ATE209208T1 - Zwischenprodukte und verfahren zur herstellung olanzapin - Google Patents

Zwischenprodukte und verfahren zur herstellung olanzapin

Info

Publication number
ATE209208T1
ATE209208T1 AT97307383T AT97307383T ATE209208T1 AT E209208 T1 ATE209208 T1 AT E209208T1 AT 97307383 T AT97307383 T AT 97307383T AT 97307383 T AT97307383 T AT 97307383T AT E209208 T1 ATE209208 T1 AT E209208T1
Authority
AT
Austria
Prior art keywords
olnzapine
producing
intermediate products
products
producing olnzapine
Prior art date
Application number
AT97307383T
Other languages
English (en)
Inventor
Charles Arthur Bunnell
Samuel Dean Larsen
John Richard Nichols
Susan Marie Reutzel
Gregory Alan Stephenson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE209208(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE209208T1 publication Critical patent/ATE209208T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
AT97307383T 1996-09-23 1997-09-22 Zwischenprodukte und verfahren zur herstellung olanzapin ATE209208T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23

Publications (1)

Publication Number Publication Date
ATE209208T1 true ATE209208T1 (de) 2001-12-15

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97307383T ATE209208T1 (de) 1996-09-23 1997-09-22 Zwischenprodukte und verfahren zur herstellung olanzapin

Country Status (36)

Country Link
US (1) US6020487A (de)
EP (1) EP0831098B1 (de)
JP (2) JP2001500877A (de)
KR (1) KR100560015B1 (de)
CN (1) CN1122036C (de)
AR (1) AR013838A1 (de)
AT (1) ATE209208T1 (de)
AU (1) AU719441B2 (de)
BR (1) BR9712100A (de)
CA (1) CA2265712C (de)
CO (1) CO4910140A1 (de)
CZ (1) CZ299248B6 (de)
DE (1) DE69708428T2 (de)
DK (1) DK0831098T3 (de)
EA (1) EA001642B1 (de)
EG (1) EG23861A (de)
ES (1) ES2166051T3 (de)
HK (1) HK1009807A1 (de)
HU (1) HU226484B1 (de)
ID (1) ID27275A (de)
IL (1) IL128962A (de)
IN (1) IN187156B (de)
MY (1) MY125565A (de)
NO (1) NO323980B1 (de)
NZ (1) NZ334448A (de)
PE (1) PE110398A1 (de)
PL (3) PL196068B1 (de)
PT (1) PT831098E (de)
RS (1) RS49598B (de)
SI (1) SI0831098T1 (de)
SV (1) SV1997000081A (de)
TR (1) TR199900640T2 (de)
TW (1) TW470746B (de)
UA (1) UA59371C2 (de)
WO (1) WO1998012199A1 (de)
ZA (1) ZA978515B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004507548A (ja) * 2000-08-31 2004-03-11 ドクター・レディーズ・ラボラトリーズ・リミテッド オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法
US6740753B2 (en) * 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
WO2003037903A1 (en) * 2001-10-29 2003-05-08 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
JP4530664B2 (ja) 2001-12-24 2010-08-25 サン・ファーマシューティカル・インダストリーズ・リミテッド ２−メチル−４−（４−メチル−１−ピペラジニル）−１０Ｈ−チエノ［２，３−ｂ］［１，５］ベンゾジアゼピンの結晶形Ｉ、この結晶形Ｉの製造方法、及び医薬組成物
AU2003243153A1 (en) * 2002-04-23 2003-11-10 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
WO2003101997A1 (en) 2002-05-31 2003-12-11 Geneva Pharmaceuticals, Inc. Process of preparation of olanzapine form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
WO2004058773A1 (en) * 2002-12-24 2004-07-15 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
WO2005049090A2 (en) * 2003-11-18 2005-06-02 3M Innovative Properties Company Olanzapine containing transdermal drug delivery compositions
PT1611139E (pt) * 2003-12-22 2008-07-17 Teva Pharma Métodos de preparação de olanzapina
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
EP1716154A1 (de) * 2004-02-19 2006-11-02 Neuland Laboratories Ltd Verfahren zur herstellung der form 1 von olanzapin, die sich als antipsychotisches arzneimittel eignet
DE05783995T1 (de) * 2004-07-14 2007-10-11 Shasun Chemicals and Drugs Ltd., Chennai Verbessertes verfahren zur herstellung von form i aus olanzapin
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
US7829700B2 (en) 2004-09-06 2010-11-09 Shasun Chemicals And Drugs Limited Process for preparation of a pharmaceutically pure polymorphic form I of Olanzapine
US7910577B2 (en) * 2004-11-16 2011-03-22 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (de) 2011-02-14 2012-08-15 Labtec GmbH Orale Filmformulierungen für Olanzapin mit schneller Zersetzung
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
PT582368E (pt) * 1992-05-29 2001-05-31 Lilly Co Eli Derivados de tienobenzodiazepina para o tratamento de doencas de cns
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
KR100516088B1 (ko) * 1996-09-23 2005-09-22 일라이 릴리 앤드 캄파니 올란자핀 이수화물 ｄ

Also Published As

Publication number Publication date
JP2001500877A (ja) 2001-01-23
PT831098E (pt) 2002-04-29
CN1234802A (zh) 1999-11-10
TW470746B (en) 2002-01-01
PL196068B1 (pl) 2007-12-31
KR100560015B1 (ko) 2006-03-15
CA2265712A1 (en) 1998-03-26
CZ299248B6 (cs) 2008-05-28
NO991382D0 (no) 1999-03-22
US6020487A (en) 2000-02-01
ZA978515B (en) 1999-03-23
UA59371C2 (uk) 2003-09-15
ID27275A (id) 2001-03-22
YU15599A (sh) 2001-12-26
EP0831098A3 (de) 1998-04-29
EA001642B1 (ru) 2001-06-25
JP2009242407A (ja) 2009-10-22
IN187156B (de) 2002-02-16
IL128962A0 (en) 2000-02-17
EG23861A (en) 2007-11-18
PL196069B1 (pl) 2007-12-31
NO991382L (no) 1999-03-22
EA199900326A1 (ru) 1999-08-26
AR013838A1 (es) 2001-01-31
SV1997000081A (es) 1999-01-14
AU719441B2 (en) 2000-05-11
IL128962A (en) 2003-01-12
EP0831098B1 (de) 2001-11-21
TR199900640T2 (xx) 1999-06-21
BR9712100A (pt) 1999-08-31
RS49598B (sr) 2007-06-04
CN1122036C (zh) 2003-09-24
HU226484B1 (en) 2009-03-02
HUP0000066A3 (en) 2000-11-28
KR20000048520A (ko) 2000-07-25
DK0831098T3 (da) 2002-05-21
CA2265712C (en) 2006-10-31
CO4910140A1 (es) 2000-04-24
ES2166051T3 (es) 2002-04-01
NZ334448A (en) 2000-08-25
WO1998012199A1 (en) 1998-03-26
PE110398A1 (es) 1999-01-14
NO323980B1 (no) 2007-07-30
DE69708428T2 (de) 2002-07-04
SI0831098T1 (en) 2002-04-30
CZ99099A3 (cs) 1999-11-17
PL194565B1 (pl) 2007-06-29
HK1009807A1 (en) 1999-06-11
MY125565A (en) 2006-08-30
AU4484197A (en) 1998-04-14
PL332482A1 (en) 1999-09-13
DE69708428D1 (de) 2002-01-03
EP0831098A2 (de) 1998-03-25
HUP0000066A2 (hu) 2000-06-28

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