9711541A (pt) * | 1996-09-23 | 1999-08-24 | Lilly Co Eli | Dihidrato d de olanzapina |
-
1997
- 1997-09-02 ZA ZA978515A patent/ZA978515B/xx unknown
- 1997-09-18 CA CA002265712A patent/CA2265712C/en not_active Expired - Lifetime
- 1997-09-18 PL PL97332482A patent/PL194565B1/pl unknown
- 1997-09-18 AU AU44841/97A patent/AU719441B2/en not_active Expired
- 1997-09-18 NZ NZ334448A patent/NZ334448A/en not_active IP Right Cessation
- 1997-09-18 BR BR9712100-2A patent/BR9712100A/pt not_active Application Discontinuation
- 1997-09-18 PL PL381479A patent/PL196068B1/pl unknown
- 1997-09-18 CN CN97198137A patent/CN1122036C/zh not_active Expired - Lifetime
- 1997-09-18 EA EA199900326A patent/EA001642B1/ru not_active IP Right Cessation
- 1997-09-18 HU HU0000066A patent/HU226484B1/hu unknown
- 1997-09-18 UA UA99031635A patent/UA59371C2/uk unknown
- 1997-09-18 RS YUP-155/99A patent/RS49598B/sr unknown
- 1997-09-18 IL IL12896297A patent/IL128962A/xx not_active IP Right Cessation
- 1997-09-18 WO PCT/US1997/016499 patent/WO1998012199A1/en not_active Application Discontinuation
- 1997-09-18 JP JP10514842A patent/JP2001500877A/ja not_active Withdrawn
- 1997-09-18 PL PL381478A patent/PL196069B1/pl unknown
- 1997-09-18 KR KR1019997002424A patent/KR100560015B1/ko not_active IP Right Cessation
- 1997-09-18 TR TR1999/00640T patent/TR199900640T2/xx unknown
- 1997-09-18 CZ CZ0099099A patent/CZ299248B6/cs not_active IP Right Cessation
- 1997-09-18 ID IDW990058D patent/ID27275A/id unknown
- 1997-09-19 IN IN1736CA1997 patent/IN187156B/en unknown
- 1997-09-22 AT AT97307383T patent/ATE209208T1/de active
- 1997-09-22 SV SV1997000081A patent/SV1997000081A/es not_active Application Discontinuation
- 1997-09-22 CO CO97055061A patent/CO4910140A1/es unknown
- 1997-09-22 DE DE69708428T patent/DE69708428T2/de not_active Expired - Lifetime
- 1997-09-22 SI SI9730288T patent/SI0831098T1/xx unknown
- 1997-09-22 ES ES97307383T patent/ES2166051T3/es not_active Expired - Lifetime
- 1997-09-22 MY MYPI97004392A patent/MY125565A/en unknown
- 1997-09-22 DK DK97307383T patent/DK0831098T3/da active
- 1997-09-22 PT PT97307383T patent/PT831098E/pt unknown
- 1997-09-22 EP EP97307383A patent/EP0831098B1/en not_active Expired - Lifetime
- 1997-09-23 US US08/935,884 patent/US6020487A/en not_active Expired - Lifetime
- 1997-09-23 AR ARP970104362A patent/AR013838A1/es not_active Application Discontinuation
- 1997-09-23 PE PE1997000855A patent/PE110398A1/es active IP Right Grant
- 1997-09-23 EG EG98697A patent/EG23861A/xx active
-
1998
- 1998-02-27 TW TW086113832A patent/TW470746B/zh not_active IP Right Cessation
- 1998-09-21 HK HK98110796A patent/HK1009807A1/xx not_active IP Right Cessation
-
1999
- 1999-03-22 NO NO19991382A patent/NO323980B1/no not_active IP Right Cessation
-
2009
- 2009-06-05 JP JP2009135901A patent/JP2009242407A/ja active Pending
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| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |